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Article ; Online: Therapeutic Effect of Yi-Chi-Tsung-Ming-Tang on Amyloid β-Induced Alzheimer's Disease-Like Phenotype via an Increase of Acetylcholine and Decrease of Amyloid β.

Yeh, Chung-Hsin / Hsieh, Ming-Tsuen / Hsueh, Chi-Mei / Wu, Chi-Rei / Huang, Yi-Chun / Liao, Jiunn-Wang / Chow, Kuan-Chih

Evidence-based complementary and alternative medicine : eCAM

2012 Volume 2012, Page(s) 414536

Abstract: ... accumulation, neuronal death, and cognitive impairments. Yi-Chi-Tsung-Ming-Tang (YCTMT) is ...

Abstract	Alzheimer's disease (AD) is an irreversible neurodegenerative disorder characterized by amyloid accumulation, neuronal death, and cognitive impairments. Yi-Chi-Tsung-Ming-Tang (YCTMT) is a traditional Chinese medicine and has never been used to enhance cognitive function and treat neurodegenerative disorders such as senile dementia. Whether YCTMT has a beneficial role in improving learning and memory in AD patients remains unclear. The present study showed that oral administration of YCTMT ameliorated amyloid-β- (Aβ(1-40)) injection-induced learning and memory impairments in rats, examined using passive avoidance and Morris water-maze tests. Immunostaining and Western Blot results showed that continuous Aβ(1-40) infusion caused amyloid accumulation and decreased acetylcholine level in hippocampus. Oral administration of medium and high dose of YCTMT 7 days after the Aβ(1-40) infusion decreased amyloid accumulation area and reversed acetylcholine decline in the Aβ(1-40)-injected hippocampus, suggesting that YCTMT might inhibit Aβ plague accumulation and rescue reduced acetylcholine expression. This study has provided evidence on the beneficial role of YCTMT in ameliorating amyloid-induced AD-like symptom, indicating that YCTMT may offer an alternative strategy for treating AD.
Language	English
Publishing date	2012-06-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2012/414536
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Therapeutic Effect of Yi-Chi-Tsung-Ming-Tang on Amyloid β1−40-Induced Alzheimer's Disease-Like Phenotype via an Increase of Acetylcholine and Decrease of Amyloid β

Chung-Hsin Yeh / Ming-Tsuen Hsieh / Chi-Mei Hsueh / Chi-Rei Wu / Yi-Chun Huang / Jiunn-Wang Liao / Kuan-Chih Chow

Evidence-Based Complementary and Alternative Medicine, Vol

2012 Volume 2012

Abstract: ... accumulation, neuronal death, and cognitive impairments. Yi-Chi-Tsung-Ming-Tang (YCTMT) is ...

Abstract	Alzheimer's disease (AD) is an irreversible neurodegenerative disorder characterized by amyloid accumulation, neuronal death, and cognitive impairments. Yi-Chi-Tsung-Ming-Tang (YCTMT) is a traditional Chinese medicine and has never been used to enhance cognitive function and treat neurodegenerative disorders such as senile dementia. Whether YCTMT has a beneficial role in improving learning and memory in AD patients remains unclear. The present study showed that oral administration of YCTMT ameliorated amyloid-β- (Aβ1−40) injection-induced learning and memory impairments in rats, examined using passive avoidance and Morris water-maze tests. Immunostaining and Western Blot results showed that continuous Aβ1−40 infusion caused amyloid accumulation and decreased acetylcholine level in hippocampus. Oral administration of medium and high dose of YCTMT 7 days after the Aβ1−40 infusion decreased amyloid accumulation area and reversed acetylcholine decline in the Aβ1−40-injected hippocampus, suggesting that YCTMT might inhibit Aβ plague accumulation and rescue reduced acetylcholine expression. This study has provided evidence on the beneficial role of YCTMT in ameliorating amyloid-induced AD-like symptom, indicating that YCTMT may offer an alternative strategy for treating AD.
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: She hui yi liao bao xian ke chi xu fa zhan ji zhi yan jiu

Wu, Chuanjian

(Shi hui yi liao bao xian cheng shou li yu ke chi xu fa zhan xi lie)

2014

Author's details	Wu Chuanjian, Wang Yufang zhu
Series title	Shi hui yi liao bao xian cheng shou li yu ke chi xu fa zhan xi lie
MeSH term(s)	Insurance, Health/economics ; Health Care Costs ; Socioeconomic Factors
Keywords	China
Language	Chinese
Size	3, 3, 245 p. :, ill.
Edition	Di 1 ban.
Publisher	Jing ji ke xue chu ban she
Publishing place	Beijing
Document type	Book
ISBN	9787514152050 ; 7514152059
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Thoughts of social distancing experiences affect food intake and hypothetical binge eating: Implications for people in home quarantine during COVID-19.

