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Article ; Online: Deciphering Tumor Cell Evolution in Cutaneous T-Cell Lymphomas: Distinct Differentiation Trajectories in Mycosis Fungoides and Sézary Syndrome.

Jiang, Tony T / Cao, Simon / Kruglov, Oleg / Virmani, Aman / Geskin, Larisa J / Falo, Louis D / Akilov, Oleg E

The Journal of investigative dermatology

2023 Volume 144, Issue 5, Page(s) 1088–1098

Abstract: Cutaneous T-cell lymphomas are a heterogeneous group of neoplasms originating in the skin ...

Abstract	Cutaneous T-cell lymphomas are a heterogeneous group of neoplasms originating in the skin, with mycosis fungoides (MF) and Sézary syndrome (SS) representing the most common variants. The cellular origin of cutaneous lymphomas has remained controversial owing to their immense phenotypic heterogeneity that obfuscates lineage reconstruction on the basis of classical surface biomarkers. To overcome this heterogeneity and reconstruct the differentiation trajectory of malignant cells in MF and SS, TCR sequencing was performed in parallel with targeted transcriptomics at the single-cell resolution among cutaneous samples in MF and SS. Unsupervised lineage reconstruction showed that Sézary cells exist as a population of CD4
MeSH term(s)	Humans ; Sezary Syndrome/pathology ; Sezary Syndrome/genetics ; Sezary Syndrome/immunology ; Mycosis Fungoides/pathology ; Mycosis Fungoides/genetics ; Mycosis Fungoides/immunology ; Skin Neoplasms/pathology ; Skin Neoplasms/genetics ; Skin Neoplasms/immunology ; Cell Differentiation ; Male ; Lymphoma, T-Cell, Cutaneous/pathology ; Lymphoma, T-Cell, Cutaneous/genetics ; Middle Aged ; Female ; Aged ; Cell Proliferation/genetics
Language	English
Publishing date	2023-11-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80136-7
ISSN	1523-1747 ; 0022-202X
ISSN (online)	1523-1747
ISSN	0022-202X
DOI	10.1016/j.jid.2023.10.018
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Article ; Online: T-blocker

Hanyoup Kim / Aaron E Ruby / Harini G Shandilya / Arvind K Virmani / Nandita Rahman / Christina M Strange / Jarkko Huuskonen

BioTechniques, Vol 65, Iss 4, Pp 205-

a simple and robust probe-free quantitative PCR assay to detect somatic mutations down to 0.1% frequency

2018 Volume 210

Abstract: ... a novel T-blocker concept to the allele-specific PCR method. Four new KRAS and BRAF mutation detection ... with selective wild-type suppression by the T-blocker concept enabled 0.1% detection sensitivity using ... consistency in sensitivity and specificity of the T-blocker assay concept was demonstrated. ...

Abstract	We have developed a simple and robust probe-free quantitative PCR (qPCR) assay method that can detect minor mutant alleles with a frequency as low as 0.1% in a heterogeneous sample by introducing a novel T-blocker concept to the allele-specific PCR method. Four new KRAS and BRAF mutation detection assays were developed and their performance was demonstrated by testing a large number of replicates, utilizing a customized PCR protocol. Highly efficient and specific mutant amplification in conjunction with selective wild-type suppression by the T-blocker concept enabled 0.1% detection sensitivity using the intercalating dye-based qPCR chemistry instead of more complex target-specific dye-labeled probes. Excellent consistency in sensitivity and specificity of the T-blocker assay concept was demonstrated.
Keywords	intercalating dye ; qPCR ; somatic mutation detection ; T-blocker ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2018-10-01T00:00:00Z
Publisher	Future Science Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Single-cell analysis shows that adipose tissue of persons with both HIV and diabetes is enriched for clonal, cytotoxic, and CMV-specific CD4+ T cells.

Wanjalla, Celestine N / McDonnell, Wyatt J / Ram, Ramesh / Chopra, Abha / Gangula, Rama / Leary, Shay / Mashayekhi, Mona / Simmons, Joshua D / Warren, Christian M / Bailin, Samuel / Gabriel, Curtis L / Guo, Liang / Furch, Briana D / Lima, Morgan C / Woodward, Beverly O / Hannah, LaToya / Pilkinton, Mark A / Fuller, Daniela T / Kawai, Kenji /

Virmani, Renu / Finn, Aloke V / Hasty, Alyssa H / Mallal, Simon A / Kalams, Spyros A / Koethe, John R

Cell reports. Medicine

2021 Volume 2, Issue 2, Page(s) 100205

Abstract: ... Adipose tissue is an important regulator of glucose and lipid metabolism, and adipose tissue T cells modulate ...

