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Article ; Online: Development of a Fission Neutron Spectrum from a D-T Neutron Generator by Spectrum Subtraction Technique.

Scates, Wade W / Schrader, Bradley J / Casanova, Konner M

2021 Volume 121, Issue 3, Page(s) 181–192

Abstract: ... in an energy spectrum as close to that of 252Cf as possible. Deuterium-tritium (D-T) neutron generators are ... technology discussed in this paper simulates the 252Cf fission spectrum through a D-T neutron generator ...

Abstract	Abstract: Californium-252 (252Cf) is considered essential by the National Institute of Standards and Technology for the calibration of neutron instrumentation and dosimetry. Californium-252 has a relatively short half-life of 2.645 y; consequently, it must be replaced frequently to produce an adequate neutron flux for calibration. The user community is currently looking for a replacement for 252Cf. The patented technology described herein has a high probability of being that replacement. A preferred method to replace 252Cf would use an affordable and easily maintained neutron source that generates neutrons in an energy spectrum as close to that of 252Cf as possible. Deuterium-tritium (D-T) neutron generators are both affordable and easily maintained, which makes them highly attractive for replacing 252Cf. The patented technology discussed in this paper simulates the 252Cf fission spectrum through a D-T neutron generator by using spectral subtraction. The primary spectrum is built using principally (n,xn) and (n,n') reactions in a variety of materials. In conjunction with the primary spectrum, an engineered background spectrum is generated using a second set of materials. This engineered background spectrum corrects for differences between the primary and desired spectra. This subtraction technique generates a spectrum very similar to 252Cf while maintaining a reasonable flux. Further, by choosing different scattering materials, any fission spectrum can be matched, including the thermal and epithermal components. This flexibility expands the potential use of this technology beyond simulating 252Cf to any desired neutron spectrum below 14 MeV.
MeSH term(s)	Calibration ; Californium ; Neutrons ; Radiometry ; Subtraction Technique ; Tritium
Chemical Substances	Tritium (10028-17-8) ; Californium (975X05H15A)
Language	English
Publishing date	2021-05-07
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2406-5
ISSN	1538-5159 ; 0017-9078
ISSN (online)	1538-5159
ISSN	0017-9078
DOI	10.1097/HP.0000000000001431
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Zs.A 128: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Hodgson, J., Lamson, A., Mendenhall, T., & Crane, D. (Eds.) (2014). Medical family therapy: Advanced applications. New York, NY: Springer, 489 pp. $89.99.

Rosenberg, Tziporah / Turnipseed, Wade

Journal of marital and family therapy

2016 Volume 42, Issue 4, Page(s) 754–755

Language	English
Publishing date	2016-10
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	224679-x
ISSN	1752-0606 ; 0194-472X
ISSN (online)	1752-0606
ISSN	0194-472X
DOI	10.1111/jmft.12163
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Zs.A 6389: Show issues

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Article ; Online: How often is the diagnosis of the permanent vegetative state incorrect? A review of the evidence.

Wade, D T

European journal of neurology

2018 Volume 25, Issue 4, Page(s) 619–625

Abstract: Some research suggests that 40% of people in the vegetative state are misdiagnosed. This review investigates the frequency, nature and causes of reported misdiagnosis of patients in the vegetative state, focusing on the nature of the error. It is a ... ...

Abstract	Some research suggests that 40% of people in the vegetative state are misdiagnosed. This review investigates the frequency, nature and causes of reported misdiagnosis of patients in the vegetative state, focusing on the nature of the error. It is a systematic review of all relevant literature, using references from key papers identified. The data are summarized in tables. Five clinical studies of the rate of misdiagnosis in practice were identified, encompassing 236 patients in the vegetative state of whom 80 (34%) were reclassified as having some awareness, often minimal. The studies often included patients in the recovery phase after acute injury, and were poorly reported. Five systematic reviews of signs and technologically based neurophysiological tests were identified, and they showed that most studies were small, lacked accurate or important details, and were subject to bias. Studies were not replicated. Many signs and tests did not differ between people in the vegetative state and in the minimally conscious state, and those that did were unable to diagnose an individual patient. The few single case reports suggest that failure to ensure an accurate diagnosis of the underlying neurological damage and dysfunction could, rarely, lead to significant misdiagnosis usually in patients who had brain-stem damage with little thalamic or cortical damage. Significant misdiagnosis of awareness, with an apparently 'vegetative' patient having good awareness, is rare. Careful neurological assessment of the cause and routine measurement of awareness using the Coma Recovery Scale - Revised should further reduce mistakes.
MeSH term(s)	Diagnostic Errors/statistics & numerical data ; Humans ; Persistent Vegetative State/diagnosis
Language	English
Publishing date	2018-02-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1280785-0
ISSN	1468-1331 ; 1351-5101 ; 1471-0552
ISSN (online)	1468-1331
ISSN	1351-5101 ; 1471-0552
DOI	10.1111/ene.13572
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Zs.A 4738: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 592: Show issues

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Book: <<The> burden of hyperkalemia in patients with cardiovascular and renal disease

Dunn, Jeffrey D. / Benton, Wade W. / Orozco-Torrentera, Ernesto / Adamson, Robert T.

