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Article ; Online: L-glutamine as a T

Joo, Chan Gyu / Yang, Seung-Hyun / Choi, Yuna / Son, Hye-Young / Kim, Dong-Hyun / Huh, Yong-Min

2020 Volume 84, Issue 4, Page(s) 2055–2062

Abstract: Purpose: The potential of L-glutamine as a T: Methods: The T: Results: The T ...

Abstract	Purpose: The potential of L-glutamine as a T Methods: The T Results: The T
MeSH term(s)	Animals ; Contrast Media ; Glutamine ; Magnetic Resonance Imaging ; Mice
Chemical Substances	Contrast Media ; Glutamine (0RH81L854J)
Language	English
Publishing date	2020-05-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605774-3
ISSN	1522-2594 ; 0740-3194
ISSN (online)	1522-2594
ISSN	0740-3194
DOI	10.1002/mrm.28305
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Article ; Online: Corrigendum to Zhang J, Cai J, Cui Y, Jiang S, Wei J, Kim YC, Chan J, Thalakola A, Le T, Xu L, Wang L, Jiang K, Wang X, Wang H, Cheng F, Buggs J, Koepsell H, Vallon V, Liu R. "Role of the macula densa sodium glucose cotransporter type 1-neuronal nitric oxide synthase-tubuloglomerular feedback pathway in diabetic hyperfiltration." Kidney Int. 2022;101:541-550.

Zhang, Jie / Cai, Jing / Cui, Yu / Jiang, Shan / Wei, Jin / Kim, Young Chul / Chan, Jenna / Thalakola, Anish / Le, Thanh / Xu, Lan / Wang, Lei / Jiang, Kun / Wang, Ximing / Wang, Haibo / Cheng, Feng / Buggs, Jacentha / Koepsell, Hermann / Vallon, Volker / Liu, Ruisheng

Kidney international

2022 Volume 102, Issue 2, Page(s) 448

Language	English
Publishing date	2022-07-20
Publishing country	United States
Document type	Published Erratum
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2022.05.011
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Article ; Online: L or G or B or T: Matching Sexual and Gender Minorities with Subpopulation-Specific Interventions.

Matsuno, Em / Goodman, Joshua A / Israel, Tania / Choi, Andrew Young / Lin, Yen-Jui / Kary, Krishna G

Journal of homosexuality

2020 , Page(s) 1–23

Abstract: Sexual and gender minorities (SGM) may benefit from psychological interventions tailored to specific subpopulations (e.g., lesbians, gay men, bisexual people, transgender people) given differing experiences with stigma. However, determining the inclusion/ ...

Abstract	Sexual and gender minorities (SGM) may benefit from psychological interventions tailored to specific subpopulations (e.g., lesbians, gay men, bisexual people, transgender people) given differing experiences with stigma. However, determining the inclusion/exclusion process for subpopulation-specific interventions is challenging and recommendations for this process are scarce. We developed and evaluated a matching procedure to place 1183 SGM participants into four targeted online interventions designed to reduce internalized stigma for lesbian, gay, bisexual, and transgender people. We evaluated participant attrition, efficacy, satisfaction with placement, and qualitative feedback across the four interventions. Results indicated that our matching procedure was time-efficient and largely successful in terms of low attrition, high satisfaction, and reaching segments of the SGM population not usually captured with the LGBT acronym. Based on these findings, we offer six practical guidelines for devising the inclusion/exclusion process or matching procedure for future subpopulation-specific SGM interventions studies.
Language	English
Publishing date	2020-10-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	193138-6
ISSN	1540-3602 ; 0091-8369
ISSN (online)	1540-3602
ISSN	0091-8369
DOI	10.1080/00918369.2020.1819714
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Article ; Online: Efficacy and Safety of a Pegasparaginase-Based Chemotherapy Regimen vs an L-asparaginase-Based Chemotherapy Regimen for Newly Diagnosed Advanced Extranodal Natural Killer/T-Cell Lymphoma: A Randomized Clinical Trial.

Wang, Xinhua / Zhang, Lei / Liu, Xiangli / Li, Xin / Li, Ling / Fu, Xiaorui / Sun, Zhenchang / Wu, Jingjing / Zhang, Xudong / Yan, Jiaqin / Chang, Yu / Nan, Feifei / Zhou, Zhiyuan / Wu, Xiaolong / Tian, Li / Ma, Minrui / Li, Zhaoming / Yu, Hui / Zhu, Linan /

JAMA oncology

2022 Volume 8, Issue 7, Page(s) 1035–1041

Abstract: Importance: The L-asparaginase-based SMILE (dexamethasone, methotrexate, ifosfamide, L ... III/IV) extranodal natural killer/T-cell lymphoma (ENKL).: Design, setting, and participants ...

