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  1. Article ; Online: Post translational modifications of milk proteins in geographically diverse goat breeds.

    Rout, P K / Verma, M

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 5619

    Abstract: ... developmental biology and metabolism pathways. P ...

    Abstract Goat milk is a source of nutrition in difficult areas and has lesser allerginicity than cow milk. It is leading in the area for nutraceutical formulation and drug development using goat mammary gland as a bioreactor. Post translational modifications of a protein regulate protein function, biological activity, stabilization and interactions. The protein variants of goat milk from 10 breeds were studied for the post translational modifications by combining highly sensitive 2DE and Q-Exactive LC-MS/MS. Here we observed high levels of post translational modifications in 201 peptides of 120 goat milk proteins. The phosphosites observed for CSN2, CSN1S1, CSN1S2, CSN3 were 11P, 13P, 17P and 6P, respectively in 105 casein phosphopeptides. Whey proteins BLG and LALBA showed 19 and 4 phosphosites respectively. Post translational modification was observed in 45 low abundant non-casein milk proteins mainly associated with signal transduction, immune system, developmental biology and metabolism pathways. P
    MeSH term(s) Animals ; Female ; Goats/metabolism ; Milk Proteins/metabolism ; Phosphopeptides/metabolism ; Protein Processing, Post-Translational
    Chemical Substances Milk Proteins ; Phosphopeptides
    Language English
    Publishing date 2021-03-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-85094-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multiple hairy nodules in an adolescent girl.

    Gupta, Priyansh / Sirka, Chandra Shekhar / Shetty, Madhusmita / Rout, Arpita Nibedita

    Indian journal of dermatology, venereology and leprology

    2024  , Page(s) 1–3

    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 416068-x
    ISSN 0973-3922 ; 0019-5162 ; 0378-6323
    ISSN (online) 0973-3922
    ISSN 0019-5162 ; 0378-6323
    DOI 10.25259/IJDVL_939_2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 85: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: The Attitude of Medical Students Toward Voluntary Body Donation: A Single Institute Survey and Narrative Review of Global Trends.

    Ganapathy, Arthi / Joy, Praisy / Rout, Sipra / Gaikwad, Manisha

    Cureus

    2023  Volume 15, Issue 6, Page(s) e40775

    Abstract: ... body donation by strangers (p=0.043) and family members (p=0.035). The religion of the participants ... significantly affected their opinions on VBD and their willingness to pledge themselves (p=0.034 ...

    Abstract Introduction: Voluntary body donation (VBD) programs form the backbone of cadaveric teaching and learning in medical schools. It benefits the medical fraternity the most. Yet, there is a dearth of VBD practice among medical students. We aimed to understand the knowledge and attitude of first-year medical students in a tertiary institute with a systematic review of willingness toward VBD among undergraduate students worldwide.
    Methods:  The first-year medical undergraduates were given a 12-item questionnaire to assess their knowledge and attitude toward VBD. Statistical tests were applied to analyze the difference between the variables. We systematically searched Google Scholar, PubMed, and SCOPUS databases until October 15, 2022. Data concerning knowledge, awareness, and attitude toward VBD among undergraduates of medical backgrounds were extracted and analyzed qualitatively.
    Results: A total of 82.5% of students returned the completed responses. A significant association was seen between their attitudes toward whole body donation by strangers (p=0.043) and family members (p=0.035). The religion of the participants significantly affected their opinions on VBD and their willingness to pledge themselves (p=0.034). For the review, 20 studies were selected to be analyzed qualitatively. These studies included 4232 undergraduate students globally who were assessed for knowledge, awareness, and attitude toward VBD. Around 50% of the studies were published in India. The first study included was published in 2008. Seven studies were exclusively conducted on medical undergraduates, while the rest consisted of a mixed cohort. The attitude and knowledge of medical undergraduates on VBD were assessed via questionnaires containing both open-ended and closed-ended questions.
    Conclusion: Based on observations from our survey and review, we concluded that while undergraduate students have a highly positive attitude toward VBD, their rate of pledging is low. The most prominent barrier to this attitude is their experience with cadavers in the dissection hall. Hence, we recommend a revisit of cadaver handling practices and the establishment of appropriate protocols for safe and deferential cadaver handling.
    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.40775
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Construction of Nickel Molybdenum Sulfide/Black Phosphorous 3D Hierarchical Structure Toward High Performance Supercapacitor Electrodes.

    Pathak, Mansi / Mane, Pratap / Chakraborty, Brahmananda / Cho, Jung Sang / Jeong, Sang Mun / Rout, Chandra Sekhar

    Small (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e2310120

    Abstract: Supercapacitors (SCs) with outstanding versatility have a lot of potential applications in next-generation electronics. However, their practical uses are limited by their short working potential window and ultralow-specific capacity. Herein, the facile ... ...

