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Article ; Online: Dry beans (Phaseolus vulgaris L.) modulate the kinetics of lipid digestion in vitro: Impact of the bean matrix and processing.

Lin, Tiantian / O'Keefe, Sean / Duncan, Susan / Fernández-Fraguas, Cristina

Food research international (Ottawa, Ont.)

2023 Volume 173, Issue Pt 1, Page(s) 113245

Abstract: The lipid-lowering effect of dry beans and their impact on lipid and cholesterol metabolism have been established. This study investigates the underlying mechanisms of this effect and explore how the structural integrity of processed beans influences ... ...

Abstract	The lipid-lowering effect of dry beans and their impact on lipid and cholesterol metabolism have been established. This study investigates the underlying mechanisms of this effect and explore how the structural integrity of processed beans influences their ability to modulate lipolysis using the INFOGEST static in vitro digestion model. Dietary fiber (DF) fractions were found to decrease lipolysis by increasing the digesta viscosity, leading to depletion-flocculation and/or coalescence of lipid droplets. Bean flours exhibited a more pronounced reduction in lipolysis compared to DF. Furthermore, different levels of bean structural integrity showed varying effects on modulating lipolysis, with medium-sized bean particles demonstrating a stronger reduction. Hydrothermal treatment compromised the ability of beans to modulate lipid digestion, while hydrostatic-pressure treatment (600 MPa/5min) enhanced the effect. These findings highlight that the lipid-lowering effect of beans is not solely attributed to DF but also to the overall bean matrix, which can be manipulated through processing techniques.
MeSH term(s)	Phaseolus/chemistry ; Dietary Fiber/metabolism ; Lipolysis ; Lipids ; Digestion
Chemical Substances	Dietary Fiber ; Lipids
Language	English
Publishing date	2023-07-06
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2023.113245
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Article ; Online: Performance of alternative drying techniques on hop (Humulus lupulus L.) aroma quality: An HS-SPME-GC-MS-O and chemometrics combined approach.

Su, Xueqian / Hurley, Ken / Xu, Zhiyuan / Xu, Yixiang / Rutto, Laban / O'Keefe, Sean / Scoggins, Holly / Yin, Yun

Food chemistry

2022 Volume 381, Page(s) 132289

Abstract: ... solid-phase microextraction-gas chromatography-mass spectrometry-olfactometry (HS-SPME-GC-MS-O) was employed to analyze ...

Abstract	Economically feasible and effective hop drying strategies are urgently needed to respond to the increasing number of microbrewers in US. In this study, hops were dried by dehydrator-drying (52 °C), oven-drying (52 °C) and freeze-drying (25 °C) until the final moisture content reached 8-10%. Headspace solid-phase microextraction-gas chromatography-mass spectrometry-olfactometry (HS-SPME-GC-MS-O) was employed to analyze the aroma profiles in all dried hops. Methyl octanoate, β-myrcene, trans-α-bergamotene, linalool and geraniol were perceived as high-intensity aromas in all samples. Generally, dehydrator-dried hops contained the highest contents of aroma compounds among all groups, showing an increase of 5-23% and 6-37% when compared to freeze- and oven-dried hops, respectively. Principal component and hierarchical cluster analyses also revealed aroma content differences from three drying methods. Dehydrator drying at 52 °C was therefore considered as an alternative and promising drying approach for smaller-scale hop processing, which can largely benefit regional producers and local craft breweries.
MeSH term(s)	Chemometrics ; Gas Chromatography-Mass Spectrometry/methods ; Humulus ; Odorants/analysis ; Solid Phase Microextraction/methods ; Volatile Organic Compounds/analysis
Chemical Substances	Volatile Organic Compounds
Language	English
Publishing date	2022-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2022.132289
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Article ; Online: Dry beans (Phaseolus vulgaris L.) modulate the kinetics of lipid digestion in vitro: Impact of the bean matrix and processing

