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  1. Article ; Online: Biodegradation of high-molecular-weight polycyclic aromatic hydrocarbons under anaerobic conditions: Overview of studies, proposed pathways and future perspectives.

    Nzila, Alexis

    Environmental pollution (Barking, Essex : 1987)

    2018  Volume 239, Page(s) 788–802

    Abstract: The biodegradation of low- and high-molecular-weight polycyclic aromatic hydrocarbons (PAHs) (LWM-PAHs and HMW-PAHs, respectively) has been studied extensively under aerobic conditions. Molecular ... ...

    Abstract The biodegradation of low- and high-molecular-weight polycyclic aromatic hydrocarbons (PAHs) (LWM-PAHs and HMW-PAHs, respectively) has been studied extensively under aerobic conditions. Molecular O
    MeSH term(s) Anaerobiosis ; Bacteria, Anaerobic/drug effects ; Biodegradation, Environmental ; Bioreactors/microbiology ; Denitrification ; Environmental Pollutants/analysis ; Microbial Consortia/drug effects ; Molecular Weight ; Polycyclic Aromatic Hydrocarbons/analysis
    Chemical Substances Environmental Pollutants ; Polycyclic Aromatic Hydrocarbons
    Language English
    Publishing date 2018-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2018.04.074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2599: Show issues Location:
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  2. Article ; Online: Current Status of the Degradation of Aliphatic and Aromatic Petroleum Hydrocarbons by Thermophilic Microbes and Future Perspectives.

    Nzila, Alexis

    International journal of environmental research and public health

    2018  Volume 15, Issue 12

    Abstract: Contamination of the environment by petroleum products is a growing concern worldwide, and strategies to remove these contaminants have been evaluated. One of these strategies is biodegradation, which consists of the use of microorganisms. Biodegradation ...

    Abstract Contamination of the environment by petroleum products is a growing concern worldwide, and strategies to remove these contaminants have been evaluated. One of these strategies is biodegradation, which consists of the use of microorganisms. Biodegradation is significantly improved by increasing the temperature of the medium, thus, the use of thermophiles, microbes that thrive in high-temperature environments, will render this process more efficient. For instance, various thermophilic enzymes have been used in industrial biotechnology because of their unique catalytic properties. Biodegradation has been extensively studied in the context of mesophilic microbes, and the mechanisms of biodegradation of aliphatic and aromatic petroleum hydrocarbons have been elucidated. However, in comparison, little work has been carried out on the biodegradation of petroleum hydrocarbons by thermophiles. In this paper, a detailed review of the degradation of petroleum hydrocarbons (both aliphatic and aromatic) by thermophiles was carried out. This work has identified the characteristics of thermophiles, and unraveled specific catabolic pathways of petroleum products that are only found with thermophiles. Gaps that limit our understanding of the activity of these microbes have also been highlighted, and, finally, different strategies that can be used to improve the efficiency of degradation of petroleum hydrocarbons by thermophiles were proposed.
    MeSH term(s) Biodegradation, Environmental ; Hydrocarbons/chemistry ; Hydrocarbons, Aromatic/chemistry ; Petroleum
    Chemical Substances Hydrocarbons ; Hydrocarbons, Aromatic ; Petroleum
    Language English
    Publishing date 2018-12-07
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph15122782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mini review: Update on bioaugmentation in anaerobic processes for biogas production.

    Nzila, Alexis

    Anaerobe

    2017  Volume 46, Page(s) 3–12

    Abstract: Anaerobic digestion (AD) is increasingly being used and exploited as a strategy to generate biomethane, which can be used as a renewable and clean energy. AD rests on the biodegradation of organic compounds in anaerobic condition, and these organic ... ...

