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Article ; Online: The pandemic characteristics of 2019-nCoV: case-control study for severity and geographic locations for 2019-nCoV epidemics worldwide.

Ronchetti, Roberto / Bianco, Pietro Massimiliano

2020 Volume 46, Issue 1, Page(s) 94

Abstract: Using available official data we found 248 epidemics curves caused worldwide by the 2019-nCoV in the period December 2019-March 31st 2020. The analysis of this material allowed two main observations: 1) it is possible to describe the main geographical ... ...

Abstract	Using available official data we found 248 epidemics curves caused worldwide by the 2019-nCoV in the period December 2019-March 31st 2020. The analysis of this material allowed two main observations: 1) it is possible to describe the main geographical pathway of the diffusion of the virus in different directions. This strongly suggests a unique point of origin of the pandemics in Wuhan, China, from where it spread in many different directions. 2) of the 74 epidemics which were characterized by at least 1000 cases, 65 (90%) were located in the geographic region of the world delimitated by 52-30 degrees latitude North. Viceversa 110 (60%) of the 176 epidemics with less than 1000 cases were located outside the cited geographical world region. These results suggest considerations on the pandemic characteristics of 2019-nCoV.
MeSH term(s)	Betacoronavirus/isolation & purification ; COVID-19 ; Case-Control Studies ; China/epidemiology ; Communicable Disease Control/organization & administration ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Disease Outbreaks/statistics & numerical data ; Female ; Geography ; Global Health ; Humans ; Male ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index
Keywords	covid19
Language	English
Publishing date	2020-07-08
Publishing country	England
Document type	Letter
ZDB-ID	2088556-8
ISSN	1824-7288 ; 1720-8424
ISSN (online)	1824-7288
ISSN	1720-8424
DOI	10.1186/s13052-020-00856-x
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Article ; Online: The pandemic characteristics of 2019-nCoV

Roberto Ronchetti / Pietro Massimiliano Bianco

Italian Journal of Pediatrics, Vol 46, Iss 1, Pp 1-

case-control study for severity and geographic locations for 2019-nCoV epidemics worldwide

2020 Volume 4

Abstract: Abstract Using available official data we found 248 epidemics curves caused worldwide by the 2019-nCoV in the period December 2019–March 31st 2020. The analysis of this material allowed two main observations: 1) it is possible to describe the main ... ...

Abstract	Abstract Using available official data we found 248 epidemics curves caused worldwide by the 2019-nCoV in the period December 2019–March 31st 2020. The analysis of this material allowed two main observations: 1) it is possible to describe the main geographical pathway of the diffusion of the virus in different directions. This strongly suggests a unique point of origin of the pandemics in Wuhan, China, from where it spread in many different directions. 2) of the 74 epidemics which were characterized by at least 1000 cases, 65 (90%) were located in the geographic region of the world delimitated by 52–30 degrees latitude North. Viceversa 110 (60%) of the 176 epidemics with less than 1000 cases were located outside the cited geographical world region. These results suggest considerations on the pandemic characteristics of 2019-nCoV.
Keywords	Coronavirus ; 2019-nCoV ; COVID-19 outbreak ; Epidemics ; Pathway of spread ; Severity of epidemics ; Pediatrics ; RJ1-570 ; covid19
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The pandemic characteristics of 2019-nCoV: case-control study for severity and geographic locations for 2019-nCoV epidemics worldwide

Ronchetti, Roberto / Bianco, Pietro Massimiliano

Ital J Pediatr

Abstract	Using available official data we found 248 epidemics curves caused worldwide by the 2019-nCoV in the period December 2019-March 31st 2020. The analysis of this material allowed two main observations: 1) it is possible to describe the main geographical pathway of the diffusion of the virus in different directions. This strongly suggests a unique point of origin of the pandemics in Wuhan, China, from where it spread in many different directions. 2) of the 74 epidemics which were characterized by at least 1000 cases, 65 (90%) were located in the geographic region of the world delimitated by 52-30 degrees latitude North. Viceversa 110 (60%) of the 176 epidemics with less than 1000 cases were located outside the cited geographical world region. These results suggest considerations on the pandemic characteristics of 2019-nCoV.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #635582
Database	COVID19

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Article: I molti dubbi sul rapporto tra casi di microcefalia e infezione da virus Zika in Brasile.

