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  1. Article: ZWERGE MIT DURCHSCHLAGSKRAFT. Nanotechnik gilt als Schlüsseltechnologie des 21. Jahrhunderts. Allerdings können die winzigen Partikel offenbar in jedes Gewebe im Körper eindringen - auch in das Gehirn. Welche Folgen das für den Organismus haben kann, beschreibt die Biologin Anna von Mikecz

    von Mikecz, Anna

    Gehirn & Geist

    2010  Volume -, Issue 3, Page(s) 58

    Language German
    Document type Article
    ZDB-ID 2072879-7
    ISSN 1618-8519
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5667: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Elegant Nematodes Improve Our Understanding of Human Neuronal Diseases, the Role of Pollutants and Strategies of Resilience.

    von Mikecz, Anna

    Environmental science & technology

    2023  Volume 57, Issue 44, Page(s) 16755–16763

    Abstract: The prevalence of neurodegenerative disorders such as Alzheimer's and Parkinson's disease are rising globally. The role of environmental pollution in neurodegeneration is largely unknown. Thus, this perspective advocates exposome research ... ...

    Abstract The prevalence of neurodegenerative disorders such as Alzheimer's and Parkinson's disease are rising globally. The role of environmental pollution in neurodegeneration is largely unknown. Thus, this perspective advocates exposome research in
    MeSH term(s) Animals ; Humans ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Alzheimer Disease ; Environmental Pollutants ; Genome-Wide Association Study ; Nematoda ; Neurons ; Disease Models, Animal
    Chemical Substances Environmental Pollutants
    Language English
    Publishing date 2023-10-24
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.3c04580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exposome, Molecular Pathways and One Health: The Invertebrate

    von Mikecz, Anna

    International journal of molecular sciences

    2022  Volume 23, Issue 16

    Abstract: Due to its preferred habitats in the environment, the free-living ... ...

    Abstract Due to its preferred habitats in the environment, the free-living nematode
    MeSH term(s) Animals ; Caenorhabditis elegans/genetics ; Disease Models, Animal ; Exposome ; Humans ; Nematoda/genetics ; One Health
    Language English
    Publishing date 2022-08-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23169084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pollution - bring the field into the lab.

    von Mikecz, Anna / Scharf, Andrea

    Nature

    2022  Volume 602, Issue 7897, Page(s) 386

    MeSH term(s) Air Pollutants ; Environmental Pollution/analysis ; Environmental Pollution/prevention & control
    Chemical Substances Air Pollutants
    Language English
    Publishing date 2022-02-12
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-022-00444-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
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    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  5. Article ; Online: Silica Nanoparticles Disclose a Detailed Neurodegeneration Profile throughout the Life Span of a Model Organism.

    Limke, Annette / Poschmann, Gereon / Stühler, Kai / Petzsch, Patrick / Wachtmeister, Thorsten / von Mikecz, Anna

    Journal of xenobiotics

    2024  Volume 14, Issue 1, Page(s) 135–153

    Abstract: The incidence of age-related neurodegenerative diseases is rising globally. However, the temporal sequence of neurodegeneration throughout adult life is poorly understood. To identify the starting points and schedule of neurodegenerative events, ... ...

    Abstract The incidence of age-related neurodegenerative diseases is rising globally. However, the temporal sequence of neurodegeneration throughout adult life is poorly understood. To identify the starting points and schedule of neurodegenerative events, serotonergic and dopaminergic neurons were monitored in the model organism
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649720-7
    ISSN 2039-4713 ; 2039-4713
    ISSN (online) 2039-4713
    ISSN 2039-4713
    DOI 10.3390/jox14010008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Thesis: Molekulare Mechanismen der systemischen Autoimmunität

    Mikecz, Anna von

    Prozessierung von nucleären Autoantigenen durch das Ubiquitin-Proteasomen-System

    (Berichte aus der Medizin)

    2004  

    Author's details Anna von Mikecz
    Series title Berichte aus der Medizin
    Keywords Autoantigen ; Antigen-Prozessierung ; Proteasom ; Ubiquitin
    Subject ATP-abhängiger Proteolysefaktor 1 ; Prosom ; Proteosom ; MCP ; Multicatalytic proteinase ; Multicatalytic endopeptidase complex ; EC 3.4.99.46 ; Ingensin ; Macropain ; Antigenprocessing ; Antigen processing
    Language German
    Size 48 S. : Ill., graph. Darst.
    Publisher Shaker
    Publishing place Aachen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Düsseldorf, Univ., Habil.-Schr., 2002
    HBZ-ID HT014185084
    ISBN 3-8322-3313-X ; 978-3-8322-3313-6
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2005 A 3771 order for loan Magazin

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  7. Article: How to keep up with the analysis of classic and emerging neurotoxins: Age-resolved fitness tests in the animal model

    Hering, Indra / Le, Dang Tri / von Mikecz, Anna

    EXCLI journal

    2022  Volume 21, Page(s) 344–353

    Abstract: The global chemical inventory includes neurotoxins that are mostly interrogated concerning the biological response in developing organisms. Effects of pollutants on adults receive less attention, although vulnerabilities can be expected throughout the ... ...

