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  1. Article ; Online: The paramount importance of serological surveys of SARS-CoV-2 infection and immunity.

    Goudsmit, Jaap

    European journal of epidemiology

    2020  Volume 35, Issue 4, Page(s) 331–333

    MeSH term(s) Antibodies, Viral/blood ; Betacoronavirus/immunology ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Global Health ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; Serologic Tests
    Chemical Substances Antibodies, Viral
    Keywords covid19
    Language English
    Publishing date 2020-04-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 632614-6
    ISSN 1573-7284 ; 0393-2990
    ISSN (online) 1573-7284
    ISSN 0393-2990
    DOI 10.1007/s10654-020-00635-2
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  3. Article ; Online: The paramount importance of serological surveys of SARS-CoV-2 infection and immunity

    Goudsmit, Jaap

    European Journal of Epidemiology

    2020  Volume 35, Issue 4, Page(s) 331–333

    Keywords Epidemiology ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 632614-6
    ISSN 1573-7284 ; 0393-2990
    ISSN (online) 1573-7284
    ISSN 0393-2990
    DOI 10.1007/s10654-020-00635-2
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book: Viral sex

    Goudsmit, Jaap

    the nature of AIDS

    1997  

    Author's details Jaap Goudsmit
    Keywords HIV Infections / virology ; HIV / genetics
    Language English
    Size XIX, 260 S. : Ill., graph. Darst., Kt.
    Publisher Oxford Univ. Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT008008756
    ISBN 0-19-509728-9 ; 978-0-19-509728-3
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1997 A 9023 order for loan Magazin

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  5. Article ; Online: The incubation period of Alzheimer's disease and the timing of tau versus amyloid misfolding and spreading within the brain.

    Goudsmit, Jaap

    European journal of epidemiology

    2016  Volume 31, Issue 2, Page(s) 99–105

    MeSH term(s) Aging/metabolism ; Alzheimer Disease/etiology ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/metabolism ; Brain/metabolism ; Brain/pathology ; Humans ; Plaque, Amyloid/metabolism ; Time Factors
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2016-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 632614-6
    ISSN 1573-7284 ; 0393-2990
    ISSN (online) 1573-7284
    ISSN 0393-2990
    DOI 10.1007/s10654-016-0144-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Retrospective. Joep Lange (1954-2014).

    Goudsmit, Jaap

    Science (New York, N.Y.)

    2014  Volume 345, Issue 6199, Page(s) 881

    MeSH term(s) Acquired Immunodeficiency Syndrome/blood ; Acquired Immunodeficiency Syndrome/history ; Acquired Immunodeficiency Syndrome/immunology ; HIV/immunology ; HIV Antibodies/blood ; HIV Antibodies/history ; History, 20th Century ; History, 21st Century ; Humans ; Netherlands
    Chemical Substances HIV Antibodies
    Language English
    Publishing date 2014-08-22
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1259453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 77: Show issues

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  7. Book ; Thesis: The human papovavirus BK

    Goudsmit, Jaap

    natural history and pathogenesis in man

    1982  

    Size 106 S.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Amsterdam, Univ., Diss., 1982
    HBZ-ID HT002694229
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
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  8. Article ; Online: External validity of phase III trials on vaccines against SARS-CoV-2 to a middle-aged and elderly Western European population.

    Terzikhan, Natalie / Hofman, Albert / Goudsmit, Jaap / Ikram, Mohammad Arfan

    European journal of epidemiology

    2021  Volume 36, Issue 3, Page(s) 319–324

    Abstract: Initial results from various phase-III trials on vaccines against SARS-CoV-2 are promising. For proper translation of these results to clinical guidelines, it is essential to determine how well the general population is reflected in the study populations ...

    Abstract Initial results from various phase-III trials on vaccines against SARS-CoV-2 are promising. For proper translation of these results to clinical guidelines, it is essential to determine how well the general population is reflected in the study populations of these trials. This study was conducted among 7162 participants (age-range: 51-106 years; 58% women) from the Rotterdam Study. We quantified the proportion of participants that would be eligible for the nine ongoing phase-III trials. We further quantified the eligibility among participants at high risk to develop severe COVID-19. Since many trials were not explicit in their exclusion criterion with respect to 'acute' or 'unstable preexisting' diseases, we performed two analyses. First, we included all participants irrespective of this criterion. Second, we excluded persons with acute or 'unstable preexisting' diseases. 97% of 7162 participants was eligible for any trial with eligibility for separate trials ranging between 11-97%. For high-risk individuals the corresponding numbers were 96% for any trial with separate trials ranging from 5-96%. Importantly, considering persons ineligible due to 'acute' or 'unstable pre-existing' disease drastically dropped the eligibilities for all trials below 43% for the total population and below 36% for high-risk individuals. The eligibility for ongoing vaccine trials against SARS-CoV-2 can reduce by half depending on interpretation and application of a single unspecified exclusion criterion. This exclusion criterion in our study would especially affect the elderly and those with pre-existing morbidities. These findings thus indicate the difficulty as well as importance of developing clinical recommendations for vaccination and applying these to the appropriate target populations. This becomes especially paramount considering the fact that many countries worldwide have initiated their vaccination programs by first targeting the elderly and most vulnerable persons.
    MeSH term(s) Aged ; Aged, 80 and over ; COVID-19/prevention & control ; COVID-19 Vaccines ; Comorbidity ; Europe/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Reproducibility of Results ; Research Design/statistics & numerical data ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-02-26
    Publishing country Netherlands
    Document type Clinical Trial, Phase III ; Journal Article ; Multicenter Study
    ZDB-ID 632614-6
    ISSN 1573-7284 ; 0393-2990
    ISSN (online) 1573-7284
    ISSN 0393-2990
    DOI 10.1007/s10654-021-00729-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: SARS-CoV-2 elicits non-sterilizing immunity and evades vaccine-induced immunity: implications for future vaccination strategies.