Ronchetti, Roberto / Bianco, Pietro Massimiliano

Epidemiologia e prevenzione

2016 Volume 40, Issue 6, Page(s) 466–471

Abstract: During the last few years, Zika virus rapidly spread across Central and South America and in the last months has spread also across Southern States of USA. As the epidemic began in Brazil, an increase of microcephaly cases was registered, causing concern ...

Title translation	Many doubts about the relationship between cases of microcephaly and Zika virus in Brazil.
Abstract	During the last few years, Zika virus rapidly spread across Central and South America and in the last months has spread also across Southern States of USA. As the epidemic began in Brazil, an increase of microcephaly cases was registered, causing concern and inducing the World Health Organization to raise an alarm. Certainly, the Zika virus, as many other viruses, has the capacity to induce severe cerebral lesions in foetuses of women infected during the first months of pregnancy. Moreover, more than 80% of cases of craniostenosys that verisimilarly took place in Brazil from September 2015 up to now were registered in few states of North- Eastern Brazil, where peaks of this malformation were registered several years before the appearance of Zika virus. In addition, in none of the 60 Countries where Zika virus is epidemiologically active an increase of the incidence of microcephaly has been reported. This paper intends to analyse some doubts concerning the link between Zika virus and the epidemic of craniostenosys.
Language	Italian
Publishing date	2016-11
Publishing country	Italy
Document type	Journal Article ; English Abstract
ZDB-ID	1038112-0
ISSN	1120-9763
ISSN	1120-9763
DOI	10.19191/EP16.6.P466.128
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Article: Fetal lead exposure and infant mental development index.

Ronchetti, Roberto

Environmental health perspectives

2007 Volume 115, Issue 4, Page(s) A186; author reply A186–7

MeSH term(s)	Bone and Bones/chemistry ; Child Development/drug effects ; Child, Preschool ; Cognition/drug effects ; Environmental Pollutants/blood ; Environmental Pollutants/pharmacokinetics ; Humans ; Lead/blood ; Lead/pharmacokinetics ; Reproducibility of Results
Chemical Substances	Environmental Pollutants ; Lead (2P299V784P)
Language	English
Publishing date	2007-04
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/ehp.115-a186a
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Article: Euchromatic Histone Lysine Methyltransferase 2 Inhibition Enhances Carfilzomib Sensitivity and Overcomes Drug Resistance in Multiple Myeloma Cell Lines.

Mereu, Elisabetta / Abbo, Damiano / Paradzik, Tina / Cumerlato, Michela / Bandini, Cecilia / Labrador, Maria / Maccagno, Monica / Ronchetti, Domenica / Manicardi, Veronica / Neri, Antonino / Piva, Roberto

Cancers

2023 Volume 15, Issue 8

Abstract: Proteasome inhibitors (PIs) are extensively used for the therapy of multiple myeloma. However, patients continuously relapse or are intrinsically resistant to this class of drugs. In addition, adverse toxic effects such as peripheral neuropathy and ... ...