Yi-Chi Chang, Yevvon / Wu, Pai-Lu / Chiou, Wen-Bin

Social science & medicine (1982)

2021 Volume 284, Page(s) 114218

Abstract: Backgrond and rationale: Social distance regulations have been suggested as one of the best ways to control and prevent the spread of COVID-19. Social connection and food are intertwined because both have played critical evolutionary roles in human ... ...

Abstract	Backgrond and rationale: Social distance regulations have been suggested as one of the best ways to control and prevent the spread of COVID-19. Social connection and food are intertwined because both have played critical evolutionary roles in human survival. We tested whether the substitutability hypothesis in human motivation applies here in that cues signaling scarcity in one domain (e.g., social connection) might enhance the desire to acquire resources in another domain (e.g., food). Methods: We recruited 140 adults from Kaohsiung City (the largest city in southern Taiwan) to participate in a laboratory experiment. Participants were randomly assigned to receive either social distancing or neutral primes via an emotional-event recollection technique. The amount of ice cream eaten during a taste test and the self-reported likelihood of binge eating served as the dependent measures. Results: We found that, compared with controls, participants primed with social distancing consumed more ice cream in a taste test and reported a greater likelihood that they would engage in binge eating if they were placed in home quarantine. Conclusions: We may be the first to provide experimental evidence that social distancing can enhance the desire for food. The link between social distancing and the desire for food is pertinent to understanding how strongly social distance regulations may influence weight gain. Our findings have far-reaching implications for weight control under social distance regulations for prevention and control of COVID-19.
MeSH term(s)	Adult ; Binge-Eating Disorder ; COVID-19 ; Eating ; Humans ; Physical Distancing ; Quarantine ; SARS-CoV-2
Language	English
Publishing date	2021-07-10
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	4766-1
ISSN	1873-5347 ; 0037-7856 ; 0277-9536
ISSN (online)	1873-5347
ISSN	0037-7856 ; 0277-9536
DOI	10.1016/j.socscimed.2021.114218
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Article ; Online: Reply to "Protecting against COVID-19 aerosol infection during intubation".

Wu, Yi-Chi / Chen, Ching-Sung / Chan, Yu-Jiun

Journal of the Chinese Medical Association : JCMA

2020 Volume 83, Issue 6, Page(s) 583

MeSH term(s)	Aerosols ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Intubation, Intratracheal ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
Chemical Substances	Aerosols
Keywords	covid19
Language	English
Publishing date	2020-06-05
Publishing country	Netherlands
Document type	Journal Article ; Comment
ZDB-ID	2107283-8
ISSN	1728-7731 ; 1726-4901
ISSN (online)	1728-7731
ISSN	1726-4901
DOI	10.1097/JCMA.0000000000000331
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Zs.A 2699: Show issues

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Article ; Online: Modulations of ocean-atmosphere interactions on squid abundance over Southwest Atlantic.

Ko, Chia-Ying / Lee, Yu-Chi / Wang, Yi-Chi / Hsu, Huang-Hsiung / Chow, Chun Hoe / Chen, Ruei-Gu / Liu, Tsung-Han / Chen, Chih-Shin / Chiu, Tai-Sheng / Chiang, Don-Hsieh / Wu, Ren-Fen / Tseng, Wan-Ling

Environmental research

2024 Volume 250, Page(s) 118444

Abstract: Anthropogenic shifts in seas are reshaping fishing trends, with significant implications for aquatic food sources throughout this century. Examining a 21-year abundance dataset of Argentine shortfin squids Illex argentinus paired with a regional oceanic ... ...

