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  1. Article ; Online: JTM advances in uncharted territories: diseases and disorders of unknown etiology.

    Panelli, Monica C

    Journal of translational medicine

    2017  Volume 15, Issue 1, Page(s) 192

    Abstract: We are delighted to announce a new section in the Journal of Translational Medicine, 'Illnesses of Unknown Etiology'. This section aims to provide a translational medicine forum for the publication of research on illnesses, multisystem diseases and ... ...

    Abstract We are delighted to announce a new section in the Journal of Translational Medicine, 'Illnesses of Unknown Etiology'. This section aims to provide a translational medicine forum for the publication of research on illnesses, multisystem diseases and syndromes of unknown etiology. Examples of these include Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia Syndrome.
    MeSH term(s) Clinical Trials as Topic ; Disease ; Humans ; Periodicals as Topic ; United States ; United States Food and Drug Administration
    Language English
    Publishing date 2017-09-13
    Publishing country England
    Document type Editorial
    ISSN 1479-5876
    ISSN (online) 1479-5876
    DOI 10.1186/s12967-017-1293-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: JTM advances in uncharted territories

    Monica C. Panelli

    Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-

    diseases and disorders of unknown etiology

    2017  Volume 3

    Abstract: Abstract We are delighted to announce a new section in the Journal of Translational Medicine, ‘Illnesses of Unknown Etiology’. This section aims to provide a translational medicine forum for the publication of research on illnesses, multisystem diseases ... ...

    Abstract Abstract We are delighted to announce a new section in the Journal of Translational Medicine, ‘Illnesses of Unknown Etiology’. This section aims to provide a translational medicine forum for the publication of research on illnesses, multisystem diseases and syndromes of unknown etiology. Examples of these include Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia Syndrome.
    Keywords Etiology ; Aetiology ; Myalgic Encephalomyelitis ; Chronic Fatigue Syndrome ; Fibromyalgia Syndrome ; Medicine ; R
    Language English
    Publishing date 2017-09-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Sentinel Lymph Node Gene Expression Signature Predicts Recurrence-Free Survival in Cutaneous Melanoma.

    Karapetyan, Lilit / Gooding, William / Li, Aofei / Yang, Xi / Knight, Andrew / Abushukair, Hassan M / Vargas De Stefano, Danielle / Sander, Cindy / Karunamurthy, Arivarasan / Panelli, Monica / Storkus, Walter J / Tarhini, Ahmad A / Kirkwood, John M

    Cancers

    2022  Volume 14, Issue 20

    Abstract: ... < 0.0001) and produced a bootstrap C index of 0.888. In univariate analysis, Breslow thickness ...

    Abstract We sought to develop a sentinel lymph node gene expression signature score predictive of disease recurrence in patients with cutaneous melanoma. Gene expression profiling was performed on SLN biopsies using U133A 2.0 Affymetrix gene chips. The top 25 genes associated with recurrence-free survival (RFS) were selected and a penalized regression function was used to select 12 genes with a non-zero coefficient. A proportional hazards regression model was used to evaluate the association between clinical covariates, gene signature score, and RFS. Among the 45 patients evaluated, 23 (51%) had a positive SLN. Twenty-one (46.7%) patients developed disease recurrence. For the top 25 differentially expressed genes (DEG), 12 non-zero penalized coefficients were estimated (CLGN, C1QTNF3, ADORA3, ARHGAP8, DCTN1, ASPSCR1, CHRFAM7A, ZNF223, PDE6G, CXCL3, HEXIM1, HLA-DRB). This 12-gene signature score was significantly associated with RFS (p < 0.0001) and produced a bootstrap C index of 0.888. In univariate analysis, Breslow thickness, presence of primary tumor ulceration, SLN positivity were each significantly associated with RFS. After simultaneously adjusting for these prognostic factors in relation to the gene signature, the 12-gene score remained a significant independent predictor for RFS (p < 0.0001). This SLN 12-gene signature risk score is associated with melanoma recurrence regardless of SLN status and may be used as a prognostic factor for RFS.
    Language English
    Publishing date 2022-10-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14204973
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  4. Article: The pathway to biomarker discovery: carbonic anhydrase IX and the prediction of immune responsiveness.

