LIVIVO - Search results -

Search results

Result 1 - 10 of total 11081

Search options

Article: Study on the Mechanism of Qing-Fei-Shen-Shi Decoction on Asthma Based on Integrated 16S rRNA Sequencing and Untargeted Metabolomics.

Hu, Haibo / Zhao, Guojing / Wang, Kun / Han, Ping / Ye, Haiyan / Wang, Fengchan / Liu, Na / Zhou, Peixia / Lu, Xuechao / Zhou, Zhaoshan / Cui, Huantian

Evidence-based complementary and alternative medicine : eCAM

2023 Volume 2023, Page(s) 1456844

Abstract: Qing-Fei-Shen-Shi decoction (QFSS) consists of ...

Abstract	Qing-Fei-Shen-Shi decoction (QFSS) consists of
Language	English
Publishing date	2023-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2023/1456844
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5995: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: SIRT1 inhibitors within Qing-Luo-Yin alleviated white adipose tissues-mediated inflammation in antigen-induced arthritis mice.

Ye, Peng / Wang, Qi-Hai / Liu, Chun-Sheng / Li, Guo-Hao / Olatunji, Opeyemi Joshua / Lin, Jia-Ting / Zuo, Jian

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 122, Page(s) 155132

Abstract: ... the involvement of WAT in the treatments of antigen-induced arthritis (AIA) mice with the herbal formula Qing-Luo ...

Abstract	Background: White adipose tissues (WAT) release large amounts of inflammatory mediators, which are responsible for the pathology of rheumatoid arthritis (RA). Purpose: The current study investigated the involvement of WAT in the treatments of antigen-induced arthritis (AIA) mice with the herbal formula Qing-Luo-Yin (QLY). Methods: Cytokines and biochemical/metabolic indicators were determined by ELISA and colorimetry methods, respectively. Monocytes were analyzed by flow cytometry. Tissues were subjected to PCR, western-blot and histological analyses. Pre-adipocytes were cultured in the different mouse serum from the in vivo experiment, and some of them were treated by certain compounds or/and lipopolysaccharide. Afterwards, the catalytic activity and thermostability of SIRT1 were tested. Gene/protein expression and cytokine production were investigated too. NAMPT and SIRT1 were silenced in some cells by siRNA. Results: AIA mice suffered from inflammatory adipokines-mediated metabolism and immune disorders. Besides joint protective effects, QLY therapies favored adipocyte differentiation and suppressed inflammatory adipokines release. The up-regulation of fatty acid oxidation and inflammatory monocyte polarization was therefore inhibited in peripheral tissues. PPARγ expression was generally promoted by QLY. Whereas, SIRT1 activity was always impaired, indicated by the declined NAD Conclusion: SIRT1 inhibitors in QLY reduced eNAMPT production and up-regulated PPARγ in AIA mice, leading to inflammation remission. These clues show that except for the well-known anti-inflammatory functions, SIRT1 participates in inflammatory reactions too and could be a potential anti-rheumatic target.
MeSH term(s)	Mice ; Animals ; Sirtuin 1/metabolism ; PPAR gamma ; Cytokines/metabolism ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/pathology ; Adipokines ; Inflammation/drug therapy
Chemical Substances	Sirtuin 1 (EC 3.5.1.-) ; PPAR gamma ; Cytokines ; Adipokines
Language	English
Publishing date	2023-10-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.155132
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4115: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Wan-Nian-Qing, a Herbal Composite Prescription, Suppresses the Progression of Liver Cancer in Mice by Regulating Immune Response.

Zhang, Xinrui / Liu, Xin / Zhang, Yue / Yang, Anhui / Zhang, Yongfeng / Tong, Zhijun / Wang, Yingwu / Qiu, Ye

Frontiers in oncology

2021 Volume 11, Page(s) 696282

Abstract: The Wan-Nian-Qing prescription (WNQP), an herbal composite containing ...

Abstract	The Wan-Nian-Qing prescription (WNQP), an herbal composite containing
Language	English
Publishing date	2021-07-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2021.696282
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Cytokine Storm in Acute Viral Respiratory Injury: Role of Qing-Fei-Pai-Du Decoction in Inhibiting the Infiltration of Neutrophils and Macrophages through TAK1/IKK/NF-[Formula: see text]B Pathway.

The American journal of Chinese medicine

2023 Volume 51, Issue 5, Page(s) 1153–1188

Abstract: COVID-19 has posed unprecedented challenges to global public health since its outbreak. The Qing ...