Abstract	Anthropogenic shifts in seas are reshaping fishing trends, with significant implications for aquatic food sources throughout this century. Examining a 21-year abundance dataset of Argentine shortfin squids Illex argentinus paired with a regional oceanic analysis, we noted strong correlations between squid annual abundance and sea surface temperature (SST) in January and February and eddy kinetic energy (EKE) from March to May in the Southwest Atlantic. A deeper analysis revealed combined ocean-atmosphere interactions, pinpointed as the primary mode in a rotated empirical orthogonal function analysis of SST. This pattern produced colder SST and amplified EKE in the surrounding seas, factors crucial for the unique life stages of squids. Future projections from the CMIP6 archive indicated that this ocean-atmosphere pattern, referred to as the Atlantic symmetric pattern, would persist in its cold SST phase, promoting increased squid abundance. However, rising SSTs due to global warming might counteract the abundance gains. Our findings uncover a previously unrecognized link between squids and specific environmental conditions governed by broader ocean-atmosphere interactions in the Southwest Atlantic. Integrating these insights with seasonal and decadal projections can offer invaluable information to stakeholders in squid fisheries and marine conservation under a changing climate.
Language	English
Publishing date	2024-02-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2024.118444
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Article: Resveratrol prevents age-related heart impairment through inhibiting the Notch/NF-κB pathway.

Wang, Le-Feng / Li, Wen-Juan / Zhang, Xian-Yi / Zhang, Yi-Chi / Chen, Guang-Feng / Zhou, Xing-Yu / Xv, Dong-Mei / Wu, Qiong

Food science & nutrition

2023 Volume 12, Issue 2, Page(s) 1035–1045

Abstract: Resveratrol (RSV) is a natural polyphenol compound found in various plants that has been shown to have potential benefits for preventing aging and supporting cardiovascular health. However, the specific signal pathway by which RSV protects the aging ... ...

Abstract	Resveratrol (RSV) is a natural polyphenol compound found in various plants that has been shown to have potential benefits for preventing aging and supporting cardiovascular health. However, the specific signal pathway by which RSV protects the aging heart is not yet well understood. This study aimed to explore the protective effects of RSV against age-related heart injury and investigate the underlying mechanisms using a D-galactose-induced aging model. The results of the study indicated that RSV provided protection against age-related heart impairment in mice. This was evidenced by the reduction of cardiac histopathological changes as well as the attenuation of apoptosis. RSV-induced cardioprotection was linked to a significant increase in antioxidant activity and mitochondrial transmembrane potential, as well as a reduction in oxidative damage. Additionally, RSV inhibited the production of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α). Furthermore, the expression of toll-like receptor 4 (TLR4), nuclear factor kappa-B p65 (NF-κB p65), and notch 1 protein were inhibited by RSV, indicating that inhibiting the Notch/NF-κB pathway played a critical role in RSV-triggered heart protection in aging mice. Moreover, further data on intestinal function demonstrated that RSV significantly increased short-chain fatty acids (SCFAs) in intestinal contents and reduced the pH value in the feces of aging mice. RSV alleviated aging-induced cardiac dysfunction through the suppression of oxidative stress and inflammation via the Notch/NF-κB pathway in heart tissue. Furthermore, this therapeutic effect was found to be associated with its protective roles in the intestine.
Language	English
Publishing date	2023-11-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703010-6
ISSN	2048-7177
ISSN	2048-7177
DOI	10.1002/fsn3.3817
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Transient hepatic portal venous gas secondary to emphysematous infectious spondylodiscitis.

Hung, Yi-Chi / Chang, Chen-Jung / Fu-Zong, Wu

British journal of hospital medicine (London, England : 2005)

2020 Volume 81, Issue 8, Page(s) 1–2

MeSH term(s)	Aged ; Discitis/complications ; Emphysema/complications ; Female ; Humans ; Portal Vein/pathology ; Staphylococcal Infections/complications ; Staphylococcus epidermidis
Language	English
Publishing date	2020-08-25
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1750-8460
ISSN	1750-8460
DOI	10.12968/hmed.2020.0170
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of different cardiopulmonary resuscitation education interventions among university students: A randomized controlled trial.

Chang, Yu-Tung / Wu, Kun-Chia / Yang, Hsiang-Wen / Lin, Chung-Yi / Huang, Tzu-Fu / Yu, Yi-Chi / Hu, Yih-Jin

PloS one

2023 Volume 18, Issue 3, Page(s) e0283099

Abstract: Cardiopulmonary resuscitation (CPR) education for the public may improve bystander intention to perform CPR on cardiac arrest patients. Studies have shown that different CPR education intervention methods can improve learning performance, with key ... ...

