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Kitamura, Yukinobu

Past, Present and Future

(Hitotsubashi University IER Economic Research Series)

2022

Series title	Hitotsubashi University IER Economic Research Series
Keywords	Macroeconomics ; Financial services industry ; Money ; Cryptocurrency ; Digital currency ; Central bank ; Denomination ; Number theory
Language	0\|e
Size	1 electronic resource (151 pages)
Publisher	Springer Nature
Publishing place	Singapore
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021620916
ISBN	9789811955914 ; 9811955913
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online: Quest for Good Money

Kitamura, Yukinobu

Past, Present and Future

(Hitotsubashi University IER Economic Research Series ; 48)

2022

Author's details	by Yukinobu Kitamura
Series title	Hitotsubashi University IER Economic Research Series ; 48
Keywords	Macroeconomics ; Financial services industry
Subject code	339
Language	English
Size	1 Online-Ressource (XV, 151 p. 25 illus., 12 illus. in color)
Edition	1st ed. 2022
Publisher	Springer Nature Singapore ; Imprint: Springer
Publishing place	Singapore
Document type	Book ; Online
HBZ-ID	HT021626502
ISBN	978-981-19-5591-4 ; 9789811955907 ; 9789811955921 ; 9789811955938 ; 981-19-5591-3 ; 9811955905 ; 9811955921 ; 981195593X
DOI	10.1007/978-981-19-5591-4
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Scan-Free Absorbance Spectral Imaging A(x, y, λ) of Single Live Algal Cells for Quantifying Absorbance of Cell Suspensions.

Isono, Takumi / Yamashita, Kyohei / Momose, Daisuke / Kobayashi, Hiroki / Kitamura, Masashi / Nishiyama, Yusuke / Hosoya, Takahiro / Kanda, Hiroaki / Kudo, Ayane / Okada, Norihide / Yagi, Takafumi / Nakata, Kazuaki / Mineki, Shigeru / Tokunaga, Eiji

PloS one

2015 Volume 10, Issue 6, Page(s) e0128002

Abstract: Label-free, non-invasive, rapid absorbance spectral imaging A(x,y,λ) microscopy of single live ... free acquisition of three-dimensional information of A(x,y,λ) was realized. The space-resolved ...

Abstract	Label-free, non-invasive, rapid absorbance spectral imaging A(x,y,λ) microscopy of single live cells at 1.2 μm × 1.2 μm resolution with an NA = 0.85 objective was developed and applied to unicellular green algae Chlamydomonas reinhardtii. By introducing the fiber assembly to rearrange a two-dimensional image to the one-dimensional array to fit the slit of an imaging spectrograph equipped with a CCD detector, scan-free acquisition of three-dimensional information of A(x,y,λ) was realized. The space-resolved absorbance spectra of the eyespot, an orange organelle about 1 μm, were extracted from the green-color background in a chlorophyll-rich single live cell absorbance image. Characteristic absorbance change in the cell suspension after hydrogen photoproduction in C. reinhardtii was investigated to find a single 715-nm absorption peak was locally distributed within single cells. The formula to calculate the absorbance of cell suspensions from that of single cells was presented to obtain a quantitative, parameter-free agreement with the experiment. It is quantitatively shown that the average number of chlorophylls per cell is significantly underestimated when it is evaluated from the absorbance of the cell suspensions due to the package effect.
MeSH term(s)	Chlamydomonas reinhardtii/chemistry ; Chlorophyll/chemistry ; Chlorophyta/chemistry ; Microspectrophotometry/methods ; Suspensions/chemistry
Chemical Substances	Suspensions ; Chlorophyll (1406-65-1)
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0128002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Neuropeptide Y functions as a facilitator of GDNF-induced budding of the Wolffian duct.

Choi, Yohan / Tee, James B / Gallegos, Thomas F / Shah, Mita M / Oishi, Hideto / Sakurai, Hiroyuki / Kitamura, Shinji / Wu, Wei / Bush, Kevin T / Nigam, Sanjay K

Development (Cambridge, England)

2009 Volume 136, Issue 24, Page(s) 4213–4224

Abstract: ... as well as neuropeptide Y (NPY). By using ANOVA with pattern matching, NPY was also found to correlate ...

Abstract	Ureteric bud (UB) emergence from the Wolffian duct (WD), the initiating step in metanephric kidney morphogenesis, is dependent on GDNF; however, GDNF by itself is generally insufficient to induce robust budding of the isolated WD in culture. Thus, additional factors, presumably peptides or polypeptide growth factors, might be involved. Microarray data from in vivo budding and non-budding conditions were analyzed using non-negative matrix factorization followed by gene ontology filtering and network analysis to identify sets of genes that are highly regulated during budding. These included the GDNF co-receptors GFRalpha1 and RET, as well as neuropeptide Y (NPY). By using ANOVA with pattern matching, NPY was also found to correlate most significantly to the budded condition with a high degree of connectedness to genes with developmental roles. Exogenous NPY [as well as its homolog, peptide YY (PYY)] augmented GDNF-dependent budding in the isolated WD culture; conversely, inhibition of NPY signaling or perturbation of NPY expression inhibited budding, confirming that NPY facilitates this process. NPY was also found to reverse the decreased budding, the downregulation of RET expression, the mislocalization of GFRalpha1, and the inhibition of AKT phosphorylation that resulted from the addition of BMP4 to the isolated WD cultures, suggesting that NPY acts through the budding pathway and is reciprocally regulated by GDNF and BMP4. Thus, the outgrowth of the UB from the WD might result from a combination of the upregulation of the GDNF receptors together with genes that support GDNF signaling in a feed-forward loop and/or counteraction of the inhibitory pathway regulated by BMP4.
MeSH term(s)	Animals ; Bone Morphogenetic Protein 4/physiology ; Cells, Cultured ; Female ; Gene Expression Regulation, Developmental ; Glial Cell Line-Derived Neurotrophic Factor Receptors/physiology ; Morphogenesis ; Neuropeptide Y/physiology ; Oligonucleotide Array Sequence Analysis ; Proto-Oncogene Proteins c-ret/physiology ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; Up-Regulation ; Wolffian Ducts/embryology ; Wolffian Ducts/physiology
Chemical Substances	Bone Morphogenetic Protein 4 ; Glial Cell Line-Derived Neurotrophic Factor Receptors ; Neuropeptide Y ; Proto-Oncogene Proteins c-ret (EC 2.7.10.1)
Language	English
Publishing date	2009-11-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.037580
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Article: Extracardiac total cavopulmonary connection using a Y-shaped graft.

Okano, Takahisa / Yamagishi, Masaaki / Shuntoh, Keisuke / Yamada, Yoshiaki / Hayashida, Kyoko / Shinkawa, Takeshi / Kitamura, Nobuo

The Annals of thoracic surgery

2002 Volume 74, Issue 6, Page(s) 2195–2197

Abstract: ... who underwent a successful extracardiac total cavopulmonary connection using a Y-shaped bifurcated graft ...

Abstract	We report on 17-year-old Fontan candidate with a severely distorted central pulmonary artery (PA) who underwent a successful extracardiac total cavopulmonary connection using a Y-shaped bifurcated graft. A nonanatomic pathway from the inferior vena cava to the left PA was constructed and positioned anterior to the ascending aorta. The other arm was used as a conduit between the inferior vena cava and the right PA. All procedures were performed under temporary venous bypass without cardiopulmonary bypass.
MeSH term(s)	Adolescent ; Blood Vessel Prosthesis ; Fontan Procedure ; Heart Defects, Congenital/surgery ; Humans ; Male ; Pulmonary Artery/abnormalities ; Pulmonary Artery/surgery ; Vena Cava, Inferior/surgery
Language	English
Publishing date	2002-08-23
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/s0003-4975(02)03978-4
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Article: Innervation and functional changes in mesenteric perivascular calcitonin gene-related peptide- and neuropeptide Y-containing nerves following topical phenol treatment.

Hobara, N / Goda, M / Kitamura, Y / Takayama, F / Kawasaki, H

Neuroscience

2006 Volume 141, Issue 2, Page(s) 1087–1099

Abstract: ... calcitonin gene-related peptide- and adrenergic neuropeptide Y-containing nerves after topical treatment with phenol ... of calcitonin gene-related peptide-like immunoreactivity containing fibers and neuropeptide Y-like immunoreactivity containing fibers ... of calcitonin gene-related peptide- and neuropeptide Y-like immunoreactivity fibers than in phenol-treated rats and restored ...

Abstract	We have previously shown that age-related reduction of innervation and function in mesenteric perivascular calcitonin gene-related peptide-containing vasodilator nerves takes place in spontaneously hypertensive rats. The present study was performed to investigate innervation and functional changes in perivascular calcitonin gene-related peptide- and adrenergic neuropeptide Y-containing nerves after topical treatment with phenol, which damages nerve fibers, around the rat superior mesenteric artery. Under pentobarbital-Na anesthesia, 8-week-old Wistar rats underwent in vivo topical application of phenol (10% phenol in 90% ethanol) or saline (sham rats) to the superior mesenteric artery proximal to the bifurcation of the abdominal aorta. After the treatment, the animals were subjected to immunohistochemistry of the 3rd branch of small arteries proximal to the intestine and to vascular responsiveness testing on day 3 through day 14. The innervation levels of calcitonin gene-related peptide-like immunoreactivity containing fibers and neuropeptide Y-like immunoreactivity containing fibers were markedly reduced on day 3 to day 14 and on day 5 to day 14 after the treatment, compared with those in sham-operated rats, respectively. In perfused mesenteric vascular beds isolated from phenol-treated rats, adrenergic nerve-mediated vasoconstriction and calcitonin gene-related peptide nerve-mediated vasodilation in response to periarterial nerve stimulation (2-12 Hz) were significantly decreased on day 3 and day 7. Neurogenic release of norepinephrine in phenol-treated rats on day 7 was significantly smaller that that in sham-operated rats. Nerve growth factor content in the mesenteric arteries of phenol-treated rats was significantly lower than that in sham-operated rats. Administration of nerve growth factor using osmotic mini-pumps for 7 days after the phenol treatment resulted in greater density of calcitonin gene-related peptide- and neuropeptide Y-like immunoreactivity fibers than in phenol-treated rats and restored decreased vascular responses to periarterial nerve stimulation. These results suggest that topical phenol-treatment of the mesenteric artery effectively induces functional denervation of perivascular nerves, which can be prevented or reversed by nerve growth factor treatment.
MeSH term(s)	Administration, Topical ; Analysis of Variance ; Animals ; Anti-Infective Agents, Local/administration & dosage ; Blood Pressure/drug effects ; Calcitonin Gene-Related Peptide/metabolism ; Dose-Response Relationship, Drug ; Drug Interactions ; Enzyme-Linked Immunosorbent Assay/methods ; Immunohistochemistry/methods ; Mesenteric Arteries/innervation ; Nerve Fibers/drug effects ; Nerve Fibers/metabolism ; Nerve Growth Factor/administration & dosage ; Neuropeptide Y/metabolism ; Norepinephrine/pharmacology ; Phenol/administration & dosage ; Rats ; Rats, Wistar ; Time Factors ; Vasoconstriction/drug effects
Chemical Substances	Anti-Infective Agents, Local ; Neuropeptide Y ; Phenol (339NCG44TV) ; Nerve Growth Factor (9061-61-4) ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z) ; Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	2006-05-18
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	196739-3
ISSN	1873-7544 ; 0306-4522
ISSN (online)	1873-7544
ISSN	0306-4522
DOI	10.1016/j.neuroscience.2006.04.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1215: Show issues

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Article ; Online: Scan-Free Absorbance Spectral Imaging A(x, y, λ) of Single Live Algal Cells for Quantifying Absorbance of Cell Suspensions.

Takumi Isono / Kyohei Yamashita / Daisuke Momose / Hiroki Kobayashi / Masashi Kitamura / Yusuke Nishiyama / Takahiro Hosoya / Hiroaki Kanda / Ayane Kudo / Norihide Okada / Takafumi Yagi / Kazuaki Nakata / Shigeru Mineki / Eiji Tokunaga

PLoS ONE, Vol 10, Iss 6, p e

2015 Volume 0128002

Abstract	Label-free, non-invasive, rapid absorbance spectral imaging A(x,y,λ) microscopy of single live cells at 1.2 μm × 1.2 μm resolution with an NA = 0.85 objective was developed and applied to unicellular green algae Chlamydomonas reinhardtii. By introducing the fiber assembly to rearrange a two-dimensional image to the one-dimensional array to fit the slit of an imaging spectrograph equipped with a CCD detector, scan-free acquisition of three-dimensional information of A(x,y,λ) was realized. The space-resolved absorbance spectra of the eyespot, an orange organelle about 1 μm, were extracted from the green-color background in a chlorophyll-rich single live cell absorbance image. Characteristic absorbance change in the cell suspension after hydrogen photoproduction in C. reinhardtii was investigated to find a single 715-nm absorption peak was locally distributed within single cells. The formula to calculate the absorbance of cell suspensions from that of single cells was presented to obtain a quantitative, parameter-free agreement with the experiment. It is quantitatively shown that the average number of chlorophylls per cell is significantly underestimated when it is evaluated from the absorbance of the cell suspensions due to the package effect.
Keywords	Medicine ; R ; Science ; Q
Subject code	571
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Epigenetic priming in the male germline.

Kitamura, Yuka / Namekawa, Satoshi H

Current opinion in genetics & development

2024 Volume 86, Page(s) 102190

Abstract: Epigenetic priming presets chromatin states that allow the rapid induction of gene expression programs in response to differentiation cues. In the germline, it provides the blueprint for sexually dimorphic unidirectional differentiation. In this review, ... ...

Abstract	Epigenetic priming presets chromatin states that allow the rapid induction of gene expression programs in response to differentiation cues. In the germline, it provides the blueprint for sexually dimorphic unidirectional differentiation. In this review, we focus on epigenetic priming in the mammalian male germline and discuss how cellular memories are regulated and inherited to the next generation. During spermatogenesis, epigenetic priming predetermines cellular memories that ensure the lifelong maintenance of spermatogonial stem cells and their subsequent commitment to meiosis and to the production of haploid sperm. The paternal chromatin state is also essential for the recovery of totipotency after fertilization and contributes to paternal epigenetic inheritance. Thus, epigenetic priming establishes stable but reversible chromatin states during spermatogenesis and enables epigenetic inheritance and reprogramming in the next generation.
Language	English
Publishing date	2024-04-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1077312-5
ISSN	1879-0380 ; 0959-437X
ISSN (online)	1879-0380
ISSN	0959-437X
DOI	10.1016/j.gde.2024.102190
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Zs.A 3240: Show issues

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Article: Construction of block-shuffled libraries of DNA for evolutionary protein engineering: Y-ligation-based block shuffling.

Kitamura, Koichiro / Kinoshita, Yasunori / Narasaki, Shinsuke / Nemoto, Naoto / Husimi, Yuzuru / Nishigaki, Koichi

Protein engineering

2002 Volume 15, Issue 10, Page(s) 843–853

Abstract: ... A cycle of processes for producing combinatorial diversity was devised and designated Y-ligation-based ...

Abstract	Evolutionary protein engineering is now proceeding to a new stage in which novel technologies, besides the conventional point mutations, to generate a library of proteins, are required. In this context, a novel method for shuffling and rearranging DNA blocks (leading to protein libraries) is reported. A cycle of processes for producing combinatorial diversity was devised and designated Y-ligation-based block shuffling (YLBS). Methodological refinement was made by applying it to the shuffling of module-sized and amino acid-sized blocks. Running three cycles of YLBS with module-sized GFP blocks resulted in a high diversity of an eight-block shuffled library. Partial shuffling of the central four blocks of GFP was performed to obtain in-effect shuffled protein, resulting in an intact arrangement. Shuffling of amino acid monomer-sized blocks by YLBS was also performed and a diversity of more than 10(10) shuffled molecules was attained. The deletion problems encountered during these experiments were shown to be solved by additional measures which tame type IIS restriction enzymes. The frequency of appearance of each block was skewed but was within a permissible range. Therefore, YLBS is the first general method for generating a huge diversity of shuffled proteins, recombining domains, exons and modules with ease.
MeSH term(s)	Combinatorial Chemistry Techniques/methods ; DNA/chemistry ; DNA/genetics ; DNA Primers/genetics ; Deoxyribonucleases, Type II Site-Specific/metabolism ; Electrophoresis, Polyacrylamide Gel ; Gene Library ; Green Fluorescent Proteins ; Luminescent Proteins/chemistry ; Luminescent Proteins/genetics ; Nucleic Acid Conformation ; Nucleic Acid Denaturation ; Oligonucleotides/chemistry ; Oligonucleotides/genetics ; Point Mutation/genetics ; Polymerase Chain Reaction ; Protein Engineering/methods ; RNA Ligase (ATP)/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Sequence Analysis, DNA ; Sequence Deletion/genetics ; Subtilisin/genetics
Chemical Substances	DNA Primers ; Luminescent Proteins ; Oligonucleotides ; Recombinant Proteins ; Green Fluorescent Proteins (147336-22-9) ; DNA (9007-49-2) ; Deoxyribonucleases, Type II Site-Specific (EC 3.1.21.4) ; Subtilisin (EC 3.4.21.62) ; RNA Ligase (ATP) (EC 6.5.1.3)
Language	English
Publishing date	2002-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	56453-9
ISSN	1460-213X ; 0269-2139
ISSN (online)	1460-213X
ISSN	0269-2139
DOI	10.1093/protein/15.10.843
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2370: Show issues

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Article: Photoinduced magnetization in the organic-based magnet Mn(TCNE)(x)* y(CH2Cl2).

Pejaković, Dusan A / Kitamura, Chitoshi / Miller, Joel S / Epstein, Arthur J

Physical review letters

2002 Volume 88, Issue 5, Page(s) 57202

Abstract: ... Upon optical excitation in the blue region of spectrum, Mn(tetracyanoethylene)(x)*y(CH2Cl2) (x approximately 2 ... y is approximately 0.8) exhibits increased magnetic susceptibility at temperatures as high as 75 K ...

Abstract	Photoinduced magnetization in a magnet based on organic species is reported for the first time. Upon optical excitation in the blue region of spectrum, Mn(tetracyanoethylene)(x)*y(CH2Cl2) (x approximately 2, y is approximately 0.8) exhibits increased magnetic susceptibility at temperatures as high as 75 K, accompanied with photoinduced absorption in the visible and infrared spectral regions. These effects are partially reversible by lower energy visible light and fully reversible by thermal treatment. The results suggest trapping of the photoexcited charge in a metastable state with enhanced exchange interaction.
Language	English
Publishing date	2002-02-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.88.057202
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