    Abstract Supercapacitors (SCs) with outstanding versatility have a lot of potential applications in next-generation electronics. However, their practical uses are limited by their short working potential window and ultralow-specific capacity. Herein, the facile one-step in-situ hydrothermal synthesis is employed for the construction of a NiMo
    Language English
    Publishing date 2024-01-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202310120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Clipped Wings of "Jatayu"- A Double Set of Bilateral Sequential Bipedicled Flaps to Primarily Close the Secondary Defects on the Back Following the Harvest of a Trapezius Myo-cutaneous Flap.

    Rout, Sunil Kumar / Mallik, Mainak / Rajpoot, Akanksha / Pant, Priyanka

    Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

    2023  Volume 76, Issue 1, Page(s) 1351–1354

    Abstract: We report an innovative technique for closure of a large secondary donor-site defect (in a post-electric-burn primary defect in cervico-occipital area, reconstructed with Trapezius myo-cutaneous flap) by using a double set of sequential bilateral ... ...

    Abstract We report an innovative technique for closure of a large secondary donor-site defect (in a post-electric-burn primary defect in cervico-occipital area, reconstructed with Trapezius myo-cutaneous flap) by using a double set of sequential bilateral bipedicled flaps which resembled "Jatayu", the holy bird with clipped wings as per the epic "Ramayana".
    Language English
    Publishing date 2023-11-10
    Publishing country India
    Document type Journal Article
    ZDB-ID 1471137-0
    ISSN 0973-7707 ; 2231-3796 ; 0019-5421
    ISSN (online) 0973-7707
    ISSN 2231-3796 ; 0019-5421
    DOI 10.1007/s12070-023-04328-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5300: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Post translational modifications of milk proteins in geographically diverse goat breeds

    P. K. Rout / M. Verma

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 16

    Abstract: Abstract Goat milk is a source of nutrition in difficult areas and has lesser allerginicity than cow milk. It is leading in the area for nutraceutical formulation and drug development using goat mammary gland as a bioreactor. Post translational ... ...

    Abstract Abstract Goat milk is a source of nutrition in difficult areas and has lesser allerginicity than cow milk. It is leading in the area for nutraceutical formulation and drug development using goat mammary gland as a bioreactor. Post translational modifications of a protein regulate protein function, biological activity, stabilization and interactions. The protein variants of goat milk from 10 breeds were studied for the post translational modifications by combining highly sensitive 2DE and Q-Exactive LC-MS/MS. Here we observed high levels of post translational modifications in 201 peptides of 120 goat milk proteins. The phosphosites observed for CSN2, CSN1S1, CSN1S2, CSN3 were 11P, 13P, 17P and 6P, respectively in 105 casein phosphopeptides. Whey proteins BLG and LALBA showed 19 and 4 phosphosites respectively. Post translational modification was observed in 45 low abundant non-casein milk proteins mainly associated with signal transduction, immune system, developmental biology and metabolism pathways. Pasp is reported for the first time in 47 sites. The rare conserved peptide sequence of (SSSEE) was observed in αS1 and αS2 casein. The functional roles of identified phosphopeptides included anti-microbial, DPP-IV inhibitory, anti-inflammatory and ACE inhibitory. This is first report from tropics, investigating post translational modifications in casein and non-casein goat milk proteins and studies their interactions.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Enhanced IL-17 Producing and Maintained Cytolytic Effector Functions of Gut Mucosal CD161

    Thirugnanam, Siva / Walker, Edith M / Schiro, Faith / Aye, Pyone P / Rappaport, Jay / Rout, Namita

    Viruses

    2023  Volume 15, Issue 9

    Abstract: Previous studies have indicated that the loss of CD161-expressing ... ...

    Abstract Previous studies have indicated that the loss of CD161-expressing CD4
    MeSH term(s) Animals ; Humans ; CD8-Positive T-Lymphocytes ; Macaca mulatta ; HIV Infections ; Interleukin-17/therapeutic use ; Intestinal Mucosa ; Simian Acquired Immunodeficiency Syndrome/drug therapy ; Simian Immunodeficiency Virus
    Chemical Substances Interleukin-17
    Language English
    Publishing date 2023-09-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15091944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Drosophila melanogaster

    Rout, Pratiti / Preußner, Mathieu / Önel, Susanne Filiz

    Cells

    2022  Volume 11, Issue 3

    Abstract: Muscle fibers are multinucleated cells that arise during embryogenesis through the fusion of mononucleated myoblasts. Myoblast fusion is a lifelong process that is crucial for the growth and regeneration of muscles. Understanding the molecular mechanism ... ...