Abstract	Cardiopulmonary resuscitation (CPR) education for the public may improve bystander intention to perform CPR on cardiac arrest patients. Studies have shown that different CPR education intervention methods can improve learning performance, with key indicators including attitude toward to CPR, intention to perform CPR, and degree of CPR knowledge and skills. The present study compared the traditional face-to-face method to hybrid and virtual reality (VR) methods to observe difference in learning performance and length of performance retention. This study adopted randomized controlled trial to compare CPR learning performance between traditional face-to-face, hybrid, and VR methods. Participants from each intervention group completed a pretest and 2 posttests. The measurement tools included an attitude and intention questionnaire, knowledge examination, and skill examination with a RESUSCI ANNE QCPR ® manikin. The performance among all participants in pretest showed no significant difference between the intervention groups, indicating no difference in their background attitude, knowledge, and skill level. Significant differences were observed in the average degree of intention to perform CPR between the hybrid and traditional groups in 1st and 2nd posttest. Compared to the pretest results, the posttests revealed significantly higher attitude toward CPR, intention to perform CPR, knowledge examination results, accuracy of overall chest compression, accuracy of CPR procedure, accuracy of AED usage, accuracy of chest compression rate, and accuracy of chest compression depth. The average time to reattending CPR learning and practice session was 11-12 weeks reported by participants. The hybrid and VR methods to CPR education resulted in the same level of improvement in learning performance as traditional face-to-face teaching. The suggested frequency for renewing CPR knowledge and skills is 12 weeks which may be considered in new strategies aimed at promoting CPR education and exposure to the public.
MeSH term(s)	Humans ; Cardiopulmonary Resuscitation/methods ; Universities ; Heart Arrest ; Manikins ; Students
Language	English
Publishing date	2023-03-14
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0283099
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Cayratia albifolia C.L.Li exerts anti-rheumatoid arthritis effect by inhibiting macrophage activation and neutrophil extracellular traps (NETs).

Wang, Wei / Zhang, Zai-Qi / Zhang, Yi-Chi / Wu, Yi-Qiang / Yang, Zhuo / Zheng, Yong-Zhe / Lu, Jia-Hong / Tu, Peng-Fei / Zeng, Ke-Wu

Chinese medicine

2024 Volume 19, Issue 1, Page(s) 42

Abstract: Background: Cayratia albifolia C.L.Li (CAC), commonly known as "Jiao-Mei-Gu" in China, has been extensively utilized by the Dong minority for several millennia to effectively alleviate symptoms associated with autoimmune diseases. CAC extract is ... ...

Abstract	Background: Cayratia albifolia C.L.Li (CAC), commonly known as "Jiao-Mei-Gu" in China, has been extensively utilized by the Dong minority for several millennia to effectively alleviate symptoms associated with autoimmune diseases. CAC extract is believed to possess significant anti-inflammatory properties within the context of Dong medicine. However, an in-depth understanding of the specific pharmaceutical effects and underlying mechanisms through which CAC extract acts against rheumatoid arthritis (RA) has yet to be established. Methods: Twenty-four Sprague-Dawley rats were divided into four groups, with six rats in each group. To induce the collagen-induced arthritis (CIA) model, the rats underwent a process of double immunization with collagen and adjuvant. CAC extract (100 mg/kg) was orally administered to rats. The anti-RA effects were evaluated in CIA rats by arthritis score, hind paw volume and histopathology analysis. Pull-down assay was conducted to identify the potential targets of CAC extract from RAW264.7 macrophage lysates. Moreover, mechanism studies of CAC extract were performed by immunofluorescence assays, real-time PCR and Western blot. Results: CAC extract was found to obviously down-regulate hind paw volume of CIA rats, with diminished inflammation response and damage. 177 targets were identified from CAC extract by MS-based pull-down assay. Bioinformatics analysis found that these targets were mainly enriched in macrophage activation and neutrophils extracellular traps (NETs). Additionally, we reported that CAC extract owned significant anti-inflammatory activity by regulating PI3K-Akt-mTOR signal pathway, and inhibited NETosis in response to PMA. Conclusions: We clarified that CAC extract significantly attenuated RA by inactivating macrophage and reducing NETosis via a multi-targets regulation.
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-024-00910-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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