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Article ; Online: In the "Plant-Based" Era, Patients With Chronic Kidney Disease Should Focus on Eating Healthy.

Freeman, Natasha S / Turner, Jeffrey M

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation

2023 Volume 34, Issue 1, Page(s) 4–10

Abstract: In the era of plant-based diets, it is important for Nephrology providers to know the evidence regarding their healthfulness in patients with chronic kidney disease (CKD). A whole food, plant-based diet, which emphasizes fresh, minimally processed or ... ...

Abstract	In the era of plant-based diets, it is important for Nephrology providers to know the evidence regarding their healthfulness in patients with chronic kidney disease (CKD). A whole food, plant-based diet, which emphasizes fresh, minimally processed or refined plant-based foods and limits animal products, has shown benefits for patients with CKD. These include reduced dietary acid load, lower bioavailability of potassium and phosphorus, increased dietary fiber intake, nutritional adequacy, and cardiovascular and mortality benefits. Potential drawbacks include the need for specific knowledge, skills, and cost involved in preparing varied, healthy, and appetizing plant-based meals, leading to lower acceptability and accessibility to certain populations. Liberalization of the standard CKD diet to include healthy, minimally processed foods such as fruits, vegetables, nuts, legumes, and whole grains is likely beneficial, though more research is needed to determine whether a plant-based-only diet is the optimal way to achieve healthier eating in patients with CKD.
MeSH term(s)	Animals ; Humans ; Diet ; Vegetables ; Renal Insufficiency, Chronic ; Fruit ; Fabaceae
Language	English
Publishing date	2023-08-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1080003-7
ISSN	1532-8503 ; 1051-2276
ISSN (online)	1532-8503
ISSN	1051-2276
DOI	10.1053/j.jrn.2023.08.010
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Article ; Online: Reexamining predictors of trial outcomes in New York State's sex offender civil management process.

Kemper, Nathan S / Reilly, Marie L / Freeman, Naomi J / Sandler, Jeffrey C

Law and human behavior

2024 Volume 48, Issue 1, Page(s) 67–82

Abstract: Objective: In 2007, New York enacted the Sex Offender Management and Treatment Act, empowering the state to civilly manage individuals who have committed sexual offenses (respondents) and are deemed to have a mental abnormality (MA) that predisposes ... ...

Abstract	Objective: In 2007, New York enacted the Sex Offender Management and Treatment Act, empowering the state to civilly manage individuals who have committed sexual offenses (respondents) and are deemed to have a mental abnormality (MA) that predisposes them to sexually recidivate after serving their criminal sentences. We sought to replicate and extend a previous study (Lu et al., 2015) to identify factors predicting legal decisions. Hypotheses: We predicted, on the basis of previous research, that clinical information (e.g., diagnosis) as well as empirically supported risk factors (e.g., sexual deviance) would predict trial outcomes. Method: We analyzed multiple pieces of demographic, criminogenic, and clinical data on three nested subsamples of respondents on the basis of the legal process: MA consent ( Results: The strongest predictor of waiving the trial was geographic location; respondents outside New York City and Long Island were more likely to waive their trials ( Conclusions: Judges and juries give significant weight to clinical information, particularly pedophilia diagnoses, when making civil management legal decisions. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
MeSH term(s)	Humans ; Criminals ; Sexual Behavior ; Sex Offenses ; Paraphilic Disorders/diagnosis ; New York City
Language	English
Publishing date	2024-01-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2017882-7
ISSN	1573-661X ; 0147-7307
ISSN (online)	1573-661X
ISSN	0147-7307
DOI	10.1037/lhb0000550
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Article ; Online: You may delay, but time will not. Beta cells lost are never found again: a case for timely initiation of basal insulin in type 2 diabetes.

Renda, Susan / Freeman, Jeffrey

Postgraduate medicine

2024 Volume 136, Issue 2, Page(s) 150–161

Abstract: Since its first use just over a century ago, insulin treatment has evolved dramatically, such that the molecules are physiologic in nature, and treatment can now closely resemble the natural hormone response over 24 hours. Newer, longer-acting basal ... ...

