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Article ; Online: Peer review report 1 on “Surgical versus percutaneous techniques for peritoneal dialysis catheter placement

Andreas Bourdoumis

Annals of Medicine and Surgery, Vol 5, Iss S1, p S

A meta-analysis of the outcomes”

2016 Volume 180

Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Does the mineral content of tap water correlate with urinary calculus composition?

Michael, Kirolos G F T / Michael, Sarah / Abusada, Ehab / Srirangam, Shalom J / Bourdoumis, Andreas / Surange, Raveendra

Urolithiasis

2022 Volume 50, Issue 6, Page(s) 691–699

Abstract: The association between the mineral content of drinking water and urolithiasis remains elusive. The aim of this study is to investigate whether the mineral composition of tap water correlates with urinary calculus composition. Patients with calculi that ... ...

Abstract	The association between the mineral content of drinking water and urolithiasis remains elusive. The aim of this study is to investigate whether the mineral composition of tap water correlates with urinary calculus composition. Patients with calculi that underwent biochemical analysis at two urological centres in the North-West of England between November 2015 and December 2020 were included. Calculus composition was reviewed with respect to patient demographics, serum biochemical variables, and water mineral composition data obtained from the local water supply company using patient postcodes. 1711 urinary tract calculi from 1518 patients, living in 87 water supply zones were included. Water sodium concentration was an independent predictor of mixed calcium oxalate/uric acid calculi (OR 1.157, p < 0.001) and a negative independent predictor of calcium oxalate monohydrate (OR 0.896, p = 0.001) and dihydrate (OR 0.742, p = 0.034) calculi. Moreover, the magnesium-to-calcium ratio of tap water was a negative independent predictor of calcium oxalate monohydrate calculi (OR < 0.001, p = < 0.001), while tap water magnesium concentration inversely correlated with the percentage of calcium oxalate within calculi (r
MeSH term(s)	Humans ; Calcium Oxalate/analysis ; Magnesium ; Calcium/analysis ; Uric Acid/analysis ; Drinking Water/analysis ; Urinary Calculi/etiology ; Urinary Calculi/chemistry ; Urolithiasis ; Minerals ; Urinary Tract/chemistry ; Sodium
Chemical Substances	Calcium Oxalate (2612HC57YE) ; Magnesium (I38ZP9992A) ; Calcium (SY7Q814VUP) ; Uric Acid (268B43MJ25) ; Drinking Water ; Minerals ; Sodium (9NEZ333N27)
Language	English
Publishing date	2022-08-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2703553-0
ISSN	2194-7236 ; 2194-7228
ISSN (online)	2194-7236
ISSN	2194-7228
DOI	10.1007/s00240-022-01358-7
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Article: Commentary/guest editorial on: "Treatment of fragmented and severely encrusted urethral D-J stent forgotten for 11 years through multimodal endourological methods".

Bourdoumis, Andreas / Calleary, John / Sountoulides, Petros

Urology annals

2019 Volume 11, Issue 1, Page(s) 113–114

Language	English
Publishing date	2019-01-30
Publishing country	India
Document type	Journal Article
ISSN	0974-7796
ISSN	0974-7796
DOI	10.4103/UA.UA_146_18
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Article ; Online: Optimizing Upper-Tract Imaging for Non-Visible Haematuria.

Michael, Kirolos G F T / Ravindranath, Navin / Michael, Sarah / German, Annette / Riley, Thomas / Calleary, John Gerard / Bourdoumis, Andreas / Surange, Raveendra

Urologia internationalis

2022 Volume 107, Issue 1, Page(s) 23–28

Abstract: Introduction: Non-visible haematuria (NVH) is associated with a small risk of upper-tract urothelial carcinoma (UTUC), though there is little consensus on its investigation, particularly with regard to upper-tract imaging. This study aimed to determine ... ...

