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Article: A case of Corynebacterium striatum endocarditis successfully treated with an early switch to oral antimicrobial therapy.

Biscarini, Simona / Colaneri, Marta / Mariani, Bianca / Pieri, Teresa Chiara / Bruno, Raffaele / Seminari, Elena

2021 Volume 29, Issue 1, Page(s) 138–144

Abstract: Patients with Corynebacterium striatum endocarditis are usually managed with long-term intravenous antibiotic therapy and hospitalization. Here we describe a case of a 76-year-old woman with hepatitis C virus (HCV) related cirrhosis who developed ... ...

Abstract	Patients with Corynebacterium striatum endocarditis are usually managed with long-term intravenous antibiotic therapy and hospitalization. Here we describe a case of a 76-year-old woman with hepatitis C virus (HCV) related cirrhosis who developed endocarditis due to Corynebacterium striatum associated with severe aortic regurgitation. To our knowledge, this is the first case to be successfully treated with an early switch to oral linezolid after three weeks of vancomycin. We performed a literature review using the PubMed database and found 27 cases which showed the enhanced virulence of this pathogen especially for long-term hospitalized patients with a frequent need of surgical treatment (44.4%) and long course of parenteral antimicrobial therapy, with vancomycin as drug of choice. There are no studies confirming the possibility of using oral treatment in non-diphtheritic Corynebacteria infective endocarditis. This case report provides us with the evidence that once the patient is in a stable condition, the efficacy and safety of linezolid might be similar to vancomycin administration. New trials and prospective studies are needed to confirm the opportunity of an early switch to oral therapy in this specific setting.
MeSH term(s)	Aged ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/therapeutic use ; Corynebacterium ; Endocarditis/drug therapy ; Endocarditis, Bacterial/drug therapy ; Female ; Humans ; Linezolid/therapeutic use ; Vancomycin/therapeutic use
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents ; Vancomycin (6Q205EH1VU) ; Linezolid (ISQ9I6J12J)
Language	English
Publishing date	2021-03-05
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2041081-5
ISSN	1124-9390
ISSN	1124-9390
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5576: Show issues

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Article: Clinical and microbiological characteristics of reactive infectious mucocutaneous eruption: A case series of 5 patients.

Vassallo, Camilla / Ruffo Di Calabria, Valentina / Isoletta, Eugenio / Biscarini, Simona / Di Filippo, Alessandro / Brazzelli, Valeria

JAAD case reports

2021 Volume 17, Page(s) 152–156

Language	English
Publishing date	2021-10-05
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834220-3
ISSN	2352-5126
ISSN	2352-5126
DOI	10.1016/j.jdcr.2021.09.029
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Article ; Online: In operando

Benaglia, Simone / Drakopoulou, Sofia / Biscarini, Fabio / Garcia, Ricardo

Nanoscale

2022 Volume 14, Issue 38, Page(s) 14146–14154

Abstract: Understanding the interplay between the nanomechanical properties of organic electronic materials and their electronic properties is central to developing sensors and transducers for applications ranging from immunosensing to e-skin. Controlling organic ... ...

Abstract	Understanding the interplay between the nanomechanical properties of organic electronic materials and their electronic properties is central to developing sensors and transducers for applications ranging from immunosensing to e-skin. Controlling organic device operations in aqueous electrolyte solutions and their mechanical compliance with the host tissue or living systems, as for instance in active implants for the recording or stimulation of neural signals, is still largely unexplored. Here, we implemented bimodal AFM to map the nanomechanical and structural properties of thin films made from poly(3,4-ethylenedioxythiophene):poly(styrene-sulfonate) (PEDOT:PSS), the most widely used conducting polymer blend, during operation as a microelectrode in an electrolyte solution. Nanomechanical maps showed the film consisting of a granular structure made from PEDOT:PSS regions embedded in the PSS matrix. The film swelled upon immersion in an aqueous solution.
Language	English
Publishing date	2022-10-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d2nr02177c
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Article ; Online: Daptomycin Pharmacokinetics and Pharmacodynamics in Patients on Methadone Substitution Therapy.

De Gregori, Simona / De Silvestri, Annalisa / Molinaro, Maria Delfina / Monzillo, Vincenzina / Biscarini, Simona / Colaneri, Marta / Gallazzi, Ilaria / Bartoli, Antonella / Bruno, Raffaele / Seminari, Elena

European journal of drug metabolism and pharmacokinetics

2021 Volume 46, Issue 4, Page(s) 547–554

Abstract: Background and objective: When administered for severe infections in intravenous drug users (IDUs) at a daily dose of 6 mg/kg, daptomycin displayed abnormal pharmacokinetic parameters compared with those seen in healthy volunteers; specifically, ... ...