Abstract	Since its first use just over a century ago, insulin treatment has evolved dramatically, such that the molecules are physiologic in nature, and treatment can now closely resemble the natural hormone response over 24 hours. Newer, longer-acting basal insulin analogs have provided insulin therapies with improved characteristics and, therefore, ease of use, and can readily be incorporated as part of routine treatment for type 2 diabetes (T2D), but evidence suggests that insulin remains underused in people with T2D. We review the barriers to initiation of basal insulin and the education needed to address these barriers, and we provide practical pointers, supported by evidence, for primary care physicians and advanced practice providers to facilitate timely initiation of basal insulin in the people with T2D who will benefit from such treatment.
MeSH term(s)	Diabetes Mellitus, Type 2/drug therapy ; Humans ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/administration & dosage ; Insulin-Secreting Cells/drug effects ; Insulin/therapeutic use ; Insulin/administration & dosage ; Insulin, Long-Acting/therapeutic use ; Insulin, Long-Acting/administration & dosage
Chemical Substances	Hypoglycemic Agents ; Insulin ; Insulin, Long-Acting
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	410138-8
ISSN	1941-9260 ; 0032-5481
ISSN (online)	1941-9260
ISSN	0032-5481
DOI	10.1080/00325481.2024.2328511
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Article ; Online: Risk factors for traumatic bonding and associations with PTSD symptoms: A moderated mediation.

Shaughnessy, Emma V / Simons, Raluca M / Simons, Jeffrey S / Freeman, Harry

Child abuse & neglect

2023 Volume 144, Page(s) 106390

Abstract: Background: Traumatic bonding, defined as attachment to a perpetrator of intimate partner violence (IPV), offers one explanation as to why many people with abusive romantic partners do not break off these relationships. But what individual-level risk ... ...

Abstract	Background: Traumatic bonding, defined as attachment to a perpetrator of intimate partner violence (IPV), offers one explanation as to why many people with abusive romantic partners do not break off these relationships. But what individual-level risk factors make some victims of IPV more likely than others to develop traumatic bonding toward their partners? What is the nature of the potential association between traumatic bonding and PTSD symptoms? Participants: A path model tested the potential roles of childhood maltreatment and attachment insecurity as risk factors for traumatic bonding, as well as the potential association between traumatic bonding and PTSD symptoms, in a high-risk sample of 354 participants in current abusive relationships. Results: As hypothesized, childhood maltreatment and attachment insecurity significantly predicted traumatic bonding over and above the effects of age, gender, and romantic love. In addition, attachment insecurity moderated the association between childhood maltreatment and traumatic bonding, such that at higher levels of attachment insecurity, the association between childhood maltreatment and traumatic bonding was stronger than at mean or lower levels of attachment insecurity. Traumatic bonding was positively associated with PTSD symptoms. Conclusions: Overall, the results support the role of childhood maltreatment as a risk factor for both traumatic bonding and PTSD symptoms and highlight the importance of attachment insecurity in these associations. This was the first study to examine a complex model of risk factors for traumatic bonding. Theoretical and clinical implications are discussed.
MeSH term(s)	Humans ; Stress Disorders, Post-Traumatic/etiology ; Intimate Partner Violence ; Risk Factors
Language	English
Publishing date	2023-08-10
Publishing country	England
Document type	Journal Article
ZDB-ID	799143-5
ISSN	1873-7757 ; 0145-2134
ISSN (online)	1873-7757
ISSN	0145-2134
DOI	10.1016/j.chiabu.2023.106390
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Article: Initial combination therapy for patients with type 2 diabetes mellitus: considerations for metformin plus linagliptin.

Freeman, Jeffrey S

Drugs in context

2013 Volume 2013, Page(s) 212256

Abstract: For patients with type 2 diabetes mellitus, management of hyperglycemia is typically complex, and few patients successfully achieve and maintain recommended targets for glycated hemoglobin (HbA1c). Increasingly, combination therapy is recommended early ... ...