Abstract	Introduction: Non-visible haematuria (NVH) is associated with a small risk of upper-tract urothelial carcinoma (UTUC), though there is little consensus on its investigation, particularly with regard to upper-tract imaging. This study aimed to determine whether the presentation of UTUC can guide investigation of NVH in patients under 60 years old. Methods: All patients investigated at our one-stop haematuria clinics under a cancer pathway were reviewed during a 5-year period, with all patients undergoing cystoscopy and upper-tract imaging. Retrospective analysis of all UTUC cases from our urological cancer multidisciplinary team meeting database over a 10-year period was also undertaken. Results: 2,129 patients with a median age of 67 years underwent urgent investigation for haematuria between March 2015 and February 2020. 449 cases presented with NVH, of whom 124 (27.6%) were under 60. Out of 21 cases of UTUC, only 2 presented with NVH; both were over the age of 60 years. Factors that independently predicted diagnosis with urinary-tract malignancy were age ≥60 (OR 3.70, p < 0.001), visible haematuria (OR 2.50, p = 0.006), and suspicious cystoscopic findings (OR 58.06, p < 0.001). Review of all 119 UTUC cases over 10 years found 6 cases (5.0%) presenting with NVH, with one (0.8%) also presenting under 60 years. Conclusion: Diagnosis with UTUC is rare in patients presenting with NVH under the age of 60 years. Routine use of CTU in this low-risk group is best avoided, with ultrasonography constituting a safer first-line upper-tract imaging modality. Guidelines that risk-stratify NVH patients may be effective in reducing unnecessary investigations.
MeSH term(s)	Humans ; Aged ; Middle Aged ; Hematuria/diagnosis ; Urinary Bladder Neoplasms/diagnosis ; Carcinoma, Transitional Cell/diagnosis ; Retrospective Studies ; Urologic Neoplasms
Language	English
Publishing date	2022-08-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	204045-1
ISSN	1423-0399 ; 0042-1138
ISSN (online)	1423-0399
ISSN	0042-1138
DOI	10.1159/000525458
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Article ; Online: Ex vivo Comparison of 2 Disposable versus a State-of-the-Art Reusable Ureterorenoscope.

Bourdoumis, Andreas / El Howairis, Mohammed El Fatih / Stephen, Binu / Buchholz, Noor

Urologia internationalis

2019 Volume 104, Issue 5-6, Page(s) 437–444

Abstract: Introduction: The success of upper urinary tract endoscopy on one hand and the high cost of purchase and maintenance of the scopes on the other hand have driven the development of disposable digital flexible ureterorenoscopy (fURS).: Materials and ... ...

Abstract	Introduction: The success of upper urinary tract endoscopy on one hand and the high cost of purchase and maintenance of the scopes on the other hand have driven the development of disposable digital flexible ureterorenoscopy (fURS). Materials and methods: We performed an ex vivo comparison of 2 disposable digital fURS from different companies with a state-of-the-art reusable endoscope from another well-established scope manufacturer. The scopes were tested comparing parameters such as instrument handling, irrigation flow, image quality, and deflection. For the disposable scopes, the latter 2 were evaluated both, before and after vigorous stress testing. Results: Expectedly, the most consistent finding among the 3 instruments was the marked decrease on irrigation flow following insertion of a working element, most notably a guidewire. Depth perception and ergonomic handling were comparable in all 3 instruments. Poststress testing revealed a significant loss of upward deflection in both disposable instruments, more so when an auxiliary instrument is inserted into the working channel. However, this did not appear to be the case in downward deflection. Conclusions: To our knowledge, this is the first study that used a vigorous stress testing protocol comparing disposable and reusable fURS. The newer generation disposable scope fared better than the older one. Results are encouraging and indicate that improvements are ongoing and progressing, bringing the quality of disposable scopes to the level that we are used to from our reusable high performance scopes while at the same time avoiding costly damage repairs. Continuous research and evidence-based interpretation of results in the absence of commercial bias are paramount to ensure this ongoing development.
MeSH term(s)	Disposable Equipment ; Equipment Design ; Equipment Reuse ; Ureteroscopes
Language	English
Publishing date	2019-08-29
Publishing country	Switzerland
Document type	Comparative Study ; Journal Article
ZDB-ID	204045-1
ISSN	1423-0399 ; 0042-1138
ISSN (online)	1423-0399
ISSN	0042-1138
DOI	10.1159/000502759
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Article ; Online: How well do we manage non-muscle invasive bladder tumors? A UK audit of real-life practices.

Sountoulides, Petros / Mutomba, Wilbert Fana / Bouras, Emmanouil / Lim, Jieqi / Bourdoumis, Andreas / Jain, Arun

Urologia

2020 Volume 87, Issue 3, Page(s) 142–148

Abstract: Objective: The aim of this study was to assess the quality of TURBT (transurethral resection of bladder tumor) using surrogate parameters and evaluate adherence to the guidelines regarding the management of bladder tumors.: Materials and methods: A ... ...

