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  1. Article: Oncolytic viruses: Narcissistic or altruistic arsonists?

    Kendall, Luke / Vile, Richard G

    Molecular therapy oncolytics

    2023  Volume 29, Page(s) 42–43

    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Editorial
    ISSN 2372-7705
    ISSN 2372-7705
    DOI 10.1016/j.omto.2023.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Current Status and Challenges of Oncolytic Virotherapy for the Treatment of Glioblastoma.

    Webb, Mason J / Sener, Ugur / Vile, Richard G

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 6

    Abstract: Despite decades of research and numerous clinical trials, the prognosis of patients diagnosed with glioblastoma (GBM) remains dire with median observed survival at 8 months. There is a critical need for novel treatments for GBM, which is the most common ... ...

    Abstract Despite decades of research and numerous clinical trials, the prognosis of patients diagnosed with glioblastoma (GBM) remains dire with median observed survival at 8 months. There is a critical need for novel treatments for GBM, which is the most common malignant primary brain tumor. Major advances in cancer therapeutics such as immune checkpoint inhibitors and chimeric antigen receptor (CAR) T-cell therapy have not yet led to improved outcomes for GBM. Conventional therapy of surgery followed by chemoradiation with or without tumor treating fields remains the standard of care. One of the many approaches to GBM therapy currently being explored is viral therapies. These typically work by selectively lysing target neoplastic cells, called oncolysis, or by the targeted delivery of a therapeutic transgene via a viral vector. In this review, we discuss the underlying mechanisms of action and describe both recent and current human clinical trials using these viruses with an emphasis on promising viral therapeutics that may ultimately break the field's current stagnant paradigm.
    Language English
    Publishing date 2023-05-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16060793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Immune System in Oncolytic Immunovirotherapy: Gospel, Schism and Heresy.

    Vile, Richard G

    Molecular therapy : the journal of the American Society of Gene Therapy

    2018  Volume 26, Issue 4, Page(s) 942–946

    MeSH term(s) Immune System ; Immunotherapy ; Oncolytic Virotherapy ; Oncolytic Viruses
    Language English
    Publishing date 2018-03-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1016/j.ymthe.2018.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Parking CAR T Cells in Tumours: Oncolytic Viruses as Valets or Vandals?

    Evgin, Laura / Vile, Richard G

    Cancers

    2021  Volume 13, Issue 5

    Abstract: Oncolytic viruses (OVs) and adoptive T cell therapy (ACT) each possess direct tumour cytolytic capabilities, and their combination potentially seems like a match made in heaven to complement the strengths and weakness of each modality. While providing ... ...

    Abstract Oncolytic viruses (OVs) and adoptive T cell therapy (ACT) each possess direct tumour cytolytic capabilities, and their combination potentially seems like a match made in heaven to complement the strengths and weakness of each modality. While providing strong innate immune stimulation that can mobilize adaptive responses, the magnitude of anti-tumour T cell priming induced by OVs is often modest. Chimeric antigen receptor (CAR) modified T cells bypass conventional T cell education through introduction of a synthetic receptor; however, realization of their full therapeutic properties can be stunted by the heavily immune-suppressive nature of the tumour microenvironment (TME). Oncolytic viruses have thus been seen as a natural ally to overcome immunosuppressive mechanisms in the TME which limit CAR T cell infiltration and functionality. Engineering has further endowed viruses with the ability to express transgenes in situ to relieve T cell tumour-intrinsic resistance mechanisms and decorate the tumour with antigen to overcome antigen heterogeneity or loss. Despite this helpful remodeling of the tumour microenvironment, it has simultaneously become clear that not all virus induced effects are favourable for CAR T, begging the question whether viruses act as valets ushering CAR T into their active site, or vandals which cause chaos leading to both tumour and T cell death. Herein, we summarize recent studies combining these two therapeutic modalities and seek to place them within the broader context of viral T cell immunology which will help to overcome the current limitations of effective CAR T therapy to make the most of combinatorial strategies.
    Language English
    Publishing date 2021-03-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13051106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Current Status and Challenges of Oncolytic Virotherapy for the Treatment of Glioblastoma

    Mason J. Webb / Ugur Sener / Richard G. Vile

    Pharmaceuticals, Vol 16, Iss 793, p

    2023  Volume 793

    Abstract: Despite decades of research and numerous clinical trials, the prognosis of patients diagnosed with glioblastoma (GBM) remains dire with median observed survival at 8 months. There is a critical need for novel treatments for GBM, which is the most common ... ...

