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Article: The Impact of Cytomegalovirus Infection on Natural Killer and CD8+ T Cell Phenotype in Multiple Sclerosis.

Perri, Valentina / Zingaropoli, Maria Antonella / Pasculli, Patrizia / Ciccone, Federica / Tartaglia, Matteo / Baione, Viola / Malimpensa, Leonardo / Ferrazzano, Gina / Mastroianni, Claudio Maria / Conte, Antonella / Ciardi, Maria Rosa

Biology

2024 Volume 13, Issue 3

Abstract: Multiple sclerosis (MS) is a debilitating neurological disease that has been classified as an immune-mediated attack on myelin, the protective sheath of nerves. Some aspects of its pathogenesis are still unclear; nevertheless, it is generally established ...

Abstract	Multiple sclerosis (MS) is a debilitating neurological disease that has been classified as an immune-mediated attack on myelin, the protective sheath of nerves. Some aspects of its pathogenesis are still unclear; nevertheless, it is generally established that viral infections influence the course of the disease. Cytomegalovirus (CMV) is a major pathogen involved in alterations of the immune system, including the expansion of highly differentiated cytotoxic CD8+ T cells and the accumulation of adaptive natural killer (NK) cells expressing high levels of the NKG2C receptor. In this study, we evaluated the impact of latent CMV infection on MS patients through the characterization of peripheral NK cells, CD8+ T cells, and NKT-like cells using flow cytometry. We evaluated the associations between immune cell profiles and clinical features such as MS duration and MS progression, evaluated using the Expanded Disability Status Scale (EDSS). We showed that NK cells, CD8+ T cells, and NKT-like cells had an altered phenotype in CMV-infected MS patients and displayed high levels of the NKG2C receptor. Moreover, in MS patients, increased NKG2C expression levels were found to be associated with higher EDSS scores. Overall, these results support the hypothesis that CMV infection imprints the immune system by modifying the phenotype and receptor repertoire of NK and CD8+ T cells, suggesting a detrimental role of CMV on MS progression.
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology13030154
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: COVID-19 vaccination in cancer patients: Immune responses one year after the third dose.

Campagna, Roberta / Dominelli, Federica / Zingaropoli, Maria Antonella / Ciurluini, Fabio / Grilli, Giorgia / Amoroso, Alessandra / De Domenico, Angelo / Amatore, Donatella / Lia, Maria Stella / Cortesi, Enrico / Picone, Vincenzo / Mastroianni, Claudio Maria / Ciardi, Maria Rosa / De Santis, Riccardo / Lista, Florigio / Antonelli, Guido / Turriziani, Ombretta

Vaccine

2024 Volume 42, Issue 10, Page(s) 2687–2694

Abstract: Cancer patients (CPs), being immunosuppressed due to the treatment received or to the disease itself, are more susceptible to infections and their potential complications, showing therefore an increased risk of developing severe COVID-19 compared to the ... ...

Abstract	Cancer patients (CPs), being immunosuppressed due to the treatment received or to the disease itself, are more susceptible to infections and their potential complications, showing therefore an increased risk of developing severe COVID-19 compared to the general population. We evaluated the immune responses to anti-SARS-CoV-2 vaccination in patients with solid tumors one year after the administration of the third dose and the effect of cancer treatment on vaccine immunogenicity was assessed. Healthy donors (HDs) were enrolled. Binding and neutralizing antibody (Ab) titers were evaluated using chemiluminescence immunoassay (CLIA) and Plaque Reduction Neutralization Test (PRNT) respectively. T-cell response was analyzed using multiparametric flow cytometry. CPs who were administered three vaccine doses showed lower Ab titers than CPs with four doses and HDs. Overall, a lower cell-mediated response was found in CPs, with a predominance of monofunctional T-cells producing TNFα. Lower Ab titers and a weaker T-cell response were observed in CPs without prior SARS-CoV-2 infection when compared to those with a previous infection. While no differences in the humoral response were found comparing immunotherapy and non-immunotherapy patients, a stronger T-cell response in CPs treated with immunotherapy was observed. Our results emphasize the need of booster doses in cancer patients to achieve a level of protection similar to that observed in healthy donors and underlines the importance of considering the treatment received to reach a proper immune response.
MeSH term(s)	Humans ; COVID-19 Vaccines ; COVID-19/prevention & control ; SARS-CoV-2 ; Vaccination ; Neoplasms/therapy ; Antibodies, Viral ; Antibodies, Neutralizing
Chemical Substances	COVID-19 Vaccines ; Antibodies, Viral ; Antibodies, Neutralizing
Language	English
Publishing date	2024-03-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2024.03.017
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Article: The Long-Term Immunogenicity of mRNABNT162b Third Vaccine Dose in Solid Organ Transplant Recipients.