Abstract	Importance: The L-asparaginase-based SMILE (dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide) chemotherapy regimen has shown higher response rates and survival benefit over an anthracycline-containing regimen. However, the safety profile was not satisfied. A well-tolerated regimen with promising efficacy is lacking. Objective: To compare the efficacy and safety of the DDGP (dexamethasone, cisplatin, gemcitabine, and pegaspargase) regimen with the SMILE regimen in newly diagnosed advanced-stage (III/IV) extranodal natural killer/T-cell lymphoma (ENKL). Design, setting, and participants: This was an open-label, multicenter, randomized clinical trial that took place across 12 participating hospitals in China from January 2011 to February 2019. Patients were eligible if they were 14 to 70 years old with newly diagnosed ENKL in stages III/IV and had an Eastern Cooperative Oncology Group performance status of 0 to 2. Eligible patients were evenly randomized to either the DDGP or SMILE group. Interventions: Patients in each group were treated with the assigned regimen every 21 days for 6 cycles. Main outcomes and measures: The primary end point was progression-free survival (PFS), and secondary end points included overall response rate and overall survival (OS). The adverse events between the DDGP and SMILE groups were compared. Results: Among the 87 randomized patients, 80 received treatment (40 in the DDGP group and 40 in the SMILE group); the median (IQR) age was 43 (12) years, and 51 (64%) were male. The baseline characteristics were similar between the groups. At a median follow-up of 41.5 months, the median PFS was not reached in the DDGP group vs 6.8 months in the SMILE group (HR, 0.42; 95% CI, 0.23-0.77; P = .004), and the median OS was not reached in the DDGP group vs 75.2 months in the SMILE group (HR, 0.41; 95% CI, 0.19-0.89, P = .02). The PFS rate at 3 years and OS rate at 5 years were higher in the DDGP group vs the SMILE group (3-year PFS, 56.6% vs 41.8%; 5-year OS, 74.3% vs 51.7%). The overall response rate was higher in the DDGP group than in the SMILE group (90.0% vs 60.0%; P = .002). Grade 3 and 4 hematologic toxic effects were more frequently reported in the SMILE group vs the DDGP group (leukopenia, 85.0% vs 62.5%; neutropenia, 85.0% vs 65.0%). Conclusions and relevance: In this randomized clinical trial, the DDGP regimen showed promising preliminary results for patients with newly diagnosed local advanced ENKL. A confirmation trial based on larger population is warranted. Trial registration: ClinicalTrials.gov Identifier: NCT01501149.
MeSH term(s)	Adult ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Asparaginase/adverse effects ; Asparaginase/therapeutic use ; Dexamethasone/adverse effects ; Dexamethasone/therapeutic use ; Female ; Humans ; Killer Cells, Natural/pathology ; Lymphoma, Extranodal NK-T-Cell/drug therapy ; Lymphoma, Extranodal NK-T-Cell/pathology ; Male ; Middle Aged
Chemical Substances	Dexamethasone (7S5I7G3JQL) ; Asparaginase (EC 3.5.1.1)
Language	English
Publishing date	2022-06-16
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ISSN	2374-2445
ISSN (online)	2374-2445
DOI	10.1001/jamaoncol.2022.1968
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Article ; Online: Re: Surgical Management of Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia: AUA Guideline Amendment 2019H. E. Foster, P. Dahm, T. S. Kohler, L. B. Lerner, J. K. Parsons, T. J. Wilt and K. T. McVary

Young, Shamar / Golzarian, Jafar

The Journal of urology

2020 Volume 203, Issue 6, Page(s) 1219

MeSH term(s)	Humans ; Lower Urinary Tract Symptoms ; Male ; Prostatic Hyperplasia
Language	English
Publishing date	2020-02-18
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1097/JU.0000000000000801
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Article ; Online: A Recombinant Rhesus Monkey Rhadinovirus Deleted of Glycoprotein L Establishes Persistent Infection of Rhesus Macaques and Elicits Conventional T Cell Responses.

Hahn, Alexander S / Bischof, Georg F / Großkopf, Anna K / Shin, Young C / Domingues, Aline / Gonzalez-Nieto, Lucas / Rakasz, Eva G / Watkins, David I / Ensser, Armin / Martins, Mauricio A / Desrosiers, Ronald C

Journal of virology

2020 Volume 94, Issue 2

Abstract: ... protein of SIVmac239 was constructed in the context of a glycoprotein L (gL) deletion mutation. Deletion ...

