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  1. Article ; Online: Retraction.

    Brand, Toni M / Iida, Mari / Corrigan, Kelsey L / Braverman, Cara M / Coan, John P / Flanigan, Bailey G / Stein, Andrew P / Salgia, Ravi / Rolff, Jana / Kimple, Randall J / Wheeler, Deric L

    Science signaling

    2021  Volume 14, Issue 708, Page(s) eabn0168

    Language English
    Publishing date 2021-11-09
    Publishing country United States
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 2417226-1
    ISSN 1937-9145 ; 1945-0877
    ISSN (online) 1937-9145
    ISSN 1945-0877
    DOI 10.1126/scisignal.abn0168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Corrigendum to: "Nuclear EGFR as a molecular target in cancer" [Radiother Oncol 108 (2013) 370-77].

    Brand, Toni M / Iida, Mari / Luthar, Neha / Starr, Megan M / Huppert, Evan J / Wheeler, Deric L

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2018  Volume 130, Page(s) 195

    Language English
    Publishing date 2018-11-13
    Publishing country Ireland
    Document type Published Erratum
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2018.10.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1926: Show issues Location:
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  3. Article ; Online: Correction: Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer.

    Brand, Toni M / Hartmann, Stefan / Bhola, Neil E / Li, Hua / Zeng, Yan / O'Keefe, Rachel A / Ranall, Max V / Bandyopadhyay, Sourav / Soucheray, Margaret / Krogan, Nevan J / Kemp, Carolyn / Duvvuri, Umamaheswar / LaVallee, Theresa / Johnson, Daniel E / Ozbun, Michelle A / Bauman, Julie E / Grandis, Jennifer R

    Cancer research

    2022  Volume 82, Issue 17, Page(s) 3187

    Language English
    Publishing date 2022-09-02
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-22-1308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Editor's Note: Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer.

    Brand, Toni M / Hartmann, Stefan / Bhola, Neil E / Li, Hua / Zeng, Yan / O'Keefe, Rachel A / Ranall, Max V / Bandyopadhyay, Sourav / Soucheray, Margaret / Krogan, Nevan J / Kemp, Carolyn / Duvvuri, Umamaheswar / LaVallee, Theresa / Johnson, Daniel E / Ozbun, Michelle A / Bauman, Julie E / Grandis, Jennifer R

    Cancer research

    2022  Volume 82, Issue 17, Page(s) 3188

    Language English
    Publishing date 2022-09-02
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-22-1307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Correction: Human Papillomavirus Regulates HER3 Expression in Head and Neck Cancer: Implications for Targeted HER3 Therapy in HPV

    Brand, Toni M / Hartmann, Stefan / Bhola, Neil E / Peyser, Noah D / Li, Hua / Zeng, Yan / Wechsler, Erin Isaacson / Ranall, Max V / Bandyopadhyay, Sourav / Duvvuri, Umamaheswar / LaVallee, Theresa M / Jordan, Richard C K / Johnson, Daniel E / Grandis, Jennifer R

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2021  Volume 27, Issue 14, Page(s) 4129

    Language English
    Publishing date 2021-07-16
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-21-2141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4223: Show issues Location:
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  6. Article ; Online: KRAS mutant colorectal tumors: past and present.

    Brand, Toni M / Wheeler, Deric L

    Small GTPases

    2012  Volume 3, Issue 1, Page(s) 34–39

    Abstract: The treatment of metastatic colorectal cancer (mCRC) remains one of the largest hurdles in cancer therapeutics to date. The most advanced treatment option for mCRC patients are anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs) ... ...

