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Article ; Online: PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia.

Goswami, Swagata / Mani, Rajeswaran / Nunes, Jessica / Chiang, Chi-Ling / Zapolnik, Kevan / Hu, Eileen / Frissora, Frank / Mo, Xiaokui / Walker, Logan A / Yan, Pearlly / Bundschuh, Ralf / Beaver, Larry / Devine, Raymond / Tsai, Yo-Ting / Ventura, Ann / Xie, Zhiliang / Chen, Min / Lapalombella, Rosa / Walker, Alison /

Mims, Alice / Larkin, Karilyn / Grieselhuber, Nicole / Bennett, Chad / Phelps, Mitch / Hertlein, Erin / Behbehani, Gregory / Vasu, Sumithira / Byrd, John C / Muthusamy, Natarajan

Blood

2021 Volume 139, Issue 9, Page(s) 1340–1358

Abstract: ... pharmacological agent, OSU-2S, in parallel with genetic approaches, we discovered that PP2A enforced c-Myc and p21 ... in vivo. Our findings identify the PP2A/c-Myc/p21 axis as a critical regulator of the differentiation ...

Abstract	Dysregulated cellular differentiation is a hallmark of acute leukemogenesis. Phosphatases are widely suppressed in cancers but have not been traditionally associated with differentiation. In this study, we found that the silencing of protein phosphatase 2A (PP2A) directly blocks differentiation in acute myeloid leukemia (AML). Gene expression and mass cytometric profiling revealed that PP2A activation modulates cell cycle and transcriptional regulators that program terminal myeloid differentiation. Using a novel pharmacological agent, OSU-2S, in parallel with genetic approaches, we discovered that PP2A enforced c-Myc and p21 dependent terminal differentiation, proliferation arrest, and apoptosis in AML. Finally, we demonstrated that PP2A activation decreased leukemia-initiating stem cells, increased leukemic blast maturation, and improved overall survival in murine Tet2-/-Flt3ITD/WT and human cell-line derived xenograft AML models in vivo. Our findings identify the PP2A/c-Myc/p21 axis as a critical regulator of the differentiation/proliferation switch in AML that can be therapeutically targeted in malignancies with dysregulated maturation fate.
MeSH term(s)	Animals ; Cell Line, Tumor ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Humans ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/metabolism ; Mice ; Mice, Knockout ; Protein Phosphatase 2/genetics ; Protein Phosphatase 2/metabolism ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism
Chemical Substances	CDKN1A protein, human ; Cdkn1a protein, mouse ; Cyclin-Dependent Kinase Inhibitor p21 ; MYC protein, human ; Myc protein, mouse ; Proto-Oncogene Proteins c-myc ; Protein Phosphatase 2 (EC 3.1.3.16)
Language	English
Publishing date	2021-11-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2020010344
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Article ; Online: Improved equations estimating GFR in children with chronic kidney disease using an immunonephelometric determination of cystatin C.

Schwartz, George J / Schneider, Michael F / Maier, Paula S / Moxey-Mims, Marva / Dharnidharka, Vikas R / Warady, Bradley A / Furth, Susan L / Muñoz, Alvaro

Kidney international

2012 Volume 82, Issue 4, Page(s) 445–453

Abstract: ... equations utilizing serum creatinine, blood urea nitrogen, height, gender, and cystatin C measured ... by an immunoturbidimetric method; however, the correlation coefficient of cystatin C and GFR(0.69) was less robust ... of immunonephelometric cystatin C was as well correlated with iGFR as was height/serum creatinine (both 0.88 ...