    Panelli, Monica C / Wang, Ena / Marincola, Francesco M

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2005  Volume 11, Issue 10, Page(s) 3601–3603

    MeSH term(s) Antigens, Neoplasm/genetics ; Antigens, Neoplasm/pharmacology ; Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor ; Carbonic Anhydrase IX ; Carbonic Anhydrases/genetics ; Carbonic Anhydrases/pharmacology ; Carcinoma, Renal Cell/drug therapy ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/immunology ; Humans ; Interleukin-2/therapeutic use ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/genetics ; Kidney Neoplasms/immunology ; Patient Selection ; Prognosis ; Treatment Outcome
    Chemical Substances Antigens, Neoplasm ; Antineoplastic Agents ; Biomarkers, Tumor ; Interleukin-2 ; CA9 protein, human (EC 4.2.1.1) ; Carbonic Anhydrase IX (EC 4.2.1.1) ; Carbonic Anhydrases (EC 4.2.1.1)
    Language English
    Publishing date 2005-05-15
    Publishing country United States
    Document type Journal Article ; Review ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-05-0475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4223: Show issues Location:
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  5. Article: Gene profiling of immune responses against tumors.

    Wang, Ena / Panelli, Monica C / Marincola, Francesco M

    Current opinion in immunology

    2005  Volume 17, Issue 4, Page(s) 423–427

    Abstract: Clinical trials of tumor-antigen-specific immunization have clearly shown that immune-mediated tumor rejection requires more than simple T cell-target cell interactions. In vivo generation of tumor-specific T cells is one of a series of steps necessary ... ...

    Abstract Clinical trials of tumor-antigen-specific immunization have clearly shown that immune-mediated tumor rejection requires more than simple T cell-target cell interactions. In vivo generation of tumor-specific T cells is one of a series of steps necessary for the induction of clinically relevant immune responses. In recent years, high-throughput functional genomics exposed the complexity of tumor immune biology, which underlies the kaleidoscopic array of variables associated with cancer instability and immunogenetic variability in humans. In the quest to understand immune rejection, hypothesis-driven approaches have failed to take into account the intricacy of human pathology by relying mostly on hypotheses derived from experimental models rather than direct clinical observation. Future investigations should reframe scientific thinking when applied to humans, utilizing descriptive tools to generate novel hypotheses relevant to human disease.
    MeSH term(s) Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/genetics ; Gene Expression Regulation, Neoplastic/immunology ; Humans ; Interleukin-2/immunology ; Interleukin-2/therapeutic use ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/immunology ; Vaccination
    Chemical Substances Interleukin-2
    Language English
    Publishing date 2005-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2005.05.007
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    Zs.MG 13: Show issues

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  6. Article: Understanding the response to immunotherapy in humans.

    Wang, Ena / Panelli, Monica C / Marincola, Francesco M

    Springer seminars in immunopathology

    2005  Volume 27, Issue 1, Page(s) 105–117

    Abstract: Whether the efforts of the last decade aimed at the development of vaccines against tumor-specific antigens encountered success or failure is a matter of expectations. On the bright side, we could optimistically observe that anti-cancer-vaccines stand as ...

    Abstract Whether the efforts of the last decade aimed at the development of vaccines against tumor-specific antigens encountered success or failure is a matter of expectations. On the bright side, we could optimistically observe that anti-cancer-vaccines stand as an outstanding example of the successful implementation of modern biotechnology tools for the development of biologically sound therapeutics. In particular, vaccines against melanoma (the prototype model of tumor immunology in humans) can reproducibly induce cytotoxic T cell (CTL) responses exquisitely specific for cancer cells. This achievement trespasses the specificity of any other anti-cancer therapy. The skeptics, on the other end, might point out that immunization only rarely leads to cancer regression, labeling, therefore, this approach is ineffective. In our opinion this judgment stems from the naïve expectation that CTL induction is sufficient for an effective immune response. Here we propose that more needs to be understood about the mechanisms required for the induction of a therapeutically relevant immune response in humans. In particular, we will discuss the variables related to cancer heterogeneity, the weight of individual patients' polymorphism(s), the role of the T cell activation and differentiation and, finally, the complex relationship between immune and cancer cells within the tumor microenvironment.
    MeSH term(s) Antigens, Neoplasm/immunology ; Cancer Vaccines/immunology ; Humans ; Immunization ; Immunotherapy ; Neoplasms/immunology ; Neoplasms/therapy ; T-Lymphocytes, Cytotoxic/immunology
    Chemical Substances Antigens, Neoplasm ; Cancer Vaccines
    Language English
    Publishing date 2005-06
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 6177-3
    ISSN 1432-2196 ; 0344-4325 ; 0172-6641
    ISSN (online) 1432-2196
    ISSN 0344-4325 ; 0172-6641
    DOI 10.1007/s00281-004-0198-7
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    Zs.A 1425: Show issues Location:
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  7. Article ; Online: Adjuvant therapy with high-dose interferon alpha 2b in patients with high-risk stage IIB/III melanoma.

