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  1. Article ; Online: Hypertension, Neurodegeneration, and Cognitive Decline.

    Pacholko, Anthony / Iadecola, Costantino

    Hypertension (Dallas, Tex. : 1979)

    2024  Volume 81, Issue 5, Page(s) 991–1007

    Abstract: Elevated blood pressure is a well-established risk factor for age-related cognitive decline. Long linked to cognitive impairment on vascular bases, increasing evidence suggests a potential association of hypertension with the neurodegenerative pathology ... ...

    Abstract Elevated blood pressure is a well-established risk factor for age-related cognitive decline. Long linked to cognitive impairment on vascular bases, increasing evidence suggests a potential association of hypertension with the neurodegenerative pathology underlying Alzheimer disease. Hypertension is well known to disrupt the structural and functional integrity of the cerebral vasculature. However, the mechanisms by which these alterations lead to brain damage, enhance Alzheimer pathology, and promote cognitive impairment remain to be established. Furthermore, critical questions concerning whether lowering blood pressure by antihypertensive medications prevents cognitive impairment have not been answered. Recent developments in neurovascular biology, brain imaging, and epidemiology, as well as new clinical trials, have provided insights into these critical issues. In particular, clinical and basic findings on the link between neurovascular dysfunction and the pathobiology of neurodegeneration have shed new light on the overlap between vascular and Alzheimer pathology. In this review, we will examine the progress made in the relationship between hypertension and cognitive impairment and, after a critical evaluation of the evidence, attempt to identify remaining knowledge gaps and future research directions that may advance our understanding of one of the leading health challenges of our time.
    MeSH term(s) Humans ; Alzheimer Disease ; Hypertension ; Cognitive Dysfunction ; Brain ; Antihypertensive Agents/therapeutic use
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.123.21356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Revisiting atherosclerosis and dementia.

    Iadecola, Costantino

    Nature neuroscience

    2020  Volume 23, Issue 6, Page(s) 691–692

    MeSH term(s) Alzheimer Disease ; Atherosclerosis ; Brain ; Humans ; Intracranial Arteriosclerosis ; Proteomics
    Language English
    Publishing date 2020-05-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/s41593-020-0626-6
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  3. Article ; Online: When the BBB goes MIA.

    Pearson, Caroline A / Iadecola, Costantino

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 19, Page(s) e2204159119

    Language English
    Publishing date 2022-05-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2204159119
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  4. Article ; Online: Introduction to the Compendium on Stroke and Neurocognitive Impairment.

    Iadecola, Costantino / Fisher, Marc / Sacco, Ralph L

    Circulation research

    2022  Volume 130, Issue 8, Page(s) 1073–1074

    MeSH term(s) Brain Ischemia ; Humans ; Intracranial Hemorrhages ; Stroke/epidemiology ; Stroke/therapy
    Language English
    Publishing date 2022-04-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.122.321073
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  5. Article ; Online: Untangling Neurons With Endothelial Nitric Oxide.

    Iadecola, Costantino

    Circulation research

    2016  Volume 119, Issue 10, Page(s) 1052–1054

    MeSH term(s) Alzheimer Disease ; Humans ; Neurons ; Nitric Oxide ; tau Proteins
    Chemical Substances tau Proteins ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2016--28
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.116.309927
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  6. Article ; Online: Calcium transients in nNOS neurons underlie distinct phases of the neurovascular response to barrel cortex activation in awake mice.

    Ahn, Sung Ji / Anfray, Antoine / Anrather, Josef / Iadecola, Costantino

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2023  Volume 43, Issue 10, Page(s) 1633–1647

    Abstract: Neuronal nitric oxide (NO) synthase (nNOS), a ... ...

    Abstract Neuronal nitric oxide (NO) synthase (nNOS), a Ca
    MeSH term(s) Animals ; Mice ; Calcium/metabolism ; Cerebral Cortex/metabolism ; Neurons/metabolism ; Neurovascular Coupling ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type I/metabolism ; Wakefulness
    Chemical Substances Calcium (SY7Q814VUP) ; Nitric Oxide (31C4KY9ESH) ; Nitric Oxide Synthase Type I (EC 1.14.13.39)
    Language English
    Publishing date 2023-05-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X231173175
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  7. Article ; Online: Immune compartments at the brain's borders in health and neurovascular diseases.

    Goertz, Jennifer E / Garcia-Bonilla, Lidia / Iadecola, Costantino / Anrather, Josef

    Seminars in immunopathology

    2023  Volume 45, Issue 3, Page(s) 437–449

    Abstract: Recent evidence implicates cranial border immune compartments in the meninges, choroid plexus, circumventricular organs, and skull bone marrow in several neuroinflammatory and neoplastic diseases. Their pathogenic importance has also been described for ... ...