(The American journal of managed care ; November 2015, vol. 21, no. 15, Sup.)

2015

Author's details	Jeffrey D. Dunn, PharmD, MBA; Wade W. Benton, PharmD; Ernesto Orozco-Torrentera, MD; and Robert T. Adamson, PharmD, FASHP
Series title	The American journal of managed care ; November 2015, vol. 21, no. 15, Sup.
Collection
Language	English
Size	Seite S305-S316, Diagramme
Publisher	Managed Care & Healthcare Communications, LLC
Publishing place	Plainsboro NJ
Publishing country	United States
Document type	Book
HBZ-ID	HT018897328
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Article ; Online: Associations between forgiveness and physical and mental health in the context of long COVID.

Sirotiak, Zoe / Thomas, Emily B K / Wade, Nathaniel G / Brellenthin, Angelique G

Journal of psychosomatic research

2024 Volume 178, Page(s) 111612

Abstract: ... trait forgiveness. T-tests were performed to assess differences in types of trait forgiveness between ... Individuals with long COVID reported significantly less forgiveness of self (p < 0.001, d = 0.33), forgiveness ... of others (p = 0.004, d = 0.16), and forgiveness of situations (p < 0.001, d = 0.34) than those without long ...

Abstract	Objective: Forgiveness has been positively associated with health in those with functional disorders. This cross-sectional study examined the relationships among dimensions of forgiveness and physical and mental health in individuals with and without long COVID. Methods: Adults (N = 4316) in the United States took part in an online survey study detailing long COVID presence, physical and mental health, and trait forgiveness. T-tests were performed to assess differences in types of trait forgiveness between individuals with and without long COVID. Linear regression models assessed the contribution of demographic covariates and forgiveness subscales to the physical and mental health of individuals with and without long COVID. Results: Of 4316 participants, 379 (8.8%) reported current long COVID. Participants were an average age of 43.7, and most identified as female (51.9%), white (87.8%), and non-Hispanic/Latino (86.6%). Individuals with long COVID reported significantly less forgiveness of self (p < 0.001, d = 0.33), forgiveness of others (p = 0.004, d = 0.16), and forgiveness of situations (p < 0.001, d = 0.34) than those without long COVID. Among the long COVID sample, forgiveness of self and situations were positively associated with mental health (p < 0.05), but not physical health (p > 0.05). Forgiveness of others was negatively associated with both physical and mental health (p < 0.05). Conclusion: Forgiveness may be an important consideration in understanding health among individuals with long COVID, emphasizing the importance of developing a multifaceted understanding of the condition.
MeSH term(s)	Adult ; Humans ; Female ; United States ; Mental Health ; Forgiveness ; Post-Acute COVID-19 Syndrome ; Health Status ; Cross-Sectional Studies ; COVID-19
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	80166-5
ISSN	1879-1360 ; 0022-3999
ISSN (online)	1879-1360
ISSN	0022-3999
DOI	10.1016/j.jpsychores.2024.111612
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Article ; Online: Using L. minor and C. elegans to assess the ecotoxicity of real-life contaminated soil samples and their remediation by clay- and carbon-based sorbents.

Rivenbark, Kelly J / Fawkes, Leanne S / Nikkhah, Hasan / Wang, Meichen / Sansom, Garett T / Beykal, Burcu / Wade, Terry L / Phillips, Timothy D

Environmental pollution (Barking, Essex : 1987)

2024 Volume 347, Page(s) 123762

Abstract: Toxic substances, such as polycyclic aromatic hydrocarbons (PAHs) and heavy metals, can accumulate in soil, posing a risk to human health and the environment. To reduce the risk of exposure, rapid identification and remediation of potentially hazardous ... ...

