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  1. Article ; Online: Entrapment of the Impella device by the guiding catheter: a cautionary pitfall of Impella-protected percutaneous coronary intervention.

    Yamamoto, Hiroyuki / Watanabe, Nobuhiro / Matsuo, Koki / Takaya, Tomofumi

    European heart journal. Case reports

    2024  Volume 8, Issue 3, Page(s) ytae096

    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytae096
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  2. Article ; Online: Proximal migration of in-stent neoatherosclerosis debris following cutting balloon angioplasty leading to catastrophic no-flow phenomenon.

    Watanabe, Nobuhiro / Yamamoto, Hiroyuki / Takaya, Tomofumi

    Coronary artery disease

    2024  Volume 35, Issue 2, Page(s) 162–163

    MeSH term(s) Humans ; Angioplasty, Balloon, Coronary/adverse effects ; Angioplasty, Balloon/adverse effects ; Stents ; Treatment Outcome
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1047268-x
    ISSN 1473-5830 ; 0954-6928
    ISSN (online) 1473-5830
    ISSN 0954-6928
    DOI 10.1097/MCA.0000000000001310
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3039: Show issues Location:
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  3. Article ; Online: Carotid Web and High-Risk Patent Foramen Ovale With Cryptogenic Stroke.

    Takafuji, Hiroya / Obunai, Kotaro / Makihara, Yu / Kato, Nahoko / Watanabe, Hiroyuki

    JACC. Cardiovascular interventions

    2024  

    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2024.01.312
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    Zs.A 6669: Show issues Location:
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  4. Article ; Online: Fundamental evaluation regarding the relationship between albumin-binding and tumor accumulation of PSMA-targeting radioligands.

    Kazuta, Nobuki / Tsuchihashi, Shohei / Watanabe, Hiroyuki / Ono, Masahiro

    Annals of nuclear medicine

    2024  

    Abstract: Objective: The marked success of prostate-specific membrane antigen (PSMA)-targeting radioligands with albumin binder (ALB) is attributed to the improvement of blood retention and tumor accumulation. [: Method: The [: Results: The [: Conclusions! ...

    Abstract Objective: The marked success of prostate-specific membrane antigen (PSMA)-targeting radioligands with albumin binder (ALB) is attributed to the improvement of blood retention and tumor accumulation. [
    Method: The [
    Results: The [
    Conclusions: These results indicate that the moderate reversible binding of ALB with albumin, not covalent binding, may play a critical role in enhancing the tumor accumulation of PSMA-targeting radioligands.
    Language English
    Publishing date 2024-04-27
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1146984-5
    ISSN 1864-6433 ; 0914-7187
    ISSN (online) 1864-6433
    ISSN 0914-7187
    DOI 10.1007/s12149-024-01930-8
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    Zs.A 3657: Show issues Location:
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  5. Article ; Online: Synthesis and biological evaluation of novel

    Saito, Haruka / Watanabe, Hiroyuki / Ono, Masahiro

    Bioorganic & medicinal chemistry letters

    2024  Volume 99, Page(s) 129625

    Abstract: The ghrelin receptor (GHSR) is known to regulate various physiological processes including appetite, food intake, and growth hormone release. Its expression is mainly observed in the brain, pancreas, stomach, and intestine. However, the functions of the ... ...

    Abstract The ghrelin receptor (GHSR) is known to regulate various physiological processes including appetite, food intake, and growth hormone release. Its expression is mainly observed in the brain, pancreas, stomach, and intestine. However, the functions of the receptor have not been fully elucidated. GHSR imaging with positron emission tomography (PET) is expected to further understanding of the functions and pathologies of the receptor. In this study, we newly designed and synthesized diaminopyrimidine derivatives ([
    MeSH term(s) Animals ; Mice ; Brain/diagnostic imaging ; Brain/metabolism ; Positron-Emission Tomography/methods ; Pyrimidines ; Receptors, Ghrelin/metabolism ; Tissue Distribution ; Fluorine Radioisotopes/chemistry
    Chemical Substances 2,4-diaminopyrimidine (156-81-0) ; Pyrimidines ; Receptors, Ghrelin ; Fluorine Radioisotopes
    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2024.129625
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    Zs.A 3203: Show issues Location:
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  6. Article ; Online: Is non-synesthetes' B Blue? Grapheme-color association improves non-synesthetes' detection in visual search.