Abstract	Objective: The aim of this study was to assess the quality of TURBT (transurethral resection of bladder tumor) using surrogate parameters and evaluate adherence to the guidelines regarding the management of bladder tumors. Materials and methods: A clinical audit of all new diagnosis of bladder cancer was undertaken from January 2016 to January 2017. A total of 101 new bladder cancer cases were included. Surrogates of TURBT quality including presence of detrusor in the specimen, rate of re-TUR, presence of carcinoma in situ, and 3-month recurrence rates were analyzed. Adherence to guidelines regarding management of non-muscle invasive bladder cancer including time to re-TUR and utilization of single instillation chemotherapy was evaluated. Results: Absence of detrusor muscle in the specimen of the initial TURBT was noted in 22.8% of the cases. The chance of including muscle in the specimen was almost four-fold for tumors larger than 3 cm. A single instillation of intravesical chemotherapy following TURBT was administered in only 40% of eligible patients; 54.3% of patients had a re-TUR, the majority (61.3%) for high-grade non-muscle invasive bladder cancer on initial TURBT. Re-TUR was done on average 10 weeks after initial TURBT. The 3-month recurrence rate was 36.0% with larger tumors (>3 cm) being more prone to early recurrences. Early recurrences were not affected by intravesical instillations with bacillus Calmette-Guérin or mitomycin C although there was a positive association between the presence of carcinoma in situ on initial resection and early recurrences. Discussion and conclusion: One in two patients will have a re-TUR, and approximately one in two patients will have tumor on re-TUR. Single immediate chemotherapy instillations after TURBT are underutilized. The presence of carcinoma in situ on initial TURBT and tumor size were predictors of early recurrences.
MeSH term(s)	Aged ; Carcinoma in Situ/epidemiology ; Carcinoma in Situ/pathology ; Carcinoma in Situ/surgery ; Cystectomy/standards ; Guideline Adherence/statistics & numerical data ; Humans ; Medical Audit ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local/epidemiology ; Retrospective Studies ; United Kingdom ; Urinary Bladder Neoplasms/epidemiology ; Urinary Bladder Neoplasms/pathology ; Urinary Bladder Neoplasms/surgery
Language	English
Publishing date	2020-01-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	204043-8
ISSN	1724-6075 ; 0376-0057 ; 0391-5603
ISSN (online)	1724-6075
ISSN	0376-0057 ; 0391-5603
DOI	10.1177/0391560319899303
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Article ; Online: Is it the End for Urologic Pelvic Laparoscopic Surgery?

Athanasiadis, Grigorios / Bourdoumis, Andreas / Masood, Junaid

Surgical laparoscopy, endoscopy & percutaneous techniques

2017 Volume 27, Issue 3, Page(s) 139–146

Abstract: Aim: To scrutinize the rapid development of robotic versus traditional laparoscopic technique in pelvic urologic surgery.: Introduction: In the last few decades, advances in research and development have led to tremendous progress in medical ... ...

Abstract	Aim: To scrutinize the rapid development of robotic versus traditional laparoscopic technique in pelvic urologic surgery. Introduction: In the last few decades, advances in research and development have led to tremendous progress in medical diagnostics and treatment of disease. Minimally invasive surgery has moved from experimental to becoming the dominant form of surgical management across the surgical specialties. Laparoscopy is nowadays used widely in abdominal surgery, from simple diagnostic laparoscopy to complex colorectal and gynecologic cancer procedures. Methods: A literature search of electronic databases (PubMed, Medscape, Embase) using the key words: "pelvic laparoscopy, urologic oncology, robotic surgery, minimally invasive access" was performed for all relevant articles in the English language. Data were extrapolated from the abstracts alone to avoid subjective bias in drawing conclusions. Results: Telemedicine and telesurgery, the diagnostic and operative process is conducted from a distance. The surgeon uses computer-assisted surgery away from the bedside via a robotic system and performs the surgical task at hand. In pelvic urological cancer surgery the use of robotic technique expands to female and reconstructive procedures as well. The leap forward is so massive, that traditional laparoscopic surgery is starting to be considered less, with a growing number of organizations being now more interested in developing a robotic service. Minimally invasive surgical techniques aim to improve surgical outcome in conjunction with delivery of high-quality patient care. Quality studies demonstrating superiority and cost effectiveness are lacking, however. Conclusions: Although tremendous accomplishments took place over a few years, there is still a lot of ground to be covered in standardizing the learning process and evaluating the outcome from the application of new technologies in the field of robotic pelvic surgery.
Language	English
Publishing date	2017-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1475108-2
ISSN	1534-4908 ; 1530-4515 ; 1051-7200
ISSN (online)	1534-4908
ISSN	1530-4515 ; 1051-7200
DOI	10.1097/SLE.0000000000000406
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Article ; Online: Forming a stone in pelviureteric junction obstruction: Cause or effect?