Abstract	Persons with HIV are at increased risk for diabetes mellitus compared with individuals without HIV. Adipose tissue is an important regulator of glucose and lipid metabolism, and adipose tissue T cells modulate local inflammatory responses and, by extension, adipocyte function. Persons with HIV and diabetes have a high proportion of CX3CR1
MeSH term(s)	Adipose Tissue/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cytomegalovirus/immunology ; Cytomegalovirus Infections/immunology ; Diabetes Mellitus/metabolism ; HIV Infections/immunology ; Humans ; Single-Cell Analysis/methods ; T-Lymphocyte Subsets/immunology
Language	English
Publishing date	2021-02-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2666-3791
ISSN (online)	2666-3791
DOI	10.1016/j.xcrm.2021.100205
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Article ; Online: Primary cutaneous aggressive epidermotropic cytotoxic T-cell lymphomas: reappraisal of a provisional entity in the 2016 WHO classification of cutaneous lymphomas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

2017 Volume 30, Issue 5, Page(s) 761–772

Abstract: Primary cutaneous CD8-positive aggressive epidermotropic T-cell lymphoma is a rare and poorly ... lesions. We identified cases with lack of CD8 or αβ T-cell receptor expression yet with similar clinical ... remissions in 5/6 patients. We recommend the term primary cutaneous aggressive epidermotropic cytotoxic T ...

Abstract	Primary cutaneous CD8-positive aggressive epidermotropic T-cell lymphoma is a rare and poorly characterized variant of cutaneous lymphoma still considered a provisional entity in the latest 2016 World Health Organization Classification of Cutaneous lymphomas. We sought to better characterize and provide diagnostic and therapeutic guidance of this rare cutaneous lymphoma. Thirty-four patients with a median age of 77 years (range 19-89 years) presented primarily with extensive annular necrotic plaques or tumor lesions with frequent mucous membrane involvement. The 5-year survival was 32% with a median survival of 12 months. A subset of 17 patients had a prodrome of chronic patches prior to the development of aggressive ulcerative lesions. We identified cases with lack of CD8 or αβ T-cell receptor expression yet with similar clinical and pathological presentation. Allogeneic stem cell transplantation provided partial or complete remissions in 5/6 patients. We recommend the term primary cutaneous aggressive epidermotropic cytotoxic T-cell lymphoma as this more broad designation better describes this clinical-pathologic presentation, which allows the inclusion of cases with CD8 negative and/or αβ/γδ T-cell receptor chain double-positive or double-negative expression. We have identified early skin signs of chronic patch/plaque lesions that are often misdiagnosed as eczema, psoriasis, or mycosis fungoides. Our experience confirms the poor prognosis of this entity and highlights the inefficacy of our standard therapies with the exception of allogeneic stem cell transplantation in selected cases.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Lymphoma, T-Cell, Cutaneous ; Male ; Middle Aged ; Skin Neoplasms ; T-Lymphocytes, Cytotoxic/pathology ; World Health Organization ; Young Adult
Language	English
Publishing date	2017-01-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	645073-8
ISSN	1530-0285 ; 0893-3952
ISSN (online)	1530-0285
ISSN	0893-3952
DOI	10.1038/modpathol.2016.240
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Zs.A 2450: Show issues

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Article ; Online: Systemic therapy for cutaneous T-cell lymphoma: who, when, what, and why?

Virmani, Pooja / Hwang, Susan H / Hastings, Justin G / Haverkos, Bradley M / Kohnken, Becca / Gru, Alejandro A / Mishra, Anjali / Fabbro, Stephanie K / Horwitz, Steve M / Porcu, Pierluigi

Expert review of hematology

2017 Volume 10, Issue 2, Page(s) 111–121

Abstract: Introduction: CTCL are rare neoplasms. Optimal care requires integrated use of diagnostic and treatment modalities spanning multiple specialties. Current instruments for patient risk stratification and disease measurement across all anatomical ... ...