    Abstract Anaerobic digestion (AD) is increasingly being used and exploited as a strategy to generate biomethane, which can be used as a renewable and clean energy. AD rests on the biodegradation of organic compounds in anaerobic condition, and these organic compounds are generally agricultural-, industrial- and domestic-wastes. However, problems of AD decrease efficiency, as the result of bioreactor stress, are generally encountered. The primarily cause of this stress is the presence of high concentrations of inhibitory substances such as nitrate, sulfate, heavy metals and oxygen among others. Another cause of AD decrease efficiency is the use of organic compounds that are less amenable to biodegradation such as lignocellulosic compounds. One of the strategies to overcome these limitations is the addition in bioreactors of "stress resistant"- or "efficient biomethane generating"- microorganisms to improve AD process. This strategy, known as bioaugmentation, has been used for the last 15 years to increase biomethane production. In this review, work carried out on this bioaugmentation process has been summarised, and new strategies that could be used or exploited to improve the success of this approach have also been discussed.
    Language English
    Publishing date 2017-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1237621-8
    ISSN 1095-8274 ; 1075-9964
    ISSN (online) 1095-8274
    ISSN 1075-9964
    DOI 10.1016/j.anaerobe.2016.11.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4318: Show issues Location:
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  4. Article ; Online: Current Status of the Degradation of Aliphatic and Aromatic Petroleum Hydrocarbons by Thermophilic Microbes and Future Perspectives

    Alexis Nzila

    International Journal of Environmental Research and Public Health, Vol 15, Iss 12, p

    2018  Volume 2782

    Abstract: Contamination of the environment by petroleum products is a growing concern worldwide, and strategies to remove these contaminants have been evaluated. One of these strategies is biodegradation, which consists of the use of microorganisms. Biodegradation ...

    Abstract Contamination of the environment by petroleum products is a growing concern worldwide, and strategies to remove these contaminants have been evaluated. One of these strategies is biodegradation, which consists of the use of microorganisms. Biodegradation is significantly improved by increasing the temperature of the medium, thus, the use of thermophiles, microbes that thrive in high-temperature environments, will render this process more efficient. For instance, various thermophilic enzymes have been used in industrial biotechnology because of their unique catalytic properties. Biodegradation has been extensively studied in the context of mesophilic microbes, and the mechanisms of biodegradation of aliphatic and aromatic petroleum hydrocarbons have been elucidated. However, in comparison, little work has been carried out on the biodegradation of petroleum hydrocarbons by thermophiles. In this paper, a detailed review of the degradation of petroleum hydrocarbons (both aliphatic and aromatic) by thermophiles was carried out. This work has identified the characteristics of thermophiles, and unraveled specific catabolic pathways of petroleum products that are only found with thermophiles. Gaps that limit our understanding of the activity of these microbes have also been highlighted, and, finally, different strategies that can be used to improve the efficiency of degradation of petroleum hydrocarbons by thermophiles were proposed.
    Keywords biodegradation ; thermophiles ; petroleum hydrocarbons ; aliphatics ; aromatics ; metabolites ; Medicine ; R
    Language English
    Publishing date 2018-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  5. Article: Biodegradation of high-molecular-weight polycyclic aromatic hydrocarbons under anaerobic conditions: Overview of studies, proposed pathways and future perspectives

    Nzila, Alexis

    Environmental pollution. 2018 Aug., v. 239

    2018  

    Abstract: The biodegradation of low- and high-molecular-weight polycyclic aromatic hydrocarbons (PAHs) (LWM-PAHs and HMW-PAHs, respectively) has been studied extensively under aerobic conditions. Molecular O2 plays 2 critical roles in this biodegradation process. ... ...

    Abstract The biodegradation of low- and high-molecular-weight polycyclic aromatic hydrocarbons (PAHs) (LWM-PAHs and HMW-PAHs, respectively) has been studied extensively under aerobic conditions. Molecular O2 plays 2 critical roles in this biodegradation process. O2 activates the aromatic rings through hydroxylation prior to ring opening and serves as a terminal electron acceptor (TEA). However, several microorganisms have devised ways of activating aromatic rings, leading to ring opening (and thus biodegradation) when TEAs other than O2 are used (under anoxic conditions). These microorganisms belong to the sulfate-, nitrate-, and metal-ion-reducing bacteria and the methanogens. Although the anaerobic biodegradation of monocyclic aromatic hydrocarbons and LWM-PAH naphthalene have been studied, little information is available about the biodegradation of HMW-PAHs. This manuscript reviews studies of the anaerobic biodegradation of HMW-PAHs and identifies gaps that limit both our understanding and the efficiency of this biodegradation process. Strategies that can be employed to overcome these limitations are also discussed.
    Keywords aerobic conditions ; anaerobic conditions ; bacteria ; biodegradation ; hydroxylation ; methanogens ; naphthalene ; oxygen ; polycyclic aromatic hydrocarbons
    Language English
    Dates of publication 2018-08
    Size p. 788-802.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2018.04.074
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4136: Show issues

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  6. Article ; Online: Current Status of and Future Perspectives in Bacterial Degradation of Benzo[a]pyrene

    Alexis Nzila / Musa M. Musa

    International Journal of Environmental Research and Public Health, Vol 18, Iss 262, p

    2021  Volume 262

    Abstract: Benzo[a]pyrene (BaP) is one the main pollutants belonging to the high-molecular-weight PAHs (HMW-PAHs) class and its degradation by microorganisms remains an important strategy for its removal from the environment. Extensive studies have been carried out ...

    Abstract Benzo[a]pyrene (BaP) is one the main pollutants belonging to the high-molecular-weight PAHs (HMW-PAHs) class and its degradation by microorganisms remains an important strategy for its removal from the environment. Extensive studies have been carried out on the isolation and characterisation of microorganisms that can actively degrade low-molecular-weight PAHs (LMW-PAHs), and to a certain extent, the HMW-PAH pyrene. However, so far, limited work has been carried out on BaP biodegradation. BaP consists of five fused aromatic rings, which confers this compound a high chemical stability, rendering it less amenable to biodegradation. The current review summarizes the emerging reports on BaP biodegradation. More specifically, work carried out on BaP bacterial degradation and current knowledge gaps that limit our understanding of BaP degradation are highlighted. Moreover, new avenues of research on BaP degradation are proposed, specifically in the context of the development of “omics” approaches.
    Keywords benzo[a]pyrene ; biodegradation ; co-metabolism ; bioaugmentation ; catabolic pathways ; omics ; Medicine ; R
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Current Knowledge and Future Challenges on Bacterial Degradation of the Highly Complex Petroleum Products Asphaltenes and Resins

    Alexis Nzila / Musa M. Musa

    Frontiers in Environmental Science, Vol

    2021  Volume 9

    Abstract: Petroleum products consist mainly of aliphatics, aromatics, asphaltenes and resins. After oil exploitation, the concentrations of asphaltenes and resins are high in oil reservoirs; however, they are also the petroleum pollutants most recalcitrant to ... ...

    Abstract Petroleum products consist mainly of aliphatics, aromatics, asphaltenes and resins. After oil exploitation, the concentrations of asphaltenes and resins are high in oil reservoirs; however, they are also the petroleum pollutants most recalcitrant to degradation, leading to high oil viscosity. A sizable amount of work has been dedicated to understand the degradation mechanisms of aliphatics and aromatics; however, in comparison, little work has been carried out on asphaltene and resin degradation. This review discusses our current knowledge on the understanding of asphaltene and resin degradation. More specifically, it sheds light on work carried out to date on the degradation of these pollutants, and highlights the major gaps that limit our understanding of their degradation pathways. It also presents new potential research areas that can be explored to fill in these gaps.
    Keywords asphaltenes ; resins ; asphalt ; bitumen ; biodegradation ; bacteria ; Environmental sciences ; GE1-350
    Subject code 910
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Current Status of and Future Perspectives in Bacterial Degradation of Benzo[a]pyrene.

    Nzila, Alexis / Musa, Musa M

    International journal of environmental research and public health

    2020  Volume 18, Issue 1

    Abstract: Benzo[a]pyrene (BaP) is one the main pollutants belonging to the high-molecular-weight PAHs (HMW-PAHs) class and its degradation by microorganisms remains an important strategy for its removal from the environment. Extensive studies have been carried out ...