    Abstract The treatment of metastatic colorectal cancer (mCRC) remains one of the largest hurdles in cancer therapeutics to date. The most advanced treatment option for mCRC patients are anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs) that bind to and inhibit the activity of EGFR. While the use of anti-EGFR mABs has had great impact in the treatment of mCRC, it has now been widely accepted that mCRC tumors with a mutation in the small GTPase KRAS do not respond to these therapies. KRAS mutations allow for EGFR independent activation of various oncogenic signaling cascades. In attempts to inhibit KRAS mutant tumor growth, BRAF, MEK and farsenyltransferase inhibitors have been used, however, their clinical efficacy is still accruing in the setting of CRC. Recent data suggests that various other inhibitors, including inhibitors of Src family kinases (SFK) and hepatocyte growth factor receptor (MET), may have potential preclinical and clinical success in KRAS mutant tumors. Additionally, it is becoming increasingly clear that different KRAS missense mutations may have varied biological responses to cetuximab, suggesting that cetuximab may still be a potential therapeutic option in some KRAS mutant tumors. In this review, we highlight the importance for both improved multimodality approaches for treating KRAS mutant mCRC tumors and stratification of KRAS mutations in response to different treatment regimes in order to optimize the best possible care for mCRC patients.
    MeSH term(s) Animals ; Antibodies, Monoclonal/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Colorectal Neoplasms/drug therapy ; Humans ; Male ; Proto-Oncogene Proteins/genetics ; Pyrimidines/pharmacology ; Thiazoles/pharmacology ; ras Proteins/genetics
    Chemical Substances Antibodies, Monoclonal ; Proto-Oncogene Proteins ; Pyrimidines ; Thiazoles ; ras Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2012-06-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2682247-7
    ISSN 2154-1256 ; 2154-1248
    ISSN (online) 2154-1256
    ISSN 2154-1248
    DOI 10.4161/sgtp.18751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Treating PIK3CA and EGFR overexpressing breast cancers with lithium citrate.

    Brand, Toni M / Wheeler, Deric L

    Cancer biology & therapy

    2011  Volume 11, Issue 3, Page(s) 368–370

    MeSH term(s) Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Citrates/therapeutic use ; Class I Phosphatidylinositol 3-Kinases ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Female ; Humans ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Prognosis
    Chemical Substances Citrates ; lithium citrate (5Z6E9K79YV) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Class I Phosphatidylinositol 3-Kinases (EC 2.7.1.137) ; PIK3CA protein, human (EC 2.7.1.137) ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2011-02-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2146305-0
    ISSN 1555-8576 ; 1538-4047
    ISSN (online) 1555-8576
    ISSN 1538-4047
    DOI 10.4161/cbt.11.3.14696
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5887: Show issues Location:
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  8. Article ; Online: Biomechanical testing of different fixation techniques for intraoperative proximal femur fractures: a technical note.

    Wendler, Toni / Fischer, Benjamin / Brand, Alexander / Weidling, Martin / Fakler, Johannes / Zajonz, Dirk / Osterhoff, Georg

    International biomechanics

    2022  Volume 9, Issue 1, Page(s) 27–32

    Abstract: Intraoperative proximal femoral fractures (IPFF) represent a rare but challenging complication of total hip arthroplasties. They usually occur as a longitudinal split. This pilot trial aimed to compare the biomechanical primary stability of different ... ...

