LIVIVO - Search results -

Search results

Result 1 - 10 of total 720

Search options

Article ; Online: Using Billing Codes to Create a Pediatric Functional Status e-Score for Children Receiving Inpatient Rehabilitation.

Lundine, Jennifer P / Huling, Jared D / Adelson, P David / Burd, Randall S / Fuentes, Molly / Haarbauer-Krupa, Juliet / Hagen, Kaitlin / Iske, Cynthia / Koterba, Christine / Kurowski, Brad G / Petrucci, Stephanie / Rose, Sean C / Sadowsky, Cristina L / Westendorf, Jennifer / Truelove, Annie / Leonard, Julie C

Archives of physical medicine and rehabilitation

2023 Volume 104, Issue 11, Page(s) 1882–1891

Abstract: Objective: Provide proof-of-concept for development of a Pediatric Functional Status eScore (PFSeS). Demonstrate that expert clinicians rank billing codes as relevant to patient functional status and identify the domains that codes inform in a way that ... ...

Abstract	Objective: Provide proof-of-concept for development of a Pediatric Functional Status eScore (PFSeS). Demonstrate that expert clinicians rank billing codes as relevant to patient functional status and identify the domains that codes inform in a way that reliably matches analytical modeling. Design: Retrospective chart review, modified Delphi, and nominal group techniques. Setting: Large, urban, quaternary care children's hospital in the Midwestern United States. Participants: Data from 1955 unique patients and 2029 hospital admissions (2000-2020); 12 expert consultants representing the continuum of rehabilitation care reviewed 2893 codes (procedural, diagnostic, pharmaceutical, durable medical equipment). Main outcome measures: Consensus voting to determine whether codes were associated with functional status at discharge and, if so, what domains they informed (self-care, mobility, cognition/ communication). Results: The top 250 and 500 codes identified by statistical modeling were mostly composed of codes selected by the consultant panel (78%-80% of the top 250 and 71%-78% of the top 500). The results provide evidence that clinical experts' selection of functionally meaningful codes corresponds with codes selected by statistical modeling as most strongly associated with WeeFIM domain scores. The top 5 codes most strongly related to functional independence ratings from a domain-specific assessment indicate clinically sensible relationships, further supporting the use of billing data in modeling to create a PFSeS. Conclusions: Development of a PFSeS that is predicated on billing data would improve researchers' ability to assess the functional status of children who receive inpatient rehabilitation care for a neurologic injury or illness. An expert clinician panel, representing the spectrum of medical and rehabilitative care, indicated that proposed statistical modeling identifies relevant codes mapped to 3 important domains: self-care, mobility, and cognition/communication.
MeSH term(s)	Child ; Humans ; Retrospective Studies ; Inpatients ; Functional Status ; Activities of Daily Living ; Self Care
Language	English
Publishing date	2023-04-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80057-0
ISSN	1532-821X ; 0003-9993
ISSN (online)	1532-821X
ISSN	0003-9993
DOI	10.1016/j.apmr.2023.03.025
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ue I Zs.71: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A public e-survey to explore community understanding of the role of the midwife in Australia.

McKellar, Lois / Brown, Angela / Adelson, Pamela

European journal of midwifery

2019 Volume 3, Page(s) 20

Abstract: ... the role of the midwife. This study undertook an e-survey to explore Australian public perceptions ... of the role of the midwife.: Methods: A public opinion sample e-survey, using an exploratory design ...

Abstract	Introduction: There is compelling evidence that when a woman sees the same midwife there are better outcomes. Yet in Australia, access to midwifery continuity of care remains limited. There are a number of reasons for this but one barrier appears to be a lack of public understanding regarding the role of the midwife. This study undertook an e-survey to explore Australian public perceptions of the role of the midwife. Methods: A public opinion sample e-survey, using an exploratory design, a Likert scale and open-ended questions, was distributed through social media over six weeks. The survey was open to Australian residents and was completed by 1657 participants. Of these, 96.9% identified as female and 82.1% of participants had children. Results: Nearly half of the participants believed that a woman must see a doctor during pregnancy and after birth, compared to 21.9% during birth. Many participants described midwives as caring and supportive but there was a lack of understanding about their level of skill and expertise. A dominant theme was the alignment of medical care with safety and the perception that medical practitioners reduce risk. These misperceptions may impact on women making an informed choice regarding midwifery model of care in Australia. Conclusions: There is an underlying public narrative whereby the public primarily associate midwives with birth and perceive them as assistants rather than lead care providers. The study findings informed a public awareness campaign in South Australia conducted to educate the public's understanding of the role of the midwife.
Language	English
Publishing date	2019-11-29
Document type	Journal Article
ISSN	2585-2906
ISSN (online)	2585-2906
DOI	10.18332/ejm/114226
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Recombinant osmotin inclusion bodies from Calotropis procera produced in E. coli BL21(DE3) prevent acute inflammation in a mouse model of listeriosis.

