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  1. Book: Cancer metabolomics

    Hu, Shen

    methods and applications

    (Advances in experimental medicine and biology ; volume 1280)

    2021  

    Author's details Shen Hu editor
    Series title Advances in experimental medicine and biology ; volume 1280
    Collection
    Language English
    Size xiv, 312 Seiten, Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT020895102
    ISBN 978-3-030-51651-2 ; 9783030516529 ; 3-030-51651-2 ; 3030516520
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 3192 -1280- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: [

    Ludwig, Vinicius / Maliha, Peter George / Shen, John / Tonnelet, David / Raman, Steve / Litwin, Mark S / Calais, Jeremie

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2024  

    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.124.267609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Estimating the United States Patient Population Size Meeting Audiologic Candidacy for Cochlear Implantation.

    Yu, Kevin / Shen, Sarek / Bowditch, Steve / Sun, Daniel

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2023  Volume 170, Issue 3, Page(s) 870–876

    Abstract: Objective: This study aimed to estimate the size of the United States candidacy pool meeting expanded Center for Medicare Services criteria for cochlear implantation.: Study design: Retrospective cross-sectional.: Setting: Tertiary care center.: ...

    Abstract Objective: This study aimed to estimate the size of the United States candidacy pool meeting expanded Center for Medicare Services criteria for cochlear implantation.
    Study design: Retrospective cross-sectional.
    Setting: Tertiary care center.
    Methods: Preimplantation audiometric data from 486 patients seen at a single academic medical center were collected retrospectively and used to generate a predictive model of AzBio score based on audiometric pure tone thresholds. This model was then used to estimate nationally representative cochlear implantation (CI)-candidacy using pure tone averages included in the National Health and Nutrition Examination Survey. Qualitative and quantitative analyses were performed.
    Results: We find that the estimated prevalence of CI candidacy in individuals 65 years of age or older is expected to more than double with a change in the CI candidacy criteria from ≤40% to ≤60% (from 1.42%, 95% confidence interval [1.33, 1.63] to 3.73% [2.71, 6.56]) on speech testing. We also found the greatest absolute increase in candidacy in the 80+ age group, increasing from 4.14% [3.72, 5.1] of the population meeting the ≤40% criteria to 12.12% [9.19, 18.35] meeting the ≤60% criteria.
    Conclusion: The United States population size meeting expanded CMS audiologic criteria for cochlear implantation is estimated to be 2.5 million adults and 2.1 million age 65 or older. Changing the CI candidacy criteria from ≤40% to ≤60% on CI testing has the greatest effect on the eligible patient population in the >65-year-old age group. The determination of utilization rates in newly eligible patients will require further study.
    MeSH term(s) Adult ; Humans ; Aged ; United States ; Cochlear Implantation ; Retrospective Studies ; Population Density ; Nutrition Surveys ; Cross-Sectional Studies ; Medicare ; Cochlear Implants ; Speech Perception
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1002/ohn.589
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  4. Article ; Online: Reciprocating Rasp for Use in Mandibular Anterior Subapical Osteotomy.

    Zhang, Wenbin / Shen, Steve Guofang / Shi, Jun

    The Journal of craniofacial surgery

    2022  Volume 34, Issue 2, Page(s) e138–e139

    Abstract: The article describes a reciprocating rasp used in the mandibular anterior subapical osteotomy. Over the past 2 years, reciprocating rasp osteotomy was introduced in the Oral and Craniomaxillofacial Surgery Department of Shanghai Ninth People's Hospital. ...

    Abstract The article describes a reciprocating rasp used in the mandibular anterior subapical osteotomy. Over the past 2 years, reciprocating rasp osteotomy was introduced in the Oral and Craniomaxillofacial Surgery Department of Shanghai Ninth People's Hospital. No complication such as bleeding, wound infection, or tissue necrosis has been encountered. The use of reciprocating rasp avoids iatrogenic damage to adjacent structures and reduces the time spent operating mandibular anterior subapical osteotomy. Therefore, it is recommended for mandibular anterior subapical osteotomy.
    MeSH term(s) Humans ; China ; Mandibular Osteotomy ; Osteotomy ; Mandible/surgery
    Language English
    Publishing date 2022-08-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1159501-2
    ISSN 1536-3732 ; 1049-2275
    ISSN (online) 1536-3732
    ISSN 1049-2275
    DOI 10.1097/SCS.0000000000008884
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  5. Article ; Online: Mesoporous bioactive glass scaffolds for the delivery of bone marrow stem cell-derived osteoinductive extracellular vesicles lncRNA promote senescent bone defect repair by targeting the miR-1843a-5p/Mob3a/YAP axis.

    Qi, Lei / Pan, Cancan / Yan, Jinge / Ge, Weiwen / Wang, Jing / Liu, Lu / Zhang, Lei / Lin, Dan / Shen, Steve G F

    Acta biomaterialia

    2024  Volume 177, Page(s) 486–505

    Abstract: Bone repair in elderly patients poses a huge challenge due to the age-related progressive decline in regenerative abilities attributed to the senescence of bone marrow stem cells (BMSCs). Bioactive scaffolds have been applied in bone regeneration due to ... ...

