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  1. AU=Pruimboom Leo
  2. AU="Naama, Moriyah"
  3. AU=Khan Israr
  4. AU="Ansary, Delwar"
  5. AU="Gamerra, Mario"
  6. AU="Eric M. Yoshida"
  7. AU="Raj, Rahul"
  8. AU="Semaan, Marie"
  9. AU="Trafton, Jodie"
  10. AU="Victoria Walker-Sperling"
  11. AU="Song, Wuqi"
  12. AU="Pham, K.‐C"
  13. AU="Boria Alegre, Felix"
  14. AU="Vecsey-Nagy, Milán"
  15. AU=Bazak Remon
  16. AU="Shaaban, Mahmoud"
  17. AU="Perminow, Gøri"
  18. AU="Akrim, Faraz"
  19. AU="Haider, Najm"
  20. AU="Jain, Divyanu"
  21. AU="Halpert, Richard"
  22. AU="Alkorta, Ibon"
  23. AU="Kwon, Kyungmi"
  24. AU="Bernardo Salasnich"
  25. AU="Hassan, Zurina"
  26. AU="Belarbi, M"
  27. AU="Rout, Ranjeet K"
  28. AU="Moreira, Catarina"
  29. AU=Warn-Cramer Bonnie J
  30. AU="Morral, Núria"
  31. AU="Silman, Miles R."
  32. AU="Palfi Salavat, Mădălina-Casiana"
  33. AU="Mohamed, Eid"
  34. AU="Hudson, Lance"
  35. AU="Imane Mihoub" AU="Imane Mihoub"
  36. AU="D. M. Wuchenich"

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  1. Artikel ; Online: Editorial: Long COVID-19: ultimate reasoning as a need for the search of proximate solutions.

    Pruimboom, Leo

    Frontiers in cellular and infection microbiology

    2023  Band 13, Seite(n) 1227626

    Mesh-Begriff(e) Humans ; COVID-19 ; Post-Acute COVID-19 Syndrome ; SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2023-06-05
    Erscheinungsland Switzerland
    Dokumenttyp Editorial
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1227626
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Editorial

    Leo Pruimboom

    Frontiers in Cellular and Infection Microbiology, Vol

    Long COVID-19: ultimate reasoning as a need for the search of proximate solutions

    2023  Band 13

    Schlagwörter SARS-CoV-2 ; long COVID ; lifestyle ; evolutionary medicine ; COVID prevention ; Microbiology ; QR1-502
    Sprache Englisch
    Erscheinungsdatum 2023-06-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Methylation Pathways and SARS-CoV-2 Lung Infiltration and Cell Membrane-Virus Fusion Are Both Subject to Epigenetics.

    Pruimboom, Leo

    Frontiers in cellular and infection microbiology

    2020  Band 10, Seite(n) 290

    Abstract: The recent pandemic SARS-CoV-2 outbreak affects all kinds of individuals worldwide. The health, social, and economic impacts of the pandemic are dramatic, and vaccines or specific treatment options are not yet available. The only approaches that we ... ...

    Abstract The recent pandemic SARS-CoV-2 outbreak affects all kinds of individuals worldwide. The health, social, and economic impacts of the pandemic are dramatic, and vaccines or specific treatment options are not yet available. The only approaches that we currently have available to stop the epidemic are those of classical epidemic control, such as case isolation, contact tracing and quarantine, physical distancing, and hygiene measures. It is therefore essential to find further preventive measures and possible interventions that can slow down the number of infected individuals and decrease the severity of disease when affected by SARS-CoV-2. It seems that epigenetic mechanisms are an important part of the pathophysiology and illness severity of COVID-19. These mechanisms have been identified in SARS-CoV-2 but also in other viral infections. If and when these mechanisms are confirmed, then epigenetic interventions influencing DNA methylation could be indicated as primary and/or secondary preventive options.
    Mesh-Begriff(e) Aging ; Angiotensin-Converting Enzyme 2 ; Betacoronavirus/genetics ; Betacoronavirus/physiology ; COVID-19 ; Cell Fusion ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; DNA Methylation ; Disease Susceptibility ; Epigenesis, Genetic ; Female ; Gene Silencing ; Humans ; Lung/virology ; Male ; Pandemics ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; Receptors, Coronavirus ; Receptors, Virus/genetics ; Receptors, Virus/metabolism ; SARS-CoV-2 ; Virus Internalization ; COVID-19 Drug Treatment
    Chemische Substanzen Receptors, Coronavirus ; Receptors, Virus ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-05-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2020.00290
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: SARS-CoV 2; Possible alternative virus receptors and pathophysiological determinants.