Abstract	For patients with type 2 diabetes mellitus, management of hyperglycemia is typically complex, and few patients successfully achieve and maintain recommended targets for glycated hemoglobin (HbA1c). Increasingly, combination therapy is recommended early in the disease course, or even directly at diagnosis in patients with relatively high HbA1c levels. A recent randomized, placebo-controlled, Phase III trial investigated the initial combination of linagliptin and metformin in patients with inadequate glycemic control to assess the benefits of initial combination compared with monotherapy. Linagliptin and metformin act in complementary ways, and the combination treatment showed superior efficacy compared with either monotherapy. Notably, responses were largest in patients with higher baseline HbA1c levels compared with moderate levels, suggesting this combination could be considered in these patients. This may be particularly relevant for those unwilling to start insulin because they prefer oral therapy or need to avoid body weight gain. Neither metformin nor linagliptin is associated with weight gain, and in this trial the combination was also weight neutral. As this combination therapy was well tolerated, with a low frequency of hypoglycemia, these findings suggest that initial combination of linagliptin plus metformin may have advantages for a large proportion of patients in clinical practice.
Language	English
Publishing date	2013-08-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2719560-0
ISSN	1740-4398 ; 1745-1981
ISSN (online)	1740-4398
ISSN	1745-1981
DOI	10.7573/dic.212256
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Article ; Online: Frontline therapy with bendamustine rituximab (BR) and rituximab cyclophosphamide vincristine prednisone (RCVP) confers similar long-term outcomes in patients with treatment naïve Waldenström macroglobulinemia in a real-world setting: a population-based analysis.

Kim, Jowon Laura / Gerrie, Alina S / Savage, Kerry Joane / Villa, Diego / Scott, David / Craig, Jeffrey W / Farinha, Pedro / Skinnider, Brian / Slack, Graham / Connors, Joseph M / Sehn, Laurie H / Venner, Christopher / Freeman, Ciara L

Leukemia & lymphoma

2023 Volume 65, Issue 3, Page(s) 346–352

Abstract: We report on outcomes of 111 patients with treatment naïve Waldenström macroglobulinemia (TN WM) treated with frontline bendamustine-rituximab (BR) ( ...

Abstract	We report on outcomes of 111 patients with treatment naïve Waldenström macroglobulinemia (TN WM) treated with frontline bendamustine-rituximab (BR) (
MeSH term(s)	Humans ; Rituximab/adverse effects ; Waldenstrom Macroglobulinemia/diagnosis ; Waldenstrom Macroglobulinemia/drug therapy ; Waldenstrom Macroglobulinemia/etiology ; Bendamustine Hydrochloride/adverse effects ; Vincristine/adverse effects ; Prednisone/adverse effects ; Cyclophosphamide/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/adverse effects
Chemical Substances	Rituximab (4F4X42SYQ6) ; Bendamustine Hydrochloride (981Y8SX18M) ; Vincristine (5J49Q6B70F) ; Prednisone (VB0R961HZT) ; Cyclophosphamide (8N3DW7272P)
Language	English
Publishing date	2023-12-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.1080/10428194.2023.2290466
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Zs.A 2997: Show issues

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Article ; Online: Review of insulin-dependent and insulin-independent agents for treating patients with type 2 diabetes mellitus and potential role for sodium-glucose co-transporter 2 inhibitors.

Freeman, Jeffrey S

Postgraduate medicine

2013 Volume 125, Issue 3, Page(s) 214–226

Abstract: Diabetes, especially type 2 diabetes mellitus (T2DM), continues to be a global health care problem. Although the beneficial effects of glycemic control are well established, in the United States, > 40% of adults with diabetes fail to achieve target ... ...