    Abstract Bone repair in elderly patients poses a huge challenge due to the age-related progressive decline in regenerative abilities attributed to the senescence of bone marrow stem cells (BMSCs). Bioactive scaffolds have been applied in bone regeneration due to their various biological functions. In this study, we aimed to fabricate functionalized bioactive scaffolds through loading osteoinductive extracellular vesicles (OI-EVs) based on mesoporous bioactive glass (MBG) scaffolds (10
    MeSH term(s) Humans ; Aged ; Osteogenesis ; Tissue Scaffolds ; RNA, Long Noncoding/genetics ; Bone Regeneration ; Cell Differentiation ; MicroRNAs/genetics ; Extracellular Vesicles ; Bone Marrow Cells ; Glass
    Chemical Substances RNA, Long Noncoding ; MicroRNAs
    Language English
    Publishing date 2024-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2024.01.044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A Robust FISH Assay to Detect FGFR2 Translocations in Intrahepatic Cholangiocarcinoma Patients.

    Zhang, Lei / Zheng, Hao / Xu, Linyu / You, Si / Shen, Yuanyuan / Han, Yang / Anderson, Steve

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 12

    Abstract: FGFR fusions retaining the FGFR kinase domain are active kinases that are either overexpressed or constitutively activated throughout diverse cancer types. The presence of FGFR translocations enhances tumor cell proliferation and contributes to ... ...

    Abstract FGFR fusions retaining the FGFR kinase domain are active kinases that are either overexpressed or constitutively activated throughout diverse cancer types. The presence of FGFR translocations enhances tumor cell proliferation and contributes to significant sensitivity to FGFR kinase inhibitors. FGFR2 as an actionable target in intrahepatic cholangiocarcinoma (iCCA) has been tested in many clinical trials. FISH (fluorescence in situ hybridization) and NGS (next-generation sequence) are well-known tools to investigate the translocations of FGFR with multiple or unknown translocation partners. A rapid and robust FISH assay was developed and validated to detect FGFR2 translocations from FFPE specimens in iCCA. The analytical performance of the FISH assay was evaluated for probe localization, probe sensitivity and specificity, and assay precision. Twenty-five archival FFPE specimens from local iCCA patients were tested for FGFR2 translocations. FISH results were correlated with that of NGS on some samples. Biallelic translocations and a novel FGFR2 translocation involving the partner gene, SHROOM3, t(4;10) (q21;q26), were identified in a local iCCA patient.
    Language English
    Publishing date 2023-06-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13122088
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  7. Article ; Online: Precise Intraoral Condylectomy With the Guide of Three-Dimensional Printed Template in a Mandibular Condylar Hyperplasia Patient.

    Yuan, Hao / Jiang, Tengfei / Shi, Jun / Shen, Steve G F

    The Journal of craniofacial surgery

    2022  Volume 33, Issue 7, Page(s) e685–e688

    Abstract: Purpose: This study aimed to introduce an innovative method for mandibular condylectomy. A customized three-dimensional (3D) printed template is used to perform precise condylectomy in an intraoral approach.: Methods: Condylectomy combined with ... ...

    Abstract Purpose: This study aimed to introduce an innovative method for mandibular condylectomy. A customized three-dimensional (3D) printed template is used to perform precise condylectomy in an intraoral approach.
    Methods: Condylectomy combined with orthognathic surgery was used for the treatment of facial asymmetry secondary to unilateral condylar hyperplasia. The customized 3D printed osteotomy guide was placed with an intraoral approach under endoscopy, in order to perform a precise condylectomy.
    Result: With the customized 3D printed template, the condylectomy was performed more precisely, and the conventional extraoral incision was avoided. The osteotomy line was accurately transferred from the virtual surgical plan to the real surgery, which assured the precise resection.
    Conclusions: The intraoral approach combined with a 3D printed template provides a novel solution to perform the condylectomy precisely.
    MeSH term(s) Facial Asymmetry/diagnostic imaging ; Facial Asymmetry/pathology ; Facial Asymmetry/surgery ; Humans ; Hyperplasia/pathology ; Hyperplasia/surgery ; Malocclusion/pathology ; Mandibular Condyle/diagnostic imaging ; Mandibular Condyle/pathology ; Mandibular Condyle/surgery ; Orthognathic Surgical Procedures/methods
    Language English
    Publishing date 2022-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1159501-2
    ISSN 1536-3732 ; 1049-2275
    ISSN (online) 1536-3732
    ISSN 1049-2275
    DOI 10.1097/SCS.0000000000008558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A Robust FISH Assay to Detect FGFR2 Translocations in Intrahepatic Cholangiocarcinoma Patients

    Lei Zhang / Hao Zheng / Linyu Xu / Si You / Yuanyuan Shen / Yang Han / Steve Anderson

    Diagnostics, Vol 13, Iss 2088, p

    2023  Volume 2088

    Abstract: FGFR fusions retaining the FGFR kinase domain are active kinases that are either overexpressed or constitutively activated throughout diverse cancer types. The presence of FGFR translocations enhances tumor cell proliferation and contributes to ... ...

