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Article ; Online: PLATELET FUNCTION IN TRAUMA: IS CURRENT TECHNOLOGY IN FUNCTION TESTING MISSING THE MARK IN INJURED PATIENTS?

Schriner, Jacob B / George, Mitchell J / Cardenas, Jessica C / Olson, Scott D / Mankiewicz, Kimberly A / Cox, Charles S / Gill, Brijesh S / Wade, Charles E

Shock (Augusta, Ga.)

2022 Volume 58, Issue 1, Page(s) 1–13

Abstract: Abstract: Platelets are subcellular anucleate components of blood primarily responsible for initiating and maintaining hemostasis. After injury to a blood vessel, platelets can be activated via several pathways, resulting in changed shape, adherence to ... ...

Abstract	Abstract: Platelets are subcellular anucleate components of blood primarily responsible for initiating and maintaining hemostasis. After injury to a blood vessel, platelets can be activated via several pathways, resulting in changed shape, adherence to the injury site, aggregation to form a plug, degranulation to initiate activation in other nearby platelets, and acceleration of thrombin formation to convert fibrinogen to fibrin before contracting to strengthen the clot. Platelet function assays use agonists to induce and measure one or more of these processes to identify alterations in platelet function that increase the likelihood of bleeding or thrombotic events. In severe trauma, these assays have revealed that platelet dysfunction is strongly associated with poor clinical outcomes. However, to date, the mechanism(s) causing clinically significant platelet dysfunction remain poorly understood. We review the pros, cons, and evidence for use of many of the popular assays in trauma, discuss limitations of their use in this patient population, and present approaches that can be taken to develop improved functional assays capable of elucidating mechanisms of trauma-induced platelet dysfunction. Platelet dysfunction in trauma has been associated with need for transfusions and mortality; however, most of the current platelet function assays were not designed for evaluating trauma patients, and there are limited data regarding their use in this population. New or improved functional assays will help define the mechanisms by which platelet dysfunction occurs, as well as help optimize future treatment.
MeSH term(s)	Blood Platelets/metabolism ; Fibrin/metabolism ; Hemostasis/physiology ; Humans ; Platelet Aggregation ; Platelet Function Tests/methods ; Thrombosis ; Wounds and Injuries/metabolism
Chemical Substances	Fibrin (9001-31-4)
Language	English
Publishing date	2022-07-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1185432-7
ISSN	1540-0514 ; 1073-2322
ISSN (online)	1540-0514
ISSN	1073-2322
DOI	10.1097/SHK.0000000000001948
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Article ; Online: Mark Blaug on the normativity of welfare economics

Hands, D. Wade / Blaug, Mark

Erasmus journal for philosophy and economics : EJPE Vol. 6, No. 3 , p. 1-25

2013 Volume 6, Issue 3, Page(s) 1–25

Author's details	D. Wade Hands
Keywords	positive and normative economics ; Pareto optimality ; welfare economics ; ethical and methodological norms ; Blaug-Hennipman debate
Language	English
Size	Online-Ressource
Publisher	Erasmus Univ
Publishing place	Rotterdam
Document type	Article ; Online
ZDB-ID	2474551-0
ISSN	1876-9098
Database	ECONomics Information System

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Article: The MBD protein family-reading an epigenetic mark?

Dhasarathy, Archana / Wade, Paul A

Mutation research

2008 Volume 647, Issue 1-2, Page(s) 39–43

Abstract: A family of proteins conserved throughout the eukaryotic lineage is characterized by the presence of a common sequence motif-the methyl-CpG-binding domain, or MBD. This sequence motif corresponds to a structural domain which, in some but not all cases, ... ...