Abstract	Diabetes, especially type 2 diabetes mellitus (T2DM), continues to be a global health care problem. Although the beneficial effects of glycemic control are well established, in the United States, > 40% of adults with diabetes fail to achieve target glycated hemoglobin levels. Antidiabetic drug classes vary with respect to their mechanisms of action, glucose-lowering potential, and safety and tolerability profiles. Antidiabetic drug classes include some agents that depend on the presence or action of insulin for their therapeutic effect. As the disease state of T2DM progresses, patient pancreatic β-cell function declines, and therapies that stimulate insulin secretion or improve insulin sensitivity become less effective for this population. Therefore, the development of additional antidiabetic agents with novel mechanisms of action that can be used alone or in combination with currently approved medications may help patients achieve glycemic control. Agents that have comparable glucose-lowering capabilities but different mechanisms of action may fill treatment gaps or meet the needs of patient subpopulations. For example, inhibitors of sodium-glucose co-transporter 2 (SGLT2) represent an emerging class of glucose-lowering agents. The SGLT2 inhibitors reduce glucose reabsorption by the kidney, leading to increased urinary glucose excretion and caloric loss. In clinical trials, these agents have been shown to improve glycemic control and to reduce body weight in patients with T2DM. Additionally, SGLT2 inhibitors pose a low risk for hypoglycemia and are generally well tolerated; however, their use has been associated with an increase in the frequency of genital infections and, in some studies, urinary tract infections. Sodium-glucose co-transporter 2 inhibitors may provide an alternative or an addition to existing therapies for the treatment of patients with T2DM.
MeSH term(s)	Benzhydryl Compounds ; Canagliflozin ; Diabetes Mellitus, Type 2/drug therapy ; Glucosides/therapeutic use ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin/therapeutic use ; Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors ; Thiophenes/therapeutic use
Chemical Substances	Benzhydryl Compounds ; Glucosides ; Hypoglycemic Agents ; Insulin ; SLC5A2 protein, human ; Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors ; Thiophenes ; Canagliflozin (0SAC974Z85) ; dapagliflozin (1ULL0QJ8UC)
Language	English
Publishing date	2013-06-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	410138-8
ISSN	1941-9260 ; 0032-5481
ISSN (online)	1941-9260
ISSN	0032-5481
DOI	10.3810/pgm.2013.05.2672
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Article ; Online: Genetics, genomics and mechanisms responsible for high levels of pyrethroid resistance in Musca domestica.

Freeman, Jamie C / Scott, Jeffrey G

Pesticide biochemistry and physiology

2023 Volume 198, Page(s) 105752

Abstract: ... suppressed by the insecticide synergists piperonyl butoxide and S,S,S-tributylphosphorothionate, but not ...

Abstract	Insecticide resistance is both economically important and evolutionarily interesting phenomenon. Identification of the mutations responsible for resistance allows for highly sensitive resistance monitoring and allows tools to study the forces (population genetics, fitness costs, etc.) that shape the evolution of resistance. Genes coding for insecticide targets have many well-characterized mutations, but the mutations responsible for enhanced detoxification have proven difficult to identify. We employed multiple strategies to identify the mutations responsible for the extraordinarily high permethrin resistance in the KS17-R strain of house fly (Musca domestica): insecticide synergist assays, linkage analysis, bulk segregant analyses (BSA), transcriptomics and long read DNA (Nanopore) sequencing. The >85,100-fold resistance in KS17-R was partially suppressed by the insecticide synergists piperonyl butoxide and S,S,S-tributylphosphorothionate, but not by diethyl maleate nor by injection. This suggests the involvement of target site insensitivity, CYP-mediated resistance, possibly hydrolase mediated resistance and potentially other unknown factors. Linkage analysis identified chromosomes 1, 2, 3 and 5 as having a role in resistance. BSA mapped resistance loci on chromosomes 3 and 5. The locus on chromosome 3 was centered on the voltage sensitive sodium channel. The locus on chromosome 5 was associated with a duplication of multiple detoxification genes. Transcriptomic analyses and long read DNA sequencing revealed overexpressed CYPs and esterases and identified a complex set of structural variants at the chromosome 5 locus.
MeSH term(s)	Animals ; Insecticides/pharmacology ; Houseflies/genetics ; Permethrin ; Insecticide Resistance/genetics ; Cytochrome P-450 Enzyme System ; Genomics ; Pyrethrins/pharmacology
Chemical Substances	Insecticides ; Permethrin (509F88P9SZ) ; Cytochrome P-450 Enzyme System (9035-51-2) ; Pyrethrins
Language	English
Publishing date	2023-12-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	184819-7
ISSN	1095-9939 ; 0048-3583 ; 0048-3575
ISSN (online)	1095-9939
ISSN	0048-3583 ; 0048-3575
DOI	10.1016/j.pestbp.2023.105752
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Article ; Online: Dermatology's role in the fight against human trafficking: A report from the AAD Ad Hoc Task Force and call to action.