Abstract	A replication-competent, recombinant strain of rhesus monkey rhadinovirus (RRV) expressing the Gag protein of SIVmac239 was constructed in the context of a glycoprotein L (gL) deletion mutation. Deletion of gL detargets the virus from Eph family receptors. The ability of this gL-minus Gag recombinant RRV to infect, persist, and elicit immune responses was evaluated after intravenous inoculation of two
MeSH term(s)	Animals ; Antigens, CD/immunology ; B-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Line ; Gene Deletion ; Gene Products, gag/genetics ; Gene Products, gag/immunology ; Genetic Vectors/genetics ; Genetic Vectors/immunology ; Herpesviridae Infections/genetics ; Herpesviridae Infections/immunology ; Humans ; Macaca mulatta ; Rhadinovirus/genetics ; Rhadinovirus/immunology ; SAIDS Vaccines/genetics ; SAIDS Vaccines/immunology ; Simian Immunodeficiency Virus/genetics ; Simian Immunodeficiency Virus/immunology ; Viral Envelope Proteins/genetics ; Viral Envelope Proteins/immunology
Chemical Substances	Antigens, CD ; Gene Products, gag ; SAIDS Vaccines ; Viral Envelope Proteins
Language	English
Publishing date	2020-01-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.01093-19
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Article ; Online: Immunostimulatory effects of polysaccharides isolated from young barley leaves (Hordeum vulgare L.) with dual activation of Th1 and Th2 in splenic T cells and cyclophosphamide-induced immunosuppressed mice.

Han, Hee-Soo / Shin, Ji-Sun / Song, Young-Ran / Rhee, Young Kyoung / Cho, Chang-Won / Ryu, Jong Hoon / Inn, Kyung-Soo / Hong, Hee-Do / Lee, Kyung-Tae

International journal of biological macromolecules

2019 Volume 147, Page(s) 954–964

Abstract: ... of polysaccharides isolated from barley leaf (Hordeum vulgare L.) (BLE0) in splenocytes and cyclophosphamide (CYP ... splenocytes. Molecular data revealed that BLE0 up-regulated the expression of T-bet with enhanced ... increased Th1 and Th2 cytokines, T-bet, and GATA3 mRNA expression. Dietary intake of BLE0 improves ...

Abstract	Botanical polysaccharides have been widely known to possess immunological activity. The objective of this study was to investigate the molecular mechanisms underlying the immunostimulatory properties of polysaccharides isolated from barley leaf (Hordeum vulgare L.) (BLE0) in splenocytes and cyclophosphamide (CYP)-induced immunosuppressed mice. BLE0 showed cell proliferative activity and markedly increased the secretion of both Th1-cytokines (IFN-γ and IL-2) and Th2-cytokines (IL-4 and IL-10) in CD3/CD28-activated splenocytes. Molecular data revealed that BLE0 up-regulated the expression of T-bet with enhanced phosphorylation of Janus kinase (JAK)-signal transducer and activator of transcription (STAT) 1 signaling pathway. BLE0 also increase the phosphorylation of GATA3 via toll-like receptor (TLR) 2-mediated signaling pathway with nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and activator protein 1 (AP-1) activation. Oral administration of BLE0 effectively improved CYP-induced decrease of body weight, splenocyte proliferation, and natural killer (NK) cell cytotoxic activity and significantly increased Th1 and Th2 cytokines, T-bet, and GATA3 mRNA expression. Dietary intake of BLE0 improves the immunological manifestations by stimulating both Th1 and Th2 responses via JAK/STAT1/T-bet and TLR2/GATA3, respectively.
MeSH term(s)	Adjuvants, Immunologic/chemistry ; Adjuvants, Immunologic/pharmacology ; Animals ; Cyclophosphamide/pharmacology ; Hordeum/chemistry ; Immunosuppression ; Male ; Mice ; Mice, Inbred ICR ; Plant Leaves/chemistry ; Polysaccharides/chemistry ; Polysaccharides/pharmacology ; Spleen/immunology ; Th1 Cells/immunology ; Th2 Cells/immunology
Chemical Substances	Adjuvants, Immunologic ; Polysaccharides ; Cyclophosphamide (8N3DW7272P)
Language	English
Publishing date	2019-11-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2019.10.062
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Article ; Online: Therapeutic effect of a novel histone deacetylase 6 inhibitor, CKD-L, on collagen-induced arthritis in vivo and regulatory T cells in rheumatoid arthritis in vitro.