Zingaropoli, Maria Antonella / Guardiani, Mariasilvia / Dominelli, Federica / Tortellini, Eeva / Garofalo, Manuela / Cogliati Dezza, Francesco / Centofanti, Anastasia / Carillo, Carolina / Napoli, Anna / Venuta, Federico / Mastroianni, Claudio Maria / Pretagostini, Renzo / Lichtner, Miriam / Ciardi, Maria Rosa / Russo, Gianluca

Vaccines

2024 Volume 12, Issue 3

Abstract: We investigated humoral and T-cell response to a SARS-CoV-2 mRNA vaccine in solid organ transplant recipients (SOT-Rs) and healthy donors (HDs) before (T0) and after two (T1) and twelve months (T2) since the third dose administration. SOT-Rs were ... ...

Abstract	We investigated humoral and T-cell response to a SARS-CoV-2 mRNA vaccine in solid organ transplant recipients (SOT-Rs) and healthy donors (HDs) before (T0) and after two (T1) and twelve months (T2) since the third dose administration. SOT-Rs were stratified according to the transplanted organ and to the time elapsed since the transplant. In SOT-Rs, detectable levels of anti-S antibodies were observed in 44%, 81% and 88% at T0, T1 and T2, respectively. Conversely, anti-S antibody levels were detected in 100% of HD at all time points. Lower antibody titers were observed in SOT-Rs compared to HDs, even stratifying by transplanted organs and the time elapsed since transplant. Lower percentages of responding and polyfunctional T-cells were observed in SOT-Rs as well as in each subgroup of SOT-Rs compared to HDs. At both T0 and T1, in SOT-Rs, a predominance of one cytokine production shortly was observed. Conversely, at T2, a dynamic change in the T-cells subset distribution was observed, similar to what was observed in HDs. In SOT-Rs, the third dose increased the rate of seroconversion, although anti-S levels remained lower compared to HDs, and a qualitatively inferior T-cell response to vaccination was observed. Vaccine effectiveness in SOT-Rs is still suboptimal and might be improved by booster doses and prophylactic strategies.
Language	English
Publishing date	2024-02-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines12030224
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Article ; Online: Biomarkers of Neurological Damage: From Acute Stage to Post-Acute Sequelae of COVID-19.

Zingaropoli, Maria Antonella / Pasculli, Patrizia / Barbato, Christian / Petrella, Carla / Fiore, Marco / Dominelli, Federica / Latronico, Tiziana / Ciccone, Federica / Antonacci, Michele / Liuzzi, Grazia Maria / Talarico, Giuseppina / Bruno, Giuseppe / Galardo, Gioacchino / Pugliese, Francesco / Lichtner, Miriam / Mastroianni, Claudio Maria / Minni, Antonio / Ciardi, Maria Rosa

Cells

2023 Volume 12, Issue 18

Abstract: ... ...

Abstract	Background
MeSH term(s)	Humans ; Male ; Female ; COVID-19/complications ; Post-Acute COVID-19 Syndrome ; Brain ; Biomarkers ; Disease Progression
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-09-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12182270
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Article ; Online: COVID-19 Affects Serum Brain-Derived Neurotrophic Factor and Neurofilament Light Chain in Aged Men: Implications for Morbidity and Mortality.

Petrella, Carla / Zingaropoli, Maria Antonella / Ceci, Flavio Maria / Pasculli, Patrizia / Latronico, Tiziana / Liuzzi, Grazia Maria / Ciardi, Maria Rosa / Angeloni, Antonio / Ettorre, Evaristo / Menghi, Michela / Barbato, Christian / Ferraguti, Giampiero / Minni, Antonio / Fiore, Marco

Cells

2023 Volume 12, Issue 4

Abstract: Background and methods: Severe COVID-19 is known to induce neurological damage (NeuroCOVID), mostly in aged individuals, by affecting brain-derived neurotrophic factor (BDNF), matrix metalloproteinases (MMP) 2 and 9 and the neurofilament light chain ( ... ...

