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Article ; Online: Role of mitochondrial alterations in human cancer progression and cancer immunity.

Wang, Sheng-Fan / Tseng, Ling-Ming / Lee, Hsin-Chen

2023 Volume 30, Issue 1, Page(s) 61

Abstract: Dysregulating cellular metabolism is one of the emerging cancer hallmarks. Mitochondria are essential organelles responsible for numerous physiologic processes, such as energy production, cellular metabolism, apoptosis, and calcium and redox homeostasis. ...

Abstract	Dysregulating cellular metabolism is one of the emerging cancer hallmarks. Mitochondria are essential organelles responsible for numerous physiologic processes, such as energy production, cellular metabolism, apoptosis, and calcium and redox homeostasis. Although the "Warburg effect," in which cancer cells prefer aerobic glycolysis even under normal oxygen circumstances, was proposed a century ago, how mitochondrial dysfunction contributes to cancer progression is still unclear. This review discusses recent progress in the alterations of mitochondrial DNA (mtDNA) and mitochondrial dynamics in cancer malignant progression. Moreover, we integrate the possible regulatory mechanism of mitochondrial dysfunction-mediated mitochondrial retrograde signaling pathways, including mitochondrion-derived molecules (reactive oxygen species, calcium, oncometabolites, and mtDNA) and mitochondrial stress response pathways (mitochondrial unfolded protein response and integrated stress response) in cancer progression and provide the possible therapeutic targets. Furthermore, we discuss recent findings on the role of mitochondria in the immune regulatory function of immune cells and reveal the impact of the tumor microenvironment and metabolism remodeling on cancer immunity. Targeting the mitochondria and metabolism might improve cancer immunotherapy. These findings suggest that targeting mitochondrial retrograde signaling in cancer malignancy and modulating metabolism and mitochondria in cancer immunity might be promising treatment strategies for cancer patients and provide precise and personalized medicine against cancer.
MeSH term(s)	Humans ; Calcium/metabolism ; Neoplasms/drug therapy ; Mitochondria/metabolism ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/metabolism ; DNA, Mitochondrial/therapeutic use ; Reactive Oxygen Species/metabolism ; Tumor Microenvironment
Chemical Substances	Calcium (SY7Q814VUP) ; DNA, Mitochondrial ; Reactive Oxygen Species
Language	English
Publishing date	2023-07-31
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1193378-1
ISSN	1423-0127 ; 1021-7770
ISSN (online)	1423-0127
ISSN	1021-7770
DOI	10.1186/s12929-023-00956-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: SARS-CoV-2 Entry Related Viral and Host Genetic Variations: Implications on COVID-19 Severity, Immune Escape, and Infectivity.

Huang, Szu-Wei / Wang, Sheng-Fan

International journal of molecular sciences

2021 Volume 22, Issue 6

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved to display particular patterns of genetic diversity in the genome across geographical regions. These variations in the virus and genetic variation in human populations can determine ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved to display particular patterns of genetic diversity in the genome across geographical regions. These variations in the virus and genetic variation in human populations can determine virus transmissibility and coronavirus disease 2019 (COVID-19) severity. Genetic variations and immune differences in human populations could be the driving forces in viral evolution. Recently emerged SARS-CoV-2 variants show several mutations at the receptor binding domain in the spike (S) glycoprotein and contribute to immune escape and enhanced binding with angiotensin 1-converting enzyme 2 (ACE2). Since ACE2 and transmembrane protease serine 2 (TMPRSS2) play important roles in SARS-CoV-2 entry into the cell, genetic variation in these host entry-related proteins may be a driving force for positive selection in the SARS-CoV-2 S glycoprotein. Dendritic or liver/lymph cell-specific intercellular adhesion molecule (ICAM)-3-grabbing non-integrin is also known to play vital roles in several pathogens. Genetic variations of these host proteins may affect the susceptibility to SARS-CoV-2. This review summarizes the latest research to describe the impacts of genetic variation in the viral S glycoprotein and critical host proteins and aims to provide better insights for understanding transmission and pathogenesis and more broadly for developing vaccine/antiviral drugs and precision medicine strategies, especially for high risk populations with genetic risk variants.
MeSH term(s)	Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/genetics ; COVID-19/epidemiology ; COVID-19/genetics ; COVID-19/transmission ; COVID-19/virology ; Genetic Variation ; Humans ; Immune Evasion ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; SARS-CoV-2/metabolism ; SARS-CoV-2/pathogenicity ; Severity of Illness Index ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/metabolism ; Virus Internalization
Chemical Substances	Spike Glycoprotein, Coronavirus ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2021-03-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22063060
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Fan ch'ieh sheng ch'an chi shu wen ta