Oh, Bo Ram / Suh, Dong-Hyeon / Bae, Daekwon / Ha, Nina / Choi, Young Il / Yoo, Hyun Jung / Park, Jin Kyun / Lee, Eun Young / Lee, Eun Bong / Song, Yeong Wook

Arthritis research & therapy

2017 Volume 19, Issue 1, Page(s) 154

Abstract: ... effect of a new selective HDAC6 inhibitor, CKD-L, compared to ITF 2357 or Tubastatin A on CIA and ... regulatory T (Treg) cells in patients with rheumatoid arthritis (RA).: Methods: CIA was induced by bovine ... Cytotoxic T-lymphocyte associated protein (CTLA)-4 expression in induced Treg cells was analyzed and ...

Abstract	Background: Histone deacetylase (HDAC) inhibitor has recently been reported to have a therapeutic effect as an anti-inflammatory agent in collagen-induced arthritis (CIA). We investigated the therapeutic effect of a new selective HDAC6 inhibitor, CKD-L, compared to ITF 2357 or Tubastatin A on CIA and regulatory T (Treg) cells in patients with rheumatoid arthritis (RA). Methods: CIA was induced by bovine type II collagen (CII) in DBA/1 J mice. Mice were treated with HDAC inhibitor for 18 days. Arthritis score was assessed and histological analysis was performed by hematoxylin and eosin (H&E) stain. Cytotoxic T-lymphocyte associated protein (CTLA)-4 expression in induced Treg cells was analyzed and suppression assay was analyzed using Treg cells and effector T (Teff) cells isolated from naive C57BL/6 mice by flow cytometry. Cytokines were analyzed in peripheral blood mononuclear cells (PBMC) of five patients with RA by enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (PCR). Tumor necrosis factor (TNF) was analyzed using PMA- activated THP-1 cells by ELISA. Suppression assay was analyzed using Treg cells and Teff cells isolated from RA patients by flow cytometry. Results: In the CIA model, CKD-L and Tubastatin A significantly decreased the arthritis score. CKD-L increased CTLA-4 expression in Foxp3 Conclusion: CKD-L decreased the arthritis score in CIA, reduced the expression of TNF and IL-1β, and increased the expression of IL-10 in PBMC from RA patients. CKD-L increased CTLA-4 expression and the suppressive function of Treg cells. These results suggest that CKD-L may have a beneficial effect in the treatment of RA.
Language	English
Publishing date	2017-07-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2107602-9
ISSN	1478-6362 ; 1478-6354
ISSN (online)	1478-6362
ISSN	1478-6354
DOI	10.1186/s13075-017-1357-2
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Article ; Online: Comparison of Native Escherichia coli L-Asparaginase versus Pegylated Asparaginase, in Combination with Ifosfamide, Methotrexate, Etoposide, and Prednisolone, in Extranodal NK/T-Cell Lymphoma, Nasal Type.

Kim, Hyun Jee / Ock, Chan-Young / Kim, Tae Min / Lee, Sung Hee / Lee, Ju-Yeun / Jung, Sun Hoi / Cho, Yoon Sook / Kim, Miso / Keam, Bhumsuk / Kim, Dong-Wan / Kim, Il Han / Heo, Dae Seog

Cancer research and treatment

2017 Volume 50, Issue 3, Page(s) 670–680

Abstract: ... preparations, namely native Escherichia coli L-asparaginase (L-ASP) and pegylated asparaginase (PEG-ASP ... in combination with ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) in natural killer (NK)/T-cell ... coli L-ASP or PEG-ASP at Seoul National University Hospital were included in this study between January ...