Abstract	Background and methods: Severe COVID-19 is known to induce neurological damage (NeuroCOVID), mostly in aged individuals, by affecting brain-derived neurotrophic factor (BDNF), matrix metalloproteinases (MMP) 2 and 9 and the neurofilament light chain (NFL) pathways. Thus, the aim of this pilot study was to investigate BDNF, MMP-2, MMP-9, and NFL in the serum of aged men affected by COVID-19 at the beginning of the hospitalization period and characterized by different outcomes, i.e., attending a hospital ward or an intensive care unit (ICU) or with a fatal outcome. As a control group, we used a novelty of the study, unexposed age-matched men. We also correlated these findings with the routine blood parameters of the recruited individuals. Results: We found in COVID-19 individuals with severe or lethal outcomes disrupted serum BDNF, NFL, and MMP-2 presence and gross changes in ALT, GGT, LDH, IL-6, ferritin, and CRP. We also confirmed and extended previous data, using ROC analyses, showing that the ratio MMPs (2 and 9) versus BDNF and NFL might be a useful tool to predict a fatal COVID-19 outcome. Conclusions: Serum BDNF and NFL and/or their ratios with MMP-2 and MMP-9 could represent early predictors of NeuroCOVID in aged men.
MeSH term(s)	Male ; Humans ; Aged ; Brain-Derived Neurotrophic Factor ; Matrix Metalloproteinase 9 ; Matrix Metalloproteinase 2 ; Intermediate Filaments ; Pilot Projects ; COVID-19 ; Morbidity
Chemical Substances	Brain-Derived Neurotrophic Factor ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Matrix Metalloproteinase 2 (EC 3.4.24.24)
Language	English
Publishing date	2023-02-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12040655
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Immunogenicity and Efficacy of Vaccination in People Living with Human Immunodeficiency Virus.

Tortellini, Eeva / Fosso Ngangue, Yann Collins / Dominelli, Federica / Guardiani, Mariasilvia / Falvino, Carmen / Mengoni, Fabio / Carraro, Anna / Marocco, Raffaella / Pasculli, Patrizia / Mastroianni, Claudio Maria / Ciardi, Maria Rosa / Lichtner, Miriam / Zingaropoli, Maria Antonella

Viruses

2023 Volume 15, Issue 9

Abstract: People living with HIV (PLWH) remain at high risk of mortality and morbidity from vaccine-preventable diseases, even though antiretroviral therapy (ART) has restored life expectancy and general well-being. When, which, and how many doses of vaccine ... ...

Abstract	People living with HIV (PLWH) remain at high risk of mortality and morbidity from vaccine-preventable diseases, even though antiretroviral therapy (ART) has restored life expectancy and general well-being. When, which, and how many doses of vaccine should be administered over the lifetime of PLWH are questions that have become clinically relevant. Immune responses to most vaccines are known to be impaired in PLWH. Effective control of viremia with ART and restored CD4+ T-cell count are correlated with an improvement in responsiveness to routine vaccines. However, the presence of immune alterations, comorbidities and co-infections may alter it. In this article, we provide a comprehensive review of the literature on immune responses to different vaccines in the setting of HIV infection, emphasizing the potential effect of HIV-related factors and presence of comorbidities in modulating such responses. A better understanding of these issues will help guide vaccination and prevention strategies for PLWH.
Language	English
Publishing date	2023-08-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15091844
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Article ; Online: Tissue Inhibitor of Matrix Metalloproteinases-1 (TIMP-1) and Pulmonary Involvement in COVID-19 Pneumonia.

Zingaropoli, Maria Antonella / Latronico, Tiziana / Pasculli, Patrizia / Masci, Giorgio Maria / Merz, Roberta / Ciccone, Federica / Dominelli, Federica / Del Borgo, Cosmo / Lichtner, Miriam / Iafrate, Franco / Galardo, Gioacchino / Pugliese, Francesco / Panebianco, Valeria / Ricci, Paolo / Catalano, Carlo / Ciardi, Maria Rosa / Liuzzi, Grazia Maria / Mastroianni, Claudio Maria

Biomolecules

2023 Volume 13, Issue 7

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Tissue Inhibitor of Metalloproteinase-1 ; Matrix Metalloproteinase 9 ; Matrix Metalloproteinase 2 ; Tissue Inhibitor of Metalloproteinase-2 ; COVID-19 ; Matrix Metalloproteinase 1
Chemical Substances	Tissue Inhibitor of Metalloproteinase-1 ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Tissue Inhibitor of Metalloproteinase-2 (127497-59-0) ; Matrix Metalloproteinase 1 (EC 3.4.24.7)
Language	English
Publishing date	2023-06-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13071040
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Article ; Online: Evaluation of the anti-proliferative activity of violacein, a natural pigment of bacterial origin, in urinary bladder cancer cell lines.

Neroni, Bruna / Zingaropoli, Maria Antonella / Radocchia, Giulia / Ciardi, Maria Rosa / Mosca, Luciana / Pantanella, Fabrizio / Schippa, Serena

Oncology letters

2022 Volume 23, Issue 4, Page(s) 132

Abstract: Violacein is a natural pigment, a pyrrolidone, and a bisindole derived from the condensation of two tryptophan molecules, which gives a blue violet color to several gram-negative violacein-producing bacteria. Violacein production provides a competitive ... ...