    Sasaki, Hiroyuki / Watanabe, Nana

    Consciousness and cognition

    2023  Volume 118, Page(s) 103632

    Abstract: Grapheme-color synesthesia is expected to provide a clue to solving the "binding problem" of visual features. Synesthetic research uses non-synesthetes as a control group and shows that synesthetes perform better with synesthetic color congruency, while ... ...

    Abstract Grapheme-color synesthesia is expected to provide a clue to solving the "binding problem" of visual features. Synesthetic research uses non-synesthetes as a control group and shows that synesthetes perform better with synesthetic color congruency, while non-synesthetes' performances do not. However, non-synesthetes also have certain grapheme-color associations. Therefore, this study examined whether non-synesthetes' grapheme-color associations improve their performance in a visual search task. The results indicated that non-synesthetes were significantly faster at detecting congruent targets with their grapheme-color associations, such as red for "A," blue for "B," and yellow for "C." However, the effect was not found in relation to numerical characters. This study has implications for future neuroscience and consciousness research regarding grapheme-color synesthesia.
    MeSH term(s) Humans ; Synesthesia ; Perceptual Disorders ; Photic Stimulation/methods ; Color Perception ; Pattern Recognition, Visual
    Language English
    Publishing date 2023-12-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1106647-7
    ISSN 1090-2376 ; 1053-8100
    ISSN (online) 1090-2376
    ISSN 1053-8100
    DOI 10.1016/j.concog.2023.103632
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    Zs.A 3692: Show issues Location:
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  7. Article: Telemental health in rural areas: a systematic review.

    Watanabe, Jun / Teraura, Hiroyuki / Nakamura, Akihisa / Kotani, Kazuhiko

    Journal of rural medicine : JRM

    2023  Volume 18, Issue 2, Page(s) 50–54

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2023-04-05
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2768933-5
    ISSN 1880-4888 ; 1880-487X
    ISSN (online) 1880-4888
    ISSN 1880-487X
    DOI 10.2185/jrm.2022-059
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  8. Article ; Online: Synthesis and evaluation of novel trifunctional chelating agents for pretargeting approach using albumin binder to improve tumor accumulation.

    Tsuchihashi, Shohei / Nakashima, Kazuma / Watanabe, Hiroyuki / Ono, Masahiro

    Nuclear medicine and biology

    2024  Volume 132-133, Page(s) 108911

    Abstract: Introduction: The pretargeting approach consists of in vivo ligation between pre-injected antibodies and low-molecular-weight radiolabeled effectors. The advantage of the pretargeting approach is to improve a tumor-to-background ratio, but the ... ...

    Abstract Introduction: The pretargeting approach consists of in vivo ligation between pre-injected antibodies and low-molecular-weight radiolabeled effectors. The advantage of the pretargeting approach is to improve a tumor-to-background ratio, but the disadvantage is to compromise tumor accumulation. In this study, we applied albumin binder (ALB) to the pretargeting approach to overcome low tumor accumulation.
    Methods: We synthesized two novel trifunctional effectors containing an ALB moiety, a chelator, and a different tetrazine and two corresponding effectors without an ALB moiety. Albumin-binding assays and stability assays were performed using
    Results: In albumin-binding assays, ALB-containing effectors exhibited a marked binding to albumin. Two ALB-containing effectors showed the difference in the reactivity and the slight difference in the stability. In biodistribution studies without the pretargeting approach, two ALB-containing effectors showed different pharmacokinetics in blood retention. With the pretargeting approach, the tumor accumulation was improved by the introduction of ALB and the highest tumor accumulation was observed in using the ALB-containing effector with higher blood retention.
    Conclusion: These results suggest that the application of ALB to the pretargeting approach is effective to improve tumor accumulation, and the structure of tetrazine influences the utility of ALB-containing effectors.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1138098-6
    ISSN 1872-9614 ; 0883-2897 ; 0969-8051
    ISSN (online) 1872-9614
    ISSN 0883-2897 ; 0969-8051
    DOI 10.1016/j.nucmedbio.2024.108911
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    Zs.A 1090: Show issues Location:
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  9. Article ; Online: [Evaluation of Solubility and Membrane Permeability of Middle-Molecule Compounds Using Artificial Membranes and Living Cells].