    Abstract Muscle fibers are multinucleated cells that arise during embryogenesis through the fusion of mononucleated myoblasts. Myoblast fusion is a lifelong process that is crucial for the growth and regeneration of muscles. Understanding the molecular mechanism of myoblast fusion may open the way for novel therapies in muscle wasting and weakness. Recent reports in
    MeSH term(s) Animals ; Cell Communication ; Cell Fusion ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Mammals/metabolism ; Muscle Fibers, Skeletal/metabolism ; Myoblasts/metabolism
    Chemical Substances Drosophila Proteins
    Language English
    Publishing date 2022-01-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11030321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Devising a selection strategy for the Jamunapari goat for improving lactation performance.

    Dige, M S / Rout, P K / Bhusan, S / Gowane, G R

    Tropical animal health and production

    2022  Volume 54, Issue 6, Page(s) 408

    Abstract: This study aimed to evaluate the genetic potential of the Jamunapari goat and formulate a selection strategy for improving lactation traits. The data set included 4049 phenotypic records for across parity milk yield at 90 days (MY90), 140 days (MY140), ... ...

    Abstract This study aimed to evaluate the genetic potential of the Jamunapari goat and formulate a selection strategy for improving lactation traits. The data set included 4049 phenotypic records for across parity milk yield at 90 days (MY90), 140 days (MY140), total milk yield (TMY), and lactation length (LL) obtained from the progeny of 83 sires and 1643 dams between the period 1990 and 2019. Animal model employing average information restricted maximum likelihood (AIREML) was used to estimate genetic parameters for milk yield traits and LL. The direct additive heritability estimates for across parity lactation traits that used repeatability model were 0.10 ± 0.03, 0.08 ± 0.03, and 0.12 ± 0.02 for MY90, MY140, and TMY, respectively, while it was low for LL (0.06 ± 0.02). The repeatability estimates were moderate ranging from 0.17 to 0.22 for milk yield traits and LL, indicating persistent performance over the parities. Animal permanent environment influence (c
    MeSH term(s) Animals ; Female ; Pregnancy ; Goats/genetics ; Milk ; Lactation/genetics ; Parity ; Maternal Inheritance
    Language English
    Publishing date 2022-11-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603363-5
    ISSN 1573-7438 ; 0049-4747
    ISSN (online) 1573-7438
    ISSN 0049-4747
    DOI 10.1007/s11250-022-03410-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2159: Show issues Location:
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  10. Article ; Online: Differential expression and regulation of HSP70 gene during growth phase in ruminants in response to heat stress.

    Kaushik, Rakesh / Goel, Anjana / Rout, P K

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 18310

    Abstract: ... gene expression and thermotolerance in age-specific manner in ruminants has not been analysed. Therefore m-RNA ... period. The m-RNA HSP70 expression level at 9-month age of animals was up-regulated and significantly ... heat stress tolerant (HST) individuals and the expression of m-RNA HSP70 was analysed at different ages ...

    Abstract Heat shock proteins regulate the physiological mechanism of heat stress adaptation at cellular level. The present investigation was carried out to analyse the HSP70 gene regulation in various growth stage in ruminants in peripheral blood mononuclear cells (PBMCs). The relationship between HSP gene expression and thermotolerance in age-specific manner in ruminants has not been analysed. Therefore m-RNA HSP70 expression level was examined in different age groups of Jamunpari goat during hot climatic conditions. The experiment was carried out in 32 animals of Jamunapari goat belonging to the age groups of 3-months, 9-months, 12-months, and adults (2-3 year). Total RNA was isolated from peripheral blood mononuclear cells. The physiological response such as rectal temperature (RT), respiration rate (RR) and heart rate (HR) was used as indicator to heat stress. Temperature Humidity Index (THI) was used as an indicator of severity of environmental stress. The THI range varied from 82.00-92.08 during experimental period. The m-RNA HSP70 expression level at 9-month age of animals was up-regulated and significantly higher than other age groups. It was observed that the level of HSP70 transcripts in PBMCs was highest at 9-month age group, and age-related decline in HSP70 expression was observed in adult age. Based on the physiological response, the contrasting heat-stress phenotypes were recognised as heat stress susceptible (HSS) and heat stress tolerant (HST) individuals and the expression of m-RNA HSP70 was analysed at different ages in response to chronic heat stress. The differential mRNA expression of HSS individuals at 3 and 9-month of age showed the highest fold expression than HST. Age and phenotype had significant effect (p < 0.01) on the crossing point (CP) value. The m-RNA HSP70 gene expression in different age groups was correlated with heat stress tolerance and this could be used as biomarker for breeders to analyse the HSP response in -vivo in ruminants.
    MeSH term(s) Animals ; Leukocytes, Mononuclear/metabolism ; Heat Stress Disorders/genetics ; Heat-Shock Response/genetics ; HSP70 Heat-Shock Proteins/metabolism ; Goats/genetics ; Goats/metabolism ; Gene Expression Regulation ; RNA/metabolism ; Hot Temperature
    Chemical Substances HSP70 Heat-Shock Proteins ; RNA (63231-63-0)
    Language English
    Publishing date 2022-10-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-22728-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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