    Beukenhorst, Anna L / Koch, Clarissa M / Hadjichrysanthou, Christoforos / Alter, Galit / de Wolf, Frank / Anderson, Roy M / Goudsmit, Jaap

    European journal of epidemiology

    2023  Volume 38, Issue 3, Page(s) 237–242

    Abstract: Neither vaccination nor natural infection result in long-lasting protection against SARS-COV-2 infection and transmission, but both reduce the risk of severe COVID-19. To generate insights into optimal vaccination strategies for prevention of severe ... ...

    Abstract Neither vaccination nor natural infection result in long-lasting protection against SARS-COV-2 infection and transmission, but both reduce the risk of severe COVID-19. To generate insights into optimal vaccination strategies for prevention of severe COVID-19 in the population, we extended a Susceptible-Exposed-Infectious-Removed (SEIR) mathematical model to compare the impact of vaccines that are highly protective against severe COVID-19 but not against infection and transmission, with those that block SARS-CoV-2 infection. Our analysis shows that vaccination strategies focusing on the prevention of severe COVID-19 are more effective than those focusing on creating of herd immunity. Key uncertainties that would affect the choice of vaccination strategies are: (1) the duration of protection against severe disease, (2) the protection against severe disease from variants that escape vaccine-induced immunity, (3) the incidence of long-COVID and level of protection provided by the vaccine, and (4) the rate of serious adverse events following vaccination, stratified by demographic variables.
    MeSH term(s) Humans ; SARS-CoV-2 ; Post-Acute COVID-19 Syndrome ; COVID-19/epidemiology ; COVID-19/prevention & control ; Vaccination ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2023-02-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 632614-6
    ISSN 1573-7284 ; 0393-2990
    ISSN (online) 1573-7284
    ISSN 0393-2990
    DOI 10.1007/s10654-023-00965-x
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  10. Article ; Online: Genetic Correlates of Biological Aging and the Influence on Prediction of Mortality.

    Akeju, Oluwasefunmi / Mens, Michelle M J / Warmerdam, Robert / Dijkema, Marjolein / van den Biggelaar, Anita H J / Franke, Lude / Goudsmit, Jaap / Wu, Julia W

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2024  Volume 79, Issue 4

    Abstract: Longevity and disease-free survival are influenced by a combination of genetics and lifestyle. Biological age (BioAge), a measure of aging based on composite biomarkers, may outperform chronological age in predicting health and longevity. This study ... ...

    Abstract Longevity and disease-free survival are influenced by a combination of genetics and lifestyle. Biological age (BioAge), a measure of aging based on composite biomarkers, may outperform chronological age in predicting health and longevity. This study investigated the relationship between genetic risks, lifestyle factors, and delta age (Δage), estimated as the difference between biological and chronological age. BioAge and Δage were calculated for 52 418 participants from the population-based Lifelines cohort. We computed 2 independent polygenic risk scores (PRS) for health span and DNA methylation-based aging clock to characterize genetic risks. The capacity of BioAge to predict all-cause mortality when adjusted for chronological age and genetic risks for aging, was assessed. Obesity, lifestyle, socioeconomic status, sex, and genetic variations in a population contributed to the differences in the rates of accelerated aging. The overall risk of death for a 1-year increase in BioAge for a given chronological age and sex among the genotyped participants was 11% (HR = 1.11; 95% CI: 1.09, 1.13). After adjusting for genetic factors, BioAge maintained its sensitivity for predicting mortality. Findings from this study ascertain that BioAge can be a useful tool for risk stratification in research and aging interventions.
    MeSH term(s) Humans ; Aging/genetics ; Longevity/genetics ; DNA Methylation ; Risk Factors ; Biomarkers ; Epigenesis, Genetic
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/glae024
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