    Abstract The global chemical inventory includes neurotoxins that are mostly interrogated concerning the biological response in developing organisms. Effects of pollutants on adults receive less attention, although vulnerabilities can be expected throughout the entire life span in young, middle-aged and old individuals. We use the animal model
    Language English
    Publishing date 2022-01-31
    Publishing country Germany
    Document type Journal Article
    ISSN 1611-2156
    ISSN 1611-2156
    DOI 10.17179/excli2021-4626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Tire components, age and temperature accelerate neurodegeneration in C. elegans models of Alzheimer's and Parkinson's disease.

    Limke, Annette / Scharpf, Inge / Blesing, Fabienne / von Mikecz, Anna

    Environmental pollution (Barking, Essex : 1987)

    2023  Volume 328, Page(s) 121660

    Abstract: Increasingly, traffic-related air pollution is linked with Alzheimer's disease, Parkinson's disease and other neurodegenerative conditions. The molecular pathways underlying the epidemiologic observations are unknown. In this study, models of ... ...

    Abstract Increasingly, traffic-related air pollution is linked with Alzheimer's disease, Parkinson's disease and other neurodegenerative conditions. The molecular pathways underlying the epidemiologic observations are unknown. In this study, models of neurodegenerative disorders in the nematode Caenorhabditis elegans were used to investigate effects of the tire wear component nano silica. Life span-resolved exposition of reporter strain GRU102 that expresses the Alzheimer's peptide amyloid beta
    MeSH term(s) Animals ; Parkinson Disease ; Caenorhabditis elegans ; Alzheimer Disease ; Temperature ; Amyloid beta-Peptides/metabolism ; Disease Models, Animal
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2023-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2023.121660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2599: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Pollutants corrupt resilience pathways of aging in the nematode

    Scharf, Andrea / Limke, Annette / Guehrs, Karl-Heinz / von Mikecz, Anna

    iScience

    2022  Volume 25, Issue 9, Page(s) 105027

    Abstract: Delaying aging while prolonging health and lifespan is a major goal in aging research. One promising strategy is to focus on reducing negative interventions such as pollution and their accelerating effect on age-related degeneration and disease. Here, we ...

    Abstract Delaying aging while prolonging health and lifespan is a major goal in aging research. One promising strategy is to focus on reducing negative interventions such as pollution and their accelerating effect on age-related degeneration and disease. Here, we used the short-lived model organism
    Language English
    Publishing date 2022-08-28
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2022.105027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Effects of Airborne Nanoparticles on the Nervous System: Amyloid Protein Aggregation, Neurodegeneration and Neurodegenerative Diseases.

    von Mikecz, Anna / Schikowski, Tamara

    Nanomaterials (Basel, Switzerland)

    2020  Volume 10, Issue 7

    Abstract: How the environment contributes to neurodegenerative diseases such as Alzheimer's is not well understood. In recent years, science has found augmenting evidence that nano-sized particles generated by transport (e.g., fuel combustion, tire wear and brake ... ...

    Abstract How the environment contributes to neurodegenerative diseases such as Alzheimer's is not well understood. In recent years, science has found augmenting evidence that nano-sized particles generated by transport (e.g., fuel combustion, tire wear and brake wear) may promote Alzheimer's disease (AD). Individuals residing close to busy roads are at higher risk of developing AD, and nanomaterials that are specifically generated by traffic-related processes have been detected in human brains. Since AD represents a neurodegenerative disease characterized by amyloid protein aggregation, this review summarizes our current knowledge on the amyloid-generating propensity of traffic-related nanomaterials. Certain nanoparticles induce the amyloid aggregation of otherwise soluble proteins in in vitro laboratory settings, cultured neuronal cells and vertebrate or invertebrate animal models. We discuss the challenges for future studies, namely, strategies to connect the wet laboratory with the epidemiological data in order to elucidate the molecular bio-interactions of airborne nanomaterials and their effects on human health.
    Keywords covid19
    Language English
    Publishing date 2020-07-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano10071349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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