Tavares, Lethicia Souza / Mancebo, Betty Dorvigny / Santana, Lucas Nunes / Adelson do Nascimento Silva, Alluanan / Silva, Roberta Lane de Oliveira / Benko-Iseppon, Ana Maria / Ramos, Márcio Viana / Monteiro do Nascimento, Camila Tauane / Grangeiro, Thalles Barbosa / Sousa, Jeanlex Soares / Mota, Rinaldo Aparecido / Júnior, Valdemiro Amaro da Silva / Lima-Filho, José Vitor

Phytomedicine : international journal of phytotherapy and phytopharmacology

2022 Volume 102, Page(s) 154186

Abstract: ... to investigate whether recombinant osmotin inclusion bodies from C. procera (IB/rCpOsm) produced in E. coli BL21 ... as an infection model.: Methods: Cells of E. coli BL21(DE3) carrying the plasmid pET303-CpOsm were used ...

Abstract	Background: The osmotin from the medicinal plant Calotropis procera (CpOsm) has characteristics similar to adiponectin, a human protein with immunoregulatory actions. Purpose: This study aimed to investigate whether recombinant osmotin inclusion bodies from C. procera (IB/rCpOsm) produced in E. coli BL21(DE3) can prevent infection-induced inflammation. A virulent strain of Listeria monocytogenes was used as an infection model. Methods: Cells of E. coli BL21(DE3) carrying the plasmid pET303-CpOsm were used to express the recombinant osmotin, which accumulated at reasonable levels as inclusion bodies (IB/rCpOsm). IB/rCpOsm were purified from induced cells and SDS-polyacrylamide gel electrophoresis followed by mass spectrometry analyses confirmed the identity of the major protein band (23 kDa apparent molecular mass) as CpOsm. Peritoneal macrophages (pMØ) from Swiss mice were cultured with IB/rCpOsm (1 or 10 µg/ml) in 96-well plates and then infected with L. monocytogenes. IB/rCpOsm (0.1, 1 or 10 mg/kg) was also administered intravenously to Swiss mice, which were then infected intraperitoneally with L. monocytogenes. Results: Pretreatment of the pMØ with IB/rCpOsm significantly increased cell viability after infection and reduced the intracellular bacterial load. The infiltration of neutrophils into the peritoneal cavity of mice pretreated with IB/rCpOsm at 10 mg/kg (but not 0.1 and 1 mg/kg) was reduced after infection. In these mice, the bacterial load was high in the peritoneal fluid and the liver, but histological damage was discrete. The treatments with IB/rCpOsm at 10 mg/kg significantly increased the expression of the anti-inflammatory cytokine IL-10. Conclusion: This study shows that recombinant osmotin inclusion bodies from C. procera were bioactive and prompted anti-inflammatory actions at therapeutic dosages in the L. monocytogenes infection model.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Calotropis/chemistry ; Disease Models, Animal ; Escherichia coli ; Inclusion Bodies/metabolism ; Inflammation/drug therapy ; Latex/chemistry ; Listeriosis/drug therapy ; Mice ; Plant Proteins/pharmacology
Chemical Substances	Anti-Inflammatory Agents ; Latex ; Plant Proteins
Language	English
Publishing date	2022-05-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2022.154186
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4115: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Greater effect of polygenic risk score for Alzheimer's disease among younger cases who are apolipoprotein E-ε4 carriers.

Fulton-Howard, Brian / Goate, Alison M / Adelson, Robert P / Koppel, Jeremy / Gordon, Marc L / Barzilai, Nir / Atzmon, Gil / Davies, Peter / Freudenberg-Hua, Yun

Neurobiology of aging

2020 Volume 99, Page(s) 101.e1–101.e9

Abstract: To evaluate how age and apolipoprotein E-ε4 (APOE4) status interact with APOE-independent polygenic ...