    Pruimboom, Leo

    Medical hypotheses

    2020  Band 146, Seite(n) 110368

    Abstract: Understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highjacks epithelial cells and infiltrates the lung, as well as other organs and tissues, is essential for developing treatment strategies and vaccines against this highly ... ...

    Abstract Understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highjacks epithelial cells and infiltrates the lung, as well as other organs and tissues, is essential for developing treatment strategies and vaccines against this highly contagious virus. Another major goal is to fully elucidate the mechanisms by which SARS-CoV- 2 bypasses the innate immune system and induces a cytokine storm, and its effects on mortality. Currently, SARS- CoV-2 is thought to evade innate antiviral immunity, undergo endocytosis, and fuse with the host cell membrane by exploiting ACE2 receptors and the protease TMMPRSS2, with cathepsin B/L as alternative protease, for entry into the epithelial cells of tissues vulnerable to developing coronavirus disease 2019 (COVID-19) symptoms. However, the incorporation of new and unique binding sites, i.e., O-linked glycans, and the preservation and augmentation of effective binding sites (N-linked glycans) on the outer membrane of SARS-CoV-2 may represent other strategies of infecting the human host. Here, I will rationalize the possibility that other host molecules-i.e., sugar molecules and the sialic acidsN-glycolylneuraminic acid, N-acetylneuraminic acid, and their derivates could be viable candidates for the use as virus receptors by SARS-CoV-2 and/or serve as determinants for the adherence on ACE2 of SARS-CoV-2.
    Mesh-Begriff(e) Angiotensin-Converting Enzyme 2/physiology ; COVID-19/immunology ; COVID-19/physiopathology ; COVID-19/virology ; Host Microbial Interactions/immunology ; Host Microbial Interactions/physiology ; Humans ; Immune Evasion ; Immunity, Innate ; Models, Biological ; Receptors, Virus/physiology ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; SARS-CoV-2/physiology ; Sialic Acids/physiology ; Virus Attachment ; Virus Internalization
    Chemische Substanzen Receptors, Virus ; Sialic Acids ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-11-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110368
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: The Relationship between Abdominal Diastasis and Lumbar Pain Pressure Threshold in Women Who Have Given Birth between the Ages of 30 and 45 Years-An Observational Pilot Study.

    González-Muñoz, Ana / Pruimboom, Leo / Navarro-Ledesma, Santiago

    Medicina (Kaunas, Lithuania)

    2024  Band 60, Heft 4

    Abstract: Background and ... ...

    Abstract Background and Objectives
    Mesh-Begriff(e) Humans ; Female ; Pilot Projects ; Adult ; Low Back Pain/physiopathology ; Middle Aged ; Pain Threshold/physiology ; Rectus Abdominis/physiopathology ; Pain Measurement/methods ; Diastasis, Muscle/physiopathology ; Diastasis, Muscle/complications ; Pressure ; Surveys and Questionnaires ; Lumbosacral Region/physiopathology
    Sprache Englisch
    Erscheinungsdatum 2024-04-03
    Erscheinungsland Switzerland
    Dokumenttyp Observational Study ; Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60040591
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6270: Hefte anzeigen Standort:
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  6. Artikel: A new perspective of frozen shoulder pathology; the interplay between the brain and the immune system.

    Navarro-Ledesma, Santiago / Hamed-Hamed, Dina / Pruimboom, Leo

    Frontiers in physiology

    2024  Band 15, Seite(n) 1248612

    Abstract: Frozen shoulder (FS), also known as adhesive capsulitis of the shoulder (FS), is a fibrotic inflammatory process of unknown etiology whose main symptoms are pain, stiffness and the loss of joint mobility. These symptoms may be associated with pathologies ...

