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Article ; Online: Three-dimensional evaluation of interproximal contacts of permanent dentition: a cone beam computed tomography study.

Muthu, M S / Kailasam, V / Rao, U / Krithika, C / Kirthiga, M / Jagadeesan, A / Warrier, A

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

2024

Abstract: Purpose: To assess the various patterns of the inter-proximal contact areas of the permanent dentition using the available cone beam computed tomography (CBCT) images.: Methods: A retrospective cross-sectional study was performed on existing CBCT ... ...

Abstract	Purpose: To assess the various patterns of the inter-proximal contact areas of the permanent dentition using the available cone beam computed tomography (CBCT) images. Methods: A retrospective cross-sectional study was performed on existing CBCT images from a University hospital and teaching department. Three thousand two hundred and fifty inter-proximal contacts were assessed from 125 existing CBCT scans of patients (age range: 14 years 3 months-29 years 9 months) who had matched the eligibility criteria. The types of inter-proximal contacts of the permanent dentition were scored at occlusal, middle, and cervical thirds, according to the OXIS inter-proximal contacts classification. Chi-square test was used to assess the contacts and gender/arches. Results: The most prevalent contact was type I for the posterior teeth contacts, and types S1 and S2 for the anterior teeth contacts. Statistical significance was not observed between the contacts on the left and right sides (P > 0.05), while statistical significance was observed between the inter-proximal contacts of the maxilla and mandible (P < 0.05). Conclusion: The CBCT-based three-dimensional assessment of the inter-proximal contact areas of the permanent dentition is representative of the OXIS classification. The occlusal level contact was predominantly representative of the overall type of the contact.
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2472851-2
ISSN	1996-9805 ; 1818-6300
ISSN (online)	1996-9805
ISSN	1818-6300
DOI	10.1007/s40368-024-00883-w
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Article: Mitochondria-containing extracellular vesicles from mouse

Dave, Kandarp M / Venna, Venugopal R / Rao, Krithika S / Stolz, Donna B / Quaicoe, Victoria A / Maniskas, Michael E / Hildebrand, Ella E / Green, Dawson / Chen, Mingxi / Milosevic, Jadranka / Zheng, Si-Yang / Shiva, Sruti S / McCullough, Louise D / Manickam, Devika S

bioRxiv : the preprint server for biology

2024

Abstract: Ischemic stroke-induced mitochondrial dysfunction in the blood-brain barrier-forming brain endothelial cells ( ...

Abstract	Ischemic stroke-induced mitochondrial dysfunction in the blood-brain barrier-forming brain endothelial cells (
Language	English
Publishing date	2024-01-16
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.16.575903
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Article ; Online: Amycolatopsis

Kim, Joyce H / Scherer, Georgia / Lumpkin, Dellencia S / Rao, Krithika / Puentes Flores, Carmen D / Van Arnam, Ethan B

Applied and environmental microbiology

2023 Volume 89, Issue 2, Page(s) e0183822

Abstract: ... ...

Abstract	Symbiotic
MeSH term(s)	Animals ; Antifungal Agents/pharmacology ; Anti-Bacterial Agents/pharmacology ; Ants/microbiology ; Amycolatopsis ; Actinobacteria ; Symbiosis ; Hypocreales ; Fungi
Chemical Substances	Antifungal Agents ; Anti-Bacterial Agents ; 13-hydroxy-2,12,14,16,22-pentamethyl-28-(N-methyl-guanidino)-octacosa-2,4,6,8,10,14,20,24-octaenoic acid (2-hydroxy-5-oxo-cyclopent-1-enyl)-amide
Language	English
Publishing date	2023-01-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	223011-2
ISSN	1098-5336 ; 0099-2240
ISSN (online)	1098-5336
ISSN	0099-2240
DOI	10.1128/aem.01838-22
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Article: Decision-making around Commencing Dialysis.

Rao, Indu Ramachandra / Vallath, Nandini / Anupama, Y J / Gupta, Krishan Lal / Rao, Krithika S

Indian journal of palliative care

2021 Volume 27, Issue Suppl 1, Page(s) S6–S10

Abstract: The decision regarding dialysis initiation is complex. Awareness that renal replacement therapy should not be regarded as default therapy for every patient with advanced renal failure is necessary. Decision to initiate dialysis and modality should be ... ...

