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  1. Article ; Online: My Crooked and Aching Neck-Surgical Management of Cervical Deformity.

    Kato, So / Shamji, Mohammed F

    World neurosurgery

    2016  Volume 91, Page(s) 644–646

    MeSH term(s) Cervical Vertebrae/surgery ; Humans ; Kyphosis/surgery ; Osteotomy ; Spinal Fusion ; Treatment Outcome
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2016.05.022
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  2. Article ; Online: The Dorsal Root Ganglion in the Pathogenesis of Chronic Neuropathic Pain.

    Guha, Daipayan / Shamji, Mohammed F

    Neurosurgery

    2016  Volume 63 Suppl 1, Page(s) 118–126

    MeSH term(s) Animals ; Ganglia, Spinal/pathology ; Ganglia, Spinal/physiopathology ; Humans ; Male ; Neuralgia/pathology ; Neuralgia/physiopathology ; Rats
    Language English
    Publishing date 2016-07-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/NEU.0000000000001255
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  3. Article ; Online: IMAGES IN CLINICAL MEDICINE. Cervical Meningocele.

    Shamji, Mohammed F / Ibrahim, Ahmed

    The New England journal of medicine

    2015  Volume 373, Issue 4, Page(s) e4

    MeSH term(s) Cervical Vertebrae/surgery ; Female ; Humans ; Meningocele/pathology ; Meningocele/surgery ; Young Adult
    Language English
    Publishing date 2015-07-23
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMicm1408098
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  4. Article ; Online: Craniocervical deformity and myelopathy after chronic odontoid fracture.

    Shamji, Mohammed F / Fehlings, Michael G

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2015  Volume 187, Issue 13, Page(s) E420

    MeSH term(s) Aged ; Chronic Disease ; Female ; Humans ; Kyphosis/diagnosis ; Kyphosis/etiology ; Odontoid Process/injuries ; Pseudarthrosis/complications ; Pseudarthrosis/diagnosis ; Spinal Cord Compression/diagnosis ; Spinal Cord Compression/etiology ; Spinal Fractures/complications ; Spinal Fractures/diagnosis
    Language English
    Publishing date 2015-05-11
    Publishing country Canada
    Document type Case Reports ; Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.140877
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  5. Article ; Online: What do we gain and lose from database studies?

    Shamji, Mohammed F

    Archives of surgery (Chicago, Ill. : 1960)

    2009  Volume 145, Issue 3, Page(s) 253–254

    MeSH term(s) Brain Neoplasms/surgery ; Continental Population Groups ; Craniotomy/statistics & numerical data ; Databases, Factual ; Evaluation Studies as Topic ; Healthcare Disparities/statistics & numerical data ; Humans
    Language English
    Publishing date 2009-11-18
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 80055-7
    ISSN 1538-3644 ; 0004-0010 ; 0096-6908 ; 0272-5533
    ISSN (online) 1538-3644
    ISSN 0004-0010 ; 0096-6908 ; 0272-5533
    DOI 10.1001/archsurg.2009.293
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  6. Article ; Online: Solitary spinal epidural cavernous haemangiomas as a rare cause of myelopathy.

    Meng, Ying / Shamji, Mohammed F

    BMJ case reports

    2015  Volume 2015

    Abstract: Cavernous haemangiomas rarely occur in the spinal epidural space. We report the case of a 27-year-old man who presented with myelopathy secondary to spinal cord compression from a purely epidural lesion. The imaging characteristics of cavernous ... ...