Lin, Tiantian / O'Keefe, Sean / Duncan, Susan / Fernández-Fraguas, Cristina

Food Research International. 2023 Nov., v. 173 p.113245-

2023

Abstract	The lipid-lowering effect of dry beans and their impact on lipid and cholesterol metabolism have been established. This study investigates the underlying mechanisms of this effect and explore how the structural integrity of processed beans influences their ability to modulate lipolysis using the INFOGEST static in vitro digestion model. Dietary fiber (DF) fractions were found to decrease lipolysis by increasing the digesta viscosity, leading to depletion-flocculation and/or coalescence of lipid droplets. Bean flours exhibited a more pronounced reduction in lipolysis compared to DF. Furthermore, different levels of bean structural integrity showed varying effects on modulating lipolysis, with medium-sized bean particles demonstrating a stronger reduction. Hydrothermal treatment compromised the ability of beans to modulate lipid digestion, while hydrostatic-pressure treatment (600 MPa/5min) enhanced the effect. These findings highlight that the lipid-lowering effect of beans is not solely attributed to DF but also to the overall bean matrix, which can be manipulated through processing techniques.
Keywords	Phaseolus vulgaris ; beans ; cholesterol metabolism ; dietary fiber ; digesta ; digestion ; food research ; hot water treatment ; lipemic effect ; lipids ; lipolysis ; models ; viscosity ; Dry beans ; Structural integrity ; Food processing ; Emulsion stability ; INFOGEST static in vitro digestion protocol ; Free fatty acids
Language	English
Dates of publication	2023-11
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2023.113245
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Analysis of 1999-2017 NHANES Data: Minimal Increase and Racial Disparities in U.S. Fiber Consumption Over 18 Years.

Cifuentes, Lizeth / O'Keefe, Stephen

Nutrition and cancer

2024 Volume 76, Issue 4, Page(s) 345–351

Abstract: Low dietary fiber consumption is associated with an increased risk of colorectal cancer, a leading cause of cancer-related mortality in the United States. The average daily fiber intake has declined over recent decades. Notably, Black Americans exhibit ... ...

Abstract	Low dietary fiber consumption is associated with an increased risk of colorectal cancer, a leading cause of cancer-related mortality in the United States. The average daily fiber intake has declined over recent decades. Notably, Black Americans exhibit lower fiber consumption than other racial/ethnic groups, possibly influencing their elevated colorectal cancer rates. We hypothesize that there has been a significant increase in dietary fiber consumption in the United States from 1999 to 2017. The study encompassed 59,204 adult NHANES participants and observed variations in caloric intake over survey years. Although there was a slight overall increase in dietary fiber intake compared to 1999, the most substantial increment occurred among individuals classified as Hispanic (AD: +2.86 g,
MeSH term(s)	Adult ; Humans ; Black or African American ; Colorectal Neoplasms/epidemiology ; Dietary Fiber/administration & dosage ; Nutrition Surveys ; United States/epidemiology ; White ; Hispanic or Latino
Chemical Substances	Dietary Fiber
Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	424433-3
ISSN	1532-7914 ; 0163-5581
ISSN (online)	1532-7914
ISSN	0163-5581
DOI	10.1080/01635581.2024.2316366
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Article ; Online: Retention of primary bile salts by dry beans (Phaseolus vulgaris L.) during in vitro digestion: Role of bean components and effect of food processing.

Lin, Tiantian / O'Keefe, Sean / Duncan, Susan / Fernández-Fraguas, Cristina

Food research international (Ottawa, Ont.)

2020 Volume 137, Page(s) 109337

Abstract: The positive effect of common beans on reducing blood cholesterol levels has been linked to their ability to sequester bile salts (BS) and prevent their recycling. We have examined the preferences of major bean components (soluble/insoluble fiber, starch ...