    Kirkwood, John M / Tarhini, Ahmad A / Moschos, Stergios J / Panelli, Monica C

    Nature clinical practice. Oncology

    2007  Volume 5, Issue 1, Page(s) 2–3

    MeSH term(s) Chemotherapy, Adjuvant/economics ; Chemotherapy, Adjuvant/statistics & numerical data ; Controlled Clinical Trials as Topic/statistics & numerical data ; Cost-Benefit Analysis ; Disease-Free Survival ; Follow-Up Studies ; Humans ; Immunologic Factors/administration & dosage ; Immunologic Factors/economics ; Immunologic Factors/therapeutic use ; Interferon alpha-2 ; Interferon-alpha/administration & dosage ; Interferon-alpha/economics ; Interferon-alpha/therapeutic use ; Lymphatic Metastasis ; Melanoma/drug therapy ; Melanoma/immunology ; Melanoma/pathology ; Melanoma/secondary ; Meta-Analysis as Topic ; Multicenter Studies as Topic/statistics & numerical data ; Neoplasm Staging ; Recombinant Proteins ; Risk ; Survival Analysis ; Treatment Outcome
    Chemical Substances Immunologic Factors ; Interferon alpha-2 ; Interferon-alpha ; Recombinant Proteins
    Language English
    Publishing date 2007-11-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2173301-6
    ISSN 1743-4262 ; 1743-4254
    ISSN (online) 1743-4262
    ISSN 1743-4254
    DOI 10.1038/ncponc1004
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    Zs.A 6029: Show issues Location:
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  8. Article: Cytokine and chemokine expression profiles of maturing dendritic cells using multiprotein platform arrays.

    Nagorsen, Dirk / Marincola, Francesco M / Panelli, Monica C

    Cytokine

    2003  Volume 25, Issue 1, Page(s) 31–35

    Abstract: Understanding the whole process of dendritic cell (DC) activation might help in the development of more efficient immunotherapeutic strategies for tumor patients. Part of this process is cytokine secretion, which has important effects on innate and ... ...

    Abstract Understanding the whole process of dendritic cell (DC) activation might help in the development of more efficient immunotherapeutic strategies for tumor patients. Part of this process is cytokine secretion, which has important effects on innate and adaptive immune response. Here, we cultured circulating monocytes for five days with interleukin-4 and GM-CSF followed by two-day culture with or without CD40 ligand and LPS to create a mature DC (mDC) and an immature DC (iDC) phenotype, respectively, characterized by differential expression of co-stimulatory molecules (CD80, CD83). We then compared the cytokine expression profile of the mDC and iDC using two protein platform arrays. Twelve supernatants from mDC paired with 12 from iDC were compared. The mDC protein expression profile showed significant increases in 16 out of 34 factors tested, including TNFalpha, IL-10, IL-12, IFNgamma, MIP1alpha, MIP1beta, IL-8, MDC, RANTES, and IL-6, which play a crucial role in the regulation of the innate immune response as well as the recruitment and activation of adaptive immune effectors. Interestingly, some of the cytokines expressed during maturation were also found in the gene expression profile identified in tumor metastases following IL-2 therapy using cDNA arrays. This finding suggests a possible role for resident DC maturation as a mediator of systemic IL-2 effects. Most important, the array of cytokines secreted during DC maturation may be considered an important component during adoptive transfer. Further characterization of the kinetics and persistence of their secretion should be undertaken in the future.
    MeSH term(s) Antigens, CD ; B7-1 Antigen/metabolism ; CD40 Ligand/pharmacology ; Cells, Cultured ; Chemokine CCL22 ; Chemokine CCL5/metabolism ; Chemokines/metabolism ; Chemokines, CC/metabolism ; Cytokines/metabolism ; Dendritic Cells/drug effects ; Dendritic Cells/physiology ; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Humans ; Immunoglobulins/metabolism ; Interleukin-2/metabolism ; Interleukin-4/metabolism ; Lipopolysaccharides/pharmacology ; Membrane Glycoproteins/metabolism ; Protein Array Analysis/methods ; CD83 Antigen
    Chemical Substances Antigens, CD ; B7-1 Antigen ; CCL22 protein, human ; Chemokine CCL22 ; Chemokine CCL5 ; Chemokines ; Chemokines, CC ; Cytokines ; Immunoglobulins ; Interleukin-2 ; Lipopolysaccharides ; Membrane Glycoproteins ; CD40 Ligand (147205-72-9) ; Interleukin-4 (207137-56-2) ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1)
    Language English
    Publishing date 2003-12-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2003.08.012
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    Zs.A 2840: Show issues Location:
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  9. Article: Cytokine polymorphism and its possible impact on cancer.