Abstract	Toxic substances, such as polycyclic aromatic hydrocarbons (PAHs) and heavy metals, can accumulate in soil, posing a risk to human health and the environment. To reduce the risk of exposure, rapid identification and remediation of potentially hazardous soils is necessary. Adsorption of contaminants by activated carbons and clay materials is commonly utilized to decrease the bioavailability of chemicals in soil and environmental toxicity in vitro, and this study aims to determine their efficacy in real-life soil samples. Two ecotoxicological models (Lemna minor and Caenorhabditis elegans) were used to test residential soil samples, known to contain an average of 5.3, 262, and 9.6 ppm of PAHs, lead, and mercury, for potential toxicity. Toxicity testing of these soils indicated that 86% and 58% of soils caused ≤50% inhibition of growth and survival of L. minor and C. elegans, respectively. Importantly, 3 soil samples caused ≥90% inhibition of growth in both models, and the toxicity was positively correlated with levels of heavy metals. These toxic soil samples were prioritized for remediation using activated carbon and SM-Tyrosine sorbents, which have been shown to immobilize PAHs and heavy metals, respectively. The inclusion of low levels of SM-Tyrosine protected the growth and survival of L. minor and C. elegans by 83% and 78%, respectively from the polluted soil samples while activated carbon offered no significant protection. These results also indicated that heavy metals were the driver of toxicity in the samples. Results from this study demonstrate that adsorption technologies are effective strategies for remediating complex, real-life soil samples contaminated with hazardous pollutants and protecting natural soil and groundwater resources and habitats. The results highlight the applicability of these ecotoxicological models as rapid screening tools for monitoring soil quality and verifying the efficacy of remediation practices.
MeSH term(s)	Animals ; Humans ; Clay ; Caenorhabditis elegans ; Charcoal ; Metals, Heavy/toxicity ; Metals, Heavy/analysis ; Polycyclic Aromatic Hydrocarbons/analysis ; Soil/chemistry ; Tyrosine ; Soil Pollutants/analysis ; Araceae
Chemical Substances	Clay (T1FAD4SS2M) ; Charcoal (16291-96-6) ; Metals, Heavy ; Polycyclic Aromatic Hydrocarbons ; Soil ; Tyrosine (42HK56048U) ; Soil Pollutants
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2024.123762
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Article ; Online: Determining whether someone has mental capacity to make a decision: clinical guidance based on a review of the evidence.

Wade, Derick T

Clinical rehabilitation

2019 Volume 33, Issue 10, Page(s) 1561–1570

Abstract: ... obviously lack capacity but will recover soon, (c) obviously have capacity, (d) capacity is in doubt and ... clinical judgement; and (d) subject to disagreement among assessors. The recommendations are as follows: (1 ...

Abstract	Valid consent to healthcare treatments depends upon a person having the capacity to give it. The Mental Health Act not only requires a presumption of capacity but also expects clinicians to take reasonable steps to establish whether the patient lacks capacity. The facts are that (1) lack of capacity is common among hospital inpatients and people in the community needing care, but is often not recognized. (2) Capacity must not be judged on the basis of the decision made: an unwise decision is not evidence of a lack of capacity, and a decision expected by the clinician is not evidence of capacity. Capacity is decision-specific and must be considered critically without preconceptions. There is no valid other test. (3) Clinically people will fall into four groups: (a) obviously lack capacity and will not recover it, (b) obviously lack capacity but will recover soon, (c) obviously have capacity, (d) capacity is in doubt and major healthcare decision needed. Only the last group need more detailed attention. (4) Capacity is (a) relative to the complexity of the information; (b) on a spectrum, not categorical; (c) decided using clinical judgement; and (d) subject to disagreement among assessors. The recommendations are as follows: (1) capacity should always be considered within the decision-making process, and the outcome should be documented, with sufficient information to understand the opinion given. (2) Detailed assessment should be reserved for situations when (a) a major decision is needed and (b) there is time to assess and discuss the assessment.
MeSH term(s)	Cognition Disorders/diagnosis ; Decision Making ; Humans ; Mental Competency ; Patient Acceptance of Health Care
Language	English
Publishing date	2019-06-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639276-3
ISSN	1477-0873 ; 0269-2155
ISSN (online)	1477-0873
ISSN	0269-2155
DOI	10.1177/0269215519853013
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Article ; Online: Late-fall satellite-based soil moisture observations show clear connections to subsequent spring streamflow.

Koster, Randal D / Liu, Qing / Crow, Wade T / Reichle, Rolf H

Nature communications

2023 Volume 14, Issue 1, Page(s) 3545

Abstract: Because runoff production is more efficient over wetter soils, and because soil moisture has an intrinsic memory, soil moisture information can potentially contribute to the accuracy of streamflow predictions at seasonal leads. In this work, we use ... ...

Abstract	Because runoff production is more efficient over wetter soils, and because soil moisture has an intrinsic memory, soil moisture information can potentially contribute to the accuracy of streamflow predictions at seasonal leads. In this work, we use surface (0-5 cm) soil moisture retrievals obtained with the National Aeronautics and Space Administration's Soil Moisture Active Passive satellite instrument in conjunction with streamflow measurements taken within 236 intermediate-scale (2000-10,000 km
MeSH term(s)	United States ; Soil ; Seasons ; Rivers
Chemical Substances	Soil
Language	English
Publishing date	2023-06-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-39318-3
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Article ; Online: Latent Classes of Adverse and Benevolent Childhood Experiences in a Multinational Sample of Parents and Their Relation to Parent, Child, and Family Functioning during the COVID-19 Pandemic.