Abstract	A family of proteins conserved throughout the eukaryotic lineage is characterized by the presence of a common sequence motif-the methyl-CpG-binding domain, or MBD. This sequence motif corresponds to a structural domain which, in some but not all cases, confers the ability to bind methylated cytosine residues in the context of the dinucleotide 5' CG 3'. Mammals have five well-characterized members of this family, each with unique biological characteristics. Recently, much progress has been made in defining the biochemical properties of one member of this family, MeCP2. This protein has a very high affinity for chromatin and considerable insight has been gained into its interactions with naked DNA and with chromatin fibers. Previous models have proposed that several members of the MBD family contribute to establishment and/or maintenance of transcriptional repression by recruiting enzymes that locally modify histones. Surprisingly, recent data indicate that MeCP2 is likely to contribute to chromatin properties through an architectural role, participating in higher order chromatin structures that facilitate both gene repression as well as gene activation. These observations suggest that existing models probably do not explain the entire gamut of biological functions performed by this very interesting protein family.
MeSH term(s)	Amino Acid Sequence ; Animals ; DNA Methylation ; DNA-Binding Proteins/genetics ; Epigenesis, Genetic ; Humans ; Molecular Sequence Data ; Protein Structure, Tertiary
Chemical Substances	DNA-Binding Proteins ; MBD2 protein, human
Language	English
Publishing date	2008-07-22
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Review
ZDB-ID	206607-5
ISSN	1873-135X ; 0027-5107 ; 1383-5718 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
ISSN (online)	1873-135X
ISSN	0027-5107 ; 1383-5718 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
DOI	10.1016/j.mrfmmm.2008.07.007
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Zs.A 1316: Show issues

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Article ; Online: Design of the POSSIBLE UStrade mark Study: postmenopausal women's compliance and persistence with osteoporosis medications.

Barrett-Connor, E / Ensrud, K / Tosteson, A N A / Varon, S F / Anthony, M / Daizadeh, N / Wade, S

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

2008 Volume 20, Issue 3, Page(s) 463–472

Abstract: Unlabelled: Failure to take prescribed medication is common. The POSSIBLE US study is evaluating the impact of physician and patient characteristics on patient-reported compliance and persistence with osteoporosis medications. We report our study design ...

Abstract	Unlabelled: Failure to take prescribed medication is common. The POSSIBLE US study is evaluating the impact of physician and patient characteristics on patient-reported compliance and persistence with osteoporosis medications. We report our study design and the baseline characteristics of 4,994 postmenopausal women recruited from primary care physician offices in 33 states. Introduction: The Prospective Observational Scientific Study Investigating Bone Loss Experience (POSSIBLE US) is a longitudinal cohort study of osteoporosis therapy in primary care. Methods: Between 2004 and 2007, 134 physicians (in 33 states) enrolled postmenopausal women initiating, changing, or continuing osteoporosis medications. After completing a baseline questionnaire, participants will provide data semi-annually for up to 3 years through 2008. Physicians provide patient data at baseline and routine follow-up visits. Participants from 23 sites also signed a release regarding administrative claims data for economic analyses and validation of self-reported data. Baseline results: Four thousand nine hundred and ninety-four evaluable women were recruited from internal medicine (n = 1,784), family practice (n = 1,556), obstetrics/gynecology (n = 1,556), and from one rheumatology practice (n = 98). Mean participant age was 64.3 years (SD = 9.97); 89% were Caucasian; 59% had some college education. Sixty-three percent used a single osteoporosis agent, usually a bisphosphonate. For monotherapy patients, concordance between clinic- and patient-reported medication use was lowest for patients prescribed estrogen therapy (70%) or calcium/vitamin D (72%). Obstetrician/gynecologists enrolled younger women, who were more likely to use estrogen therapy than patients enrolled by other physicians. The 934 women (19%) prescribed only calcium/vitamin D were younger than women prescribed pharmacologic therapy. Conclusions: POSSIBLE US provides a unique foundation for evaluating longitudinal use of osteoporosis medications and related outcomes.
MeSH term(s)	Aged ; Bone Density Conservation Agents/therapeutic use ; Calcium, Dietary/therapeutic use ; Estrogen Replacement Therapy/statistics & numerical data ; Female ; Humans ; Medication Adherence ; Middle Aged ; Osteoporosis, Postmenopausal/drug therapy ; Physician-Patient Relations ; Primary Health Care ; Prospective Studies ; Research Design ; Self Administration ; United States ; Vitamin D/therapeutic use
Chemical Substances	Bone Density Conservation Agents ; Calcium, Dietary ; Vitamin D (1406-16-2)
Language	English
Publishing date	2008-07-08
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	1064892-6
ISSN	1433-2965 ; 0937-941X
ISSN (online)	1433-2965
ISSN	0937-941X
DOI	10.1007/s00198-008-0674-3
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Article: Photographic mark-recapture analysis of clustered mammal-eating killer whales around the Aleutian Islands and Gulf of Alaska

Durban, J / Ellifrit, D / Dahlheim, M / Waite, J / Matkin, C / Barrett-Lennard, L / Ellis, G / Pitman, R / LeDuc, R / Wade, P

Marine biology. 2010 July, v. 157, no. 7

2010

Abstract: We used photographic mark-recapture methods to estimate the number of mammal-eating “transient ...