Pollock, Samara / Ferree, Sarah / Cronin, Megan / Judge, Abigail M / Berson, Diane S / Friedman, Paul M / Grimes, Pearl E / Murase, Jenny E / Freeman, Esther E / Rao, Medha / Malik, Sameer / Balk, Rosie / Miller, Jeffrey / Cronin, Terrence A / Kourosh, Arianne Shadi

Journal of the American Academy of Dermatology

2023 Volume 90, Issue 2, Page(s) 339–341

Abstract: While the majority of American Academy of Dermatology members have some broad awareness of human trafficking, most are not aware of it in their communities or of the skin signs that could prompt identification of those being exploited, and have requested ...

Abstract	While the majority of American Academy of Dermatology members have some broad awareness of human trafficking, most are not aware of it in their communities or of the skin signs that could prompt identification of those being exploited, and have requested educational resources to assist patients affected by trafficking. The American Academy of Dermatology Ad Hoc Task Force on Dermatologic Resources for the Intervention and Prevention of Human Trafficking has been working to develop relevant resources, including an online toolkit on the American Academy of Dermatology website: https://www.aad.org/member/clinical-quality/clinical-care/human-trafficking.
MeSH term(s)	Humans ; United States ; Dermatology ; Human Trafficking ; Advisory Committees ; Academies and Institutes
Language	English
Publishing date	2023-10-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2023.08.093
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Article ; Online: Living with Congenital Aortic Stenosis: Exercise Restriction, Patterns of Adherence, and Quality of Life.

Mansfield, Laura K / Reichman, Jeffrey R / Crowley, David I / Flyer, Jonathan N / Freeman, Kaitlyn / Gauvreau, Kimberlee K / Mackie, Stewart A / Marino, Bradley S / Newburger, Jane W / Ziniel, Sonja I / Brown, David W

Pediatric cardiology

2023

Abstract: Modern consensus panel guidelines recommend restriction from most organized sports for patients with moderate or severe aortic stenosis (AS). However, there is little published data on how frequently physicians deviate from guidelines, how well patients ... ...

Abstract	Modern consensus panel guidelines recommend restriction from most organized sports for patients with moderate or severe aortic stenosis (AS). However, there is little published data on how frequently physicians deviate from guidelines, how well patients adhere to exercise restrictions, or the effect of restriction on patient-reported quality of life. In this study, we surveyed 93 subjects with AS and their cardiologists regarding participation in organized sports, physical activity, weightlifting, and exercise restriction. Subjects completed the pediatric quality of life inventory (PedsQL) and the pediatric cardiac quality of life inventory (PCQLI). We found that subjects with severe AS (n = 3) were commonly, but not universally, restricted from organized sports (n = 2, 66%). Subjects with moderate AS (n = 40) were rarely restricted from organized sports (n = 6, 17%). No physician-specific characteristics were associated with increased likelihood of recommending exercise restriction. Subjects were more likely to be restricted if they were older (16 years vs. 13 years, p 0.02) and had moderate versus mild AS (p 0.013). PCQLI scores for teens and young adults with AS (age 13-25) were lower than a comparison group of patients with mild congenital heart disease. For all age groups, the PedsQL social functioning score was lower for subjects with exercise restriction (p 0.052). In summary, cardiologists apply consensus guidelines leniently when restricting patients with moderate/severe AS from organized sports and weightlifting. Patients with AS routinely adhere to exercise restriction recommendations. Children and young adults with AS and exercise restriction have lower QOL scores in the social functioning domain.
Language	English
Publishing date	2023-06-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	800857-7
ISSN	1432-1971 ; 0172-0643
ISSN (online)	1432-1971
ISSN	0172-0643
DOI	10.1007/s00246-023-03165-2
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