    Abstract Despite decades of research and numerous clinical trials, the prognosis of patients diagnosed with glioblastoma (GBM) remains dire with median observed survival at 8 months. There is a critical need for novel treatments for GBM, which is the most common malignant primary brain tumor. Major advances in cancer therapeutics such as immune checkpoint inhibitors and chimeric antigen receptor (CAR) T-cell therapy have not yet led to improved outcomes for GBM. Conventional therapy of surgery followed by chemoradiation with or without tumor treating fields remains the standard of care. One of the many approaches to GBM therapy currently being explored is viral therapies. These typically work by selectively lysing target neoplastic cells, called oncolysis, or by the targeted delivery of a therapeutic transgene via a viral vector. In this review, we discuss the underlying mechanisms of action and describe both recent and current human clinical trials using these viruses with an emphasis on promising viral therapeutics that may ultimately break the field’s current stagnant paradigm.
    Keywords glioblastoma ; oncolytic virotherapy ; clinical trials ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Subject code 610
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Socializing Individualized T-Cell Cancer Immunotherapy.

    Vile, Richard G

    Molecular therapy : the journal of the American Society of Gene Therapy

    2016  Volume 24, Issue 7, Page(s) 1170–1173

    MeSH term(s) Humans ; Immunotherapy ; Neoplasms ; Precision Medicine ; T-Lymphocytes
    Language English
    Publishing date 2016-08-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1038/mt.2016.132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Oncolytic virotherapy as immunotherapy.

    Melcher, Alan / Harrington, Kevin / Vile, Richard

    Science (New York, N.Y.)

    2021  Volume 374, Issue 6573, Page(s) 1325–1326

    Abstract: Recognizing immune responses to oncolytic virotherapy opens the way for new combinations. ...

    Abstract Recognizing immune responses to oncolytic virotherapy opens the way for new combinations.
    MeSH term(s) Animals ; Antineoplastic Agents, Immunological/therapeutic use ; Combined Modality Therapy ; Humans ; Immunotherapy ; Neoplasms/immunology ; Neoplasms/therapy ; Neoplasms/virology ; Oncolytic Virotherapy ; Oncolytic Viruses/genetics ; Oncolytic Viruses/immunology ; Oncolytic Viruses/physiology ; Randomized Controlled Trials as Topic
    Chemical Substances Antineoplastic Agents, Immunological
    Language English
    Publishing date 2021-12-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abk3436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 27: Show issues Location:
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    Zs.MG 77: Show issues

    Order via subito

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  8. Book ; Conference proceedings: Cytoreductive gene therapy

    Vile, Richard G.

    September 25 - 27, 1999 ... Rochester, Minnesota

    (Gene therapy ; 6, Suppl. 1)

    1999  

    Institution Harold W. Siebens Foundation
    Mayo Foundation
    Event/congress Harold W. Siebens Conference (1999, RochesterMinn.)
    Author's details Mayo. Funded by the Harold W. Siebens Foundation. Org. committee: Richard G. Vile
    Series title Gene therapy ; 6, Suppl. 1
    Collection
    Language English
    Size S10 S. : Ill., graph. Darst.
    Publisher Macmillan
    Publishing place Basingstoke, Hampshire
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT011138235
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3991 -6,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  9. Article ; Online: How to train your oncolytic virus: the immunological sequel.

    Vile, Richard G

    Molecular therapy : the journal of the American Society of Gene Therapy

    2014  Volume 22, Issue 11, Page(s) 1881–1884

    MeSH term(s) Animals ; B7-H1 Antigen/metabolism ; CTLA-4 Antigen/metabolism ; Lymphocytes, Tumor-Infiltrating/metabolism ; Melanoma, Experimental/therapy ; Oncolytic Viruses/immunology
    Chemical Substances B7-H1 Antigen ; CTLA-4 Antigen
    Language English
    Publishing date 2014-11-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1038/mt.2014.188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Cancer metastasis

    Vile, Richard G.

    from mechanisms to therapies

    (Molecular medical science series)

    1995  

    Author's details ed. by Richard G. Vile
    Series title Molecular medical science series
    Keywords Neoplasm Metastasis / physiopathology ; Neoplasms / drug therapy ; Metastase
    Subject Metastasierung
    Language English
    Size 210 S. : Ill.
    Publisher Wiley
    Publishing place Chichester u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT006559225
    ISBN 0-471-95266-4 ; 978-0-471-95266-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1995 A 4108 order for loan Magazin

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