Stasinou, Theodora / Bourdoumis, Andreas / Masood, Junaid

International braz j urol : official journal of the Brazilian Society of Urology

2017 Volume 43, Issue 1, Page(s) 13–19

Abstract: Objectives: To investigate a possible causal relationship for stone formation in pelviureteric junction obstruction and to outline management options.: Materials and methods: A literature search and evidence synthesis was conducted via electronic ... ...

Abstract	Objectives: To investigate a possible causal relationship for stone formation in pelviureteric junction obstruction and to outline management options. Materials and methods: A literature search and evidence synthesis was conducted via electronic databases in the English language using the key words pelviureteric junction obstruction; urolithiasis; hyperoxaluria; laparoscopic pyeloplasty; flexible nephroscopy; percutaneous nephrolithotomy, alone or in combination. Relevant articles were analysed to extract conclusions. Results: Concomitant pelviureteric junction obstruction (PUJO) and renal lithiasis has been reported only scarcely in the literature. Although PUJO has been extensively studied throughout the years, the presence of calculi in such a patient has not received equal attention and there is still doubt surrounding the pathophysiology and global management. Conclusions: Metabolic risk factors appear to play an important role, enough to justify metabolic evaluation in these patients. Urinary stasis and infection are well known factors predisposing to lithiasis and contribute to some extent. The choice for treatment is not always straightforward. Management should be tailored according to degree of obstruction, renal function, patient symptoms and stone size. Simultaneous treatment is feasible with the aid of minimally invasive operative techniques and laparoscopy in particular.
MeSH term(s)	Humans ; Hydronephrosis/complications ; Hydronephrosis/congenital ; Hydronephrosis/metabolism ; Hydronephrosis/surgery ; Kidney Pelvis/surgery ; Laparoscopy/methods ; Metabolic Diseases/complications ; Multicystic Dysplastic Kidney/complications ; Multicystic Dysplastic Kidney/metabolism ; Multicystic Dysplastic Kidney/surgery ; Nephrostomy, Percutaneous/methods ; Risk Factors ; Ureteral Obstruction/complications ; Ureteral Obstruction/metabolism ; Ureteral Obstruction/surgery ; Urolithiasis/complications ; Urolithiasis/metabolism ; Urolithiasis/surgery
Language	English
Publishing date	2017-01
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	2206649-4
ISSN	1677-6119 ; 1677-5538
ISSN (online)	1677-6119
ISSN	1677-5538
DOI	10.1590/S1677-5538.IBJU.2015.0515
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Article ; Online: Impact of Thermo-Expandable Memokath Ureteral Stent on Renal Function in the Management of Ureteroileal Anastomotic Stricture.

Miernik, Arkadiusz / Suarez-Ibarrola, Rodrigo / Bourdoumis, Andreas / Buchholz, Noor

Urologia internationalis

2018 Volume 101, Issue 3, Page(s) 313–319

Abstract: Purpose: The study aimed to assess the impact of the Memokath 051 stent (MK) on glomerular filtration rate (GFR) and split renal function in the management of ureteroileal anastomotic strictures.: Materials and methods: We treated 6 patients in the ... ...