    Abstract Frozen shoulder (FS), also known as adhesive capsulitis of the shoulder (FS), is a fibrotic inflammatory process of unknown etiology whose main symptoms are pain, stiffness and the loss of joint mobility. These symptoms may be associated with pathologies such as diabetes, Dupuytren's syndrome and the prevalence of today's sedentary lifestyle. This literature review provides an overview of the epidemiology and pathogenesis of this pathology, as well as the mechanisms of lowgrade chronic inflammation and infection, insulin resistance, and omics-science associated with it. We also propose a new hypothesis related to the possibility that the GABAergic system could play a decisive role in the development of frozen shoulder and that therefore diabetes type 1, endocrinological autoimmune disorders and frozen shoulder are connected by the same pathophysiological mechanisms. If that is true, the combined presence of psycho-emotional stress factors and pathogenic immune challenges could be the main causes of frozen shoulder syndrome. Finally, we propose a series of possible intervention strategies based on a multifactorial etiological and mechanistic concept.
    Sprache Englisch
    Erscheinungsdatum 2024-03-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2024.1248612
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Methylation Pathways and SARS-CoV-2 Lung Infiltration and Cell Membrane-Virus Fusion Are Both Subject to Epigenetics

    Leo Pruimboom

    Frontiers in Cellular and Infection Microbiology, Vol

    2020  Band 10

    Abstract: The recent pandemic SARS-CoV-2 outbreak affects all kinds of individuals worldwide. The health, social, and economic impacts of the pandemic are dramatic, and vaccines or specific treatment options are not yet available. The only approaches that we ... ...

    Abstract The recent pandemic SARS-CoV-2 outbreak affects all kinds of individuals worldwide. The health, social, and economic impacts of the pandemic are dramatic, and vaccines or specific treatment options are not yet available. The only approaches that we currently have available to stop the epidemic are those of classical epidemic control, such as case isolation, contact tracing and quarantine, physical distancing, and hygiene measures. It is therefore essential to find further preventive measures and possible interventions that can slow down the number of infected individuals and decrease the severity of disease when affected by SARS-CoV-2. It seems that epigenetic mechanisms are an important part of the pathophysiology and illness severity of COVID-19. These mechanisms have been identified in SARS-CoV-2 but also in other viral infections. If and when these mechanisms are confirmed, then epigenetic interventions influencing DNA methylation could be indicated as primary and/or secondary preventive options.
    Schlagwörter epigenetics ; methylation ; SARS-CoV-2 ; COVID-19 ; syncytium ; cell fusion ; Microbiology ; QR1-502 ; covid19
    Sprache Englisch
    Erscheinungsdatum 2020-05-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: SARS-CoV 2; Possible alternative virus receptors and pathophysiological determinants

    Pruimboom, Leo

    Medical Hypotheses

    2020  , Seite(n) 110368

    Schlagwörter General Medicine ; covid19
    Sprache Englisch
    Verlag Elsevier BV
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110368
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  9. Artikel ; Online: Methylation Pathways and SARS-CoV-2 Lung Infiltration and Cell Membrane-Virus Fusion Are Both Subject to Epigenetics

    Pruimboom, Leo

    Frontiers in Cellular and Infection Microbiology

    2020  Band 10

    Schlagwörter Immunology ; Microbiology (medical) ; Microbiology ; Infectious Diseases ; covid19
    Verlag Frontiers Media SA
    Erscheinungsland ch
    Dokumenttyp Artikel ; Online
    ZDB-ID 2619676-1
    ISSN 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2020.00290
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  10. Artikel: Methylation Pathways and SARS-CoV-2 Lung Infiltration and Cell Membrane-Virus Fusion Are Both Subject to Epigenetics

    Pruimboom, Leo

    Front Cell Infect Microbiol

    Abstract: The recent pandemic SARS-CoV-2 outbreak affects all kinds of individuals worldwide. The health, social, and economic impacts of the pandemic are dramatic, and vaccines or specific treatment options are not yet available. The only approaches that we ... ...

    Abstract The recent pandemic SARS-CoV-2 outbreak affects all kinds of individuals worldwide. The health, social, and economic impacts of the pandemic are dramatic, and vaccines or specific treatment options are not yet available. The only approaches that we currently have available to stop the epidemic are those of classical epidemic control, such as case isolation, contact tracing and quarantine, physical distancing, and hygiene measures. It is therefore essential to find further preventive measures and possible interventions that can slow down the number of infected individuals and decrease the severity of disease when affected by SARS-CoV-2. It seems that epigenetic mechanisms are an important part of the pathophysiology and illness severity of COVID-19. These mechanisms have been identified in SARS-CoV-2 but also in other viral infections. If and when these mechanisms are confirmed, then epigenetic interventions influencing DNA methylation could be indicated as primary and/or secondary preventive options.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #612813
    Datenquelle COVID19

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