Abstract	Purpose: The aim of this study was to compare asparaginase-related toxicities in two asparaginase preparations, namely native Escherichia coli L-asparaginase (L-ASP) and pegylated asparaginase (PEG-ASP) in combination with ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) in natural killer (NK)/T-cell lymphoma (NTCL). Materials and methods: A total of 41 NTCL patients who received IMEP plus native E. coli L-ASP or PEG-ASP at Seoul National University Hospital were included in this study between January 2013 and March 2016. IMEP/ASP treatment consisted of ifosfamide, methotrexate, etoposide, plus native E. coli L-ASP (6,000 IU/m2 on days 1, 3, 5, 7, 9, and 11) or PEG-ASP (2,500 IU/m2 on day 1) every 3 weeks. ASP-related toxicities, toxicity patterns, length of hospital stay, and clinical outcomes were compared between the different treatment groups. Results: The frequency of ASP-related toxicities was similar between the IMEP plus native E. coli L-ASP group and the PEG-ASP group apart from hypofibrinogenemia (native E. coli L-ASP vs. PEG-ASP group, 86.4% vs. 36.8%; p=0.001). Although post-treatment transaminase and albumin levels were significantly high and low, respectively, hepatotoxicity gradients before and after treatment did not differ significantly between the groups. Since PEG-ASP was given at an outpatient clinic in some patients, length of hospital stay was significantly shorter in the IMEP plus PEG-ASP group (median, 4.0 vs. 6.0 days; p=0.002). A favorable tendency of clinical outcomes was observed in NTCL patients treated with IMEP plus PEG-ASP (complete remission rate, 73.7% vs. 45.5%; p=0.067). Conclusion: IMEP plus PEG-ASP showed similar ASP-related toxicities, shorter length of hospital stay, and a trend towards improved clinical outcomes compared with IMEP plus native E. coli L-ASP in NTCL.
MeSH term(s)	Aged ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Asparaginase/administration & dosage ; Asparaginase/adverse effects ; Escherichia coli/enzymology ; Etoposide/administration & dosage ; Etoposide/therapeutic use ; Female ; Humans ; Ifosfamide/administration & dosage ; Ifosfamide/therapeutic use ; Length of Stay ; Lymphoma, Extranodal NK-T-Cell/drug therapy ; Male ; Methotrexate/administration & dosage ; Methotrexate/therapeutic use ; Middle Aged ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/adverse effects ; Prednisolone/administration & dosage ; Prednisolone/therapeutic use ; Treatment Outcome
Chemical Substances	Polyethylene Glycols (3WJQ0SDW1A) ; Etoposide (6PLQ3CP4P3) ; pegaspargase (7D96IR0PPM) ; Prednisolone (9PHQ9Y1OLM) ; Asparaginase (EC 3.5.1.1) ; Ifosfamide (UM20QQM95Y) ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2017-07-03
Publishing country	Korea (South)
Document type	Comparative Study ; Journal Article
ZDB-ID	2133613-1
ISSN	2005-9256 ; 1598-2998
ISSN (online)	2005-9256
ISSN	1598-2998
DOI	10.4143/crt.2017.051
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Article: Immunostimulatory effects of polysaccharides isolated from young barley leaves (Hordeum vulgare L.) with dual activation of Th1 and Th2 in splenic T cells and cyclophosphamide-induced immunosuppressed mice

Han, Hee-Soo / Shin, Ji-Sun / Song, Young-Ran / Rhee, Young Kyoung / Cho, Chang-Won / Ryu, Jong Hoon / Inn, Kyung-Soo / Hong, Hee-Do / Lee, Kyung-Tae

International journal of biological macromolecules. 2019 Oct. 06,

2019

Abstract	Botanical polysaccharides have been widely known to possess immunological activity. The objective of this study was to investigate the molecular mechanisms underlying the immunostimulatory properties of polysaccharides isolated from barley leaf (Hordeum vulgare L.) (BLE0) in splenocytes and cyclophosphamide (CYP)-induced immunosuppressed mice. BLE0 showed cell proliferative activity and markedly increased the secretion of both Th1-cytokines (IFN-γ and IL-2) and Th2-cytokines (IL-4 and IL-10) in CD3/CD28-activated splenocytes. Molecular data revealed that BLE0 up-regulated the expression of T-bet with enhanced phosphorylation of Janus kinase (JAK)-signal transducer and activator of transcription (STAT) 1 signaling pathway. BLE0 also increase the phosphorylation of GATA3 via toll-like receptor (TLR) 2-mediated signaling pathway with nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and activator protein 1 (AP-1) activation. Oral administration of BLE0 effectively improved CYP-induced decrease of body weight, splenocyte proliferation, and natural killer (NK) cell cytotoxic activity and significantly increased Th1 and Th2 cytokines, T-bet, and GATA3 mRNA expression. Dietary intake of BLE0 improves the immunological manifestations by stimulating both Th1 and Th2 responses via JAK/STAT1/T-bet and TLR2/GATA3, respectively.
Keywords	B-lymphocytes ; GATA transcription factors ; Hordeum vulgare ; T-lymphocytes ; Toll-like receptor 2 ; barley ; body weight ; cyclophosphamide ; cytotoxicity ; food intake ; gene expression ; gene expression regulation ; immunostimulants ; interferon-gamma ; interleukin-10 ; interleukin-2 ; interleukin-4 ; messenger RNA ; mice ; natural killer cells ; non-specific protein-tyrosine kinase ; oral administration ; phosphorylation ; polysaccharides ; secretion ; signal transduction ; splenocytes ; transactivators ; transcription factor NF-kappa B
Language	English
Dates of publication	2019-1006
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2019.10.062
Database	NAL-Catalogue (AGRICOLA)

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