Johnson, Dylan / Browne, Dillon T / Meade, Robert D / Prime, Heather / Wade, Mark

International journal of environmental research and public health

2022 Volume 19, Issue 20

Abstract: Adverse Childhood Experiences (ACEs) are known to contribute to later mental health. Conversely, Benevolent Childhood Experiences (BCEs) may buffer against mental health difficulties. The importance of ACEs and BCEs for mental health of both parents and ... ...

Abstract	Adverse Childhood Experiences (ACEs) are known to contribute to later mental health. Conversely, Benevolent Childhood Experiences (BCEs) may buffer against mental health difficulties. The importance of ACEs and BCEs for mental health of both parents and children may be most obvious during periods of stress, with potential consequences for functioning of the family. Subgroups of ACEs and BCEs in parents during the COVID-19 pandemic were investigated and validated in relation to indices of parent, child, and family well-being. In May 2020, ACEs/BCEs were assessed in 547 parents of 5-18-year-old children from the U.K., U.S., Canada, and Australia. Subgroups of parents with varying levels of ACEs and BCEs were identified via latent class analysis. The subgroups were validated by examining associations between class membership and indices of parent and child mental health and family well-being. Four latent classes were identified: low-ACEs/high-BCEs, moderate-ACEs/high-BCEs, moderate-ACEs/low-BCEs, and high-ACEs/moderate-BCEs. Regardless of the extent of BCEs, there was an increased risk of parent and child mental health difficulties and family dysfunction among those reporting moderate-to-high levels of ACEs. Parents' history of adversity may influence the mental health of their family. These findings highlight the importance of public health interventions for preventing early-life adversity.
MeSH term(s)	Child ; Humans ; Child, Preschool ; Adolescent ; COVID-19/epidemiology ; Pandemics ; Adverse Childhood Experiences ; Mental Health ; Family
Language	English
Publishing date	2022-10-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192013581
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Article ; Online: Rituximab-associated hypogammaglobulinemia in autoimmune rheumatic diseases: a single-center retrospective cohort study.

Wade, Stefanie D / Kyttaris, Vasileios C

Rheumatology international

2021 Volume 41, Issue 6, Page(s) 1115–1124

Abstract: ... categorical variables. Based on distribution, continuous variables were compared using the t test/ANOVA or ...

Abstract	B-cell targeted therapies, such as rituximab (RTX), are used widely in autoimmune rheumatic diseases (AIRD). RTX can cause hypogammaglobulinemia and predispose patients to infections. Herein, we asked whether the underlying diagnosis influences the risk for hypogammaglobulinemia in patients treated with RTX. All patients who received RTX infusions and carried a diagnosis of rheumatoid arthritis (RA), ANCA-associated vasculitis (AAV), or connective tissue disease (CTD) were included in this single-center retrospective cohort study. We used STATA® for analysis: Chi-square test was used for comparing categorical variables. Based on distribution, continuous variables were compared using the t test/ANOVA or the Wilcoxon/Kruskal-Wallis tests. Of the 163 patients who received RTX for an AIRD, 60 with pre- and post- RTX immunoglobulins were analyzed. A higher incidence of post-treatment hypogammaglobulinemia was seen in AAV (45%) compared to RA (22%) and CTD (9.1%) groups (p = 0.03). Glucocorticoid exposure of 10 mg or more was identified as a significant risk factor for hypogammaglobulinemia. Finally, we observed a higher number of clinically significant infections per person in the AAV group than in the RA and CTD groups. We observed an increased incidence of hypogammaglobulinemia in the RTX-treated AAV group, with almost half of patients developing post-RTX hypogammaglobulinemia. The rate of infections per person was highest in the AAV group. Screening immunoglobulins were not consistently measured pre- and post-RTX. Results highlight a need for increased awareness of the role of immunoglobulin measurement before maintenance doses of RTX, especially in patients with AAV and steroid exposure.
MeSH term(s)	Adult ; Agammaglobulinemia/chemically induced ; Aged ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy ; Antirheumatic Agents/administration & dosage ; Antirheumatic Agents/adverse effects ; Arthritis, Rheumatoid/drug therapy ; Connective Tissue Diseases/drug therapy ; Female ; Humans ; Immunoglobulin G/blood ; Male ; Middle Aged ; Retrospective Studies ; Rituximab/administration & dosage ; Rituximab/adverse effects
Chemical Substances	Antirheumatic Agents ; Immunoglobulin G ; Rituximab (4F4X42SYQ6)
Language	English
Publishing date	2021-04-03
Publishing country	Germany
Document type	Journal Article ; Observational Study
ZDB-ID	8286-7
ISSN	1437-160X ; 0172-8172
ISSN (online)	1437-160X
ISSN	0172-8172
DOI	10.1007/s00296-021-04847-x
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