Abstract	The positive effect of common beans on reducing blood cholesterol levels has been linked to their ability to sequester bile salts (BS) and prevent their recycling. We have examined the preferences of major bean components (soluble/insoluble fiber, starch and proteins) to retain BS, and the role played by the bean matrix. Additionally, the kinetics of BS-release were evaluated in bean flours generated by a combination of hydrothermal or high-hydrostatic pressure (HHP), and mechanical treatments. An in vitro digestion model combined with dialysis was used to evaluate separately the retention of primary individual BS. Soluble fiber retained a significant proportion of BS mainly due to an increased digesta viscosity; however, the protein fraction exhibited the greatest BS retention without affecting viscosity. The thermal properties of proteins and starch were more significantly affected in presence of tauro-chenodeoxycholate, which correlated to the affinity of both fractions to retain more hydrophobic BS during digestion. Glyco-chenodeoxycholate and tauro-cholate were the most and least effectively retained BS by bean flours, respectively. Neither of the processing treatments had an impact on the binding preferences of bean flours to the primary BS; however, the largest BS retention was caused by HHP at 600 MPa. Bean materials preferentially delayed the release of chenodeoxycholate BS, which is probably related to BS micelle formation. These findings demonstrate that a combination of viscosity, molecular and compositional factors is triggering the BS-retention capacity of beans, and indicate the importance of evaluating contribution of individual bean components and as whole system.
MeSH term(s)	Bile Acids and Salts ; Digestion ; Food Handling ; Phaseolus ; Renal Dialysis
Chemical Substances	Bile Acids and Salts
Language	English
Publishing date	2020-05-19
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2020.109337
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Manipulation of the dry bean (Phaseolus vulgaris L.) matrix by hydrothermal and high-pressure treatments: Impact on in vitro bile salt-binding ability.

Lin, Tiantian / O'Keefe, Sean / Duncan, Susan / Fernández-Fraguas, Cristina

Food chemistry

2019 Volume 310, Page(s) 125699

Abstract: The capacity of high-fiber foods to sequester BS during digestion is considered a mechanism to lower serum-cholesterol. We investigated the effect of hydrothermal (HT) and high-hydrostatic-pressure (HHP) on the bile salt (BS)-binding ability of dry beans, ...

Abstract	The capacity of high-fiber foods to sequester BS during digestion is considered a mechanism to lower serum-cholesterol. We investigated the effect of hydrothermal (HT) and high-hydrostatic-pressure (HHP) on the bile salt (BS)-binding ability of dry beans, and how this relates to changes in bean microstructure, fiber content (insoluble-IDF/soluble-SDF), and viscosity. HT and HHP-600 MPa led to significant IDF reduction, including resistant starch (RS), whereas 150-450 MPa significantly increased RS, without modifying IDF/SDF content. Microscopy analysis showed that heating disrupted the bean cell wall integrity, protein matrix and starch granules more severely than 600 MPa; however, tightly-packed complexes of globular starch granules-protein-cell wall fiber formed at HHP ≤ 450 MPa. While HT significantly reduced BS-binding efficiency despite no viscosity change, HHP-treatments maintained or enhanced BS-retention. 600 MPa-treatment induced the maximum BS-binding ability and viscosity. These results demonstrate that BS-binding by beans is not solely based on their fiber content or viscosity, but is influenced by additional microstructural factors.
MeSH term(s)	Bile Acids and Salts/metabolism ; Cell Wall/chemistry ; Cell Wall/ultrastructure ; Dietary Fiber/analysis ; Food Handling/methods ; Hydrostatic Pressure ; Phaseolus/chemistry ; Phaseolus/metabolism ; Phaseolus/ultrastructure ; Plant Proteins, Dietary/chemistry ; Solubility ; Starch/chemistry ; Viscosity
Chemical Substances	Bile Acids and Salts ; Dietary Fiber ; Plant Proteins, Dietary ; Starch (9005-25-8)
Language	English
Publishing date	2019-10-25
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2019.125699
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Article: Performance of alternative drying techniques on hop (Humulus lupulus L.) aroma quality: An HS-SPME-GC-MS-O and chemometrics combined approach

Su, Xueqian / Hurley, Ken / Xu, Zhiyuan / Xu, Yixiang / Rutto, Laban / O'Keefe, Sean / Scoggins, Holly / Yin, Yun

Food chemistry. 2022 July 01, v. 381

2022

Abstract: ... solid-phase microextraction–gas chromatography–mass spectrometry–olfactometry (HS-SPME–GC–MS–O) was employed to analyze ...

Abstract	Economically feasible and effective hop drying strategies are urgently needed to respond to the increasing number of microbrewers in US. In this study, hops were dried by dehydrator-drying (52 °C), oven-drying (52 °C) and freeze-drying (25 °C) until the final moisture content reached 8–10%. Headspace solid-phase microextraction–gas chromatography–mass spectrometry–olfactometry (HS-SPME–GC–MS–O) was employed to analyze the aroma profiles in all dried hops. Methyl octanoate, β-myrcene, trans-α-bergamotene, linalool and geraniol were perceived as high-intensity aromas in all samples. Generally, dehydrator-dried hops contained the highest contents of aroma compounds among all groups, showing an increase of 5–23% and 6–37% when compared to freeze- and oven-dried hops, respectively. Principal component and hierarchical cluster analyses also revealed aroma content differences from three drying methods. Dehydrator drying at 52 °C was therefore considered as an alternative and promising drying approach for smaller-scale hop processing, which can largely benefit regional producers and local craft breweries.
Keywords	Humulus lupulus ; chemometrics ; economic feasibility ; food chemistry ; freeze drying ; geraniol ; headspace analysis ; linalool ; octanoic acid ; odors ; water content
Language	English
Dates of publication	2022-0701
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2022.132289
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A Placebo-Controlled Trial of PCI for Stable Angina.

Sherrod, Charles F / O'Keefe, Evan L / Ikemura, Nobuhiro

The New England journal of medicine

2024 Volume 390, Issue 12, Page(s) 1150

MeSH term(s)	Humans ; Angina, Stable/therapy ; Percutaneous Coronary Intervention ; Coronary Artery Disease ; Coronary Angiography
Language	English
Publishing date	2024-03-20
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2400751
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Article ; Online: Spiro[3.5]nonenyl Meroterpenoid Lactones, Cryptolaevilactones G-L, an Ionone Derivative, and Total Synthesis of Cryptolaevilactone M from

Tsurumi, Fumika / Miura, Yuta / Nakano, Misaki / Saito, Yohei / Fukuyoshi, Shuichi / Miyake, Katsunori / Newman, David J / O'Keefe, Barry R / Lee, Kuo-Hsiung / Nakagawa-Goto, Kyoko

Journal of natural products

2019 Volume 82, Issue 9, Page(s) 2368–2378

Abstract: ... A ... ...

Abstract	A CH
MeSH term(s)	Antineoplastic Agents, Phytogenic/chemistry ; Cell Line, Tumor ; Cryptocarya/chemistry ; Humans ; Lactones/chemistry ; Molecular Structure ; Monoterpenes/chemistry ; Plant Leaves/chemistry ; Spectrum Analysis/methods ; Spiro Compounds/chemistry
Chemical Substances	Antineoplastic Agents, Phytogenic ; Lactones ; Monoterpenes ; Spiro Compounds
Language	English
Publishing date	2019-08-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.8b00732
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Article ; Online: In reply-regarding L-carnitine and cardiovascular disease.

DiNicolantonio, James J / O'Keefe, James H / Lavie, Carl J

Mayo Clinic proceedings

2013 Volume 88, Issue 8, Page(s) 900–901

MeSH term(s)	Carnitine/therapeutic use ; Humans ; Myocardial Infarction/prevention & control ; Secondary Prevention ; Vitamin B Complex/therapeutic use
Chemical Substances	Vitamin B Complex (12001-76-2) ; Carnitine (S7UI8SM58A)
Language	English
Publishing date	2013-08
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	124027-4
ISSN	1942-5546 ; 0025-6196
ISSN (online)	1942-5546
ISSN	0025-6196
DOI	10.1016/j.mayocp.2013.06.010
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