Abstract	Violacein is a natural pigment, a pyrrolidone, and a bisindole derived from the condensation of two tryptophan molecules, which gives a blue violet color to several gram-negative violacein-producing bacteria. Violacein production provides a competitive advantage against antagonistic species or predators. In addition, the compound has antibacterial, antifungal, antiviral, and antioxidant activities. Several studies on colon, breast, and head and neck cancer lines have already demonstrated the anti-proliferative potential of violacein. Bladder cancer is one of the most common types of cancer in urology. The therapeutic approach is mainly based on surgery, chemotherapy, and immunotherapy. The aim of the present study was to evaluate the anti-proliferative activity of violacein against the human bladder cancer cell lines, HTB4 (T24) and HTB9 (5637), using low-grade and high-grade transitional cell carcinoma models, respectively, which has never been assayed before. For this purpose, the potential violacein anti-proliferative effect on T24 and 5637 cells was evaluated by studying the cell viability, proliferation, cell cycle, and caspase-3 activation. The results showed that violacein had anti-proliferative activity in the two cell lines, which was greater for the second-stage bladder cancer cell line (5637), and a different mode of action against the two cell lines.
Language	English
Publishing date	2022-02-23
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2022.13252
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Article ; Online: Application of machine learning approach in emergency department to support clinical decision making for SARS-CoV-2 infected patients.

Casano, Nicolò / Santini, Silvano Junior / Vittorini, Pierpaolo / Sinatti, Gaia / Carducci, Paolo / Mastroianni, Claudio Maria / Ciardi, Maria Rosa / Pasculli, Patrizia / Petrucci, Emiliano / Marinangeli, Franco / Balsano, Clara

Journal of integrative bioinformatics

2023 Volume 20, Issue 2

Abstract: To support physicians in clinical decision process on patients affected by Coronavirus Disease 2019 (COVID-19) in areas with a low vaccination rate, we devised and evaluated the performances of several machine learning (ML) classifiers fed with readily ... ...

Abstract	To support physicians in clinical decision process on patients affected by Coronavirus Disease 2019 (COVID-19) in areas with a low vaccination rate, we devised and evaluated the performances of several machine learning (ML) classifiers fed with readily available clinical and laboratory data. Our observational retrospective study collected data from a cohort of 779 COVID-19 patients presenting to three hospitals of the Lazio-Abruzzo area (Italy). Based on a different selection of clinical and respiratory (ROX index and PaO2/FiO2 ratio) variables, we devised an AI-driven tool to predict safe discharge from ED, disease severity and mortality during hospitalization. To predict safe discharge our best classifier is an RF integrated with ROX index that reached AUC of 0.96. To predict disease severity the best classifier was an RF integrated with ROX index that reached an AUC of 0.91. For mortality prediction the best classifier was an RF integrated with ROX index, that reached an AUC of 0.91. The results obtained thanks to our algorithms are consistent with the scientific literature an accomplish significant performances to forecast safe discharge from ED and severe clinical course of COVID-19.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19 ; Retrospective Studies ; Emergency Service, Hospital ; Clinical Decision-Making ; Machine Learning
Language	English
Publishing date	2023-03-07
Publishing country	Germany
Document type	Observational Study ; Journal Article
ZDB-ID	2147212-9
ISSN	1613-4516 ; 1613-4516
ISSN (online)	1613-4516
ISSN	1613-4516
DOI	10.1515/jib-2022-0047
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Article: Evaluation of BAFF, APRIL and CD40L in Ocrelizumab-Treated pwMS and Infectious Risk.

Zingaropoli, Maria Antonella / Pasculli, Patrizia / Tartaglia, Matteo / Dominelli, Federica / Ciccone, Federica / Taglietti, Ambra / Perri, Valentina / Malimpensa, Leonardo / Ferrazzano, Gina / Iannetta, Marco / Del Borgo, Cosmo / Lichtner, Miriam / Mastroianni, Claudio Maria / Conte, Antonella / Ciardi, Maria Rosa

Biology

2023 Volume 12, Issue 4

Abstract: Background: The anti-CD20 monoclonal antibody ocrelizumab has been widely employed in the treatment of people with multiple sclerosis (pwMS). However, its B-cell-depleting effect may induce a higher risk of infectious events and alterations in the ... ...

Abstract	Background: The anti-CD20 monoclonal antibody ocrelizumab has been widely employed in the treatment of people with multiple sclerosis (pwMS). However, its B-cell-depleting effect may induce a higher risk of infectious events and alterations in the secretion of B-cell-activating factors, such as BAFF, APRIL and CD40L. Methods: The aim of this study was to investigate plasma BAFF, APRIL and CD40L levels and their relationship with infectious risk in ocrelizumab-treated pwMS at baseline (T0), at 6 months (T6) and at 12 months (T12) after starting the treatment. As a control group, healthy donors (HD) were enrolled too. Results: A total of 38 pwMS and 26 HD were enrolled. At baseline, pwMS showed higher plasma BAFF (
Language	English
Publishing date	2023-04-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12040587
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