LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 577

Search options

  1. Article: Are orthopaedic surgeons smart enough?

    Hoffmeyer, Pierre

    EFORT open reviews

    2024  Volume 9, Issue 1, Page(s) 1–2

    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Editorial
    ZDB-ID 2844421-8
    ISSN 2058-5241 ; 2058-5241 ; 2396-7544
    ISSN (online) 2058-5241
    ISSN 2058-5241 ; 2396-7544
    DOI 10.1530/EOR-23-0213
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: CORR Insights®: No Strength Differences Despite Greater Posterior Rotator Cuff Intramuscular Fat in Patients With Eccentric Glenohumeral Osteoarthritis.

    Hoffmeyer, Pierre

    Clinical orthopaedics and related research

    2022  Volume 480, Issue 11, Page(s) 2229–2231

    MeSH term(s) Humans ; Osteoarthritis/diagnostic imaging ; Osteoarthritis/surgery ; Rotator Cuff/diagnostic imaging ; Rotator Cuff/surgery ; Rotator Cuff Injuries/diagnostic imaging ; Rotator Cuff Injuries/surgery ; Shoulder Joint/diagnostic imaging ; Shoulder Joint/surgery
    Language English
    Publishing date 2022-06-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1097/CORR.0000000000002299
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.188: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: A most hazardous year.

    Hoffmeyer, Pierre

    EFORT open reviews

    2021  Volume 6, Issue 1, Page(s) 1–2

    Abstract: Cite this article: ...

    Abstract Cite this article:
    Language English
    Publishing date 2021-01-11
    Publishing country England
    Document type Editorial
    ZDB-ID 2844421-8
    ISSN 2058-5241 ; 2058-5241 ; 2396-7544
    ISSN (online) 2058-5241
    ISSN 2058-5241 ; 2396-7544
    DOI 10.1302/2058-5241.6.211000
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: EFORT Open Reviews

    Hoffmeyer, Pierre

    EFORT open reviews

    2020  Volume 5, Issue 10, Page(s) 568–569

    Abstract: Cite this article: ...

    Abstract Cite this article:
    Keywords covid19
    Language English
    Publishing date 2020-10-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2844421-8
    ISSN 2058-5241 ; 2058-5241 ; 2396-7544
    ISSN (online) 2058-5241
    ISSN 2058-5241 ; 2396-7544
    DOI 10.1302/2058-5241.5.200200
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors.

    Siegsmund, Michael / Brinkmann, Ulrich / Scháffeler, Elke / Weirich, Gregor / Schwab, Matthias / Eichelbaum, Michel / Fritz, Peter / Burk, Oliver / Decker, Jochen / Alken, Peter / Rothenpieler, Uwe / Kerb, Reinhold / Hoffmeyer, Sven / Brauch, Hiltrud

    Journal of the American Society of Nephrology : JASN

    2002  Volume 13, Issue 7, Page(s) 1847–1854

    Abstract: ... epithelial tumors are unknown. There is a possibility that the MDR1 encoded plasma membrane transporter P ... the occurrence of tumors (P = 0.007). When tumors were histopathologically distinguished into frequent CCRCC and ... influence by the latter (P = 0.0419). The second study established the T allele as a risk factor especially ...

    Abstract Except for hereditary disease, genetic factors that contribute to the development of renal epithelial tumors are unknown. There is a possibility that the MDR1 encoded plasma membrane transporter P-glycoprotein (PGP) influences the risk of development of renal neoplasms. PGP is known to be involved in uptake, binding, transport, and distribution of xenobiotics. There is evidence that the MDR1(C3435T) polymorphism drives expression and modulates disease risk. In an explorational case-control study, constitutional genotype frequencies were established at MDR1(C3435T) of 537 healthy control subjects and compared with those of 212 patients with renal epithelial tumors. There were 179 clear cell renal cell carcinoma (CCRCC) and 33 tumors collectively assigned as non-CCRCC. In a second study, genotypes of another 150 healthy control subjects and 50 patients with three non-CCRCC types (26 papillary RCC, 11 chromophobe RCC, and 13 renal oncocytic adenoma) were compared. PCR-restriction fragment length polymorphism-based analysis of constitutional DNA, and statistical analysis were applied. PGP expression was analyzed by quantitative immunohistochemistry. The explorational study showed a significant association between T allele frequency and the occurrence of tumors (P = 0.007). When tumors were histopathologically distinguished into frequent CCRCC and less frequent non-CCRCC, both patient groups contributed to this effect with a seemingly strong influence by the latter (P = 0.0419). The second study established the T allele as a risk factor especially for non-CCRCC (P = 0.0005) with the highest risk for homozygote TT allele carriers (P < 0.0001). Independently, MDR1(C3435T) genotype associated variations in PGP expression were shown in normal renal parenchyma with a 1.5-fold difference of median values (TT, 1.9; CC, 2.8; P = 0.0065). The data provide evidence for PGP to influence the susceptibility to develop renal epithelial tumors by virtue of its MDR1(C3435T) polymorphism and changes in expression. Especially T and TT carriers are at risk for developing non-CCRCC, i.e., papillary and chromophobe RCC as well as oncocytic adenomas.
    MeSH term(s) ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; European Continental Ancestry Group/genetics ; Female ; Gene Frequency ; Genes, MDR/genetics ; Genetic Predisposition to Disease/genetics ; Genotype ; Humans ; Kidney/metabolism ; Kidney Neoplasms/genetics ; Kidney Neoplasms/metabolism ; Male ; Middle Aged ; Polymorphism, Genetic ; Reference Values
    Chemical Substances ATP Binding Cassette Transporter, Subfamily B, Member 1
    Language English
    Publishing date 2002-06-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1097/01.asn.0000019412.87412.bc
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3344: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Les lésions du complexe biceps-bourrelet ou S.L.A.P