Abstract	Introduction: CTCL are rare neoplasms. Optimal care requires integrated use of diagnostic and treatment modalities spanning multiple specialties. Current instruments for patient risk stratification and disease measurement across all anatomical compartments are suboptimal. A common treatment dichotomy between early (Dermatology) and advanced stage (Hematology-Oncology) has hindered accrual of long term outcome data. Thus, important facts about natural history, such as frequency and determinants of stage progression, and the impact of specific treatment modalities on these endpoints, are not known. Areas covered: One of the most important decisions in the management of CTCL is when to start systemic therapy and what agents to use. This review provides background information to understand why systemic therapy is needed and what goals are currently achievable. Expert commentary: Risk-adapted approaches, based on better knowledge of host and tumor biology, and more accurate disease measurement tools are needed to optimize the use of specific systemic therapies.
MeSH term(s)	Biomedical Research ; Clinical Decision-Making ; Combined Modality Therapy ; Disease Management ; Humans ; Lymphoma, T-Cell, Cutaneous/diagnosis ; Lymphoma, T-Cell, Cutaneous/etiology ; Lymphoma, T-Cell, Cutaneous/mortality ; Lymphoma, T-Cell, Cutaneous/therapy ; Neoplasm Staging ; Risk Assessment ; Standard of Care ; Treatment Outcome
Language	English
Publishing date	2017-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2516804-6
ISSN	1747-4094 ; 1747-4086
ISSN (online)	1747-4094
ISSN	1747-4086
DOI	10.1080/17474086.2017.1270201
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Zs.A 6943: Show issues

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Article ; Online: T-blocker: a simple and robust probe-free quantitative PCR assay to detect somatic mutations down to 0.1% frequency.

Kim, Hanyoup / Ruby, Aaron E / Shandilya, Harini G / Virmani, Arvind K / Rahman, Nandita / Strange, Christina M / Huuskonen, Jarkko

BioTechniques

2018 Volume 65, Issue 4, Page(s) 205–210

Abstract	We have developed a simple and robust probe-free quantitative PCR (qPCR) assay method that can detect minor mutant alleles with a frequency as low as 0.1% in a heterogeneous sample by introducing a novel T-blocker concept to the allele-specific PCR method. Four new KRAS and BRAF mutation detection assays were developed and their performance was demonstrated by testing a large number of replicates, utilizing a customized PCR protocol. Highly efficient and specific mutant amplification in conjunction with selective wild-type suppression by the T-blocker concept enabled 0.1% detection sensitivity using the intercalating dye-based qPCR chemistry instead of more complex target-specific dye-labeled probes. Excellent consistency in sensitivity and specificity of the T-blocker assay concept was demonstrated.
MeSH term(s)	Alleles ; Coloring Agents/analysis ; DNA/analysis ; DNA/genetics ; DNA Mutational Analysis/methods ; HeLa Cells ; Humans ; Intercalating Agents/analysis ; Mutation ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins p21(ras)/genetics ; Real-Time Polymerase Chain Reaction/methods
Chemical Substances	Coloring Agents ; Intercalating Agents ; KRAS protein, human ; DNA (9007-49-2) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
Language	English
Publishing date	2018-10-04
Publishing country	England
Document type	Journal Article
ZDB-ID	48453-2
ISSN	1940-9818 ; 0736-6205
ISSN (online)	1940-9818
ISSN	0736-6205
DOI	10.2144/btn-2018-0111
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Zs.A 2435: Show issues

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Article ; Online: Managing Patients with Cutaneous B-Cell and T-Cell Lymphomas Other Than Mycosis Fungoides.

Kheterpal, Meenal / Mehta-Shah, Neha / Virmani, Pooja / Myskowski, Patricia L / Moskowitz, Alison / Horwitz, Steven M

Current hematologic malignancy reports

2016 Volume 11, Issue 3, Page(s) 224–233

Abstract: ... for managing patients with cutaneous B-cell and T-cell lymphomas other than mycosis fungoides. ...

Abstract	Cutaneous lymphomas (CL) are a heterogeneous group of neoplasms characterized with clinical and histopathological variation, as well as overlap with benign dermatoses. Diagnosis and treatment of CLs is challenging and often requires a multidisciplinary approach. However, prognostic knowledge of these conditions and awareness of treatment options can help optimize appropriate use of available regimens, thereby improving care for patients. Here, we review the most recent literature and outline treatment themes for managing patients with cutaneous B-cell and T-cell lymphomas other than mycosis fungoides.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Humans ; Lymphoma, B-Cell/diagnosis ; Lymphoma, B-Cell/drug therapy ; Lymphoma, B-Cell/radiotherapy ; Lymphoma, T-Cell/diagnosis ; Lymphoma, T-Cell/drug therapy ; Lymphoma, T-Cell/radiotherapy ; Mycosis Fungoides/diagnosis ; Mycosis Fungoides/drug therapy ; Practice Guidelines as Topic ; Recurrence ; Skin Neoplasms/diagnosis ; Skin Neoplasms/drug therapy ; Skin Neoplasms/radiotherapy ; Translocation, Genetic
Language	English
Publishing date	2016-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2229765-0
ISSN	1558-822X ; 1558-8211
ISSN (online)	1558-822X
ISSN	1558-8211
DOI	10.1007/s11899-016-0322-5
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Article ; Online: Whole exome sequencing in a multi-generation family from India reveals a genetic variation c.10C>T (p.Gln4Ter) in keratin 5 gene associated with Dowling-Degos disease.

Virmani, Neha / Vellarikkal, Shamsudheen Karuthedath / Verma, Ankit / Jayarajan, Rijith / Sakhiya, Jagdish / Desai, Chirag / Sivasubbu, Sridhar / Scaria, Vinod

Indian journal of dermatology, venereology and leprology

2018 Volume 84, Issue 3, Page(s) 344–346

MeSH term(s)	Adult ; Family ; Female ; Genetic Association Studies/methods ; Genetic Variation/genetics ; Humans ; Hyperpigmentation/diagnosis ; Hyperpigmentation/genetics ; India ; Keratin-5/genetics ; Male ; Pedigree ; Skin Diseases, Genetic/diagnosis ; Skin Diseases, Genetic/genetics ; Skin Diseases, Papulosquamous/diagnosis ; Skin Diseases, Papulosquamous/genetics ; Whole Exome Sequencing/methods
Chemical Substances	Keratin-5
Language	English
Publishing date	2018-03-30
Publishing country	India
Document type	Case Reports ; Letter
ZDB-ID	416068-x
ISSN	0973-3922 ; 0019-5162 ; 0378-6323
ISSN (online)	0973-3922
ISSN	0019-5162 ; 0378-6323
DOI	10.4103/ijdvl.IJDVL_268_17
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Article ; Online: The two-qubit singlet/triplet measurement is universal for quantum computing given only maximally-mixed initial states.

Rudolph, Terry / Virmani, Shashank Soyuz

Nature communications

2023 Volume 14, Issue 1, Page(s) 7800

Abstract: In order to delineate which minimalistic physical primitives can enable the full power of universal quantum computing, it has been fruitful to consider various measurement based architectures which reduce or eliminate the use of coherent unitary ... ...

Abstract	In order to delineate which minimalistic physical primitives can enable the full power of universal quantum computing, it has been fruitful to consider various measurement based architectures which reduce or eliminate the use of coherent unitary evolution, and also involve operations that are physically natural. In this context previous works had shown that the triplet-singlet measurement of two qubit angular momentum (or equivalently two qubit exchange symmetry) yields the power of quantum computation given access to a few additional different single qubit states or gates. However, Freedman, Hastings and Shokrian-Zini
Language	English
Publishing date	2023-11-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-43481-y
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Article ; Online: Nanocarrier-based approaches to combat chronic obstructive pulmonary disease.

Virmani, Tarun / Kumar, Girish / Virmani, Reshu / Sharma, Ashwani / Pathak, Kamla

Nanomedicine (London, England)

2022 Volume 17, Issue 24, Page(s) 1833–1854

Abstract: Abnormalities in airway mucus lead to chronic disorders in the pulmonary system such as asthma, fibrosis and chronic obstructive pulmonary disease (COPD). Among these, COPD is more prominent worldwide. Various conventional approaches are available in the ...

Abstract	Abnormalities in airway mucus lead to chronic disorders in the pulmonary system such as asthma, fibrosis and chronic obstructive pulmonary disease (COPD). Among these, COPD is more prominent worldwide. Various conventional approaches are available in the market for the treatment of COPD, but the delivery of drugs to the target site remains a challenge with conventional approaches. Nanocarrier-based approaches are considered the best due to their sustained release properties to the target site, smaller size, high surface-to-volume ratio, patient compliance, overcoming airway defenses and improved pharmacotherapy. This article provides updated information about the treatment of COPD along with nanocarrier-based approaches as well as the potential of gene therapy and stem cell therapy to combat the COPD.
MeSH term(s)	Humans ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Asthma/drug therapy ; Chronic Disease ; Mucus
Language	English
Publishing date	2022-07-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2277839-1
ISSN	1748-6963 ; 1743-5889
ISSN (online)	1748-6963
ISSN	1743-5889
DOI	10.2217/nnm-2021-0403
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