    Abstract Cavernous haemangiomas rarely occur in the spinal epidural space. We report the case of a 27-year-old man who presented with myelopathy secondary to spinal cord compression from a purely epidural lesion. The imaging characteristics of cavernous haemangiomas are unique, reflecting a highly vascular lesion. Key differentiating features from intracranial or intramedullary lesions include the lack of a surrounding hemosiderin ring and popcorn appearance. An urgent referral to a neurosurgeon is recommended given the possibility of acute neurological deterioration from intralesional haemorrhage, and good recovery from early surgical resection. Preoperative planning with thorough patient counselling and availability of matched blood is important, and an en bloc resection approach should be taken to minimise blood loss. In this case, the patient experienced complete recovery after surgical resection. No recurrence after complete resection has been reported in the literature. This suggests a good long-term outcome for the patient and that no early adjuvant therapy is necessary.
    MeSH term(s) Adult ; Back Pain/etiology ; Epidural Neoplasms/pathology ; Epidural Neoplasms/surgery ; Hemangioma, Cavernous/pathology ; Hemangioma, Cavernous/surgery ; Humans ; Laminectomy ; Lower Extremity/physiopathology ; Magnetic Resonance Imaging ; Male ; Spinal Cord Compression/etiology ; Spinal Cord Compression/surgery ; Tomography, X-Ray Computed
    Language English
    Publishing date 2015-09-25
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2015-211644
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  7. Article ; Online: Use of neuropathic pain questionnaires in predicting persistent postoperative neuropathic pain following lumbar discectomy for radiculopathy.

    Shamji, Mohammed F / Shcharinsky, Alina

    Journal of neurosurgery. Spine

    2015  Volume 24, Issue 2, Page(s) 256–262

    Abstract: OBJECT Failed-back surgery syndrome has been historically used to describe extremity neuropathic pain in lumbar disease despite structurally corrective spinal surgery. It is unclear whether specific preoperative pain characteristics can help determine ... ...

    Abstract OBJECT Failed-back surgery syndrome has been historically used to describe extremity neuropathic pain in lumbar disease despite structurally corrective spinal surgery. It is unclear whether specific preoperative pain characteristics can help determine which patients may be susceptible to such postoperative disabling symptoms. METHODS This prospective study analyzed surgical microdiscectomy patients treated for lumbar, degenerative, painful radiculopathy. Clinical parameters included general demographics, preoperative and postoperative clinical examination status, self-reported pain and disability scores, and neuropathic pain scores. The screening tests for neuropathic pain were the Douleur Neuropathique 4 and Leeds Assessment of Neuropathic Symptoms and Signs, with correlation tested for ordinal score and screen positivity. Multiple logistic regression analysis was used to define predictors of postoperative symptomatology. RESULTS Twelve percent of the 250 patients with radiculopathy who underwent microdiscectomy experienced persistent postoperative neuropathic pain (PPNP) with only modest, if any, relief of leg pain. The condition was highly associated with abnormal preoperative screen results for neuropathic pain, but not sex, smoking status, or preoperative pain severity (α = 0.05). Good correlation was seen between the 2 screening tests used in this study for both absolute ordinal score (Spearman ρ = 0.84; p < 0.001) and the threshold for terming the patient as having neuropathic pain features (Spearman ρ = 0.48; p < 0.001). Younger age at treatment also correlated with a higher likelihood of developing PPNP (p = 0.03). CONCLUSIONS This population exhibited a low overall frequency of PPNP. Higher neuropathic pain screening scores correlated strongly with likelihood of significant postoperative leg pain. Further work is required to develop more accurate prognostication tools for radiculopathy patients undergoing structural spinal surgery.
    Language English
    Publishing date 2015-10-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2158643-3
    ISSN 1547-5646 ; 1547-5654
    ISSN (online) 1547-5646
    ISSN 1547-5654
    DOI 10.3171/2015.4.SPINE141310
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  8. Article ; Online: Effects of sex on the incidence and prognosis of spinal meningiomas: a Surveillance, Epidemiology, and End Results study.

    Westwick, Harrison J / Shamji, Mohammed F

    Journal of neurosurgery. Spine

    2015  Volume 23, Issue 3, Page(s) 368–373

    Abstract: Object: Most spinal meningiomas are intradural lesions in the thoracic spine that present with both local pain and myelopathy. By using the large prospective Surveillance, Epidemiology, and End Results (SEER) database, the authors studied the incidence ... ...

