Article ; Online: Digger: directed annotation of immunoglobulin and T cell receptor V, D, and J gene sequences and assemblies.
Bioinformatics (Oxford, England)
2024 Volume 40, Issue 3
Abstract: Summary: Knowledge of immunoglobulin and T cell receptor encoding genes is derived from high-quality genomic sequencing. High-throughput sequencing is delivering large volumes of data, and precise, high-throughput approaches to annotation are needed. ... ...
Abstract | Summary: Knowledge of immunoglobulin and T cell receptor encoding genes is derived from high-quality genomic sequencing. High-throughput sequencing is delivering large volumes of data, and precise, high-throughput approaches to annotation are needed. Digger is an automated tool that identifies coding and regulatory regions of these genes, with results comparable to those obtained by current expert curational methods. Availability and implementation: Digger is published under open source license at https://github.com/williamdlees/Digger and is available as a Python package and a Docker container. |
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MeSH term(s) | Software ; Receptors, Antigen, T-Cell/genetics ; Chromosome Mapping ; Immunoglobulins/genetics ; High-Throughput Nucleotide Sequencing/methods |
Chemical Substances | Receptors, Antigen, T-Cell ; Immunoglobulins |
Language | English |
Publishing date | 2024-03-25 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 1422668-6 |
ISSN | 1367-4811 ; 1367-4803 |
ISSN (online) | 1367-4811 |
ISSN | 1367-4803 |
DOI | 10.1093/bioinformatics/btae144 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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