Abstract	The decision regarding dialysis initiation is complex. Awareness that renal replacement therapy should not be regarded as default therapy for every patient with advanced renal failure is necessary. Decision to initiate dialysis and modality should be individualized in a shared decision-making process involving the treating nephrologist and the patient. Patients should receive predialysis education early in the course of chronic kidney disease so as to help prepare them well in advance for this eventuality. Withholding dialysis may be a reasonable option in a certain subset of patients, especially elderly patient with multiple co-morbid illnesses. Comprehensive conservation care should be offered in all patients where the decision to not dialyze is taken.
Language	English
Publishing date	2021-05-30
Publishing country	India
Document type	Journal Article ; Review
ISSN	0973-1075
ISSN	0973-1075
DOI	10.4103/ijpc.ijpc_61_21
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Article: Maggots in the Intercostal Drain: Case Report of a Rare Presentation with a Brief Review of Literature.

Gupta, Mayank / Rao, Seema Rajesh / Salins, Naveen / Singhai, Pankaj / Rao, Krithika S

Indian journal of palliative care

2021 Volume 27, Issue 3, Page(s) 439–441

Abstract: Maggots are dipterous larvae of flies. Infestation of vertebrate animals (including humans) by maggots is termed as Myiasis. Warm and Humid climate, low socio-economic status, lack of knowledge and poor living conditions, malignant wounds predispose the ... ...

Abstract	Maggots are dipterous larvae of flies. Infestation of vertebrate animals (including humans) by maggots is termed as Myiasis. Warm and Humid climate, low socio-economic status, lack of knowledge and poor living conditions, malignant wounds predispose the cancer patients to maggot infestation in India. Apart from infestation in the wounds; oral, ophthalmic, nasal, aural, enteric, urogenital, trachea-pulmonary and rectal myiasis have been reported. Maggot infestation of the Intercostal drain (ICD) container without associated pleural myiasis is an extremely rare entity. We describe a rare case report of maggots in the ICD in a patient with metastatic chondrosarcoma femur with ICD in situ for malignant pleural effusion. Early detection and management are the keys to prevent the catastrophic complication of pleural myiasis.
Language	English
Publishing date	2021-09-29
Publishing country	United States
Document type	Case Reports
ISSN	0973-1075
ISSN	0973-1075
DOI	10.25259/IJPC_428_20
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Article ; Online: Decision-making around commencing dialysis

Indu Ramachandra Rao / Nandini Vallath / Y J Anupama / Krishan Lal Gupta / Krithika S Rao

Indian Journal of Palliative Care, Vol 27, Iss 5, Pp 6-

2021 Volume 10

Abstract	The decision regarding dialysis initiation is complex. Awareness that renal replacement therapy should not be regarded as default therapy for every patient with advanced renal failure is necessary. Decision to initiate dialysis and modality should be individualized in a shared decision-making process involving the treating nephrologist and the patient. Patients should receive predialysis education early in the course of chronic kidney disease so as to help prepare them well in advance for this eventuality. Withholding dialysis may be a reasonable option in a certain subset of patients, especially elderly patient with multiple co-morbid illnesses. Comprehensive conservation care should be offered in all patients where the decision to not dialyze is taken.
Keywords	dialysis ; end-stage kidney disease ; palliative care ; renal supportive care ; shared decision-making ; Medicine (General) ; R5-920
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Harnessing Epicardial Progenitor Cells and Their Derivatives for Rescue and Repair of Cardiac Tissue After Myocardial Infarction.

Rao, Krithika S / Spees, Jeffrey L

Current molecular biology reports

2017 Volume 3, Issue 3, Page(s) 149–158

Abstract: ... effective treatments. Improved understanding of epicardial cell function(s) and epicardial-mediated ...