Wang, Hai-t'ing

1989

Title translation	Technical questions and answers on tomato production.
Author's details	Wang Hai-t'ing pien chu
Keywords	Tomatoes
Language	Chinese
Size	10, 201 p. :, ill. ;, 19 cm.
Edition	Ti 1 pan.
Publisher	Shang-hai k'o hsüeh chi shu ch'u pan she
Publishing place	Shang-hai
Document type	Book
Note	Cover title also in Pinyin: Fanqie shenchan jishu wenda.
ISBN	7532315053 ; 9787532315055
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Synthesis, Assembly and Processing of Viral Proteins.

Wang, Wen-Hung / Thitithanyanont, Arunee / Wang, Sheng-Fan

Viruses

2022 Volume 14, Issue 8

Abstract: The papers published in this Special Issue include various essential steps and regulatory mechanisms involved in viral protein synthesis, protein processing, glycosylation, and assembly [ ... ]. ...

Abstract	The papers published in this Special Issue include various essential steps and regulatory mechanisms involved in viral protein synthesis, protein processing, glycosylation, and assembly [...].
MeSH term(s)	Glycosylation ; Protein Processing, Post-Translational ; Viral Proteins/metabolism
Chemical Substances	Viral Proteins
Language	English
Publishing date	2022-07-27
Publishing country	Switzerland
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14081650
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Article ; Online: The Effects of Genetic Variation on H7N9 Avian Influenza Virus Pathogenicity.

Huang, Szu-Wei / Wang, Sheng-Fan

Viruses

2020 Volume 12, Issue 11

Abstract: Since the H7N9 avian influenza virus emerged in China in 2013, there have been five seasonal waves which have shown human infections and caused high fatality rates in infected patients. A multibasic amino acid insertion seen in the HA of current H7N9 ... ...

Abstract	Since the H7N9 avian influenza virus emerged in China in 2013, there have been five seasonal waves which have shown human infections and caused high fatality rates in infected patients. A multibasic amino acid insertion seen in the HA of current H7N9 viruses occurred through natural evolution and reassortment, and created a high pathogenicity avian influenza (HPAI) virus from the low pathogenicity avian influenza (LPAI) in 2017, and significantly increased pathogenicity in poultry, resulting in widespread HPAI H7N9 in poultry, which along with LPAI H7N9, contributed to the severe fifth seasonal wave in China. H7N9 is a novel reassorted virus from three different subtypes of influenza A viruses (IAVs) which displays a great potential threat to public health and the poultry industry. To date, no sustained human-to-human transmission has been recorded by the WHO. However, the high ability of evolutionary adaptation of H7N9 and lack of pre-existing immunity in humans heightens the pandemic potential. Changes in IAVs proteins can affect the viral transmissibility, receptor binding specificity, pathogenicity, and virulence. The multibasic amino acid insertion, mutations in hemagglutinin, deletion and mutations in neuraminidase, and mutations in PB2 contribute to different virological characteristics. This review summarized the latest research evidence to describe the impacts of viral protein changes in viral adaptation and pathogenicity of H7N9, aiming to provide better insights for developing and enhancing early warning or intervention strategies with the goal of preventing highly pathogenic IAVs circulation in live poultry, and transmission to humans.
MeSH term(s)	Animals ; Evolution, Molecular ; Genetic Variation ; Hemagglutinin Glycoproteins, Influenza Virus/genetics ; Humans ; Influenza A Virus, H7N9 Subtype/genetics ; Influenza A Virus, H7N9 Subtype/pathogenicity ; Influenza in Birds/transmission ; Influenza in Birds/virology ; Influenza, Human/virology ; Poultry/virology ; Reassortant Viruses/genetics ; Virulence
Chemical Substances	Hemagglutinin Glycoproteins, Influenza Virus
Language	English
Publishing date	2020-10-28
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v12111220
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: SARS-CoV-2 Entry Related Viral and Host Genetic Variations