Abstract	Background and objective: When administered for severe infections in intravenous drug users (IDUs) at a daily dose of 6 mg/kg, daptomycin displayed abnormal pharmacokinetic parameters compared with those seen in healthy volunteers; specifically, decreased trough and maximum concentrations (C Methods: Antibiotic treatment included daptomycin (12 mg/kg daily) in combination with an antistaphylococcal β-lactam (cefazolin 2 g three times a day). The minimum inhibitory concentration (MIC) of Staphylococcus aureus isolated through blood cultures was used to calculate pharmacokinetic and pharmacodynamic parameters such as the ratio of the area under the concentration-time curve over 24 h to the MIC (AUC Results: Five IDUs hospitalized for IE were enrolled. The mean measured daptomycin C Conclusions: Treatment of Staphylococcus aureus IE in IDUs on methadone treatment requires the use of high daptomycin daily doses in order to achieve satisfactory pharmacodynamic parameters. Close monitoring of the daptomycin plasma concentration is suggested.
MeSH term(s)	Adult ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/pharmacology ; Area Under Curve ; Daptomycin/administration & dosage ; Daptomycin/pharmacokinetics ; Daptomycin/pharmacology ; Dose-Response Relationship, Drug ; Drug Interactions ; Endocarditis, Bacterial/drug therapy ; Endocarditis, Bacterial/microbiology ; Female ; Half-Life ; Humans ; Male ; Methadone/administration & dosage ; Methadone/pharmacology ; Microbial Sensitivity Tests ; Middle Aged ; Opiate Substitution Treatment ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/isolation & purification ; Tissue Distribution
Chemical Substances	Anti-Bacterial Agents ; Daptomycin (NWQ5N31VKK) ; Methadone (UC6VBE7V1Z)
Language	English
Publishing date	2021-07-06
Publishing country	France
Document type	Journal Article
ZDB-ID	196729-0
ISSN	2107-0180 ; 0398-7639 ; 0378-7966
ISSN (online)	2107-0180
ISSN	0398-7639 ; 0378-7966
DOI	10.1007/s13318-021-00690-4
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Zs.A 1236: Show issues

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Article ; Online: Mucormycosis in CAPA, a Possible Fungal Super-Infection.

Saltini, Paola / Palomba, Emanuele / Castelli, Valeria / Fava, Marco / Alagna, Laura / Biscarini, Simona / Mantero, Marco / Blasi, Francesco / Grancini, Anna / Bandera, Alessandra / Gori, Andrea / Muscatello, Antonio / Lombardi, Andrea

Journal of fungi (Basel, Switzerland)

2021 Volume 7, Issue 9

Abstract: The occurrence of pulmonary fungal superinfection due ... ...

Abstract	The occurrence of pulmonary fungal superinfection due to
Language	English
Publishing date	2021-08-28
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof7090708
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Article ; Online: Label-free immunodetection of α-synuclein by using a microfluidics coplanar electrolyte-gated organic field-effect transistor.

Ricci, Simona / Casalini, Stefano / Parkula, Vitaliy / Selvaraj, Meenu / Saygin, Gulseren Deniz / Greco, Pierpaolo / Biscarini, Fabio / Mas-Torrent, Marta

Biosensors & bioelectronics

2020 Volume 167, Page(s) 112433

Abstract: The aggregation of α-synuclein is a critical event in the pathogenesis of neurological diseases, such as Parkinson or Alzheimer. Here, we present a label-free sensor based on an Electrolyte-Gated Organic Field-Effect Transistor (EGOFET) integrated with ... ...

Abstract	The aggregation of α-synuclein is a critical event in the pathogenesis of neurological diseases, such as Parkinson or Alzheimer. Here, we present a label-free sensor based on an Electrolyte-Gated Organic Field-Effect Transistor (EGOFET) integrated with microfluidics that allows for the detection of amounts of α-synuclein in the range from 0.25 pM to 25 nM. The lower limit of detection (LOD) measures the potential of our integrated device as a tool for prognostics and diagnostics. In our device, the gate electrode is the effective sensing element as it is functionalised with anti-(α-synuclein) antibodies using a dual strategy: i) an amino-terminated self-assembled monolayer activated by glutaraldehyde, and ii) the His-tagged recombinant protein G. In both approaches, comparable sensitivity values were achieved, featuring very low LOD values at the sub-pM level. The microfluidics engineering is central to achieve a controlled functionalisation of the gate electrode and avoid contamination or physisorption on the organic semiconductor. The demonstrated sensing architecture, being a disposable stand-alone chip, can be operated as a point-of-care test, but also it might represent a promising label-free tool to explore in-vitro protein aggregation that takes place during the progression of neurodegenerative illnesses.
MeSH term(s)	Biosensing Techniques ; Electrolytes ; Microfluidics ; Transistors, Electronic ; alpha-Synuclein/analysis
Chemical Substances	Electrolytes ; alpha-Synuclein
Language	English
Publishing date	2020-07-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2020.112433
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Zs.A 2275: Show issues