Abstract	To evaluate how age and apolipoprotein E-ε4 (APOE4) status interact with APOE-independent polygenic risk score (PRS
MeSH term(s)	Age Factors ; Age of Onset ; Aged ; Alzheimer Disease/epidemiology ; Alzheimer Disease/genetics ; Apolipoprotein E4/genetics ; Female ; Heterozygote ; Humans ; Male ; Middle Aged ; Multifactorial Inheritance/genetics ; Risk Factors
Chemical Substances	Apolipoprotein E4
Language	English
Publishing date	2020-09-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604505-4
ISSN	1558-1497 ; 0197-4580
ISSN (online)	1558-1497
ISSN	0197-4580
DOI	10.1016/j.neurobiolaging.2020.09.014
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1685: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 10: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Book: History of the Kaiser Permanente medical care program / 11 / George E. Link ; conducted by Malca Chall

Adelson, David

an interview ; Kaiser Permanente medical care program oral history project

1986

Institution	Bancroft Library / Regional Oral History Office
Author's details	Regional Oral History Office, the Bancroft Library, University of California, Berkeley, California
Collection	History of the Kaiser Permanente medical care program
Language	English
Size	IX, 77 S. : Ill.
Publisher	Kaiser Permanente
Publishing place	Oakland, Calif.
Publishing country	United States
Document type	Book
HBZ-ID	HT006635396
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
1995 A 2645 -11-	order for loan	Magazin

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Book: History of the Kaiser Permanente medical care program / 18 / Eugene E. Trefethen ; conducted by Malca Chall

Adelson, David

an interview ; Kaiser Permanente medical care program oral history project

1986

Institution	Bancroft Library / Regional Oral History Office
Author's details	Regional Oral History Office, the Bancroft Library, University of California, Berkeley, California
Collection	History of the Kaiser Permanente medical care program
Language	English
Size	X, 96 S. : Ill.
Publisher	Kaiser Permanente
Publishing place	Oakland, Calif.
Publishing country	United States
Document type	Book
HBZ-ID	HT006635577
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
1995 A 2645 -18-	order for loan	Magazin

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Recombinant osmotin inclusion bodies from Calotropis procera produced in E. coli BL21(DE3) prevent acute inflammation in a mouse model of listeriosis

Phytomedicine. 2022 July 20, v. 102

2022

Abstract: ... whether recombinant osmotin inclusion bodies from C. procera (IB/rCpOsm) produced in E. coli BL21(DE3) can prevent ... Cells of E. coli BL21(DE3) carrying the plasmid pET303-CpOsm were used to express the recombinant ...

Abstract	The osmotin from the medicinal plant Calotropis procera (CpOsm) has characteristics similar to adiponectin, a human protein with immunoregulatory actions. This study aimed to investigate whether recombinant osmotin inclusion bodies from C. procera (IB/rCpOsm) produced in E. coli BL21(DE3) can prevent infection-induced inflammation. A virulent strain of Listeria monocytogenes was used as an infection model. Cells of E. coli BL21(DE3) carrying the plasmid pET303-CpOsm were used to express the recombinant osmotin, which accumulated at reasonable levels as inclusion bodies (IB/rCpOsm). IB/rCpOsm were purified from induced cells and SDS-polyacrylamide gel electrophoresis followed by mass spectrometry analyses confirmed the identity of the major protein band (23 kDa apparent molecular mass) as CpOsm. Peritoneal macrophages (pMØ) from Swiss mice were cultured with IB/rCpOsm (1 or 10 µg/ml) in 96-well plates and then infected with L. monocytogenes. IB/rCpOsm (0.1, 1 or 10 mg/kg) was also administered intravenously to Swiss mice, which were then infected intraperitoneally with L. monocytogenes. Pretreatment of the pMØ with IB/rCpOsm significantly increased cell viability after infection and reduced the intracellular bacterial load. The infiltration of neutrophils into the peritoneal cavity of mice pretreated with IB/rCpOsm at 10 mg/kg (but not 0.1 and 1 mg/kg) was reduced after infection. In these mice, the bacterial load was high in the peritoneal fluid and the liver, but histological damage was discrete. The treatments with IB/rCpOsm at 10 mg/kg significantly increased the expression of the anti-inflammatory cytokine IL-10. This study shows that recombinant osmotin inclusion bodies from C. procera were bioactive and prompted anti-inflammatory actions at therapeutic dosages in the L. monocytogenes infection model.
Keywords	Calotropis procera ; Escherichia coli ; Listeria monocytogenes ; adiponectin ; cell viability ; histology ; humans ; immunomodulation ; inflammation ; interleukin-10 ; intravenous injection ; listeriosis ; liver ; macrophages ; mass spectrometry ; medicinal plants ; mice ; microbial load ; molecular weight ; neutrophils ; plasmids ; polyacrylamide gel electrophoresis ; virulent strains
Language	English
Dates of publication	2022-0720
Publishing place	Elsevier GmbH
Document type	Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2022.154186
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 4115: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: CARBOIDRATOS FIBROSOS E NÃO FIBROSOS NA DIETA DE RUMINANTES E SEUS EFEITOS SOBRE A MICROBIOTA RUMINAL