    Jin, Ping / Panelli, Monica C / Marincola, Francesco M / Wang, Ena

    Immunologic research

    2004  Volume 30, Issue 2, Page(s) 181–190

    Abstract: Human cancer is an unpredictable disease as is its response to therapy. The intrinsic genetic heterogeneity and instability of cancer cells could in part explain such behavior. However, it is possible that, individual variation in the genetic make-up of ... ...

    Abstract Human cancer is an unpredictable disease as is its response to therapy. The intrinsic genetic heterogeneity and instability of cancer cells could in part explain such behavior. However, it is possible that, individual variation in the genetic make-up of humans may affect the relationship between host and cancer cells and, therefore, be, at least in part responsible for this extraordinary variation. Human gene polymorphism has been shown indeed to play a role in immune responses; among the immune-related genes, cytokines are often polymorphic. Some polymorphisms of cytokine and cytokine receptor may have direct functional significance by altering directly and indirectly the level of gene expression and/or its function; other may only demarcate a genetic linkage to a particular haplotype associated with a given clinical condition. The majority of polymorphisms found in cytokines or their receptors are located in the promoter, intronic and 3' untranslated regions. These sequence variations can still affect gene expression and function. In this review will we summarize the current knowledge about the role of cytokine polymorphism in disease and more specifically in cancer.
    MeSH term(s) 3' Untranslated Regions/genetics ; 3' Untranslated Regions/immunology ; Cytokines/genetics ; Cytokines/immunology ; Gene Expression Regulation, Neoplastic/genetics ; Gene Expression Regulation, Neoplastic/immunology ; Humans ; Introns/genetics ; Introns/immunology ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/pathology ; Polymorphism, Genetic/immunology ; Promoter Regions, Genetic/genetics ; Promoter Regions, Genetic/immunology ; Receptors, Cytokine/genetics ; Receptors, Cytokine/immunology
    Chemical Substances 3' Untranslated Regions ; Cytokines ; Receptors, Cytokine
    Language English
    Publishing date 2004
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632857-x
    ISSN 1559-0755 ; 0257-277X
    ISSN (online) 1559-0755
    ISSN 0257-277X
    DOI 10.1385/IR:30:2:181
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    Zs.A 1755: Show issues Location:
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  10. Article: Gene expression profiling of anticancer immune responses.

    Wang, Ena / Panelli, Monica C / Monsurró, Vladia / Marincola, Francesco M

    Current opinion in molecular therapeutics

    2004  Volume 6, Issue 3, Page(s) 288–295

    Abstract: Anticancer immune responses can be enhanced by immune manipulation, however, the biological mechanism responsible for these immune responses remains largely unexplained. Conventional immunology researchers have extensively studied specific interactions ... ...

    Abstract Anticancer immune responses can be enhanced by immune manipulation, however, the biological mechanism responsible for these immune responses remains largely unexplained. Conventional immunology researchers have extensively studied specific interactions between immune and cancer cells, and additional investigations have identified co-factors that may enhance the effectiveness of such interactions. As the molecular understanding of individual interactions increases, it is becoming apparent that no single mechanism can explain the phenomenon of tumor rejection. The contribution of several components of the innate and adaptive immune response is likely to be required for successful tumor rejection. These components may be variably recruited and activated by molecules with immune modulatory properties being produced by tumor and bystander cells within the tumor micro-environment. Such complexity can only be appreciated and solved by high-throughput tools capable of providing a global view of biological processes as they occur. This review will present selected examples of how high-throughput gene expression profiling may contribute to the understanding of anticancer immune responses. As reviews on technological aspects of the genomic analysis of cancer are already available, this review will provide a speculative discussion about their potential usefulness.
    MeSH term(s) Animals ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/immunology ; Humans ; Immunity/genetics ; Immunity/physiology ; Neoplasms/genetics ; Neoplasms/immunology ; Polymorphism, Genetic/immunology ; T-Lymphocytes/immunology
    Language English
    Publishing date 2004-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2022273-7
    ISSN 1464-8431
    ISSN 1464-8431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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