    Clayson, Patrick / Riand, Nicolas / Hoffmeyer, Pierre

    Sportmedizin und Sporttraumatologie

    2000  Volume 48, Issue 1, Page(s) 20

    Language German
    Document type Article
    ZDB-ID 1187363-2
    ISSN 1022-6699 ; 1422-0644
    Database Current Contents Medicine

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Un I Zs.501: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Risk factors for laryngeal lesions in adult acute respiratory distress syndrome: A STROBE-compliant French case-control study.

    Meguerditchian-Hoffmeyer, L / Philouze, P / Carsuzaa, F / Subtil, F / Fath, L / Fieux, M

    European annals of otorhinolaryngology, head and neck diseases

    2024  

    Abstract: ... of 5.08 (95% CI, 1.40-22.12; P=0.013). No other predictive factors were identified among the variables ...

    Abstract Introduction: The global SARS-CoV-2 pandemic led to an increased incidence of post-intubation laryngeal injuries in patients with acute respiratory distress syndrome (ARDS). The primary objective of this study was to identify risk factors for symptomatic laryngeal lesions in patients with Covid-19-related ARDS. The secondary objective was to analyze the progression of these laryngeal lesions.
    Methods: A 21 month nested case-control study was conducted in 3 university hospital centers of the Hospices Civils de Lyon (France). Cases encompassed all patients intubated for Covid-19-related ARDS who presented symptomatic laryngeal pathology. The control group consisted of all patients enrolled during the same period for Covid-19-related ARDS without evidence of laryngeal lesions (no specific ENT intervention). Uni- and multi-variate analyses were performed to identify risk factors for the occurrence of laryngeal lesions.
    Results: Forty-nine patients were included in the case group and 50 in the control group. The only significant risk factor for symptomatic laryngeal injury was the number of reintubations, with an odds ratio of 5.08 (95% CI, 1.40-22.12; P=0.013). No other predictive factors were identified among the variables analyzed: obesity, number of prone sessions, self-extubation, duration of intubation and number of days of curarization.
    Conclusion: The number of reintubations was the sole independent risk factor associated with the development of symptomatic laryngeal lesions in patients managed for Covid-19-related ARDS.
    Language English
    Publishing date 2024-02-28
    Publishing country France
    Document type Journal Article
    ZDB-ID 2558008-5
    ISSN 1879-730X ; 1879-7296
    ISSN (online) 1879-730X
    ISSN 1879-7296
    DOI 10.1016/j.anorl.2024.02.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene.

    Johne, Andreas / Köpke, Karla / Gerloff, Thomas / Mai, Ingrid / Rietbrock, Stephan / Meisel, Christian / Hoffmeyer, Sven / Kerb, Reinhold / Fromm, Martin F / Brinkmann, Ulrich / Eichelbaum, Michel / Brockmöller, Jürgen / Cascorbi, Ingolf / Roots, Ivar

    Clinical pharmacology and therapeutics

    2002  Volume 72, Issue 5, Page(s) 584–594

    Abstract: Objective: We investigated the effect of polymorphisms in the P-glycoprotein (P-gp) MDR1 gene ... of the exon 26 complementary deoxyribonucleic acid (cDNA) 3435C>T polymorphism was associated with low P ... the plasma concentration-time curve from time zero to 4 hours [AUC(0-4)] (P =.042) and C(max) (P =.043 ...