Abstract	We used photographic mark-recapture methods to estimate the number of mammal-eating “transient” killer whales using the coastal waters from the central Gulf of Alaska to the central Aleutian Islands, around breeding rookeries of endangered Steller sea lions. We identified 154 individual killer whales from 6,489 photographs collected between July 2001 and August 2003. A Bayesian mixture model estimated seven distinct clusters (95% probability interval = 7-10) of individuals that were differentially covered by 14 boat-based surveys exhibiting varying degrees of association in space and time. Markov Chain Monte Carlo methods were used to sample identification probabilities across the distribution of clusters to estimate a total of 345 identified and undetected whales (95% probability interval = 255-487). Estimates of covariance between surveys, in terms of their coverage of these clusters, indicated spatial population structure and seasonal movements from these near-shore waters, suggesting spatial and temporal variation in the predation pressure on coastal marine mammals.
Keywords	Monte Carlo method ; Otariidae ; coastal water ; covariance ; photographs ; population structure ; predation ; probability ; probability distribution ; seasonal migration ; surveys ; temporal variation ; whales ; Aleutian Islands ; Gulf of Alaska
Language	English
Dates of publication	2010-07
Size	p. 1591-1604.
Publisher	Springer-Verlag
Publishing place	Berlin/Heidelberg
Document type	Article
ZDB-ID	1117-4
ISSN	1432-1793 ; 0025-3162
ISSN (online)	1432-1793
ISSN	0025-3162
DOI	10.1007/s00227-010-1432-6
Database	NAL-Catalogue (AGRICOLA)

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Article: Design of the POSSIBLE US[trade mark sign] Study: postmenopausal women's compliance and persistence with osteoporosis medications

Barrett-Connor, E / Ensrud, K / Tosteson, A. N. A / Varon, S. F / Anthony, M / Daizadeh, N / Wade, S

Osteoporosis international a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2009 Mar., v. 20, no. 3

2009

Abstract: Summary Failure to take prescribed medication is common. The POSSIBLE US[trade mark sign] study is ... Observational Scientific Study Investigating Bone Loss Experience (POSSIBLE US[trade mark sign]) is ... prescribed pharmacologic therapy. Conclusions POSSIBLE US[trade mark sign] provides a unique foundation ...

Abstract	Summary Failure to take prescribed medication is common. The POSSIBLE US[trade mark sign] study is evaluating the impact of physician and patient characteristics on patient-reported compliance and persistence with osteoporosis medications. We report our study design and the baseline characteristics of 4,994 postmenopausal women recruited from primary care physician offices in 33 states. Introduction The Prospective Observational Scientific Study Investigating Bone Loss Experience (POSSIBLE US[trade mark sign]) is a longitudinal cohort study of osteoporosis therapy in primary care. Methods Between 2004 and 2007, 134 physicians (in 33 states) enrolled postmenopausal women initiating, changing, or continuing osteoporosis medications. After completing a baseline questionnaire, participants will provide data semi-annually for up to 3 years through 2008. Physicians provide patient data at baseline and routine follow-up visits. Participants from 23 sites also signed a release regarding administrative claims data for economic analyses and validation of self-reported data. Baseline results Four thousand nine hundred and ninety-four evaluable women were recruited from internal medicine (n = 1,784), family practice (n = 1,556), obstetrics/gynecology (n = 1,556), and from one rheumatology practice (n = 98). Mean participant age was 64.3 years (SD = 9.97); 89% were Caucasian; 59% had some college education. Sixty-three percent used a single osteoporosis agent, usually a bisphosphonate. For monotherapy patients, concordance between clinic- and patient-reported medication use was lowest for patients prescribed estrogen therapy (70%) or calcium/vitamin D (72%). Obstetrician/gynecologists enrolled younger women, who were more likely to use estrogen therapy than patients enrolled by other physicians. The 934 women (19%) prescribed only calcium/vitamin D were younger than women prescribed pharmacologic therapy. Conclusions POSSIBLE US[trade mark sign] provides a unique foundation for evaluating longitudinal use of osteoporosis medications and related outcomes.
Keywords	cohort studies ; compliance ; osteoporosis ; prospective studies
Language	English
Dates of publication	2009-03
Size	p. 463-472.
Publisher	Springer-Verlag
Publishing place	London
Document type	Article
ZDB-ID	1064892-6
ISSN	1433-2965 ; 0937-941X
ISSN (online)	1433-2965
ISSN	0937-941X
DOI	10.1007/s00198-008-0674-3
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Omitted Acknowledgment of Local Contributors to Study.

Wade, Mark

JAMA psychiatry

2019 Volume 76, Issue 4, Page(s) 447

Language	English
Publishing date	2019-02-26
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	2701203-7
ISSN	2168-6238 ; 2168-622X
ISSN (online)	2168-6238
ISSN	2168-622X
DOI	10.1001/jamapsychiatry.2018.4596
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Article: Embedding the A-EQUIP model of restorative supervision in a critical care unit by professional nurse advocates.

Wade, Rachel

British journal of nursing (Mark Allen Publishing)

2023 Volume 32, Issue 15, Page(s) 744–747

Abstract: The professional nurse advocate (PNA) programme was launched in March 2021, which was towards the end of the third wave of COVID-19 and the start of a critical point of recovery. COVID-19 placed exceptional challenges and pressure on healthcare staff, ... ...

Abstract	The professional nurse advocate (PNA) programme was launched in March 2021, which was towards the end of the third wave of COVID-19 and the start of a critical point of recovery. COVID-19 placed exceptional challenges and pressure on healthcare staff, with many experiencing feelings of stress and burnout. The role of the PNA emerged as a response to the impact this had upon the nursing workforce. PNAs are trained to facilitate restorative clinical supervision and to advocate education for quality improvement, resulting in improvements to patient care and staff wellbeing. The programme started with 400 critical care nurses; since then it has been rolled out to all specialties, with the aim to have 5000 PNAs integrated into the national workforce by April 2022. Criteria for the level 7 PNA training programme requires a registered nurse to be working in a patient-facing role, at band 5 or above, hold a level 6 qualification and have approval from their line manager. The training programme is typically 10 to 12 days in length over a 12-week period. This article explores the implementation of the PNA role in a critical care unit.
MeSH term(s)	Humans ; Peptide Nucleic Acids ; COVID-19 ; Intensive Care Units ; Critical Care ; Workforce
Chemical Substances	Peptide Nucleic Acids
Language	English
Publishing date	2023-07-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1119191-0
ISSN	0966-0461
ISSN	0966-0461
DOI	10.12968/bjon.2023.32.15.744
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Article ; Online: Polymicrobial Purulent Pericarditis From a Pancreatico-Pericardial Fistula.

Richardson, Christopher / Cromer, Mark / Tatem, Luis / Wade, Raymond / Russell, Derek

JACC. Case reports

2024 Volume 29, Issue 7, Page(s) 102288

Abstract: A 54-year-old male with chronic pancreatitis presented with dyspnea. Computed tomography scans demonstrated a subdiaphragmatic fluid collection with pericardial fistulization. Pericardial fluid cultures were polymicrobial in nature. Purulent pericarditis ...

Abstract	A 54-year-old male with chronic pancreatitis presented with dyspnea. Computed tomography scans demonstrated a subdiaphragmatic fluid collection with pericardial fistulization. Pericardial fluid cultures were polymicrobial in nature. Purulent pericarditis is rare but carries a high mortality rate. We present the first documented case of pancreatico-pericardial fistulization causing purulent pericarditis.
Language	English
Publishing date	2024-03-05
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-0849
ISSN (online)	2666-0849
DOI	10.1016/j.jaccas.2024.102288
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Article ; Online: Why we still need longitudinal mental health research with children and youth during (and after) the COVID-19 pandemic.

Wade, Mark / Prime, Heather / Browne, Dillon T

Psychiatry research

2023 Volume 323, Page(s) 115126

MeSH term(s)	Adolescent ; Child ; Humans ; COVID-19 ; Mental Health ; Pandemics
Language	English
Publishing date	2023-02-22
Publishing country	Ireland
Document type	Letter
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2023.115126
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