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Article ; Online: Genetics of Primary Ovarian Insufficiency.

Akande, Rukayat O / Ibrahim, Yetunde

2020 Volume 63, Issue 4, Page(s) 687–705

Abstract: The diagnosis of primary ovarian insufficiency (POI) has untold effects on women and a better understanding alongside potential treatments are paramount to improve quality of life of these women. Various causes have been linked to the development of POI ... ...

Abstract	The diagnosis of primary ovarian insufficiency (POI) has untold effects on women and a better understanding alongside potential treatments are paramount to improve quality of life of these women. Various causes have been linked to the development of POI with genetics playing a key role. A better understanding of the genetics of POI could lead to earlier diagnosis and broaden fertility options. This chapter discusses previously known and more recently discovered genes that have been implicated in the development of POI. It explores the varying phenotypic expressions of some genes in different populations and areas for further research in the genetics of POI.
MeSH term(s)	Female ; Fertility ; Fertility Preservation ; Humans ; Menopause, Premature ; Primary Ovarian Insufficiency/genetics ; Quality of Life
Language	English
Publishing date	2020-10-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	391207-3
ISSN	1532-5520 ; 0009-9201
ISSN (online)	1532-5520
ISSN	0009-9201
DOI	10.1097/GRF.0000000000000575
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Article ; Online: The pervasive issue of racism and its impact on infertility patients: what can we do as reproductive endocrinologists?

Ibrahim, Yetunde / Zore, Temeka

Journal of assisted reproduction and genetics

2020 Volume 37, Issue 7, Page(s) 1563–1565

Abstract: Following the horrific events surrounding the death of George Floyd, we aim to shed some light on our perceptions of the pervasive issue of racism in America and how it impacts the work we do as reproductive endocrinologists. This issue is deeply rooted, ...

Abstract	Following the horrific events surrounding the death of George Floyd, we aim to shed some light on our perceptions of the pervasive issue of racism in America and how it impacts the work we do as reproductive endocrinologists. This issue is deeply rooted, and tackling it will involve a multifaceted approach. Ultimately, we are interested in starting this conversation and hope that our colleagues will not only acknowledge that there is a problem that requires immediate attention but will join us in providing sustainable solutions to it.
MeSH term(s)	African Americans/statistics & numerical data ; Endocrinologists ; Female ; Health Services Accessibility/economics ; Health Services Accessibility/organization & administration ; Humans ; Infertility/epidemiology ; Infertility/therapy ; Racism
Keywords	covid19
Language	English
Publishing date	2020-06-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1112577-9
ISSN	1573-7330 ; 1058-0468
ISSN (online)	1573-7330
ISSN	1058-0468
DOI	10.1007/s10815-020-01863-x
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Article ; Online: Contraceptive Efficacy of Aqueous Extract of Xylopia aethiopica (Dunal) A.Rich. Fruit in Female Sprague Dawley Rats

Babatunde Ebenezer Ajayi / Yetunde Adesola Odueke / Favour Marian Ibrahim / Macdonald Ighodaro / Janet Titilayo Bamgbose

Traditional and Integrative Medicine, Vol 8, Iss

2023 Volume 4

Abstract: Globally, herbal contraceptives remain a viable option for women in rural settlements with unmet contraceptive needs. Pharmacological reports of the male contraceptive potential of Xylopia aethiopica fruit exist in literature, but there is a paucity of ... ...

Abstract	Globally, herbal contraceptives remain a viable option for women in rural settlements with unmet contraceptive needs. Pharmacological reports of the male contraceptive potential of Xylopia aethiopica fruit exist in literature, but there is a paucity of information on its female contraceptive potential. This study evaluated the efficacy of aqueous extract of X. aethiopica fruit (AEXAF) as a reversible contraceptive remedy in female Sprague Dawley rats against a combined oral contraceptive drug containing ethinyl estradiol and levonorgestrel (COC-EEL). AEXAF was obtained by boiling air-dried pulverized fruit samples in water for 15 minutes. Phytochemical screening of AEXAF was carried out. Mature female rats (30) were assigned into six groups, five per group, with ±20 g weight difference within each group. Group A received water; Groups B, C, D and E received 50, 100, 200, and 300 mg/kg/B.W. doses of AEXAF, respectively; Group F received 3.6 µg/kg/B.W. dose of COC-EEL. COC-EEL and AEXAF were administered orally, once daily, for 21 days. After 14 days of treatment, mature male rats were introduced to the females, two males per group, for 7 days. Litter size was recorded after delivery. Rats that did not produce pups were immediately re-introduced to male rats for 7 days and sacrificed after another 7 days; the number of fetuses in their uteri was determined. The data obtained was analyzed using Unpaired-t test. Phytochemical screening of AEXAF revealed the presence of alkaloids, flavonoids and saponins. High contraceptive efficacy (80%) with 100% reversibility was observed at 50 and 300 mg/kg/B.W. doses of AEXAF, whereas COC-EEL showed 60% efficacy and 100% reversibility. The 100 and 200 mg/kg/B.W. doses of AEXAF did not protect against conception. X. aethiopica possesses contraceptive potential worthy of further scientific consideration.
Keywords	Xylopia aethiopica ; Herbal contraceptives ; Ethinyl estradiol ; Levonorgestrel ; Public aspects of medicine ; RA1-1270
Subject code	590 ; 630
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sperm Epigenetics and Its Impact on Male Fertility, Pregnancy Loss, and Somatic Health of Future Offsprings.

Ibrahim, Yetunde / Hotaling, Jim

Seminars in reproductive medicine

2019 Volume 36, Issue 3-04, Page(s) 233–239

Abstract: Sperm epigenetic programming is tailored to meet the need of this specialized cell, which include its interaction with the oocyte during fertilization and early embryo development. The unique nature of the sperm epigenome has resulted in multiple studies ...

Abstract	Sperm epigenetic programming is tailored to meet the need of this specialized cell, which include its interaction with the oocyte during fertilization and early embryo development. The unique nature of the sperm epigenome has resulted in multiple studies investigating how perturbations in epigenetics might impact male fertility and early embryo development. In addition, sperm epigenetics appear to be altered by specific environmental exposures, which could provide a link for investigating the role of these triggers in somatic health of off springs produced. This has the potential of explaining otherwise missing heritability factors seen with several diseases. While this field of investigation is new and with limited validation, it is intriguing and further studies are warranted.
MeSH term(s)	Abortion, Spontaneous/etiology ; Abortion, Spontaneous/genetics ; DNA Methylation ; Epigenesis, Genetic ; Epigenomics ; Female ; Gene Expression Regulation, Developmental ; Histones/genetics ; Humans ; Infertility, Male/genetics ; Male ; Pregnancy ; Spermatozoa/metabolism
Chemical Substances	Histones
Language	English
Publishing date	2019-03-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2042479-6
ISSN	1526-4564 ; 1526-8004
ISSN (online)	1526-4564
ISSN	1526-8004
DOI	10.1055/s-0038-1677047
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Article ; Online: Coronavirus Disease (COVID-19) in Nigeria

Olayinka Rasheed Ibrahim / Yetunde T Olasinde

Ķazaķstannyṇ Klinikalyķ Medicinasy, Vol 1, Iss 55, Pp 36-

Mitigating the Global Pandemic

2020 Volume 38

Abstract: The confirmation of Covid-19 in Nigeria is not unexpected given the global spread of the disease that originated from China. With an estimated 200 million people and an infectious disease vulnerability index of 0.27, a poorly managed case of Covid-19 may ...

Abstract	The confirmation of Covid-19 in Nigeria is not unexpected given the global spread of the disease that originated from China. With an estimated 200 million people and an infectious disease vulnerability index of 0.27, a poorly managed case of Covid-19 may worsen the global pandemic. Hence, we examined the peculiarities of Nigeria as a nation and suggested ways of curtailing further spread of the disease in the country.
Keywords	coronavirus disease ; Covid-19 ; Nigeria ; global pandemic ; Internal medicine ; RC31-1245 ; Specialties of internal medicine ; RC581-951
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	National Scientific Medical Center
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The male contribution to recurrent pregnancy loss.

Ibrahim, Yetunde / Johnstone, Erica

Translational andrology and urology

2018 Volume 7, Issue Suppl 3, Page(s) S317–S327

Abstract: There are several known causes of recurrent pregnancy loss (RPL) in a couple, which include endocrine abnormalities, immunologic abnormalities, structural uterine abnormalities and karyotype abnormalities. The evaluation largely focuses on the female. ... ...

Abstract	There are several known causes of recurrent pregnancy loss (RPL) in a couple, which include endocrine abnormalities, immunologic abnormalities, structural uterine abnormalities and karyotype abnormalities. The evaluation largely focuses on the female. The male contribution to RPL remains understudied. With the exception of the karyotype analysis, there is currently no other recommended testing for the male partner of a woman who has suffered multiple pregnancy losses. Chromosomal abnormalities are well defined causes of pregnancy losses in the literature. However, despite the fact that abnormal DNA fragmentation has been implicated in the pathogenesis of unexplained RPL, it is not routinely checked during the evaluation of RPL. This is likely due to the fact that abnormal DNA fragmentation is the end result of multiple different mechanisms including environmental exposures, varicoceles, gene alteration and epigenetic changes resulting in an inherent susceptibility to DNA damage? We are just beginning to scratch the surface of our understanding of the male contribution to RPL and more studies especially focusing on epigenetic modifications and gene alterations are needed.
Language	English
Publishing date	2018-06-27
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2851630-8
ISSN	2223-4691 ; 2223-4691 ; 2223-4683
ISSN (online)	2223-4691
ISSN	2223-4691 ; 2223-4683
DOI	10.21037/tau.2018.05.14
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Article ; Online: A clinical counseling tool predicting supernumerary embryos after a fresh IVF cycle.

Ibrahim, Yetunde / Stoddard, Greg / Johnstone, Erica

Journal of assisted reproduction and genetics

2020 Volume 37, Issue 5, Page(s) 1137–1145

Abstract: Purpose: To identify factors predictive of having supernumerary embryos in a fresh IVF cycle and create a prediction model for clinical counseling.: Methods: We utilized a multivariable Poisson regression to identify predictive factors and then ... ...

Abstract	Purpose: To identify factors predictive of having supernumerary embryos in a fresh IVF cycle and create a prediction model for clinical counseling. Methods: We utilized a multivariable Poisson regression to identify predictive factors and then entered these into a logistic regression model, calculating a risk index for each significant variable. The final model was tested using a receiver operating characteristic curve. Results: A total of 60,616 fresh transfer cycles were reported to the Society for Assisted Reproductive Technology in 2014. Of these, 47.17% produced supernumerary embryos. A multivariate Poisson regression identified factors predictive of having supernumerary embryos, with age and AMH being the most predictive. Clinical prediction models were developed with acceptable and excellent discrimination. 23.5% of our cohort did not achieve a live birth following their fresh transfer and had excess embryos cryopreserved for future attempts. Conclusion: Our study suggests that in a minority of fresh IVF cycles in the USA, the fresh transfer is not successful, and there are excess embryos cryopreserved for future use. The likelihood of excess embryos beyond those that would be transferred can be predicted with satisfactory precision prior to initiation of the cycle and with improved precision after fresh embryo transfer. Providing patients with a realistic estimate of their chances of having excess embryos at an initial IVF consult especially those with suspected poor prognosis can be beneficial in determining whether to proceed with multiple embryo banking cycles as opposed to proceeding with a fresh transfer, and whether to opt for an enhanced embryo selection technique such as preimplantation genetic testing for aneuploidy (PGT-A).
MeSH term(s)	Adult ; Aneuploidy ; Cryopreservation ; Embryo Transfer/methods ; Female ; Fertilization in Vitro/trends ; Genetic Counseling/trends ; Genetic Testing ; Humans ; Live Birth ; Pregnancy ; Pregnancy Rate ; Reproductive Techniques, Assisted/trends
Language	English
Publishing date	2020-03-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1112577-9
ISSN	1573-7330 ; 1058-0468
ISSN (online)	1573-7330
ISSN	1058-0468
DOI	10.1007/s10815-020-01731-8
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Article ; Online: A validated prediction score for having two or more embryos for cryopreservation following freeze-all IVF cycles: an analysis utilizing SART CORS database.

Ibrahim, Yetunde / Stoddard, Gregory J / Johnstone, Erica

Journal of assisted reproduction and genetics

2020 Volume 38, Issue 2, Page(s) 397–405

Abstract: Purpose: To develop and validate a prediction score for having 2 or more embryos cryopreserved following an IVF cycle without a fresh transfer such that an embryo selection method may be applicable. We also developed a counseling tool on the probability ...

Abstract	Purpose: To develop and validate a prediction score for having 2 or more embryos cryopreserved following an IVF cycle without a fresh transfer such that an embryo selection method may be applicable. We also developed a counseling tool on the probability of not having any embryos following an IVF cycle without a fresh transfer. Methods: We split the data into a development set and a validation set by region within the USA using a coin flip approach and subsequently performed a logistic regression model to identify factors most predictive of cryopreservation of 2 or more embryos in the development set. This model was validated in the validation set. Subsequently, a clinical prediction score was derived using the model coefficients and the predictive accuracy measured with the concordance (c) statistic. Results: A total of 31,537 potential freeze-all cycles were reported to the Society for Assisted Reproductive Technology in 2014. Of these, 57.87% produced and cryopreserved two or more embryos. We identified that age, AMH, and the number of eggs retrieved were the most significant predictors of having 2 or more embryos cryopreserved with a validated c-statistic of 0.84 (95% CI: 0.83 to 0.85). A clinical prediction score was derived from the model. 28.9% of freeze-all cycles had no embryos created from the IVF cycle despite a cycle start and an egg retrieval. The number of eggs retrieved was the most significant predictor of having no embryos available for a transfer, with a c-statistic of 0.80 when modeled as the only predictor variable. Conclusion: We derived counseling tools with acceptable discrimination for use in clinical practice (c-statistics > 0.7). Our study further suggests that the number of eggs retrieved from an IVF cycle is most predictive of having 2 or more embryos cryopreserved and not having any embryos after an IVF cycle, suggesting that clinicians should strive to optimize oocyte yield especially in poor prognosis patients. The probability of having two more embryos cryopreserved in a freeze-all IVF cycle such that an embryo selection method is applicable can be predicted with acceptable precision prior to the IVF cycle and excellent precision following egg retrieval using the prediction score.
MeSH term(s)	Adult ; Cryopreservation ; Embryo Transfer/methods ; Female ; Fertilization in Vitro ; Humans ; Pregnancy ; Pregnancy Rate ; Reproductive Techniques, Assisted/trends
Language	English
Publishing date	2020-11-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1112577-9
ISSN	1573-7330 ; 1058-0468
ISSN (online)	1573-7330
ISSN	1058-0468
DOI	10.1007/s10815-020-02018-8
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Article: Sperm Epigenetics and Its Impact on Male Fertility, Pregnancy Loss, and Somatic Health of Future Offsprings

Ibrahim, Yetunde / Hotaling, Jim

Seminars in Reproductive Medicine

(ART and Developmental Origins of Health and Disease)

2018 Volume 36, Issue 03/04, Page(s) 233–239

Series title	ART and Developmental Origins of Health and Disease
Abstract	Sperm epigenetic programming is tailored to meet the need of this specialized cell, which include its interaction with the oocyte during fertilization and early embryo development. The unique nature of the sperm epigenome has resulted in multiple studies investigating how perturbations in epigenetics might impact male fertility and early embryo development. In addition, sperm epigenetics appear to be altered by specific environmental exposures, which could provide a link for investigating the role of these triggers in somatic health of off springs produced. This has the potential of explaining otherwise missing heritability factors seen with several diseases. While this field of investigation is new and with limited validation, it is intriguing and further studies are warranted.
Keywords	epigenetics ; male infertility ; pregnancy loss ; transgenerational effects ; somatic health
Language	English
Publishing date	2018-05-01
Publisher	Thieme Medical Publishers
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2042479-6
ISSN	1526-4564 ; 1526-8004
ISSN (online)	1526-4564
ISSN	1526-8004
DOI	10.1055/s-0038-1677047
Database	Thieme publisher's database

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Article ; Online: The hamster egg penetration test may decrease intracytoplasmic sperm injection utilization while maintaining high conventional fertilization rates.

Ibrahim, Yetunde / Einerson, Brett / Carrell, Douglas T / Emery, Benjamin R / Johnstone, Erica

Asian journal of andrology

2020 Volume 23, Issue 1, Page(s) 11–15

Abstract: This was a cohort study of in vitro fertilization (IVF) subjects at the University of Utah, Salt Lake City (UT, USA) utilizing partner sperm. Cycles where both the hamster egg penetration test (HEPT) and semen analysis were performed within 2 years prior ...

Abstract	This was a cohort study of in vitro fertilization (IVF) subjects at the University of Utah, Salt Lake City (UT, USA) utilizing partner sperm. Cycles where both the hamster egg penetration test (HEPT) and semen analysis were performed within 2 years prior to IVF cycles were stratified into four groups based on a normal or an abnormal HEPT and morphology. The mean conventional and intracytoplasmic sperm injection (ICSI) fertilization rates were calculated in each group. We performed a univariate analysis on the primary outcome comparing clinically interesting subjects. We performed a cost-effectiveness analysis of a policy of HEPT versus universal ICSI in couples with an abnormal morphology. Among patients with a normal HEPT, there was no difference in the mean conventional fertilization rates between those with a normal and an abnormal morphology. There was no difference in the mean conventional fertilization rates between subjects with a normal morphology without a hamster test and those with a normal HEPT without a morphology assessment. In 1000 simulated cycles with an abnormal morphology, a policy of HEPT was cost saving compared to universal ICSI, yet produced similar fertilization rates. The HEPT is similar to the World Health Organization edition 5 (WHO-5) morphology in predicting successful conventional fertilization while allowing decreased utilization of ICSI. A policy of HEPT for males with abnormal morphology saves cost in selecting couples for a fertilization method.
MeSH term(s)	Adult ; Animals ; Cricetinae ; Female ; Fertilization in Vitro/methods ; Humans ; Male ; Sperm Capacitation ; Sperm Injections, Intracytoplasmic/methods ; Sperm-Ovum Interactions
Language	English
Publishing date	2020-05-21
Publishing country	China
Document type	Journal Article
ZDB-ID	2075824-8
ISSN	1745-7262 ; 1008-682X
ISSN (online)	1745-7262
ISSN	1008-682X
DOI	10.4103/aja.aja_18_20
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