    Abstract Recent evidence implicates cranial border immune compartments in the meninges, choroid plexus, circumventricular organs, and skull bone marrow in several neuroinflammatory and neoplastic diseases. Their pathogenic importance has also been described for cardiovascular diseases such as hypertension and stroke. In this review, we will examine the cellular composition of these cranial border immune niches, the potential pathways through which they might interact, and the evidence linking them to cardiovascular disease.
    MeSH term(s) Humans ; Meninges ; Brain
    Language English
    Publishing date 2023-05-03
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2316828-6
    ISSN 1863-2300 ; 1863-2297
    ISSN (online) 1863-2300
    ISSN 1863-2297
    DOI 10.1007/s00281-023-00992-6
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  8. Article ; Online: The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease.

    Iadecola, Costantino

    Neuron

    2017  Volume 96, Issue 1, Page(s) 17–42

    Abstract: The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress Review Group meeting of the National Institute of Neurological Disorders and Stroke, emphasizes the intimate relationship between the brain and its vessels. Since then, ... ...

    Abstract The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress Review Group meeting of the National Institute of Neurological Disorders and Stroke, emphasizes the intimate relationship between the brain and its vessels. Since then, the NVU has attracted the interest of the neuroscience community, resulting in considerable advances in the field. Here the current state of knowledge of the NVU will be assessed, focusing on one of its most vital roles: the coupling between neural activity and blood flow. The evidence supports a conceptual shift in the mechanisms of neurovascular coupling, from a unidimensional process involving neuronal-astrocytic signaling to local blood vessels to a multidimensional one in which mediators released from multiple cells engage distinct signaling pathways and effector systems across the entire cerebrovascular network in a highly orchestrated manner. The recently appreciated NVU dysfunction in neurodegenerative diseases, although still poorly understood, supports emerging concepts that maintaining neurovascular health promotes brain health.
    MeSH term(s) Astrocytes/physiology ; Brain/blood supply ; Health ; Humans ; Models, Neurological ; Neurodegenerative Diseases/physiopathology ; Neurons/physiology ; Neurovascular Coupling/physiology ; Signal Transduction/physiology
    Language English
    Publishing date 2017-09-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2017.07.030
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  9. Article ; Online: Revisiting the neurovascular unit.

    Schaeffer, Samantha / Iadecola, Costantino

    Nature neuroscience

    2021  Volume 24, Issue 9, Page(s) 1198–1209

    Abstract: The brain is supplied by an elaborate vascular network that originates extracranially and reaches deep into the brain. The concept of the neurovascular unit provides a useful framework to investigate how neuronal signals regulate nearby microvessels to ... ...

    Abstract The brain is supplied by an elaborate vascular network that originates extracranially and reaches deep into the brain. The concept of the neurovascular unit provides a useful framework to investigate how neuronal signals regulate nearby microvessels to support the metabolic needs of the brain, but it does not consider the role of larger cerebral arteries and systemic vasoactive signals. Furthermore, the recently emerged molecular heterogeneity of cerebrovascular cells indicates that there is no prototypical neurovascular unit replicated at all levels of the vascular network. Here, we examine the cellular and molecular diversity of the cerebrovascular tree and the relative contribution of systemic and brain-intrinsic factors to neurovascular function. Evidence supports the concept of a 'neurovascular complex' composed of segmentally diverse functional modules that implement coordinated vascular responses to central and peripheral signals to maintain homeostasis of the brain. This concept has major implications for neurovascular regulation in health and disease and for brain imaging.
    MeSH term(s) Animals ; Brain/blood supply ; Brain/physiology ; Cerebrovascular Circulation/physiology ; Homeostasis/physiology ; Humans ; Neurovascular Coupling/physiology
    Language English
    Publishing date 2021-08-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/s41593-021-00904-7
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  10. Article ; Online: Risk factor for Alzheimer's disease breaks the blood-brain barrier.

    Ishii, Makoto / Iadecola, Costantino

    Nature

    2020  Volume 581, Issue 7806, Page(s) 31–32

    MeSH term(s) Alzheimer Disease ; Apolipoprotein E4 ; Blood-Brain Barrier ; Cognitive Dysfunction ; Humans ; Risk Factors
    Chemical Substances Apolipoprotein E4
    Language English
    Publishing date 2020-04-30
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-020-01152-8
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