Abstract	The Chronic Kidney Disease in Children study is a cohort of about 600 children with chronic kidney disease (CKD) in the United States and Canada. The independent variable for our observations was a measurement of glomerular filtration rate(GFR) by iohexol disappearance (iGFR) at the first two visits 1 year apart and during alternate years thereafter. In a previous report, we had developed GFR estimating equations utilizing serum creatinine, blood urea nitrogen, height, gender, and cystatin C measured by an immunoturbidimetric method; however, the correlation coefficient of cystatin C and GFR(0.69) was less robust than expected. Therefore, 495 samples were re-assayed using immunonephelometry. The reciprocal of immunonephelometric cystatin C was as well correlated with iGFR as was height/serum creatinine (both 0.88). We developed a new GFR estimating equation using a random 2/3 of 965 person-visits and applied it to the remaining 1/3 as a validation data set. In the validation dataset, the correlation of the estimated GFR with iGFR was 0.92 with high precision and no bias; 91 and 45% of eGFR values were within 30 and 10% of iGFR, respectively. This equation works well in children with CKD in a range of GFR from 15 to 75 ml/min per 1.73 m2. Further studies are needed to establish the applicability to children of normal stature and muscle mass, and higher GFR.
MeSH term(s)	Adolescent ; Biomarkers/blood ; Blood Urea Nitrogen ; Body Height ; Canada ; Child ; Child, Preschool ; Cohort Studies ; Contrast Media ; Creatinine/blood ; Cystatin C/blood ; Female ; Glomerular Filtration Rate ; Humans ; Immunoassay ; Infant ; Iohexol ; Kidney/metabolism ; Kidney/physiopathology ; Linear Models ; Male ; Models, Biological ; Multivariate Analysis ; Nephelometry and Turbidimetry ; Predictive Value of Tests ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/physiopathology ; Reproducibility of Results ; Time Factors ; United States
Chemical Substances	Biomarkers ; CST3 protein, human ; Contrast Media ; Cystatin C ; Iohexol (4419T9MX03) ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2012-05-23
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Validation Study
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1038/ki.2012.169
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Article ; Online: Is venetoclax the new backbone of acute myeloid leukaemia therapy?

Jain, Prachi / Mims, Alice S

The Lancet. Haematology

2021 Volume 8, Issue 8, Page(s) e536–e537

MeSH term(s)	Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bridged Bicyclo Compounds, Heterocyclic/therapeutic use ; Humans ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/drug therapy ; Neoplasm, Residual/diagnosis ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors ; Sulfonamides/therapeutic use ; Treatment Outcome
Chemical Substances	Antineoplastic Agents ; Bridged Bicyclo Compounds, Heterocyclic ; Proto-Oncogene Proteins c-bcl-2 ; Sulfonamides ; venetoclax (N54AIC43PW)
Language	English
Publishing date	2021-07-30
Publishing country	England
Document type	Journal Article
ISSN	2352-3026
ISSN (online)	2352-3026
DOI	10.1016/S2352-3026(21)00205-2
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Article ; Online: "The Awesomeness and the Vastness of Who You Really Are:" A Culturally Distinct Framework for Understanding the Link Between Spirituality and Health for Black Sexual Minority Men.

Lassiter, Jonathan Mathias / Mims, Ivie

Journal of religion and health

2021 Volume 61, Issue 4, Page(s) 3076–3097

Abstract: ... and physical health. These themes were: (a) suboptimal worldview, (b) emotional revelation, (c ...

Abstract	Despite health inequities, many Black sexual minority men are resilient and often utilize spirituality as a culturally distinct self-protective and self-enhancing resource to maintain their health. However, little is known about how spirituality impacts health within a cultural framework that is specific to Black sexual minority men. We conducted 10 individual in-depth interviews, reaching code saturation, with Black sexual minority men across the USA. Our study was guided by grounded theory and a Black psychology theoretical framework. Seven themes were discovered and revealed that participants' level of spiritual consciousness influenced their engagement in psychological and behavioral processes that were related to mental and physical health. These themes were: (a) suboptimal worldview, (b) emotional revelation, (c) emotional emancipation, (d) emotional regulation, (e) health motivations, (f) health behaviors, and (g) links between spiritual consciousness, mental health, and physical health. Implications of these findings for clinicians and researchers are discussed.
MeSH term(s)	Emotions ; Homosexuality, Male/psychology ; Humans ; Male ; Mental Health ; Sexual and Gender Minorities ; Spirituality
Language	English
Publishing date	2021-06-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2017250-3
ISSN	1573-6571 ; 0022-4197
ISSN (online)	1573-6571
ISSN	0022-4197
DOI	10.1007/s10943-021-01297-4
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Article ; Online: An Unusual Kidney Lesion Presenting with Facial Edema, Hematuria, and AKI.