Abstract	Proteasome inhibitors (PIs) are extensively used for the therapy of multiple myeloma. However, patients continuously relapse or are intrinsically resistant to this class of drugs. In addition, adverse toxic effects such as peripheral neuropathy and cardiotoxicity could arise. Here, to identify compounds that can increase the efficacy of PIs, we performed a functional screening using a library of small-molecule inhibitors covering key signaling pathways. Among the best synthetic lethal interactions, the euchromatic histone-lysine N-methyltransferase 2 (EHMT2) inhibitor UNC0642 displayed a cooperative effect with carfilzomib (CFZ) in numerous multiple myeloma (MM) cell lines, including drug-resistant models. In MM patients, EHMT2 expression correlated to worse overall and progression-free survival. Moreover, EHMT2 levels were significantly increased in bortezomib-resistant patients. We demonstrated that CFZ/UNC0642 combination exhibited a favorable cytotoxicity profile toward peripheral blood mononuclear cells and bone-marrow-derived stromal cells. To exclude off-target effects, we proved that UNC0642 treatment reduces EHMT2-related molecular markers and that an alternative EHMT2 inhibitor recapitulated the synergistic activity with CFZ. Finally, we showed that the combinatorial treatment significantly perturbs autophagy and the DNA damage repair pathways, suggesting a multi-layered mechanism of action. Overall, the present study demonstrates that EHMT2 inhibition could provide a valuable strategy to enhance PI sensitivity and overcome drug resistance in MM patients.
Language	English
Publishing date	2023-04-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15082199
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Article ; Online: Is Gender an Antecedent to Workplace Stressors? A Systematic Review and an Empirical Study Using a Person-Centred Approach.

Fida, Roberta / Watson, David / Ghezzi, Valerio / Barbaranelli, Claudio / Ronchetti, Matteo / Di Tecco, Cristina

International journal of environmental research and public health

2023 Volume 20, Issue 8

Abstract: Objective: Work is a key domain of life in which gender inequality can manifest, yet gender is rarely the explicit focus of research seeking to understand exposure to stressors. We investigated this research gap in two studies.: Methods: Study 1 was ... ...

Abstract	Objective: Work is a key domain of life in which gender inequality can manifest, yet gender is rarely the explicit focus of research seeking to understand exposure to stressors. We investigated this research gap in two studies. Methods: Study 1 was a systematic review of the relationship between gender and key stressors (e.g., high demands, poor support, lack of clarity and control). From a total of 13,376,130 papers met our inclusion criteria. Study 2 was a cross-sectional study that included 11,289 employees nested within 71 public organisations (50.6% men). Through a latent profile analysis, we investigated the profiles of stressors separately from men and women. Results: The systematic review revealed that, for all stressors, a significant proportion of studies found no significant gender differences, and the review found mixed evidence of greater exposure for both men and women. The results of Study 2 revealed that both genders could be optimally represented by three psychosocial risk profiles reflecting medium, low and high stressors. The results also showed that while the shape of profiles was similar for both genders, men had a higher probability than women of being in the Conclusion: Gender differences in exposure to stressors are inconsistent. Although the literature on gender role theory and the gendering of work suggests different exposures to stressors in men and women, we find little empirical support for this.
MeSH term(s)	Humans ; Male ; Female ; Cross-Sectional Studies ; Workplace/psychology ; Sex Factors ; Risk Factors ; Stress, Psychological/psychology
Language	English
Publishing date	2023-04-17
Publishing country	Switzerland
Document type	Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20085541
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Article: Lysin (K)-specific demethylase 1 inhibition enhances proteasome inhibitor response and overcomes drug resistance in multiple myeloma.

Experimental hematology & oncology

2023 Volume 12, Issue 1, Page(s) 71

Abstract: Background: Multiple myeloma (MM) is an incurable plasma cell malignancy, accounting for approximately 1% of all cancers. Despite recent advances in the treatment of MM, due to the introduction of proteasome inhibitors (PIs) such as bortezomib (BTZ) and ...