Szu-Wei Huang / Sheng-Fan Wang

International Journal of Molecular Sciences, Vol 22, Iss 3060, p

Implications on COVID-19 Severity, Immune Escape, and Infectivity

2021 Volume 3060

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved to display particular patterns of genetic diversity in the genome across geographical regions. These variations in the virus and genetic variation in human populations can determine virus transmissibility and coronavirus disease 2019 (COVID-19) severity. Genetic variations and immune differences in human populations could be the driving forces in viral evolution. Recently emerged SARS-CoV-2 variants show several mutations at the receptor binding domain in the spike (S) glycoprotein and contribute to immune escape and enhanced binding with angiotensin 1-converting enzyme 2 (ACE2). Since ACE2 and transmembrane protease serine 2 (TMPRSS2) play important roles in SARS-CoV-2 entry into the cell, genetic variation in these host entry-related proteins may be a driving force for positive selection in the SARS-CoV-2 S glycoprotein. Dendritic or liver/lymph cell-specific intercellular adhesion molecule (ICAM)-3-grabbing non-integrin is also known to play vital roles in several pathogens. Genetic variations of these host proteins may affect the susceptibility to SARS-CoV-2. This review summarizes the latest research to describe the impacts of genetic variation in the viral S glycoprotein and critical host proteins and aims to provide better insights for understanding transmission and pathogenesis and more broadly for developing vaccine/antiviral drugs and precision medicine strategies, especially for high risk populations with genetic risk variants.
Keywords	SARS-CoV-2 ; COVID-19 ; spike glycoprotein ; mutation ; genetic variation ; ACE2 ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	572
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Late cART Initiation Consistently Driven by Late HIV Presentation: A Multicenter Retrospective Cohort Study in Taiwan from 2009 to 2019.

Lee, Chun-Yuan / Lin, Yi-Pei / Wang, Sheng-Fan / Lu, Po-Liang

Infectious diseases and therapy

2022 Volume 11, Issue 3, Page(s) 1033–1056

Abstract: Introduction: Late initiation (LI) of combination antiretroviral therapy (cART)-defined as having a CD4: Methods: This multicenter retrospective cohort study enrolled 1198 patients with newly diagnosed HIV infection during 2009-2019 who were grouped ... ...

Abstract	Introduction: Late initiation (LI) of combination antiretroviral therapy (cART)-defined as having a CD4 Methods: This multicenter retrospective cohort study enrolled 1198 patients with newly diagnosed HIV infection during 2009-2019 who were grouped by status at cART initiation: those without LI (non-LI group, 56.01%); those with LI but without late presentation (LP) of HIV (LP: a CD4 + count of < 200 cells/μL at HIV presentation or AIDS events ≤ 3 months of HIV diagnosis) [LILP(-) group, 4.51%]; and those with LI and with LP of HIV [LILP(+) group, 39.48%]. Joinpoint regression was used to identify changes in LI proportion. Results: The median CD4 Conclusion: Given the rise in LI from 2015 in the era of treat-all and rapid cART initiation, strategic interventions to increase earlier cART initiation must be intensified in Taiwan, especially among populations with delayed access to HIV testing services.
Language	English
Publishing date	2022-03-18
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2701611-0
ISSN	2193-6382 ; 2193-8229
ISSN (online)	2193-6382
ISSN	2193-8229
DOI	10.1007/s40121-022-00619-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Author Correction: Antibodies from dengue patients with prior exposure to Japanese encephalitis virus are broadly neutralizing against Zika virus.