Bond, Tanner / Mims, Andrew / Davis, Cameron

Kidney360

2022 Volume 3, Issue 6, Page(s) 1118–1119

MeSH term(s)	Acute Kidney Injury/diagnosis ; Edema/diagnosis ; Glomerulonephritis ; Hematuria/diagnosis ; Humans ; Kidney Glomerulus
Language	English
Publishing date	2022-04-27
Publishing country	United States
Document type	Journal Article
ISSN	2641-7650
ISSN (online)	2641-7650
DOI	10.34067/KID.0000782022
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Article ; Online: Intrathecal bupivacaine versus chloroprocaine for transvaginal cervical cerclage placement: a retrospective cohort study.

Mims, S C / Zanolli, N C / Fuller, M / Habib, A S

International journal of obstetric anesthesia

2022 Volume 50, Page(s) 103276

Abstract: Background: Bupivacaine is commonly used in spinal anesthesia for cervical cerclage placement, but its long duration of action can delay hospital discharge. Chloroprocaine has a short duration of action and has re-emerged as an agent for ambulatory ... ...

Abstract	Background: Bupivacaine is commonly used in spinal anesthesia for cervical cerclage placement, but its long duration of action can delay hospital discharge. Chloroprocaine has a short duration of action and has re-emerged as an agent for ambulatory neuraxial anesthesia. There are limited data comparing intrathecal bupivacaine and chloroprocaine when used for cerclage placement. This retrospective study compares the time to hospital discharge between these drugs when used in spinal anesthesia for cervical cerclage placement. Methods: A retrospective analysis of patients who underwent transvaginal cerclage placement under neuraxial anesthesia with intrathecal hyperbaric bupivacaine or plain chloroprocaine between January 1, 2015 and October 31, 2020. The primary outcome was the time to hospital discharge. Secondary outcomes included the incidence of inadequate anesthesia, postoperative pain scores and postoperative neurologic symptoms. Results: Three hundred and sixty patients were included in the final analysis (bupivacaine n=236, chloroprocaine n=124). The median (IQR) intrathecal dose was 7.5 (7.5, 9) mg and 45 (45, 50) mg in the bupivacaine and chloroprocaine groups respectively. The time (median [IQR]) from spinal anesthesia to hospital discharge was significantly shorter in the chloroprocaine group compared with the bupivacaine group (218 [180, 253] vs. 370 [309, 424] min, P<0.001). There were no significant differences between the groups for secondary outcomes and neither group had a patient report neurologic symptoms. Conclusion: When utilized in spinal anesthesia for transvaginal cervical cerclage placement, chloroprocaine may reduce the time to discharge while providing comparable anesthesia to that provided by bupivacaine.
MeSH term(s)	Anesthesia, Spinal ; Anesthetics, Local ; Bupivacaine ; Cerclage, Cervical ; Double-Blind Method ; Female ; Humans ; Pregnancy ; Procaine/analogs & derivatives ; Retrospective Studies
Chemical Substances	Anesthetics, Local ; Procaine (4Z8Y51M438) ; chloroprocaine (5YVB0POT2H) ; Bupivacaine (Y8335394RO)
Language	English
Publishing date	2022-03-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1086024-1
ISSN	1532-3374 ; 0959-289X
ISSN (online)	1532-3374
ISSN	0959-289X
DOI	10.1016/j.ijoa.2022.103276
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Article ; Online: The effect of cannabinoids on wound healing: A review.