    Kanamitsu, Kayoko / Ishii, Mayumi / Watanabe, Eri / Miyachi, Hiroyuki

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2024  Volume 144, Issue 5, Page(s) 529–537

    Abstract: In contrast to small molecules, middle molecules present a promising therapeutic modality owing to their elevated specificity, minimal adverse effects, capacity to target protein-protein interactions, and, unlike antibody-based drugs, their suitability ... ...

    Abstract In contrast to small molecules, middle molecules present a promising therapeutic modality owing to their elevated specificity, minimal adverse effects, capacity to target protein-protein interactions, and, unlike antibody-based drugs, their suitability for oral administration and intracellular target engagement. Post-oral administration, the paramount considerations encompass solubility and membrane permeability during the initial phase until the drug attains systemic circulation. Furthermore, penetration of the cell membrane is essential to accessing intracellular targets. We evaluated the solubility and membrane permeability of 965 compounds sourced from middle molecule libraries affiliated with Hokkaido University, Kitasato University, and the University of Tokyo. To gauge membrane permeability, we employed both the parallel artificial membrane permeability assay (PAMPA) and Caco-2 cell monolayers. Notably, while membrane permeability in Caco-2 cells exhibited an approximate threefold increase in comparison to PAMPA measurements, certain compounds demonstrated permeability levels less than one-third of those observed in Caco-2 cells. Recognizing the potential involvement of efflux transporters expressed in Caco-2 cells in these variations, we conducted additional assessments involving directional transport in the presence of a transporter inhibitor. Our findings suggest that nearly 80% of these compounds serve as substrates for efflux transporters. Considering the relevance of intracellular targets, we shifted our focus from membrane permeation to intracellular uptake, conducting simulations tailored to assess cellular uptake.
    MeSH term(s) Humans ; Caco-2 Cells ; Solubility ; Cell Membrane Permeability ; Membranes, Artificial ; Administration, Oral ; Cell Membrane/metabolism
    Chemical Substances Membranes, Artificial
    Language Japanese
    Publishing date 2024-05-02
    Publishing country Japan
    Document type Journal Article ; Review ; English Abstract
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.23-00191-1
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    Zs.A 643: Show issues Location:
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  10. Article ; Online: Microsatellite instability: A 2024 update.

    Yamamoto, Hiroyuki / Watanabe, Yoshiyuki / Arai, Hiroyuki / Umemoto, Kumiko / Tateishi, Keisuke / Sunakawa, Yu

    Cancer science

    2024  

    Abstract: Deficient mismatch repair (dMMR) results in microsatellite instability (MSI), a pronounced mutator phenotype. High-frequency MSI (MSI-H)/dMMR is gaining increasing interest as a biomarker for advanced cancer patients to determine their eligibility for ... ...

    Abstract Deficient mismatch repair (dMMR) results in microsatellite instability (MSI), a pronounced mutator phenotype. High-frequency MSI (MSI-H)/dMMR is gaining increasing interest as a biomarker for advanced cancer patients to determine their eligibility for immune checkpoint inhibitors (ICIs). Various methods based on next-generation sequencing (NGS) have been developed to assess the MSI status. Comprehensive genomic profiling (CGP) testing can precisely ascertain the MSI status as well as genomic alterations in a single NGS test. The MSI status can be also ascertained through the liquid biopsy-based CGP assays. MSI-H has thus been identified in various classes of tumors, resulting in a greater adoption of immunotherapy, which is hypothesized to be effective against malignancies that possess a substantial number of mutations and/or neoantigens. NGS-based studies have also characterized MSI-driven carcinogenesis, including significant rates of fusion kinases in colorectal cancers (CRCs) with MSI-H that are targets for therapeutic kinase inhibitors, particularly in MLH1-methylated CRCs with wild-type KRAS/BRAF. NTRK fusion is linked to the colorectal serrated neoplasia pathway. Recent advances in investigations of MSI-H malignancies have resulted in the development of novel diagnostic or therapeutic techniques, such as a synthetic lethal therapy that targets the Werner gene. DNA sensing in cancer cells is required for antitumor immunity induced by dMMR, opening up novel avenues and biomarkers for immunotherapy. Therefore, clinical relevance exists for analyses of MSI and MSI-H-associated genomic alterations in malignancy. In this article, we provide an update on MSI-driven carcinogenesis, with an emphasis on unique landscapes of diagnostic and immunotherapeutic strategies.
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2115647-5
    ISSN 1349-7006 ; 1349-7006
    ISSN (online) 1349-7006
    ISSN 1349-7006
    DOI 10.1111/cas.16160
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