    Abstract Object: Most spinal meningiomas are intradural lesions in the thoracic spine that present with both local pain and myelopathy. By using the large prospective Surveillance, Epidemiology, and End Results (SEER) database, the authors studied the incidence of spinal meningiomas and examined demographic and treatment factors predictive of death.
    Methods: Using SEER*Stat software, the authors queried the SEER database for cases of spinal meningioma between 2000 and 2010. From the results, tumor incidence and demographic statistics were computed; incidence was analyzed as a function of tumor location, pathology, age, sex, and malignancy code. Survival was analyzed by using a Cox proportional hazards ratio in SPSS for age, sex, marital status, primary site, size quartile, treatment modality, and malignancy code. In this analysis, significance was set at a p value of 0.05.
    Results: The 1709 spinal meningiomas reported in the SEER database represented 30.7% of all primary intradural spinal tumors and 7.9% of all meningiomas. These meningiomas occurred at an age-adjusted incidence of 0.193 (95% CI 0.183-0.202) per 100,000 population and were closely related to sex (337 [19.7%] male patients and 1372 [80.3%] female patients). The Cox hazard function for mortality in males was higher (2.4 [95% CI1.7-3.5]) and statistically significant, despite the lower lesion incidence in males. All-cause survival was lowest in patients older than 80 years. Primary site and treatment modality were not significant predictors of mortality.
    Conclusions: Spinal meningiomas represent a significant fraction of all primary intradural spinal tumors and of all meningiomas. The results of this study establish the association of lesion incidence and survival with sex, with a less frequent incidence in but greater mortality among males.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Female ; Humans ; Incidence ; Male ; Meningioma/epidemiology ; Meningioma/pathology ; Middle Aged ; Prognosis ; SEER Program ; Sex Factors ; Spinal Cord Neoplasms/epidemiology ; Spinal Cord Neoplasms/pathology ; Young Adult
    Language English
    Publishing date 2015-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2158643-3
    ISSN 1547-5646 ; 1547-5654
    ISSN (online) 1547-5646
    ISSN 1547-5654
    DOI 10.3171/2014.12.SPINE14974
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  9. Article ; Online: Brown-Séquard syndrome from herniation of a thoracic disc.

    Witiw, Christopher D / Shamji, Mohammed F

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2014  Volume 186, Issue 18, Page(s) 1395

    MeSH term(s) Adult ; Brown-Sequard Syndrome/etiology ; Humans ; Intervertebral Disc Displacement/complications ; Male ; Thoracic Vertebrae
    Language English
    Publishing date 2014-08-25
    Publishing country Canada
    Document type Case Reports ; Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.140117
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  10. Article ; Online: The Advancing Role of Neuromodulation for the Management of Chronic Treatment-Refractory Pain.

    Shamji, Mohammed F / De Vos, Cecile / Sharan, Ashwini

    Neurosurgery

    2017  Volume 80, Issue 3S, Page(s) S108–S113

    Abstract: Neuropathic pain is a common cause of disability and health care utilization. While judicious pharmacotherapy and management of comorbid psychological distress can provide for improved quality of life, some patients with treatment-refractory disease ... ...

    Abstract Neuropathic pain is a common cause of disability and health care utilization. While judicious pharmacotherapy and management of comorbid psychological distress can provide for improved quality of life, some patients with treatment-refractory disease require more invasive therapies. Spinal cord stimulation can provide for improvement in pain and decrease in medication utilization, with level 1 evidence supporting its use across various pain etiologies including persistent postoperative neuropathic pain, complex regional pain syndrome, chronic inoperable limb ischemia, treatment refractory angina, and painful diabetic neuropathy. These procedures can be done with acceptably low morbidity and provide a cost-effective solution for those patients in whom medical therapies have failed. Technological innovation in lead design, implantable pulse generator capability, and stimulation algorithms and parameters may further enhance the success of this therapy. Neuromodulation of distal targets such as dorsal root ganglion may permit greater anatomic specificity of the therapy, whereas subthreshold stimulation with high-frequency or burst energy delivery may eliminate noxious and off-target paresthesiae. Such new technologies should be subject to rigorous evaluation as their mechanisms of action and long-term outcomes remain hitherto undefined.
    MeSH term(s) Chronic Pain/therapy ; Cost-Benefit Analysis ; Ganglia, Spinal ; Humans ; Neuralgia/therapy ; Pain Management/methods ; Pain, Intractable/therapy ; Quality of Life ; Spinal Cord Stimulation
    Language English
    Publishing date 2017-03-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyw047
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