Parikh, Aniruddha C / Jeffery, Christopher S / Sandhu, Zainab / Brownlee, Benjamin P / Queimado, Lurdes / Mims, Mark M

Health science reports

2024 Volume 7, Issue 2, Page(s) e1908

Abstract: Background and aims: Cannabis and its various derivatives are commonly used for both recreational and medicinal purposes. Cannabinoids have been shown to have anti-inflammatory properties. Inflammation is an important component of wound healing and the ... ...

Abstract	Background and aims: Cannabis and its various derivatives are commonly used for both recreational and medicinal purposes. Cannabinoids have been shown to have anti-inflammatory properties. Inflammation is an important component of wound healing and the effect of cannabinoids on wound healing has become a recent topic of investigation. The objective of this article is to perform a comprehensive review of the literature to summarize the effects of cannabinoids on wound healing of the skin and to guide future avenues of research. Methods: A comprehensive literature review was performed to evaluate the effects of cannabinoids on cutaneous wound healing. Results: Cannabinoids appear to improve skin wound healing through a variety of mechanisms. This is supported through a variety of in vitro and animal studies. Animal studies suggest application of cannabinoids may improve the healing of postsurgical and chronic wounds. There are few human studies which evaluate the effects of cannabinoids on wound healing and many of these are case series and observational studies. They do suggest cannabinoids may have some benefit. However, definitive conclusions cannot be drawn from them. Conclusion: While further human studies are needed, topical application of cannabinoids may be a potential therapeutic option for postsurgical and chronic wounds.
Language	English
Publishing date	2024-02-25
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2398-8835
ISSN (online)	2398-8835
DOI	10.1002/hsr2.1908
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Article: Primary Care Clinic Approaches to Facilitating Patient Health Behavior Change in Alabama.

Distler, Kyle R / Lindsey, Marla Jo / Mims, Mary Hinson / Taylor, Mary Ann / Hollingsworth, Joshua C

Cureus

2024 Volume 16, Issue 3, Page(s) e55973

Abstract: Background Non-communicable chronic diseases (NCCDs), such as cardiovascular disease, diabetes, and cancer, are the leading cause of death and disability and the leading driver of healthcare costs in the U.S. It is estimated that 80% of chronic diseases ...

Abstract	Background Non-communicable chronic diseases (NCCDs), such as cardiovascular disease, diabetes, and cancer, are the leading cause of death and disability and the leading driver of healthcare costs in the U.S. It is estimated that 80% of chronic diseases and premature deaths are attributable to modifiable lifestyle factors related to smoking and alcohol intake, poor eating patterns, and physical inactivity. Inadequate sleep also plays a significant role. Among other directives, primary care providers (PCPs) have the opportunity to contribute to preventing and treating NCCD in their patients. Comprehensive, evidence-based behavioral counseling interventions are recommended to PCPs as a first-line approach to improving outcomes. However, presumably due to a lack of PCP time, training or resources, most patients report not receiving such services. Currently, the extent to which PCPs in Alabama offer or refer patients to health behavior change (HBC) services is unknown. Objectives This study aims to assess the following: (1) Alabama PCPs' current approaches in facilitating patient HBC in the domains of eating patterns, physical activity, sleep, and stress and (2) the likelihood of the Alabama PCPs referring patients to virtual HBC programs, once developed by an osteopathic medical school in the state. Methods Data were collected from clinic personnel who were knowledgeable regarding the clinic's approach to facilitating patient HBC via scripted telephone interviews and online surveys sent via email. The clinic list utilized for the study was derived from a list of VCOM-Auburn clinical preceptors. Primary care and specialty clinics were included. Data were analyzed descriptively to determine the number of clinics that (1) provide, recommend, or refer programs, services, or resources to patients to facilitate HBC related to eating patterns, physical activity, sleep, and stress management and (2) are likely to refer patients to free virtual HBC programs, once developed by an osteopathic medical school in the state. Results Of the 198 clinics that were contacted, 75 were excluded, 46 were "no response," 53 agreed to participate, and 50 completed the survey. Of the 50 clinics that completed the survey, 33 indicated offering resources or referrals for diet, 29 stated they offered resources or referral services for physical activity, 33 indicated offering resources or referrals for sleep, and 28 indicated offering or recommending resources for stress management to patients. Most of the clinics (29/50) felt that their patients would benefit most from a program that facilitates improvement in eating patterns, and 41/50 clinics said that they are either "somewhat" or "extremely" likely to refer patients to a free VCOM-Auburn HBC program, once available. Conclusions Findings indicate that a significant percentage of PCP clinics are not offering HBC resources to patients and that most PCP clinics would consider referring patients to free VCOM-Auburn HBC programs, once available. Phone data were significantly different from email data. The primary limitations were a low response rate and potential response bias.
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.55973
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Article ; Online: A challenging case of granulomatosis with polyangiitis with cardiac involvement: a rare case report.