Abstract	Background: Multiple myeloma (MM) is an incurable plasma cell malignancy, accounting for approximately 1% of all cancers. Despite recent advances in the treatment of MM, due to the introduction of proteasome inhibitors (PIs) such as bortezomib (BTZ) and carfilzomib (CFZ), relapses and disease progression remain common. Therefore, a major challenge is the development of novel therapeutic approaches to overcome drug resistance, improve patient outcomes, and broaden PIs applicability to other pathologies. Methods: We performed genetic and drug screens to identify new synthetic lethal partners to PIs, and validated candidates in PI-sensitive and -resistant MM cells. We also tested best synthetic lethal interactions in other B-cell malignancies, such as mantle cell, Burkitt's and diffuse large B-cell lymphomas. We evaluated the toxicity of combination treatments in normal peripheral blood mononuclear cells (PBMCs) and bone marrow stromal cells (BMSCs). We confirmed the combo treatment' synergistic effects ex vivo in primary CD138+ cells from MM patients, and in different MM xenograft models. We exploited RNA-sequencing and Reverse-Phase Protein Arrays (RPPA) to investigate the molecular mechanisms of the synergy. Results: We identified lysine (K)-specific demethylase 1 (LSD1) as a top candidate whose inhibition can synergize with CFZ treatment. LSD1 silencing enhanced CFZ sensitivity in both PI-resistant and -sensitive MM cells, resulting in increased tumor cell death. Several LSD1 inhibitors (SP2509, SP2577, and CC-90011) triggered synergistic cytotoxicity in combination with different PIs in MM and other B-cell neoplasms. CFZ/SP2509 treatment exhibited a favorable cytotoxicity profile toward PBMCs and BMSCs. We confirmed the clinical potential of LSD1-proteasome inhibition in primary CD138+ cells of MM patients, and in MM xenograft models, leading to the inhibition of tumor progression. DNA damage response (DDR) and proliferation machinery were the most affected pathways by CFZ/SP2509 combo treatment, responsible for the anti-tumoral effects. Conclusions: The present study preclinically demonstrated that LSD1 inhibition could provide a valuable strategy to enhance PI sensitivity and overcome drug resistance in MM patients and that this combination might be exploited for the treatment of other B-cell malignancies, thus extending the therapeutic impact of the project.
Language	English
Publishing date	2023-08-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2669066-4
ISSN	2162-3619
ISSN	2162-3619
DOI	10.1186/s40164-023-00434-x
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Article ; Online: Activation of long non-coding RNA NEAT1 leads to survival advantage of multiple myeloma cells by supporting a positive regulatory loop with DNA repair proteins.

Taiana, Elisa / Bandini, Cecilia / Favasuli, Vanessa Katia / Ronchetti, Domenica / Silvestris, Ilaria / Puccio, Noemi / Todoerti, Katia / Erratico, Silvia / Giannandrea, Domenica / Bolli, Niccolò / Amodio, Nicola / Ciarrocchi, Alessia / Chiaramonte, Raffaella / Torrente, Yvan / Piva, Roberto / Neri, Antonino

Haematologica

2023 Volume 108, Issue 1, Page(s) 219–233

Abstract: Long non-coding RNA NEAT1 is the core structural component of the nuclear paraspeckle (PS) organelles and it has been found to be deregulated in multiple myeloma (MM) patients. Experimental evidence indicated that NEAT1 silencing negatively impacts ... ...

Abstract	Long non-coding RNA NEAT1 is the core structural component of the nuclear paraspeckle (PS) organelles and it has been found to be deregulated in multiple myeloma (MM) patients. Experimental evidence indicated that NEAT1 silencing negatively impacts proliferation and viability of MM cells, both in vitro and in vivo, suggesting a role in DNA damage repair (DDR). In order to elucidate the biological and molecular relevance of NEAT1 upregulation in MM disease we exploited the CRISPR/Cas9 synergistic activation mediator genome editing system to engineer the AMO-1 MM cell line and generate two clones that para-physiologically transactivate NEAT1 at different levels. NEAT1 overexpression is associated with oncogenic and prosurvival advantages in MM cells exposed to nutrient starvation or a hypoxic microenvironment, which are stressful conditions often associated with more aggressive disease phases. Furthermore, we highlighted the NEAT1 involvement in virtually all DDR processes through, at least, two different mechanisms. On one side NEAT1 positively regulates the posttranslational stabilization of essential PS proteins, which are involved in almost all DDR systems, thus increasing their availability within cells. On the other hand, NEAT1 plays a crucial role as a major regulator of a molecular axis that includes ATM and the catalytic subunit of DNA-PK kinase proteins, and their direct targets pRPA32 and pCHK2. Overall, we provided novel important insightsthe role of NEAT1 in supporting MM cells adaptation to stressful conditions by improving the maintenance of DNA integrity. Taken together, our results suggest that NEAT1, and probably PS organelles, could represent a potential therapeutic target for MM treatment.
MeSH term(s)	Humans ; Cell Line, Tumor ; DNA Repair ; MicroRNAs/genetics ; Multiple Myeloma/genetics ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Transcriptional Activation ; Tumor Microenvironment ; Up-Regulation
Chemical Substances	MicroRNAs ; RNA, Long Noncoding ; NEAT1 long non-coding RNA, human
Language	English
Publishing date	2023-01-01
Publishing country	Italy
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2022.281167
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Article ; Online: Is asthma caused by atopy (positive skin prick tests)? Epidemiologic evidence suggests a negative answer.