Abstract	Purpose: The study aimed to assess the impact of the Memokath 051 stent (MK) on glomerular filtration rate (GFR) and split renal function in the management of ureteroileal anastomotic strictures. Materials and methods: We treated 6 patients in the ages of 66-77 years, 2 of whom had bilateral strictures, with a total of 8 ureteroileal strictures using the MK stent. Five patients had chronic kidney disease (CKD) prior to MK insertion. Mean time between conduit surgery and MK insertion was 28.4 months. Serum creatinine, GFR, and MAG-3 renography were determined before stent insertion and postoperatively at 3 months. Results: Postoperative complications at 3-month follow-up included migration in 2 patients, occlusion in 2 patients, and urinary tract infection in 4 patients. The mean stent indwelling time was 353.4 ± 169.3 days. Mean preoperative creatinine, GFR, right, and left split renal function were 158.3 ± 76.3 μmol/L, 43.6 ± 32.9 mL/min/1.73 m2, 52.8 ± 22.2%, and 47.1 ± 22.2%, respectively. Mean postoperative values were 168.1 ± 84 μmol/L (p = 0.84), 40.8 ± 28.4 mL/min/1.73 m2 (p = 0.56), 51.1 ± 18.3% (p = 1), and 48.8 ± 18.3% (p = 1), respectively. Conclusion: MK stent is a safe and efficient minimally invasive long-term treatment option to preserve GFR in patients who develop CKD through ureteroileal anastomotic stricture. In spite of MK stent insertion and alleviation of obstruction, it was presumably inserted too late to improve renal function.
MeSH term(s)	Aged ; Anastomosis, Surgical ; Constriction, Pathologic/surgery ; Cystectomy/adverse effects ; Female ; Glomerular Filtration Rate ; Humans ; Male ; Middle Aged ; Postoperative Period ; Radioisotope Renography ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/surgery ; Retrospective Studies ; Self Expandable Metallic Stents ; Ureter/pathology ; Ureter/surgery ; Ureteral Obstruction/surgery ; Urinary Diversion/adverse effects
Language	English
Publishing date	2018-09-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	204045-1
ISSN	1423-0399 ; 0042-1138
ISSN (online)	1423-0399
ISSN	0042-1138
DOI	10.1159/000492720
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Article ; Online: Amyloidosis of the Urinary Bladder: A Systematic Review and a Proposed Management Algorithm.

Pyrgidis, Nikolaos / Mykoniatis, Ioannis / Pegios, Vasileios F / Sokolakis, Ioannis / Hatzichristodoulou, Georgios / Bourdoumis, Andreas / Vakalopoulos, Ioannis / Sountoulides, Petros

Urology

2021 Volume 156, Page(s) e12–e19

Abstract: Objective: To propose an algorithm for the management of bladder amyloidosis based on a systematic review of the literature, given that the bladder is the second most commonly affected organ of the urinary tract in the course of systemic or localized ... ...

Abstract	Objective: To propose an algorithm for the management of bladder amyloidosis based on a systematic review of the literature, given that the bladder is the second most commonly affected organ of the urinary tract in the course of systemic or localized amyloidosis. Methods: We searched PubMed, Cochrane Library and Scopus databases utilizing PRISMA methodology from inception to November 30, 2020 (PROSPERO: CRD42020207855). Results: We included 76 studies with 184 patients (9 case series and 67 case reports). Presenting symptoms of bladder amyloidosis comprised of hematuria, irritative or obstructive urinary symptoms, and cystitis-like symptoms. The diagnosis of amyloidosis was established by histologic examination of specimens retrieved during transurethral resection of bladder lesions. Complete endoscopic resection, the cornerstone of management of localized disease, was feasible in 89.1% cases. The included patients were followed up for a mean of 54 months, within which 65 patients (35.3%) recurred. The time to first amyloidosis recurrence was 20 months (range: 1-168). Additionally, 16 individuals presented with concomitant bladder amyloidosis and bladder cancer, while 4 developed bladder malignancy during follow-up. Due to the frequent and early recurrences of patients with bladder amyloidosis, a check-up cystoscopy at 3, 12, and 24 months' after initial resection is recommended. Recurrences should be managed with transurethral resection, while intravesical instillations of dimethyl sulfoxide (DMSO) and cystectomy should be reserved for refractory cases. Conclusion: We propose a management algorithm for bladder amyloidosis based on the available evidence for this rare benign entity that mimics bladder cancer.
MeSH term(s)	Algorithms ; Amyloidosis/diagnosis ; Amyloidosis/therapy ; Humans ; Urinary Bladder Diseases/diagnosis ; Urinary Bladder Diseases/therapy
Language	English
Publishing date	2021-07-25
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2021.07.013
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