    Abstract FGFR fusions retaining the FGFR kinase domain are active kinases that are either overexpressed or constitutively activated throughout diverse cancer types. The presence of FGFR translocations enhances tumor cell proliferation and contributes to significant sensitivity to FGFR kinase inhibitors. FGFR2 as an actionable target in intrahepatic cholangiocarcinoma (iCCA) has been tested in many clinical trials. FISH (fluorescence in situ hybridization) and NGS (next-generation sequence) are well-known tools to investigate the translocations of FGFR with multiple or unknown translocation partners. A rapid and robust FISH assay was developed and validated to detect FGFR2 translocations from FFPE specimens in iCCA. The analytical performance of the FISH assay was evaluated for probe localization, probe sensitivity and specificity, and assay precision. Twenty-five archival FFPE specimens from local iCCA patients were tested for FGFR2 translocations. FISH results were correlated with that of NGS on some samples. Biallelic translocations and a novel FGFR2 translocation involving the partner gene, SHROOM3, t(4;10) (q21;q26), were identified in a local iCCA patient.
    Keywords FGFR2 translocation ; intrahepatic cholangiocarcinoma ; break-apart FISH ; biallelic translocation ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Molecular determinants of inhibition of the human proton channel hHv1 by the designer peptide C6 and a bivalent derivative.

    Zhao, Ruiming / Shen, Rong / Dai, Hui / Perozo, Eduardo / Goldstein, Steve A N

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 23, Page(s) e2120750119

    Abstract: The human voltage-gated proton channel (hHv1) is important for control of intracellular pH. We designed C6, a specific peptide inhibitor of hHv1, to evaluate the roles of the channel in sperm capacitation and in the inflammatory immune response of ... ...

    Abstract The human voltage-gated proton channel (hHv1) is important for control of intracellular pH. We designed C6, a specific peptide inhibitor of hHv1, to evaluate the roles of the channel in sperm capacitation and in the inflammatory immune response of neutrophils [R. Zhao et al., Proc. Natl. Acad. Sci. U.S.A. 115, E11847–E11856 (2018)]. One C6 binds with nanomolar affinity to each of the two S3–S4 voltage-sensor loops in hHv1 in cooperative fashion so that C6-bound channels require greater depolarization to open and do so more slowly. As depolarization drives hHv1 sensors outwardly, C6 affinity decreases, and inhibition is partial. Here, we identified residues essential to C6–hHv1 binding by scanning mutagenesis, five in the hHv1 S3–S4 loops and seven on C6. A structural model of the C6–hHv1 complex was then generated by molecular dynamics simulations and validated by mutant-cycle analysis. Guided by this model, we created a bivalent C6 peptide (C62) that binds simultaneously to both hHv1 subunits and fully inhibits current with picomolar affinity. The results help delineate the structural basis for C6 state-dependent inhibition, support an anionic lipid-mediated binding mechanism, and offer molecular insight into the effectiveness of engineered C6 as a therapeutic agent or lead.
    MeSH term(s) Drug Design ; Humans ; Ion Channels/antagonists & inhibitors ; Ion Channels/chemistry ; Ion Channels/genetics ; Male ; Mutagenesis ; Peptides/chemistry ; Peptides/pharmacology ; Protein Binding ; Protons ; Sperm Capacitation
    Chemical Substances HVCN1 protein, human ; Ion Channels ; Peptides ; Protons
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2120750119
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    Zs.A 1148: Show issues Location:
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  10. Article ; Online: Magnesium-containing bioceramics stimulate exosomal miR-196a-5p secretion to promote senescent osteogenesis through targeting

    Qi, Lei / Fang, Xin / Yan, Jinge / Pan, Cancan / Ge, Weiwen / Wang, Jing / Shen, Steve Gf / Lin, Kaili / Zhang, Lei

    Bioactive materials

    2023  Volume 33, Page(s) 14–29

    Abstract: Stem cell senescence is characterized by progressive functional dysfunction and secretory phenotypic changes including decreased proliferation, dysfunction of osteogenic and angiogenic differentiation, increased secretion of the senescence-associated ... ...

    Abstract Stem cell senescence is characterized by progressive functional dysfunction and secretory phenotypic changes including decreased proliferation, dysfunction of osteogenic and angiogenic differentiation, increased secretion of the senescence-associated secretory phenotype (SASP), which bring difficulties for bone repair. Rescuing or delaying senescence of aged bone marrow mesenchymal stem cells (O-BMSCs) was considered as effective strategy for bone regeneration in aging microenvironment. Magnesium (Mg) ion released from bioceramics was reported to facilitate bone regeneration via enhancing osteogenesis and alleviating senescence. In this study, Akermanite biocreamics (Akt) containing Mg ion as a model was demonstrated to promote osteogenesis and angiogenesis effects of O-BMSCs by activating the MAPK signaling pathway
    Language English
    Publishing date 2023-11-04
    Publishing country China
    Document type Editorial
    ISSN 2452-199X
    ISSN (online) 2452-199X
    DOI 10.1016/j.bioactmat.2023.10.024
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