    Abstract Intraoperative proximal femoral fractures (IPFF) represent a rare but challenging complication of total hip arthroplasties. They usually occur as a longitudinal split. This pilot trial aimed to compare the biomechanical primary stability of different fixation techniques for IPFF. Standardised longitudinal medial split fractures of the proximal femur (type II, Modified Mallory Classification) were created in artificial osteoporotic and non-osteoporotic composite femora after implantation of a cementless femoral stem. Five different fixation techniques were compared: cerclage band, cerclage wiring with one or two wires, and lag screw fixation with one or two lag screws. A quasi-static loading protocol was applied and failure loads were evaluated. The observed median failure loads were 4192N (3982N - 5189N) for one cerclage band, 4450N (3577N - 4927N) for one cerclage wire, 5016N (4175N - 5685N) for two cerclage wires, 6085N (5000N - 8907N) for one lag screw, and 4774N (4509N - 8502N) for two lag screws. Due to the wide range of failure loads within the experimental groups, there were no observable differences between the groups. All fixation techniques provided sufficient primary stability in osteoporotic and non-osteoporotic composite bones. Further cadaveric studies with larger sample sizes may be needed to confirm the results presented here.
    MeSH term(s) Humans ; Biomechanical Phenomena ; Bone Wires ; Femoral Fractures/surgery ; Fracture Fixation, Internal/methods ; Intraoperative Complications/surgery ; Pilot Projects
    Language English
    Publishing date 2022-11-19
    Publishing country England
    Document type Clinical Trial ; Journal Article
    ZDB-ID 2819173-0
    ISSN 2333-5432 ; 2333-5432
    ISSN (online) 2333-5432
    ISSN 2333-5432
    DOI 10.1080/23335432.2022.2142159
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  9. Article ; Online: Correction: Nuclear Epidermal Growth Factor Receptor Is a Functional Molecular Target in Triple-negative Breast Cancer.

    Brand, Toni M / Iida, Mari / Dunn, Emily F / Luthar, Neha / Kostopoulos, Kellie T / Corrigan, Kelsey L / Wleklinski, Matthew J / Yang, David / Wisinski, Kari B / Salgia, Ravi / Wheeler, Deric L

    Molecular cancer therapeutics

    2019  Volume 18, Issue 4, Page(s) 868

    Language English
    Publishing date 2019-04-01
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 2063563-1
    ISSN 1538-8514 ; 1535-7163
    ISSN (online) 1538-8514
    ISSN 1535-7163
    DOI 10.1158/1535-7163.MCT-18-1183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5750: Show issues Location:
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  10. Article ; Online: Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximab.

    Brand, Toni M / Iida, Mari / Wheeler, Deric L

    Cancer biology & therapy

    2011  Volume 11, Issue 9, Page(s) 777–792

    Abstract: The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase belonging to the HER family of receptor tyrosine kinases. Receptor activation upon ligand binding leads to down stream activation of the PI3K/AKT, RAS/RAF/MEK/ERK and PLCγ/PKC ... ...

    Abstract The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase belonging to the HER family of receptor tyrosine kinases. Receptor activation upon ligand binding leads to down stream activation of the PI3K/AKT, RAS/RAF/MEK/ERK and PLCγ/PKC pathways that influence cell proliferation, survival and the metastatic potential of tumor cells. Increased activation by gene amplification, protein overexpression or mutations of the EGFR has been identified as an etiological factor in a number of human epithelial cancers (e.g., NSCLC, CRC, glioblastoma and breast cancer). Therefore, targeting the EGFR has been intensely pursued as a cancer treatment strategy over the last two decades. To date, five EGFR inhibitors, including three small molecule tyrosine kinase inhibitors (TKIs) and two monoclonal antibodies have gained FDA approval for use in oncology. Both approaches to targeting the EGFR have shown clinical promise and the anti-EGFR antibody cetuximab is used to treat HNSCC and CRC. Despite clinical gains arising from use of cetuximab, both intrinsic resistance and the development of acquired resistance are now well recognized. In this review we focus on the biology of the EGFR, the role of EGFR in human cancer, the development of antibody-based anti-EGFR therapies and a summary of their clinical successes. Further, we provide an in depth discussion of described molecular mechanisms of resistance to cetuximab and potential strategies to circumvent this resistance.
    MeSH term(s) Animals ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cetuximab ; Clinical Trials as Topic ; Drug Resistance, Neoplasm ; ErbB Receptors/antagonists & inhibitors ; Humans
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antineoplastic Agents ; ErbB Receptors (EC 2.7.10.1) ; Cetuximab (PQX0D8J21J)
    Language English
    Publishing date 2011-05-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2146305-0
    ISSN 1555-8576 ; 1538-4047
    ISSN (online) 1555-8576
    ISSN 1538-4047
    DOI 10.4161/cbt.11.9.15050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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