Abstract	COVID-19 has posed unprecedented challenges to global public health since its outbreak. The Qing-Fei-Pai-Du decoction (QFPDD), a Chinese herbal formula, is widely used in China to treat COVID-19. It exerts an impressive therapeutic effect by inhibiting the progression from mild to critical disease in the clinic. However, the underlying mechanisms remain obscure. Both SARS-CoV-2 and influenza viruses elicit similar pathological processes. Their severe manifestations, such as acute respiratory distress syndrome (ARDS), multiple organ failure (MOF), and viral sepsis, are correlated with the cytokine storm. During flu infection, QFPDD reduced the lung indexes and downregulated the expressions of MCP-1, TNF-[Formula: see text], IL-6, and IL-1[Formula: see text] in broncho-alveolar lavage fluid (BALF), lungs, or serum samples. The infiltration of neutrophils and inflammatory monocytes in lungs was decreased dramatically, and lung injury was ameliorated in QFPDD-treated flu mice. In addition, QFPDD also inhibited the polarization of M1 macrophages and downregulated the expressions of IL-6, TNF-[Formula: see text], MIP-2, MCP-1, and IP-10, while also upregulating the IL-10 expression. The phosphorylated TAK1, IKK[Formula: see text]/[Formula: see text], and I[Formula: see text]B[Formula: see text] and the subsequent translocation of phosphorylated p65 into the nuclei were decreased by QFPDD. These findings indicated that QFPDD reduces the intensity of the cytokine storm by inhibiting the NF-[Formula: see text]B signaling pathway during severe viral infections, thereby providing theoretical and experimental support for its clinical application in respiratory viral infections.
MeSH term(s)	Animals ; Mice ; Interleukin-6/metabolism ; COVID-19/metabolism ; SARS-CoV-2 ; Neutrophils/metabolism ; Cytokine Release Syndrome ; Macrophages/metabolism ; NF-kappa B/metabolism
Chemical Substances	Interleukin-6 ; NF-kappa B
Language	English
Publishing date	2023-07-05
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	193085-0
ISSN	1793-6853 ; 0090-2942 ; 0192-415X
ISSN (online)	1793-6853
ISSN	0090-2942 ; 0192-415X
DOI	10.1142/S0192415X23500532
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1110: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Gan-Qing-Ning Formula Inhibits the Growth of Hepatocellular Carcinoma by Promoting Apoptosis and Inhibiting Angiogenesis in H

Zeng, Fan-Yan / Zhao, Kai-Li / Lin, Le-Zhen / Deng, Ying / Qin, Si / Ye, Jin-Rong / Huang, Zeng-Qiong

Evidence-based complementary and alternative medicine : eCAM

2020 Volume 2020, Page(s) 6376912

Abstract: Objective: Gang-Qing-Ning (GQN) is a traditional Chinese medicine formula that has been used ...

Abstract	Objective: Gang-Qing-Ning (GQN) is a traditional Chinese medicine formula that has been used in the treatment of hepatocellular carcinoma (HCC) in the folk population for decades. However, scientific validation is still necessary to lend credibility to the traditional use of GQN against HCC. This study investigates the antitumor effect of GQN on H Methods: Fifty H Results: The tumor inhibitory rates of high, medium, and low dosages of GQN groups were 47.39%, 38.26%, and 22.17%, respectively. The high dosage of the GQN group significantly increased the protein and mRNA expression levels of Bax, Cyt-C, and cleaved Caspase 3 (or Caspase 3) ( Conclusions: The high dosage of GQN can significantly inhibit the tumor growth in H
Language	English
Publishing date	2020-08-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2020/6376912
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5995: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Protection against peripheral artery disease injury by Ruan Jian Qing Mai formula via metabolic programming.

Chen, Jian / Liang, Zhi-Qiang / Hu, Can / Gao, Yuan / Wang, Yong-Kui / Yang, Jiang-Wei / Zhao, Cheng / Cao, Ye-Min / Cao, Yong-Bing

Biotechnology and applied biochemistry

2020 Volume 68, Issue 2, Page(s) 366–380

Abstract: Ruan Jian Qing Mai formula (RJQM), a multicomponent herbal formula, has been widely used to treat ...