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Article: Could Dietary Supplementation with Different Sources of N-3 Polyunsaturated Fatty Acids Modify the Rabbit Gut Microbiota?

Curone, Giulio / Biscarini, Filippo / Cotozzolo, Elisa / Menchetti, Laura / Dal Bosco, Alessandro / Riva, Federica / Cremonesi, Paola / Agradi, Stella / Mattioli, Simona / Castiglioni, Bianca / Di Giancamillo, Alessia / Cartoni Mancinelli, Alice / Draghi, Susanna / Quattrone, Alda / Collodel, Giulia / Modina, Silvia Clotilde / Castellini, Cesare / Brecchia, Gabriele

Antibiotics (Basel, Switzerland)

2022 Volume 11, Issue 2

Abstract: The present study evaluated the effects of feed supplemented with two dietary sources of n-3 polyunsaturated fatty acids (PUFAs; fish oil and extruded flaxseed) on the gut microbiota, caecal fermentations, gastrointestinal histology, and histochemistry ... ...

Abstract	The present study evaluated the effects of feed supplemented with two dietary sources of n-3 polyunsaturated fatty acids (PUFAs; fish oil and extruded flaxseed) on the gut microbiota, caecal fermentations, gastrointestinal histology, and histochemistry in rabbits. Fifteen male New Zealand White rabbits were divided into three groups (
Language	English
Publishing date	2022-02-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics11020227
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Article: Preliminary Evidence of Good Safety Profile and Outcomes of Early Treatment with Tixagevimab/Cilgavimab Compared to Previously Employed Monoclonal Antibodies for COVID-19 in Immunocompromised Patients.

Biomedicines

2023 Volume 11, Issue 6

Abstract: Objectives: Monoclonal antibodies (mAbs) have proven to be a valuable tool against COVID-19, mostly among subjects with risk factors for progression to severe illness. Tixagevimab/cilgavimab (TIX/CIL), a combination of two Fc-modified human monoclonal ... ...

Abstract	Objectives: Monoclonal antibodies (mAbs) have proven to be a valuable tool against COVID-19, mostly among subjects with risk factors for progression to severe illness. Tixagevimab/cilgavimab (TIX/CIL), a combination of two Fc-modified human monoclonal antibodies, has been recently approved to be employed as early treatment. Methods: Two groups of immunocompromised patients exposed to different early treatments (i.e., TIX/CIL vs. other mAbs [casirivimab/imdevimab, bamlanivimab/etesevimab, sotrovimab]) were compared in terms of clinical outcomes (hospitalisation and mortality within 14 days from administration) and time to the negativity of nasal swabs. We used either Pearson's chi-square or Fisher's exact test for categorical variables, whereas the Wilcoxon rank-sum test was employed for continuous ones. Kaplan-Meier curves were produced to compare the time to nasopharyngeal swab negativity. Results: Early treatment with TIX/CIL was administered to 19 immunocompromised patients, while 89 patients received other mAbs. Most of them were solid organ transplant recipients or suffering from hematologic or solid malignancies. Overall, no significant difference was observed between the two groups regarding clinical outcomes. In the TIX/CIL group, one patient (1/19, 5.3%), who was admitted to the emergency room within the first 14 days from treatment and was hospitalised due to COVID-19 progression, died. Regarding the time to nasal swab negativity, no significant difference ( Conclusions: Early treatment of SARS-CoV-2 infection with TIX/CIL showed favourable outcomes in a small group of immunocompromised patients, reporting no significant difference compared to similar patients treated with other mAbs.
Language	English
Publishing date	2023-05-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11061540
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Article: Safety Profile and Outcomes of Early COVID-19 Treatments in Immunocompromised Patients: A Single-Centre Cohort Study.

Biscarini, Simona / Villa, Simone / Genovese, Camilla / Tomasello, Mara / Tonizzo, Anna / Fava, Marco / Iannotti, Nathalie / Bolis, Matteo / Mariani, Bianca / Valzano, Antonia Grazia / Morlacchi, Letizia Corinna / Donato, Francesca / Castellano, Giuseppe / Cassin, Ramona / Carrabba, Maria / Muscatello, Antonio / Gori, Andrea / Bandera, Alessandra / Lombardi, Andrea

Biomedicines

2022 Volume 10, Issue 8

Abstract: Background: Early treatment with remdesivir (RMD) or monoclonal antibodies (mAbs) could be a valuable tool in patients at risk of severe COVID-19 with unsatisfactory responses to vaccination. We aim to assess the safety and clinical outcomes of these ... ...

Abstract	Background: Early treatment with remdesivir (RMD) or monoclonal antibodies (mAbs) could be a valuable tool in patients at risk of severe COVID-19 with unsatisfactory responses to vaccination. We aim to assess the safety and clinical outcomes of these treatments among immunocompromised subjects. Methods: We retrospectively reviewed all nonhospitalized patients who received an early treatment with RMD or mAbs for COVID-19, from 25 November 2021 to 25 January 2022, in a large tertiary hospital. Outcomes included frequency of adverse drug reaction (ADR), duration of symptoms and molecular swab positivity, emergency department access, hospital or intensive care unit admission, and mortality in the 14 days following treatment administration. Results: Early treatments were administered to 143 patients, 106/143 (74.1%) immunocompromised, including 41 solid organ and 6 hematopoietic stem cell transplant recipients. Overall, 23/143 (16.1%) subjects reported ADRs. Median time from treatment start to SARS-CoV-2 nasopharyngeal swab negativity and symptom resolution was 10 (IQR 6-16) and 2.5 days (IQR 1.0-6.0), respectively, without differences between immunocompromised and nonimmunocompromised patients. In the 14 days after treatment administration, 5/143 patients (3.5%) were hospitalized and one died as a result of causes related to COVID-19, all of them were immunocompromised. Conclusions: RMD and mAbs have minimal ADRs and favourable outcomes in immunocompromised patients.
Language	English
Publishing date	2022-08-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10082002
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Article: The obesity paradox: Analysis from the SMAtteo COvid-19 REgistry (SMACORE) cohort

Biscarini, Simona / Colaneri, Marta / Ludovisi, Serena / Seminari, Elena / Pieri, Teresa C / Valsecchi, Pietro / Gallazzi, Ilaria / Giusti, Emanuele / Cammà, Calogero / Zuccaro, Valentina / Mondelli, Mario U

The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University Nutrition, metabolism, and cardiovascular diseases. 2020 Oct. 30, v. 30, no. 11

2020

Abstract: Obesity has been suggested as a possible risk factor for a more severe course of COVID-19; however, conclusive evidence is lacking and few studies have investigated the role of BMI as a risk factor for admission to intensive care unit (ICU) and mortality. ...

Abstract	Obesity has been suggested as a possible risk factor for a more severe course of COVID-19; however, conclusive evidence is lacking and few studies have investigated the role of BMI as a risk factor for admission to intensive care unit (ICU) and mortality.We retrospectively analyzed a COVID-19 cohort recruited during the first 40 days of the epidemic in Italy. We examined the association between obesity and 30-day mortality, admission to ICU, mortality and length of hospital stay in patients with COVID-19.Demographic, clinical and outcome data were retrospectively analyzed in 331 patients with COVID-19 admitted to hospital between 21 February and 31 March 2020. The predictive effect of obesity on mortality was assessed using a Cox proportional-hazard regression model, its effect on ICU admission and mortality in the ICU using logistic regressions, and its effect on length of hospital stay using a linear regression.Seventy-four of 331 patients had a BMI ≥30 kg/m². Among obese patients, 21 (28.4%) required admission in ICU and 25 died (33.8%). After controlling for sex, age, comorbidities and clinical data, obesity was not significantly associated with mortality, mortality in ICU and length of hospital stay. The effect of obesity on ICU admission remained significant after controlling for sex, age, interstitial lung disease, heart disease and serum C-reactive protein.Obese patients with COVID-19 were more likely to be admitted to ICU than non-obese patients. However, there were no significant differences in mortality between the two groups.
Keywords	Coronavirus infections ; age ; blood serum ; comorbidity ; heart diseases ; hospitals ; length ; metabolism ; mortality ; nutrition ; obesity ; patients ; regression analysis ; respiratory tract diseases ; risk factors ; Italy
Language	English
Dates of publication	2020-1030
Size	p. 1920-1925.
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-light
ZDB-ID	1067704-5
ISSN	0939-4753
ISSN	0939-4753
DOI	10.1016/j.numecd.2020.07.047
Database	NAL-Catalogue (AGRICOLA)

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