    Abstract Objective: We investigated the effect of polymorphisms in the P-glycoprotein (P-gp) MDR1 gene on steady-state pharmacokinetics of digoxin in Caucasians. According to earlier data, homozygous TT of the exon 26 complementary deoxyribonucleic acid (cDNA) 3435C>T polymorphism was associated with low P-gp expression in the human intestine.
    Methods: Eight healthy male homozygous carriers of the wild-type exon-26 3435C>T (CC), 8 heterozygous subjects (CT), and 8 homozygous mutant (TT) subjects were selected. Seven further MDR1 polymorphisms were determined. Digoxin was administered orally twice daily on the first two study days; on days 3 to 5, 0.25 mg was given in the morning. On day 5, kinetic parameters were analyzed for genotype-phenotype and haplotype-phenotype relationships.
    Results: The area under the plasma concentration-time curve from time zero to 4 hours [AUC(0-4)] (P =.042) and C(max) (P =.043) values of digoxin were higher in subjects with the 3435TT genotype than in those with the 3435CC. No influence of other single nucleotide polymorphisms (SNPs) on digoxin parameters was detected. Comparison of genotypes deduced from SNPs 2677G>T (exon 21) and 3435C>T revealed significant differences for AUC(0-4) (P =.034) and C(max) (P =.039), which were substantiated by haplotype analysis. Haplotype 12 (2677G/3435T), which had a frequency of 13.3% in a randomly drawn Caucasian sample (n = 687), was associated (Mann-Whitney test) with higher AUC(0-4) values (P =.009) than were found in noncarriers (mean +/- SD, 5.7 +/- 0.9 microg. h/L [n = 7] versus 4.8 +/- 0.9 microg. h/L [n = 17]). Haplotype 11 (2677G/3435C) had lower AUC(0-4) values (P =.013) compared with those of noncarriers (mean +/- SD, 4.7 +/- 0.9 microg. h/L [n = 16] versus 5.6 +/- 0.9 microg. h/L [n = 8]). Results of haplotype analysis match data of other MDR1 studies.
    Conclusion: Haplotype 12 codes for high values of AUC(0-4) and C(max) of orally administered digoxin. Analysis of MDR1 haplotypes is superior to unphased SNP analysis to predict MDR1 phenotype.
    MeSH term(s) Animals ; Digoxin/pharmacokinetics ; Female ; Genes, MDR ; Genotype ; Haplotypes ; Male ; Polymorphism, Single Nucleotide
    Chemical Substances Digoxin (73K4184T59)
    Language English
    Publishing date 2002-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1067/mcp.2002.129196
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 20: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Contagious Policies? Studying National Responses to a Global Pandemic in Europe.

    Rausis, Frowin / Hoffmeyer-Zlotnik, Paula

    Schweizerische Zeitschrift fur Politikwissenschaft = Revue suisse de science politique = Swiss political science review

    2021  Volume 27, Issue 2, Page(s) 283–296

    Abstract: Not only Covid-19 has spread all over the world-the policies responding to this pandemic have also diffused rapidly across countries. In this research note, we present findings from an original dataset that features mobility restrictions in all EU/EFTA ... ...

    Abstract Not only Covid-19 has spread all over the world-the policies responding to this pandemic have also diffused rapidly across countries. In this research note, we present findings from an original dataset that features mobility restrictions in all EU/EFTA states as well as the United Kingdom during the first wave of the pandemic. We find that most countries adopted restrictions within a few days only and that restrictions on internal mobility had been introduced prior to restrictions on cross-border mobility, but that the latter have been more persistent. Furthermore, we observe an evolution from great variation of policy choices at the outset of the pandemic towards convergence. Analyzing the mobility restrictions through a policy diffusion lens, we find tentative evidence for interdependent policy-making especially in the temporal patterns of adoption. Our research note can serve a basis for future research on policy-making and policy diffusion in times of crisis.
    Language English
    Publishing date 2021-04-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2085219-8
    ISSN 1662-6370 ; 1424-7755 ; 1420-3529
    ISSN (online) 1662-6370
    ISSN 1424-7755 ; 1420-3529
    DOI 10.1111/spsr.12450
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo.

    Hoffmeyer, S / Burk, O / von Richter, O / Arnold, H P / Brockmöller, J / Johne, A / Cascorbi, I / Gerloff, T / Roots, I / Eichelbaum, M / Brinkmann, U

    Proceedings of the National Academy of Sciences of the United States of America

    2000  Volume 97, Issue 7, Page(s) 3473–3478

    Abstract: ... MDR-1 expression and uptake of orally administered P-glycoprotein (PGP) substrates, we analyzed ...

    Abstract To evaluate whether alterations in the multidrug-resistance (MDR)-1 gene correlate with intestinal MDR-1 expression and uptake of orally administered P-glycoprotein (PGP) substrates, we analyzed the MDR-1 sequence in 21 volunteers whose PGP expression and function in the duodenum had been determined by Western blots and quantitative immunohistology (n = 21) or by plasma concentrations after orally administered digoxin (n = 8 + 14). We observed a significant correlation of a polymorphism in exon 26 (C3435T) of MDR-1 with expression levels and function of MDR-1. Individuals homozygous for this polymorphism had significantly lower duodenal MDR-1 expression and the highest digoxin plasma levels. Homozygosity for this variant was observed in 24% of our sample population (n = 188). This polymorphism is expected to affect the absorption and tissue concentrations of numerous other substrates of MDR-1.
    MeSH term(s) ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Adult ; Alleles ; Base Sequence ; DNA ; Exons ; Humans ; Intestinal Mucosa/metabolism ; Male ; Polymorphism, Genetic ; Sequence Homology, Nucleic Acid
    Chemical Substances ATP Binding Cassette Transporter, Subfamily B, Member 1 ; DNA (9007-49-2)
    Language English
    Publishing date 2000-03-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.97.7.3473
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top