Ronchetti, Roberto / Jesenak, Milos / Ronchetti, Francesco / Rennerova, Zuzana

Inflammation & allergy drug targets

2009 Volume 9, Issue 2, Page(s) 91–96

Abstract: In this paper we shortly discuss epidemiological data on the relationship between asthma and atopy according to recent personal and literature epidemiological publications. The coexistence in several subjects of asthma (and of other "atopic" diseases) ... ...

Abstract	In this paper we shortly discuss epidemiological data on the relationship between asthma and atopy according to recent personal and literature epidemiological publications. The coexistence in several subjects of asthma (and of other "atopic" diseases) and IgE hyperproduction generated the dogma that these two biological conditions are mainly genetic in origin and are linked by a strong casual relationship. In the last decades atopy increased at 5-10 % annual rate and at present atopy prevalence, although variable in different countries, reaches somewhere the prevalence of more than 60 %. Similarly, asthma prevalence increased in the last decades, especially so in western and English speaking countries, reaching in certain countries prevalence values higher than 40 %. For these reasons, although certainly dependent on a genetic predisposition, atopy and asthma can nowadays be considered to be largely determined by environmental factors. Moreover, the analysis of epidemiological data derived from studies conducted worldwide, showed that the prevalence of the two conditions were clearly not correlated so that in certain countries with a 50-60% prevalence of atopy asthma prevalence is lower than 2-6 %, while in other countries asthma prevalence is double than atopy prevalence. Further, in countries with high atopy, the prevalence this conditions is high both in asthmatics and in normal subjects and in the places where asthma prevalence reaches high levels this condition is high both in atopic and non atopic people. In conclusion, epidemiological data show that environmental factors affecting asthma prevalence are different from those affecting atopy prevalence and that subjects bearing one of the two conditions don't show any preferential tendency to develop the other one. From aetiological and pathogenetic point of view asthma and atopy appear to be independent conditions We therefore believe that the association between asthma and atopy demonstrated in almost all the "population studies" (atopy prevalence has always been found 20-30 % higher in asthmatics than in non asthmatic subjects) doesn't prove the existence of a "causal" relationship between the two conditions: this could be a kind of association without causative meaning as is the association between blond hair and blue eyes which in no way can be considered a prove that one of the two conditions is the cause of the other.
MeSH term(s)	Allergens/immunology ; Asthma/epidemiology ; Asthma/immunology ; Histamine/immunology ; Humans ; Hypersensitivity, Immediate/epidemiology ; Hypersensitivity, Immediate/genetics ; Hypersensitivity, Immediate/immunology ; Immunoglobulin E/immunology ; Prevalence ; Skin Tests
Chemical Substances	Allergens ; Immunoglobulin E (37341-29-0) ; Histamine (820484N8I3)
Language	English
Publishing date	2009-11-05
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2215862-5
ISSN	2212-4055 ; 1871-5281
ISSN (online)	2212-4055
ISSN	1871-5281
DOI	10.2174/187152810791292791
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