Abstract	Purpose of review: Ischemic heart disease and stroke lead to the greatest number of deaths worldwide. Despite decreased time to intervention and improvements in the standard of care, 1 out of 5 patients that survive a myocardial infarction (MI) still face long-term chronic heart failure and a 5-year mortality rate of about 50%. Based on their multi-potency for differentiation and paracrine activity, epicardial cells and their derivatives have potential to rescue jeopardized tissue and/or promote cardiac regeneration. Here we review the diagnosis and treatment of MI, basic epicardial cell biology, and potential treatment strategies designed to harness the reparative properties of epicardial cells. Recent findings: During cardiac development, epicardial cells covering the surface of the heart generate migratory progenitor cells that contribute to the coronary vasculature and the interstitial fibroblasts. Epicardial cells also produce paracrine signals required for myocardial expansion and cardiac growth. In adults with myocardial infarction, epicardial cells and their derivatives provide paracrine factors that affect myocardial remodeling and repair. At present, the intrinsic mechanisms and extrinsic signals that regulate epicardial cell fate and paracrine activity in adults remain poorly understood. Summary: Human diseases that result in heart failure due to negative remodeling or extensive loss of viable cardiac tissue require new, effective treatments. Improved understanding of epicardial cell function(s) and epicardial-mediated secretion of growth factors, cytokines and hormones during cardiac growth, homeostasis and injury may lead to new ways to treat patients with myocardial infarction.
Language	English
Publishing date	2017-07-15
Publishing country	Switzerland
Document type	Journal Article
ISSN	2198-6428
ISSN	2198-6428
DOI	10.1007/s40610-017-0066-6
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Article: Kannada Translation and Validation of the ESAS-r Renal for Symptom Burden Survey in Patients with End-Stage Kidney Disease.

Naik, Bharathi / Nagaraju, Shankar Prasad / Guddattu, Vasudeva / Salins, Naveen / Prabhu, Ravindra / Damani, Anuja / Naik, Prathvi / Rao, Krithika S / Rao, Indu Ramachandra / Singhai, Pankaj

Indian journal of palliative care

2023 Volume 29, Issue 2, Page(s) 195–199

Abstract: ... among Kannada-speaking ESKD patients; its Cronbach's α was 0.785, and test-retest validity was 0.896 ...

Abstract	Objectives: End-stage kidney disease (ESKD) is a life-limiting illness that leads to significant health-related suffering for the patients and their caregivers. Moreover, disease-directed options such as dialysis and renal transplant might not be universally accessible. Inadequate assessment and management of symptoms often lead to diminished quality of life. For evaluating symptoms and their associated distress, various tools have been identified. However, these are not available for the native Kannada-speaking population for assessing ESKD symptom burden. In this study, we determined the reliability and validity of the Edmonton Symptom Assessment System Revised Renal (ESAS-r: Renal) in Kannada-speaking ESKD patients. Materials and methods: ESAS-r: Renal English version was translated into Kannada using the forward and backward method. The translated version was endorsed by Nephrology, Palliative care, Dialysis technology and Nursing experts. As a pilot study, 12 ESKD patients evaluated the content of the questionnaires for appropriateness and relevance. The ESAS-r: Renal Kannada version was validated by administering this tool to 45 patients twice a fortnight. Result: The translated ESAS-r: Renal Kannada version questionnaire had an acceptable face and content validity. Experts' opinion was assessed by content validity ratio (CVR), and the value of CVR of ESAS-r: Renal Kannada version was-'1'-. Internal consistency of the tool was assessed among Kannada-speaking ESKD patients; its Cronbach's α was 0.785, and test-retest validity was 0.896. Conclusion: The validated Kannada version of ESAS-r: Renal was reliable and valid for assessing symptom burden in ESKD patients.
Language	English
Publishing date	2023-05-30
Publishing country	United States
Document type	Journal Article
ISSN	0973-1075
ISSN	0973-1075
DOI	10.25259/IJPC_216_2022
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Article ; Online: Dietary dicarboxylic acids provide a non-storable alternative fat source that protects mice against obesity.

Goetzman, Eric S / Zhang, Bob B / Zhang, Yuxun / Bharathi, Sivakama S / Bons, Joanna / Rose, Jacob / Shah, Samah / Solo, Keaton J / Schmidt, Alexandra V / Richert, Adam C / Mullett, Steven J / Gelhaus, Stacy L / Rao, Krithika S / Shiva, Sruti S / Pfister, Katherine E / Silva Barbosa, Anne / Sims-Lucas, Sunder / Dobrowolski, Steven F / Schilling, Birgit

The Journal of clinical investigation

2024

Abstract: Dicarboxylic fatty acids are generated in the liver and kidney in a minor pathway called fatty acid ω-oxidation. The effects of consuming dicarboxylic fatty acids as an alternative source of dietary fat have not been explored. Here, we fed dodecanedioic ... ...