Vinicius da Silva Oliveira / José Adelson Santana Neto / Roberta de Lima Valença / Barbará Cristina Dantas da Silva / Ana Caroline Pinho dos Santos

Veterinary News, Vol 22, Iss 2, Pp 1-

2016 Volume 18

Abstract: The objective of this review is to evaluate the concentration of fibrous carbohydrates and no fibrous in the diet of ruminants and the effects on ruminal microflora. Carbohydrates are the most abundant biomolecules nature, have structural and energetic ... ...

Abstract	The objective of this review is to evaluate the concentration of fibrous carbohydrates and no fibrous in the diet of ruminants and the effects on ruminal microflora. Carbohydrates are the most abundant biomolecules nature, have structural and energetic function, the main energy source for ruminants. Can be classified according to their structure, function and nutritional point of view, the break of fibrous and non-fibrous carbohydrates. Carbohydrates are fermented in the rumen by action of microbial flora, which has its development directly affected by the type of carbohydrate, for the rumen microorganisms have specificity as to substrate fermenting. In addition to that, the rate of fermentation of carbohydrates in the rumen alters the rumen conditions, directly affecting the development of microorganisms present in it. The non-fibrous carbohydrates have a high rate of fermentation, leading to lowering of ruminal pH, influencing the development of the rumen flora, since the nonfibrous carbohydrates have low fermentation rate, and stimulate rumination and increased salivation animal, which aids in tamponade the pH of the rumen. Therefore, the balance in the supply of fibrous and non fibrous carbohydrate is important for maintaining stable rumen. The main product of ruminal fermentation of carbohydrates are the AGV's, which are used by ruminants as the main energy source.
Keywords	microbial flora ; rumen ; VGA's ; Veterinary medicine ; SF600-1100
Subject code	660
Language	English
Publishing date	2016-07-01T00:00:00Z
Publisher	EDUFU
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: A randomised controlled trial of outpatient compared with inpatient cervical ripening with prostaglandin E₂ (OPRA study).

Wilkinson, C / Bryce, R / Adelson, P / Turnbull, D

BJOG : an international journal of obstetrics and gynaecology

2015 Volume 122, Issue 1, Page(s) 94–104

Abstract: Objective: To compare clinical outcomes from outpatient with inpatient cervical prostaglandin E2 ripening for low risk labour induction.: Design: Randomised controlled trial.: Setting: Two tertiary hospitals in Adelaide, Australia.: Population: ...

Abstract	Objective: To compare clinical outcomes from outpatient with inpatient cervical prostaglandin E2 ripening for low risk labour induction. Design: Randomised controlled trial. Setting: Two tertiary hospitals in Adelaide, Australia. Population: Women with uncomplicated term pregnancies, scheduled for induction of labour for reasons of post-dates or for social reasons. Methods: Eight hundred and twenty-seven women were randomised at induction decision to an outpatient or inpatient group. All women had CTG monitoring before and after vaginal PgE2 administration. The inpatient women were admitted and the outpatient group was discharged home overnight with instructions to return if labour established or rupture of membranes occurred. Next morning, outpatient women were admitted for rupture of membranes or further ripening. After membrane rupture, both groups received routine care. Main outcome measures: Oxytocin use, maternal and fetal outcomes, and whether planned outpatient management was achievable. Results: There were no significant differences in oxytocin use (2.5% difference, CI-4.3 to 9.4), caesarean sections (-0.59% difference, CI-6.3 to 5.1), epidural use (1.5% difference, CI-5.1 to 8.2), vaginal delivery within 24 hours (-8.2% difference, CI-17.6 to 1.3) or labour complications. More than half of the randomised women did not receive the intervention as they laboured spontaneously, or did not require ripening. The post-hoc analysis of women who received ripening also indicated no statistically significant differences in the patterns or results, with the exception of outpatient women having a longer mean length of active labour (mean difference 66 minutes, CI 4-128 minutes). Outpatient women who received ripening were diagnosed more frequently with non-reassuring CTG monitoring and hyperstimulation, with less than half of the women going home and remaining home overnight. Conclusions: This study demonstrated no clinical advantage or disadvantage in prostaglandin E2 outpatient cervical ripening. Uterine stimulation following prostaglandins may preclude a woman from going home or remaining at home overnight and may not be the best agent for outpatient ripening.
MeSH term(s)	Administration, Intravaginal ; Adult ; Ambulatory Care/methods ; Anesthesia, Epidural/utilization ; Anesthesia, Obstetrical/utilization ; Cervical Ripening ; Cesarean Section/utilization ; Delivery, Obstetric/statistics & numerical data ; Dinoprostone ; Female ; Hospitalization ; Humans ; Labor, Induced/methods ; Labor, Obstetric ; Obstetric Labor Complications/epidemiology ; Oxytocics ; Oxytocin ; Pregnancy ; Time Factors ; Treatment Outcome ; Young Adult
Chemical Substances	Oxytocics ; Oxytocin (50-56-6) ; Dinoprostone (K7Q1JQR04M)
Language	English
Publishing date	2015-01
Publishing country	England
Document type	Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2000931-8
ISSN	1471-0528 ; 0306-5456 ; 1470-0328
ISSN (online)	1471-0528
ISSN	0306-5456 ; 1470-0328
DOI	10.1111/1471-0528.12846
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Um I Zs.121: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: HEPATOTOXICIDADE INDUZIDA PELO PARACETAMOL E A UTILIZAÇÃO DO NOMOGRAMA DE RUMACK-MATTHEW PARA AVALIAR A TERAPÊUTICA COM N-ACETILCISTEÍNA