    Abstract Benzo[a]pyrene (BaP) is one the main pollutants belonging to the high-molecular-weight PAHs (HMW-PAHs) class and its degradation by microorganisms remains an important strategy for its removal from the environment. Extensive studies have been carried out on the isolation and characterisation of microorganisms that can actively degrade low-molecular-weight PAHs (LMW-PAHs), and to a certain extent, the HMW-PAH pyrene. However, so far, limited work has been carried out on BaP biodegradation. BaP consists of five fused aromatic rings, which confers this compound a high chemical stability, rendering it less amenable to biodegradation. The current review summarizes the emerging reports on BaP biodegradation. More specifically, work carried out on BaP bacterial degradation and current knowledge gaps that limit our understanding of BaP degradation are highlighted. Moreover, new avenues of research on BaP degradation are proposed, specifically in the context of the development of "omics" approaches.
    MeSH term(s) Bacteria/metabolism ; Benzo(a)pyrene/metabolism ; Biodegradation, Environmental ; Environmental Pollutants/metabolism
    Chemical Substances Environmental Pollutants ; Benzo(a)pyrene (3417WMA06D)
    Language English
    Publishing date 2020-12-31
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph18010262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Non-enzymatic detection of miR-21 in cancer cells using a homogeneous mix-and-read smart probe assay.

    Oladepo, Sulayman A / Nzila, Alexis / Aminu, Abdulmalik / Sankaran, Saravanan

    Analytical biochemistry

    2022  Volume 645, Page(s) 114601

    Abstract: We report a new assay system for the detection of miR-21 in cancer cells. The new assay works at room temperature and it does not involve enzymatic amplification. It consists a hairpin smart probe, designed to specifically recognize miR-21 target ... ...

    Abstract We report a new assay system for the detection of miR-21 in cancer cells. The new assay works at room temperature and it does not involve enzymatic amplification. It consists a hairpin smart probe, designed to specifically recognize miR-21 target sequence. We tested the performance and sequence recognition capability of the smart probe to confirm desired specifications. We used the smart probe for the sequence-specific recognition of synthetic miR-21 oligonucleotides as well as mismatch sequences and we found that the probe recognizes the target sequence-specifically, while discriminating against mismatched sequences. We determined the limit of detection and limit of quantitation for the miR-21 oligonucleotides to be 1.72 nM and 5.78 nM, respectively, while the sensitivity is 6.90 × 10
    MeSH term(s) Biological Assay ; Biosensing Techniques/methods ; Humans ; MCF-7 Cells ; MicroRNAs/analysis ; MicroRNAs/genetics ; Neoplasms/diagnosis ; Neoplasms/genetics ; Oligonucleotides/analysis
    Chemical Substances MIRN21 microRNA, human ; MicroRNAs ; Oligonucleotides
    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1110-1
    ISSN 1096-0309 ; 0003-2697
    ISSN (online) 1096-0309
    ISSN 0003-2697
    DOI 10.1016/j.ab.2022.114601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 389: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article: Mini review: Update on bioaugmentation in anaerobic processes for biogas production

    Nzila, Alexis

    Anaerobe. 2017 Aug., v. 46

    2017  

    Abstract: Anaerobic digestion (AD) is increasingly being used and exploited as a strategy to generate biomethane, which can be used as a renewable and clean energy. AD rests on the biodegradation of organic compounds in anaerobic condition, and these organic ... ...

    Abstract Anaerobic digestion (AD) is increasingly being used and exploited as a strategy to generate biomethane, which can be used as a renewable and clean energy. AD rests on the biodegradation of organic compounds in anaerobic condition, and these organic compounds are generally agricultural-, industrial- and domestic-wastes. However, problems of AD decrease efficiency, as the result of bioreactor stress, are generally encountered. The primarily cause of this stress is the presence of high concentrations of inhibitory substances such as nitrate, sulfate, heavy metals and oxygen among others. Another cause of AD decrease efficiency is the use of organic compounds that are less amenable to biodegradation such as lignocellulosic compounds. One of the strategies to overcome these limitations is the addition in bioreactors of “stress resistant”- or “efficient biomethane generating”- microorganisms to improve AD process. This strategy, known as bioaugmentation, has been used for the last 15 years to increase biomethane production. In this review, work carried out on this bioaugmentation process has been summarised, and new strategies that could be used or exploited to improve the success of this approach have also been discussed.
    Keywords anaerobic digestion ; bioaugmentation ; biodegradation ; biogas ; bioreactors ; clean energy ; heavy metals ; lignocellulose ; microorganisms ; nitrates ; organic compounds ; oxygen ; sulfates
    Language English
    Dates of publication 2017-08
    Size p. 3-12.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1237621-8
    ISSN 1075-9964
    ISSN 1075-9964
    DOI 10.1016/j.anaerobe.2016.11.007
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4318: Show issues Location:
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