Abstract	Dicarboxylic fatty acids are generated in the liver and kidney in a minor pathway called fatty acid ω-oxidation. The effects of consuming dicarboxylic fatty acids as an alternative source of dietary fat have not been explored. Here, we fed dodecanedioic acid, a 12-carbon dicarboxylic (DC12), to mice at 20% of daily caloric intake for nine weeks. DC12 increased metabolic rate, reduced body fat, reduced liver fat, and improved glucose tolerance. We observed DC12-specific breakdown products in liver, kidney, muscle, heart, and brain, indicating that oral DC12 escaped first-pass liver metabolism and was utilized by many tissues. In tissues expressing the "a" isoform of acyl-CoA oxidase-1 (ACOX1), a key peroxisomal fatty acid oxidation enzyme, DC12 was chain shortened to the TCA cycle intermediate succinyl-CoA. In tissues with low peroxisomal fatty acid oxidation capacity, DC12 was oxidized by mitochondria. In vitro, DC12 was catabolized even by adipose tissue and was not stored intracellularly. We conclude that DC12 and other dicarboxylic acids may be useful for combatting obesity and for treating metabolic disorders.
Language	English
Publishing date	2024-04-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI174186
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Article ; Online: CTGF-D4 Amplifies LRP6 Signaling to Promote Grafts of Adult Epicardial-derived Cells That Improve Cardiac Function After Myocardial Infarction.

Rao, Krithika S / Kloppenburg, Jessica E / Marquis, Taylor / Solomon, Laura / McElroy-Yaggy, Keara L / Spees, Jeffrey L

Stem cells (Dayton, Ohio)

2022 Volume 40, Issue 2, Page(s) 204–214

Abstract: Transplantation of stem/progenitor cells holds promise for cardiac regeneration in patients with myocardial infarction (MI). Currently, however, low cell survival and engraftment after transplantation present a major barrier to many forms of cell therapy. ...

Abstract	Transplantation of stem/progenitor cells holds promise for cardiac regeneration in patients with myocardial infarction (MI). Currently, however, low cell survival and engraftment after transplantation present a major barrier to many forms of cell therapy. One issue is that ligands, receptors, and signaling pathways that promote graft success remain poorly understood. Here, we prospectively isolate uncommitted epicardial cells from the adult heart surface by CD104 (β-4 integrin) and demonstrate that C-terminal peptide from connective tissue growth factor (CTGF-D4), when combined with insulin, effectively primes epicardial-derived cells (EPDC) for cardiac engraftment after MI. Similar to native epicardial derivatives that arise from epicardial EMT at the heart surface, the grafted cells migrated into injured myocardial tissue in a rat model of MI with reperfusion. By echocardiography, at 1 month after MI, we observed significant improvement in cardiac function for animals that received epicardial cells primed with CTGF-D4/insulin compared with those that received vehicle-primed (control) cells. In the presence of insulin, CTGF-D4 treatment significantly increased the phosphorylation of Wnt co-receptor LRP6 on EPDC. Competitive engraftment assays and neutralizing/blocking studies showed that LRP6 was required for EPDC engraftment after transplantation. Our results identify LRP6 as a key target for increasing EPDC engraftment after MI and suggest amplification of LRP6 signaling with CTGF-D4/insulin, or by other means, may provide an effective approach for achieving successful cellular grafts in regenerative medicine.
MeSH term(s)	Animals ; Connective Tissue Growth Factor/metabolism ; Heart ; Humans ; Insulins ; Low Density Lipoprotein Receptor-Related Protein-6/metabolism ; Myocardial Infarction/metabolism ; Myocardial Infarction/therapy ; Myocardium/metabolism ; Rats
Chemical Substances	CCN2 protein, rat ; Insulins ; LRP6 protein, human ; Low Density Lipoprotein Receptor-Related Protein-6 ; Connective Tissue Growth Factor (139568-91-5)
Language	English
Publishing date	2022-03-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1143556-2
ISSN	1549-4918 ; 1066-5099
ISSN (online)	1549-4918
ISSN	1066-5099
DOI	10.1093/stmcls/sxab016
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