Shelton, Anthony / Parikh, Suparshva / Mims, Catherine / Quintero-Del-Rio, Ana

AME case reports

2022 Volume 7, Page(s) 8

Abstract: ... negative for the cytoplasmic subset antineutrophil cytoplasmic autoantibody (c-ANCA), but positive ... the ultimate diagnosis as this is typically c-ANCA positive.: Conclusions: Other systemic vasculitides ...

Abstract	Background: Granulomatosis with polyangiitis (GPA), a systemic antineutrophil cytoplasmic antibody (ANCA) associated vasculitis, is characterized by inflammation of the small arteries, arterioles, and capillaries classically manifesting with glomerulonephritis and necrotizing granulomatous lesions of the upper and lower respiratory tract. With an incidence of approximately 12 cases per one million individuals per year it is an uncommon diagnosis that typically presents as frequent pulmonary and sinus infections; however, if left without definitive treatment progresses to more severe manifestations specifically hemoptysis and hematuria. Case description: This case report highlights a 15-year-old woman who had both classic and non-classic findings making the diagnosis challenging. Specifically, her age of presentation, improvement with anti-microbials, and coronary dilation were not classic. Additionally, her lab work was negative for the cytoplasmic subset antineutrophil cytoplasmic autoantibody (c-ANCA), but positive for serum anti-proteinase 3 antineutrophil cytoplasmic antibody (PR3-ANCA) which further delayed the ultimate diagnosis as this is typically c-ANCA positive. Conclusions: Other systemic vasculitides, such as mucocutaneous lymph node disease, are associated with cardiac pathology necessitating further medical management and follow-up to prevent increased morbidity and mortality. Knowing this, we conclude that further evaluation for cardiac pathology would be prudent as part of the initial workup of patients with a diagnosis of GPA. Included is a brief review of available literature on GPA to emphasize the typical presentation, lab findings, and importance of early diagnosis.
Language	English
Publishing date	2022-11-21
Publishing country	China
Document type	Case Reports
ISSN	2523-1995
ISSN (online)	2523-1995
DOI	10.21037/acr-22-29
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Article ; Conference proceedings: Strabology report of the 30th Annual Meeting of the American Association for Pediatric Ophthalmology and Strabismus. The Grand Hyatt, Washington, D.C. March 27-31, 2004.

Mims, James L

Binocular vision & strabismus quarterly

2004 Volume 19, Issue 2, Page(s) 98–105

MeSH term(s)	Child ; Child, Preschool ; Humans ; Infant ; Ophthalmology ; Strabismus
Language	English
Publishing date	2004
Publishing country	United States
Document type	Congresses
ZDB-ID	1477386-7
ISSN	1088-6281
ISSN	1088-6281
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