José Guedes da Silva Júnior / Natália da Silva Diniz de Souza Santos / Hallysson Douglas Andrade de Araújo / Bruno Dyogenis Cecilio Sá / José Adelson Alves do Nascimento Júnior / Nadine Gabryella Pontes Maciel / Sílvia Renata Ribeiro Araújo / Victor Felipe da Silva Araújo / Maria Auxiliadora Macêdo Callou / Talyta Valéria Siqueira do Monte

Revista Uningá, Vol 56, Iss

2019 Volume 4

Abstract: O paracetamol ou acetaminofeno pertence à classe dos anti-inflamatórios não esteroidais (AINEs) e é atualmente um dos fármacos de venda livre mais popular e consumido no mundo. Este medicamento apresenta um bom perfil de segurança quando usado em doses ... ...

Abstract	O paracetamol ou acetaminofeno pertence à classe dos anti-inflamatórios não esteroidais (AINEs) e é atualmente um dos fármacos de venda livre mais popular e consumido no mundo. Este medicamento apresenta um bom perfil de segurança quando usado em doses terapêuticas. No entanto, em casos de super-dosagem, intoxicação grave e insuficiência hepática podem ocorrer. O metabólito responsável pelos efeitos tóxicos é N-acetil-p-benzoquinonaimina (NAPQI), que após depleção dos níveis de glutationa (GSH), liga-se covalentemente a macromoléculas causando lesão nos hepatócitos. Visando disponibilizar um material fundamentado teoricamente no qual está descrito em detalhes os mecanismos que levam a hepatotoxicidade, os principais fatores que estão envolvidos nesse processo e uma solução imediata e eficaz na tentativa de reverter o quadro, foi realizada uma revisão bibliográfica utilizando material extraído das bases de dados SciElO (Scientific Electronic Library Online), BVS (Biblioteca Virtual em Saúde), Google Acadêmico e PubMed, como forma de explicar os eventos responsáveis por desencadear a toxicidade, como também medidas que podem ser tomadas diante de um paciente intoxicado com acetaminofen. Contudo, a obtenção de níveis séricos de paracetamol dentro 4-24 horas permite fazer uma estimativa da gravidade da intoxicação baseado no nomograma de Rumack-Matthews, que é um parâmetro utilizado para iniciar ou não o tratamento com N-acetilcisteína (NAC), antídoto padrão empregado em situações de overdose causado por paracetamol. Assim, a terapia antidotal de NAC visa fornecer a cisteína necessária para a síntese hepática de glutationa. Palavras-chave: Hepatotoxicidade, Paracetamol, (NAPQI), Glutationa, N-acetilcisteína e anti-inflamatórios (AINE).
Keywords	Hepatotoxicidade ; Paracetamol ; NAPQI ; Glutationa ; N-acetilcisteína ; anti-inflamatórios (AINE) ; Biology (General) ; QH301-705.5 ; Nursing ; RT1-120
Language	English
Publishing date	2019-11-01T00:00:00Z
Publisher	Editora Uningá
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED