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  1. Article ; Online: Non-invasive imaging in acute decompensated heart failure with preserved ejection fraction.

    Dhont, Sebastiaan / Verbrugge, Frederik H / Verwerft, Jan / Bertrand, Philippe B

    European heart journal. Acute cardiovascular care

    2024  

    Abstract: Non-invasive imaging plays an increasingly important role in emergency medicine, given the trend towards smaller, portable ultrasound devices, the integration of ultrasound imaging across diverse medical disciplines, and the growing evidence supporting ... ...

    Abstract Non-invasive imaging plays an increasingly important role in emergency medicine, given the trend towards smaller, portable ultrasound devices, the integration of ultrasound imaging across diverse medical disciplines, and the growing evidence supporting its clinical benefits for the patient. Heart failure with preserved ejection fraction (HFpEF) provides a compelling illustration of the impactful role that imaging plays in distinguishing diverse clinical presentations of heart failure with numerous associated comorbidities, including pulmonary, renal, or hepatic diseases. While a preserved left ventricular ejection fraction might misguide the clinician away from diagnosing cardiac disease, there are several clues provided by cardiac, vascular, and lung ultrasonography, as well as other imaging modalities, to rapidly identify (decompensated) HFpEF. Congestion remains the primary reason why patients with heart failure (irrespective of ejection fraction) seek emergency care. Furthermore, comprehensive phenotyping is becoming increasingly important, considering the development of targeted treatments for conditions exhibiting HFpEF physiology, such as cardiac amyloidosis. Timely recognition in such cases has lasting implications for long-term outcomes.
    Language English
    Publishing date 2024-04-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2663340-1
    ISSN 2048-8734 ; 2048-8726
    ISSN (online) 2048-8734
    ISSN 2048-8726
    DOI 10.1093/ehjacc/zuae041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: When therapy becomes the source of embolism.

    Dhont, Sebastiaan / Gutermann, Herbert / Van Lierde, Johan / Verbrugghe, Peter / Vandervoort, Pieter M

    European heart journal. Cardiovascular Imaging

    2023  Volume 24, Issue 9, Page(s) e275

    MeSH term(s) Humans ; Embolism ; Heart Diseases ; Pulmonary Embolism/diagnostic imaging
    Language English
    Publishing date 2023-06-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jead136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Arrythmia-Mediated Valvular Heart Disease.

    Deferm, Sébastien / Bertrand, Philippe B / Dhont, Sebastiaan / von Bardeleben, Ralph S / Vandervoort, Pieter M

    Heart failure clinics

    2023  Volume 19, Issue 3, Page(s) 357–377

    Abstract: The aging population is rising at record pace worldwide. Along with it, a steep increase in the prevalence of atrial fibrillation and heart failure with preserved ejection fraction is to be expected. Similarly, both atrial functional mitral and tricuspid ...

    Abstract The aging population is rising at record pace worldwide. Along with it, a steep increase in the prevalence of atrial fibrillation and heart failure with preserved ejection fraction is to be expected. Similarly, both atrial functional mitral and tricuspid regurgitation (AFMR and AFTR) are increasingly observed in daily clinical practice. This article summarizes all current evidence regarding the epidemiology, prognosis, pathophysiology, and therapeutic options. Specific attention is addressed to discern AFMR and AFTR from their ventricular counterparts, given their different pathophysiology and therapeutic needs.
    MeSH term(s) Humans ; Aged ; Mitral Valve Insufficiency/epidemiology ; Mitral Valve Insufficiency/etiology ; Heart Valve Diseases/complications ; Heart Valve Diseases/epidemiology ; Atrial Fibrillation/epidemiology ; Heart Atria ; Prognosis
    Language English
    Publishing date 2023-04-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2212019-1
    ISSN 1551-7136
    ISSN 1551-7136
    DOI 10.1016/j.hfc.2023.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: An eye-opening case report of constrictive pericarditis.

    Dhont, Sebastiaan / Van Belleghem, Yves / De Zaeytijd, Julie / Vandecasteele, Els

    European heart journal. Case reports

    2022  Volume 6, Issue 7, Page(s) ytac287

    Abstract: Background: Constrictive pericarditis is characterized by the encasement of the heart by a stiff pericardium leading to impaired diastolic function, which ultimately leads to congestive heart failure.: Case summary: We report a case of a young woman, ...

    Abstract Background: Constrictive pericarditis is characterized by the encasement of the heart by a stiff pericardium leading to impaired diastolic function, which ultimately leads to congestive heart failure.
    Case summary: We report a case of a young woman, who first presented to the ophthalmologist with the sudden appearance of floaters and vision reduction. Eventually, invasive haemodynamic assessment led to the diagnosis of constrictive pericarditis leading to venous congestion.
    Conclusion: Understanding the pathophysiology and integrating the results of invasive and non-invasive diagnostic work up is important in making this challenging diagnosis.
    Language English
    Publishing date 2022-07-25
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytac287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Prognostic Value of Cardiac Biomarkers and Echocardiography in Critical COVID-19.

    Zwaenepoel, Bert / Dhont, Sebastiaan / Hoste, Eric / Gevaert, Sofie / Schaubroeck, Hannah

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 752237

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-11-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.752237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Facial Deformity in a Patient with Chronic Secondary Hyperparathyroidism.

    Dhont, Sebastiaan / Viaene, Liesbeth / Evenepoel, Pieter

    Kidney360

    2020  Volume 1, Issue 5, Page(s) 430–431

    MeSH term(s) Humans ; Hyperostosis Frontalis Interna/complications ; Hyperparathyroidism, Secondary/complications
    Language English
    Publishing date 2020-05-28
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000352020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Image focus: renovascular hypertension.

    Dhont, Sebastiaan / de Niel, Chris / van Mieghem, Carlos

    Acta cardiologica

    2019  Volume 75, Issue 7, Page(s) 693–694

    Language English
    Publishing date 2019-09-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 390197-x
    ISSN 1784-973X ; 0001-5385
    ISSN (online) 1784-973X
    ISSN 0001-5385
    DOI 10.1080/00015385.2019.1665849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Analysing the accuracy of pressure measurements during exercise with pulmonary artery pressure sensors - Insights from the ACTION-MEMS study.

    Meekers, Evelyne / Petit, Thibault / Dauw, Jeroen / Gruwez, Henri / Dhont, Sebastiaan / Luwel, Evert / Nijst, Petra / Dupont, Matthias / Bertrand, Philippe B / Martens, Pieter / Mullens, Wilfried

    European journal of heart failure

    2024  Volume 26, Issue 2, Page(s) 523–524

    MeSH term(s) Humans ; Pulmonary Artery ; Micro-Electrical-Mechanical Systems ; Heart Failure ; Blood Pressure ; Exercise Test
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.3124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The use of cardiac troponins and B-type natriuretic peptide in COVID-19.

    Zwaenepoel, Bert / Dhont, Sebastiaan / Schaubroeck, Hannah / Gevaert, Sofie

    Acta cardiologica

    2021  Volume 77, Issue 7, Page(s) 567–572

    Abstract: Coronavirus disease 2019 (COVID-19) is still challenging health care systems worldwide. Over time, it has become clear that respiratory disease is not the only important entity as critically ill patients are also more prone to develop complications, such ...

    Abstract Coronavirus disease 2019 (COVID-19) is still challenging health care systems worldwide. Over time, it has become clear that respiratory disease is not the only important entity as critically ill patients are also more prone to develop complications, such as acute cardiac injury. Despite extensive research, the mainstay of treatment still relies on supportive care and targeted therapy of these complications. The development of a prognostic model which helps clinicians to diverge patients to an appropriate level of care is thus crucial. As a result, several prognostic markers have been studied in the past few months. Among them are the cardiac biomarkers, especially cardiac troponins T/I and brain natriuretic peptide, which seem to have important prognostic values as several reports have confirmed their strong association with adverse clinical outcomes and death. The use of these biomarkers as part of a prognostic tool could potentially result in more precise risk stratification of COVID-19 patients and divergence to an adequate level of care. However, several caveats persist causing international guidelines to still recommend in favour of a more conservative approach to cardiac biomarker testing for prognostic purposes.
    MeSH term(s) Humans ; Biomarkers ; COVID-19 ; Natriuretic Peptide, Brain/analysis ; Prognosis ; Troponin I/analysis ; Troponin T/analysis
    Chemical Substances Biomarkers ; Natriuretic Peptide, Brain (114471-18-0) ; Troponin I ; Troponin T
    Language English
    Publishing date 2021-08-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 390197-x
    ISSN 1784-973X ; 0001-5385
    ISSN (online) 1784-973X
    ISSN 0001-5385
    DOI 10.1080/00015385.2021.1970403
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Pulmonary hypertension in interstitial lung disease: an area of unmet clinical need.

    Dhont, Sebastiaan / Zwaenepoel, Bert / Vandecasteele, Els / Brusselle, Guy / De Pauw, Michel

    ERJ open research

    2022  Volume 8, Issue 4

    Abstract: Pulmonary hypertension (PH) is present in an important proportion of patients with interstitial lung diseases (ILDs), encompassing a large, heterogeneous group of diffuse parenchymal lung diseases. Development of ILD-related PH is associated with reduced ...

    Abstract Pulmonary hypertension (PH) is present in an important proportion of patients with interstitial lung diseases (ILDs), encompassing a large, heterogeneous group of diffuse parenchymal lung diseases. Development of ILD-related PH is associated with reduced exercise capacity, increased need for supplemental oxygen, decreased quality of life and earlier death. Diagnosis of ILD-related PH is important and requires a high index of suspicion. Noninvasive diagnostic assessment can suggest the presence of PH, although right heart catheterisation remains the gold standard to confirm the diagnosis and to assess its severity. A comprehensive assessment is needed to make sure reversible causes of PH have been ruled out, including thromboembolic events, untreated hypoxaemia and sleep disordered breathing. The results of trials concerning pulmonary vasodilators in this particular patient group have been disappointing and, in some cases, were even associated with an increased risk of harm. Newer strategies such as medications administered through inhalation and combinations with antifibrotic drugs show encouraging results. Moreover, unravelling the role of the vasculature in the pathophysiology of pulmonary fibrosis and ILD-related PH may potentially unlock new therapeutic opportunities.
    Language English
    Publishing date 2022-11-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00272-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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