Salem, Gielenny M / Galula, Jedhan Ucat / Wu, Shang-Rung / Liu, Jyung-Hurng / Chen, Yen-Hsu / Wang, Wen-Hung / Wang, Sheng-Fan / Song, Cheng-Sheng / Chen, Fan-Chi / Abarientos, Adrian B / Chen, Guan-Wen / Wang, Cheng-I / Chao, Day-Yu

Communications biology

2024 Volume 7, Issue 1, Page(s) 252

Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Published Erratum
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-024-05963-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Trends and the associated factors of optimal immunological response and virological response in late anti-retroviral therapy initiation HIV cases in Taiwan from 2009 to 2020.

Lee, Chun-Yuan / Lin, Yi-Pei / Lin, Chun-Yu / Chen, Tun-Chieh / Kuo, Shin-Huei / Lo, Shih-Hao / Wang, Sheng-Fan / Lu, Po-Liang

Journal of infection and public health

2024 Volume 17, Issue 2, Page(s) 339–348

Abstract: Background: Late cART initiation (CD4 count ≤200 cells/μL or AIDS-defining opportunistic illnesses [AOIs] at cART initiation) impedes CD4 count recovery and virologic suppression after cART initiation. However, studies to evaluate trends of and ... ...

Abstract	Background: Late cART initiation (CD4 count ≤200 cells/μL or AIDS-defining opportunistic illnesses [AOIs] at cART initiation) impedes CD4 count recovery and virologic suppression after cART initiation. However, studies to evaluate trends of and modifiable factors for optimal immunological response (IR) and virological response (VR) in people living with HIV (PLWH) with late cART initiation with the current HIV treatment strategies are limited. Methods: We retrospectively identified 475 PLWH with late cART initiation in 2009-2020. Patients were grouped based on the presence of IR (CD4 count ≥200 cells/μL) or VR (plasma viral load [PVL] ≤ 50 copies/mL) within 18 months after cART initiation (403 [84.8%] IR(+) and 72 [15.2%] IR(-); 422 [88.8%] VR(+) and 53 [11.2%] VR(-)). We used Joinpoint regression to identify IR (+) and VR(+) proportion changes. Results: From 2009 to 2020, the proportion of IR(+) patients remained unchanged (75% to 90%, P = 0.102), whereas that of VR(+) patients increased significantly (75% to 95%, P = 0.007). No join point was identified for either IR(+) or VR(+), and the annual percentage change was 0.56% (nonsignificant) and 1.35% (significant) for IR(+) and VR(+), respectively. Compared to IR(-) patients, IR(+) patients were more likely to have a higher pre-cART PVL, to start with a first-line INSTI-based regimen, or to start cART within 14 days of HIV diagnosis but were less likely to have chronic kidney disease, composite AOIs, or a lower pre-cART CD4 count. Compared to VR(-) patients, VR(+) patients were more likely to start a single-tablet regimen but were less likely to have a higher pre-cART PVL. Conclusions: Our study identified several modifiable factors for optimal IR (rapid cART initiation and INSTI-based regimen initiation) and for optimal VR (STR initiation) among late initiators, which may guide early treatment modifications to reduce their AIDS-defining event incidence and mortality.
MeSH term(s)	Humans ; Acquired Immunodeficiency Syndrome ; Retrospective Studies ; Taiwan/epidemiology ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; CD4 Lymphocyte Count ; Viral Load ; Antiretroviral Therapy, Highly Active ; Anti-HIV Agents/therapeutic use
Chemical Substances	Anti-HIV Agents
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2467587-8
ISSN	1876-035X ; 1876-0341
ISSN (online)	1876-035X
ISSN	1876-0341
DOI	10.1016/j.jiph.2023.12.022
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Emerging and Re-Emerging Diseases.

Wang, Wen-Hung / Thitithanyanont, Arunee / Urbina, Aspiro Nayim / Wang, Sheng-Fan

Pathogens (Basel, Switzerland)

2021 Volume 10, Issue 7

Abstract: Throughout history, infectious diseases have vastly impacted human civilization [ ... ]. ...

Abstract	Throughout history, infectious diseases have vastly impacted human civilization [...].
Language	English
Publishing date	2021-06-30
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens10070827
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