Abstract	Ruan Jian Qing Mai formula (RJQM), a multicomponent herbal formula, has been widely used to treat peripheral arterial disease (PAD) in China. However, its active compounds and mechanisms of action are still unknown. First, RNA sequencing analysis of 15 healthy and 16 PAD samples showed that 524 PAD differential genes were significantly enriched in Go Ontology (ribonucleotide metabolic process, oxidoreductase complex, and electron transfer activity), Kyoto Encyclopedia of Genes and Genomes (KEGG) and GSEA pathways (OXPHOS and TCA cycle), miRNA (MIR183), and kinase (PAK6). Fifty-three active ingredients in RJQM had similar structures to the seven drug molecules in CLUE. Then, network topology analysis of the 53 components-target-pathway-disease network yielded 10 active ingredients. Finally, computational toxicity estimations showed that the median lethal dose (LD50) of the 10 active ingredients was above 1000 mg/kg, and eight of them did not cause hepatotoxicity, mutagenicity, carcinogenicity, cytotoxicity, and immunotoxicity nor activate 12 toxic pathways. In conclusion, RJQM has a protection effect on PAD by regulating a complex molecular network. Part of the mechanism is associated with the regulation of OXPHOS by 10 active components, which may alleviate mitochondrial dysfunction and pathological metabolic programming.
MeSH term(s)	Drugs, Chinese Herbal/pharmacology ; Gene Expression Regulation/drug effects ; Humans ; Peripheral Arterial Disease/genetics ; Peripheral Arterial Disease/metabolism ; Peripheral Arterial Disease/prevention & control
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2020-05-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	883433-7
ISSN	1470-8744 ; 0885-4513
ISSN (online)	1470-8744
ISSN	0885-4513
DOI	10.1002/bab.1934
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1865: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Study of the analgesic activities, chronic toxicity and addictive potential of Jia-Yuan-Qing pill in rats.

Tian, Y E / Teng, Li-Rong / Wang, Zhen-Zuo / Zhao, Min / Meng, Qing-Fan / Lu, Jia-Hui / Tian, Jian-Ming / Zhang, Wei-Wei / Zheng, Xiaoyi / Wang, D I / Teng, LE-Sheng

Experimental and therapeutic medicine

2015 Volume 9, Issue 6, Page(s) 2349–2355

Abstract: Jia-Yuan-Qing pill (JYQP) composed of ...

Abstract	Jia-Yuan-Qing pill (JYQP) composed of
Language	English
Publishing date	2015-04-15
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2015.2426
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Studies on the analgesic activities of Jia-Yuan-Qing pill and its safety evaluation in mice.

Tian, Ye / Teng, Li-rong / Song, Jing-jing / Meng, Qing-fan / Lu, Jia-hui / Zhang, Wei-wei / Wei, Kang / Wang, Ning / Wang, Di / Teng, Le-sheng

Protoplasma

2014 Volume 251, Issue 5, Page(s) 1245–1253

Abstract: ... Paniculati have been reported in recent years. A new formula named Jia-Yuan-Qing pill (JYQP) is ...

Abstract	The analgesic activity of Porcellio laevis Latreille, Rhizoma Corydalis, and Radix Cynanchi Paniculati have been reported in recent years. A new formula named Jia-Yuan-Qing pill (JYQP) is therefore created by combining the three herbs at 9:7:7 ratio according to traditional Chinese theories. The present study aims to evaluate the effect of JYQP as a novel painkiller in various models. Acute toxicity test was applied to evaluate the safety of JYQP. Acetic-acid-induced writhing, hot plate test, formalin test, and naloxone-pretreated writhing test were employed to elaborate the analgesic activity of JYQP and its possible mechanism. A bone cancer pain mouse model was performed to further assess the effect of JYQP in relieving cancer pain. Test on naloxone-precipitated withdrawal symptoms was conduct to examine the physical dependence of mice on JYQP. Data revealed that JYQP reduced writhing and stretching induced by acetic acid; however, this effect could not be blocked by naloxone. JYQP specifically suppressed the phase II reaction time in formalin-treated mice; meanwhile, no analgesic effect of JYQP in hot plate test was observed, indicating that JYQP exerts analgesic activity against inflammatory pain rather than neurogenic pain. Furthermore, JYQP could successfully relieve bone cancer pain in mice. No physical dependence could be observed upon long-term administration in mice. Collectively, our present results provide experimental evidence in supporting clinical use of JYQP as an effective and safe agent for pain treatment.
MeSH term(s)	Analgesics/adverse effects ; Analgesics/pharmacology ; Animals ; Bone Neoplasms/pathology ; Corydalis/metabolism ; Cynanchum/metabolism ; Female ; Inflammation/pathology ; Isopoda/metabolism ; Male ; Medicine, Chinese Traditional/adverse effects ; Mice ; Mice, Inbred C57BL ; Naloxone/pharmacology ; Narcotic Antagonists/pharmacology ; Pain/drug therapy ; Phytotherapy ; Plant Extracts/adverse effects ; Plant Extracts/pharmacology
Chemical Substances	Analgesics ; Narcotic Antagonists ; Plant Extracts ; Naloxone (36B82AMQ7N)
Language	English
Publishing date	2014-03-28
Publishing country	Austria
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123809-7
ISSN	1615-6102 ; 0033-183X
ISSN (online)	1615-6102
ISSN	0033-183X
DOI	10.1007/s00709-014-0637-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2366: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Xiao-Qing-Long Tang Prevents Cardiomyocyte Hypertrophy, Fibrosis, and the Development of Heart Failure with Preserved Ejection Faction in Rats by Modulating the Composition of the Gut Microbiota.

Zhou, Guo-Feng / Jiang, Yue-Hua / Ma, Du-Fang / Wang, Yong-Cheng / Yang, Jin-Long / Chen, Ji-Ye / Chi, Chen-Yu / Han, Xiao-Wei / Li, Zhao-Yu / Li, Xiao

BioMed research international

2019 Volume 2019, Page(s) 9637479

Abstract: ... Xiao-Qing-Long Tang (XQLT), a traditional herbal formula, has an anti-inflammatory effect and regulates ...

Abstract	Background: Changes in the gut microbiota are associated with cardiovascular disease progression. Xiao-Qing-Long Tang (XQLT), a traditional herbal formula, has an anti-inflammatory effect and regulates the steady state of the immune system, which is also associated with the progression of heart failure with preserved ejection faction (HFpEF). In this study, we investigated whether XQLT could contribute to prevent the development of HFpEF and whether the modulation of the gut microbiota by this herbal formula could be involved in such effect. Methods: The gut microbiota, SCFAs, the histology/function of the heart, and systolic blood pressure were examined to evaluate the effect of XQLT on the gut microbiota and the progression of HFpEF after oral administration of XQLT to model rats. Furthermore, we evaluated, through fecal microbiota transplantation experiments, whether the favorable effects of XQLT could be mediated by the gut microbiota. Results: Oral administration of XQLT contributed to the reduction of elevated blood pressure, inflammation, and compensatory hypertrophy, features that are associated with the progression of HFpEF. The gut microbiota composition, SCFA levels, and intestinal mucosal histology were improved after treatment with XQLT. Moreover, fecal transfer from XQLT-treated rats was sufficient to prevent the progression of HFpEF. Conclusions: These data suggested that XQLT prevented the development of HFpEF in model rats by regulating the composition of the gut microbiota.
MeSH term(s)	Administration, Oral ; Animals ; Cardiomegaly/drug therapy ; Cardiomegaly/metabolism ; Cardiomegaly/microbiology ; Cardiomegaly/physiopathology ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Fibrosis ; Gastrointestinal Microbiome/drug effects ; Heart Failure/drug therapy ; Heart Failure/metabolism ; Heart Failure/microbiology ; Heart Failure/physiopathology ; Male ; Myocytes, Cardiac/metabolism ; Rats ; Rats, Inbred Dahl ; Stroke Volume/drug effects
Chemical Substances	Drugs, Chinese Herbal ; sho-seiryu-to
Language	English
Publishing date	2019-07-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2019/9637479
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Integrating Network Pharmacology and Metabolomics Study on Anti-rheumatic Mechanisms and Antagonistic Effects Against Methotrexate-Induced Toxicity of Qing-Luo-Yin.

Zuo, Jian / Wang, Xin / Liu, Yang / Ye, Jing / Liu, Qingfei / Li, Yan / Li, Shao

Frontiers in pharmacology

2018 Volume 9, Page(s) 1472

Abstract: Qing-Luo-Yin (QLY) is a traditional Chinese medicine (TCM) formula used to treat Hot Syndrome ...

Abstract	Qing-Luo-Yin (QLY) is a traditional Chinese medicine (TCM) formula used to treat Hot Syndrome-related rheumatoid arthritis (RA). Previously, we uncovered partial mechanisms involved in the therapeutic actions of QLY on RA. In this study, we further elucidated its anti-rheumatic mechanisms and investigated its possible interactions with methotrexate (MTX)
Language	English
Publishing date	2018-12-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2018.01472
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito