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Article ; Online: Emerging therapeutic strategy for mitigating cancer progression through inhibition of sirtuin-1 and epithelial-mesenchymal transition.

El-Ashmawy, Nahla E / Khedr, Eman G / Khedr, Naglaa F / El-Adawy, Samar A

2023 Volume 251, Page(s) 154907

Abstract: With 8.8 million deaths worldwide, cancer is the major reason for the high rate of fatalities. Malignancy's commencement, progression, development, metastasis, and therapy resistance have all been correlated with the epithelial-to-mesenchymal transition ( ...

Abstract	With 8.8 million deaths worldwide, cancer is the major reason for the high rate of fatalities. Malignancy's commencement, progression, development, metastasis, and therapy resistance have all been correlated with the epithelial-to-mesenchymal transition (EMT) pathway. EMT promotes the cancer cells' metastatic spread and starts the development of treatment resistance. Sirtuin-1 (SIRT1) is a histone deacetylase that is important for signaling, cell persistence, and apoptosis. It does this by deacetylating important cell signaling molecules and proteins that are associated with apoptosis. The function of SIRT1 in EMT and cancer progression, as well as the emerging therapeutic strategy of treating cancer through the inhibition of SIRT1 and EMT will be discussed in detail.
MeSH term(s)	Humans ; Sirtuin 1/metabolism ; Epithelial-Mesenchymal Transition ; Cell Line, Tumor ; Signal Transduction ; Neoplasms
Chemical Substances	Sirtuin 1 (EC 3.5.1.-)
Language	English
Publishing date	2023-10-25
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2023.154907
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Article ; Online: Suppression of epithelial-mesenchymal transition and SIRT1/AKT signaling pathway in breast cancer by montelukast.

El-Ashmawy, Nahla E / Khedr, Eman G / Khedr, Naglaa F / El-Adawy, Samar A

International immunopharmacology

2023 Volume 119, Page(s) 110148

Abstract: ... but upregulated E-cadherin expression. Furthermore, all treatments retarded angiogenesis as evidenced by decreased ...

Abstract	Background: Breast cancer is usually associated with metastatic features, poor prognosis, and high mortality. The epithelial-mesenchymal transition (EMT) process has been implicated in the initiation and metastasis of breast cancer. Objective: The study aimed to investigate the possible role of montelukast (Mont), the cysteinyl leukotriene receptor (CystLT1R) antagonist, in mitigating EMT in triple-negative breast cancer (TNBC) (in vitro study) and solid Ehrlich carcinoma (SEC) bearing mice (in vivo study) as well as to clarify the underlying molecular mechanisms in the presence and absence of sirtuin-1 inhibitor (sirtinol; Sirt). Methods: TNBC MDA-MB-231 cells were treated with either 5 μM Mont or 25 μM Sirt or both for 48 h. Alternatively, SEC cells were inoculated in mice to induce breast cancer. After 12 days, the mice were divided into four groups: Untreated SEC group (vehicle), Sirt group (1 mg/kg), Mont group (10 mg/kg), and cotreatment Sirt/Mont group. The mice groups received the assigned treatment for the consequent 16 days. Results: Mont and/or Sirt decreased cell proliferation, migration and suppressed EMT in both in vitro and in vivo experiments. All treatments downregulated sirtuin-1 and vimentin expression but upregulated E-cadherin expression. Furthermore, all treatments retarded angiogenesis as evidenced by decreased VEGF expression. These findings were associated with suppressing active protein kinase B (p-AKT). Conclusion: Cotreatment with Sirt and Mont proved more effective anti-tumor activity in TNBC cell line and in SEC bearing mice than either treatment alone, which could be attributed to the inhibition of sirtuin-1 and AKT- activated pathways, with the subsequent inhibition of EMT.
MeSH term(s)	Humans ; Animals ; Mice ; Triple Negative Breast Neoplasms/pathology ; Proto-Oncogene Proteins c-akt/metabolism ; Epithelial-Mesenchymal Transition ; Sirtuin 1/metabolism ; Signal Transduction ; Cell Proliferation ; Cell Line, Tumor ; Cell Movement
Chemical Substances	montelukast (MHM278SD3E) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Sirtuin 1 (EC 3.5.1.-) ; SIRT1 protein, human (EC 3.5.1.-) ; Sirt1 protein, mouse (EC 3.5.1.-)
Language	English
Publishing date	2023-04-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2023.110148
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Article ; Online: Long noncoding RNAs as regulators of epithelial mesenchymal transition in breast cancer: A recent review.

El-Ashmawy, Nahla E / Khedr, Eman G / Abo-Saif, Mariam A / Hamouda, Sara M

Life sciences

2023 Volume 336, Page(s) 122339

Abstract: Aims: Breast cancer (BC) is the most frequently occurring cancer in women worldwide. BC patients are often diagnosed at advanced stages which are characterized by low survival rates. Distant metastasis is considered a leading cause of mortalities among ... ...

Abstract	Aims: Breast cancer (BC) is the most frequently occurring cancer in women worldwide. BC patients are often diagnosed at advanced stages which are characterized by low survival rates. Distant metastasis is considered a leading cause of mortalities among BC patients. Epithelial-to-mesenchymal transition (EMT) is a transdifferentiation program that is necessary for cancer cells to acquire metastatic potential. In the last decade, long noncoding RNAs (lncRNAs) proved their significant contribution to different hallmarks of cancer, including EMT and metastasis. The primary aim of our review is to analyze recent studies concerning the molecular mechanisms of lncRNAs implicated in EMT regulation in BC. Materials and methods: We adopted a comprehensive search on databases of PubMed, Web of Science, and Google Scholar using the following keywords: lncRNAs, EMT, breast cancer, and therapeutic targeting. Key findings: The different roles of lncRNAs in the mechanisms and signaling pathways governing EMT in BC were summarized. LncRNAs could induce or inhibit EMT through WNT/β-catenin, transforming growth factor-β (TGF-β), Notch, phosphoinositide 3-kinase/protein kinase B (PI3K/AKT), signal transducer and activator of transcription 3 (STAT3), and nuclear factor kappa B (NF-κB) pathways as well as via their interaction with histone modifying complexes and miRNAs. Significance: LncRNAs are key regulators of EMT and BC metastasis, presenting potential targets for therapeutic interventions. Further research is necessary to investigate the practical application of lncRNAs in clinical therapeutics.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/pathology ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; MicroRNAs/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic
Chemical Substances	RNA, Long Noncoding ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; MicroRNAs
Language	English
Publishing date	2023-12-12
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2023.122339
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Article ; Online: Recombinant Human Lactoferrin Augments Epirubicin Chemotherapy in Solid Ehrlich Carcinoma Bearing Mice.

El-Ashmawy, Nahla E / Khedr, Eman G / El-Kady, Amira Y / Al-Ashmawy, Ghada M

Current drug safety

2022 Volume 18, Issue 3, Page(s) 345–354

Abstract: Background: Lactoferrin (LF) is a member of the transferrin family, which is known for its immunomodulatory properties. LF has been widely used as an anticancer medication in various cancers including breast cancer.: Aims: The current study aimed to ... ...

Abstract	Background: Lactoferrin (LF) is a member of the transferrin family, which is known for its immunomodulatory properties. LF has been widely used as an anticancer medication in various cancers including breast cancer. Aims: The current study aimed to examine the molecular mechanisms underlying the therapeutic potential of recombinant human lactoferrin (rhLF), either alone or combined with epirubicin (EPI), in mice bearing solid Ehrlich carcinoma (SEC). Methods: SEC-bearing female mice (n=40) were divided into 4 equal groups. Mice were given rhLF orally (100mg/kg/mouse) daily and/or EPI i.p (8mg/kg/mouse). The experiment lasted 14 days, after which samples were collected to measure IL-18 and phosphorylated c-Jun N-terminal kinase (p-JNK) by ELISA and p Results: Administration of rhLF, either alone or combined with EPI, markedly decreased the tumor volume and increased tumor inhibition rate as well as survival rate compared to either tumor control group or EPI-mono treated group. In addition, co-administration of rhLF and EPI increased the level of activated JNKs and expression of p Conclusion: Recombinant human lactoferrin exhibited potential anticancer and immune-enhancing properties in mice with breast cancer. Co-treatment with rhLF and EPI proved to be a promising strategy in cancer treatment.
MeSH term(s)	Animals ; Mice ; Humans ; Female ; Lactoferrin/pharmacology ; Lactoferrin/genetics ; Lactoferrin/metabolism ; Epirubicin/pharmacology ; Interleukin-18/metabolism ; Carcinoma/drug therapy ; Breast Neoplasms/drug therapy ; Recombinant Proteins/pharmacology
Chemical Substances	Lactoferrin (EC 3.4.21.-) ; Epirubicin (3Z8479ZZ5X) ; Interleukin-18 ; Recombinant Proteins
Language	English
Publishing date	2022-04-30
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2250840-5
ISSN	2212-3911 ; 1574-8863
ISSN (online)	2212-3911
ISSN	1574-8863
DOI	10.2174/1574886317666220429102445
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Article ; Online: Hemin versus erythropoietin: Possible role in Nrf2/HO-1 signaling pathway in rats with nephrotoxicity.

El-Ashmawy, Nahla E / Al-Ashmawy, Ghada M / Farag, Amr A / Ibrahim, Amera O

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2022 Volume 156, Page(s) 113971

Abstract: Background and aim: Gentamycin-induced nephrotoxicity is related to stimulation of oxidative stress and inflammatory cascades leading to apoptotic renal damage. Heme oxygenase-1 (HO-1) induction considered to be an adaptive response against oxidative ... ...

Abstract	Background and aim: Gentamycin-induced nephrotoxicity is related to stimulation of oxidative stress and inflammatory cascades leading to apoptotic renal damage. Heme oxygenase-1 (HO-1) induction considered to be an adaptive response against oxidative tissue damage. Our study aimed to investigate the possible nephroprotective role of HO-1 inducers (hemin and erythropoietin (EPO)) and elucidate their potential underlying molecular mechanisms by assessing their antioxidant, anti-apoptotic, and anti-inflammatory properties. Methods: Kidney function markers (urea and creatinine), lipid peroxidation and antioxidant markers (MDA and GPx), inflammation and apoptotic markers (IL-6 and Bcl-2), and the relative gene expression levels of Nrf2 and HO-1 were assessed. Histopathological changes of the kidney were examined. Results: Nephrotoxic rats pretreated with hemin showed significant decrease in serum level of urea, creatinine, and MDA, compared to non-treated group. The kidney tissues also showed significant elevation of Bcl2 level, but significant decrease of IL-6, compared to non-treated group. Moreover, hemin pre-treatment significantly upregulated gene expression of Nrf2 and HO-1 in kidney tissue to near the normal control group. On the other hand, pretreatment with EPO showed significant upregulation of HO-1 gene expression but didn't show significant difference in Nrf2 gene expression compared to control group. The histopathological examination of kidney supported the biochemical results. Conclusion: The current results proved that hemin rather than EPO, showed reno-protective effects in rats, which was mediated by activation of Nrf2 signaling pathway. This could be also attributed to the observed anti-inflammatory, antioxidant, and anti-apoptotic properties of hemin. In this regard, EPO showed lower potency.
MeSH term(s)	Rats ; Animals ; Heme Oxygenase-1/genetics ; Heme Oxygenase-1/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Hemin/pharmacology ; Antioxidants/pharmacology ; Creatinine ; Interleukin-6/pharmacology ; GA-Binding Protein Transcription Factor/metabolism ; Signal Transduction ; Erythropoietin/pharmacology ; Urea
Chemical Substances	Heme Oxygenase-1 (EC 1.14.14.18) ; NF-E2-Related Factor 2 ; Hemin (743LRP9S7N) ; Antioxidants ; Creatinine (AYI8EX34EU) ; Interleukin-6 ; GA-Binding Protein Transcription Factor ; Erythropoietin (11096-26-7) ; Urea (8W8T17847W)
Language	English
Publishing date	2022-11-07
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2022.113971
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Article: Effect of activation of liver X receptor alpha on cardiac & hepatic ABCC10 and SLC17A5 drug transporters in hypercholesterolemic rat model

El-Ashmawy, Nahla E. / Khedr, Naglaa F. / Sallam, Mohamed / Nossier, Ahmed Ibrahim

Biochemical and biophysical research communications. 2022 June 25, v. 610

2022

Abstract: Liver x receptor α (LXRα) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily. Oxysterols (endogenous oxidized cholesterol derivatives) are the most potent endogenous LXRα-agonist. LXRα has a direct impact on several ... ...

Abstract	Liver x receptor α (LXRα) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily. Oxysterols (endogenous oxidized cholesterol derivatives) are the most potent endogenous LXRα-agonist. LXRα has a direct impact on several members of drug transporter superfamilies; ATP-binding cassette (ABC) and solute linked carrier (SLC). The current study aimed to investigate the effect of LXRα-activation by either endogenous oxysterols or a synthetic LXRα-agonist (LXRa) such as TO901317 on hepatic and cardiac gene expression of ABCC10 and SLC17A5 drug transporters in an experimentally hypercholesterolemic rat model. 48 male rats were divided randomly into four groups (n = 12); control group rats received vehicle; hypercholesterolemic group (HCH group) rats received diet contain 2.5% cholesterol &deoxycholic acid for 8 weeks; (LXRa group) rats were fed standard pellet chow for 8 weeks, then a single dose of LXRa was administered (IP) at a dose of 10 mg/kg; (HCH + LXRa group) rats received diet contain 2.5% cholesterol &deoxycholic acid for 8 weeks, then a single dose of LXRa was administered (IP) at a dose of 10 mg/kg. Our findings revealed that hypercholesterolemia and LXRa significantly activated LXRα to varying degrees in both hepatic and cardiac tissues with subsequent alteration of LXRα and ABCC10 gene expression. Whereas, SLC17A5 gene expression was primarily affected by elevated serum cholesterol level and unmediated via LXRα-activation. Accordingly, it was concluded that ABCC10 is a specific LXRα-target gene and that LXRα autoregulates its own expression in rats.
Keywords	animal models ; blood serum ; diet ; drugs ; gene expression ; genes ; hypercholesterolemia ; liver ; males ; oxidation ; oxysterols ; research ; solutes ; transcription factors
Language	English
Dates of publication	2022-0625
Size	p. 133-139.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.04.046
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Article ; Online: Carnosine and crocin ameliorate oxidative stress in rats with rhabdomyolysis-induced acute kidney injury through upregulating HO-1 gene expression

El-Ashmawy, Nahla E. / Khedr, Eman G. / Doghish, Ahmed S. / Elballal, Mohammed S.

Food Bioscience. 2022 Oct., v. 49 p.101972-

2022

Abstract: We aimed to investigate whether carnosine (a natural dipeptide found in humans) and crocin (a natural product extracted from saffron and gardenia) can prevent the harmful effects of acute kidney injury (AKI) caused by glycerol-induced rhabdomyolysis with ...

Abstract	We aimed to investigate whether carnosine (a natural dipeptide found in humans) and crocin (a natural product extracted from saffron and gardenia) can prevent the harmful effects of acute kidney injury (AKI) caused by glycerol-induced rhabdomyolysis with a focus on the role of the nuclear factor E2-related factor-2/heme oxygenase-1 (Nrf2/HO-1) signaling pathway. Thirty-six male Wistar rats were divided into 6 groups: 3 of them received saline, carnosine, and crocin IP for 7 days and the other 3 groups received the same treatment in addition to a single IM injection of 50% glycerol (10 ml/kg, divided between the two limb muscles) on 8th day. All animals were sacrificed after 24 h of the IM injection. Blood samples, muscles, and kidneys were collected for further investigations. Rhabdomyolysis was evidenced by the histopathological alterations in muscle sections and increased levels of myoglobin in kidney tissue homogenate samples. Kidney injury was characterized by increased creatinine, kidney injury molecule-1, malondialdehyde, nitric oxide, and decreased catalase activity. The injury also increased inflammatory markers and histopathological alterations in kidney sections. All these effects were corrected by pretreatment with carnosine and crocin. Both agents could also elevate HO-1 gene expression. However, both agents failed to restore the declined Nrf2 expression in glycerol-treated groups. Carnosine and crocin can effectively prevent rhabdomyolysis-induced AKI in rats through augmenting gene expression of HO-1 and antioxidant system and suppressing the generation of reactive oxygen species, lipid peroxidation, and inflammatory response.
Keywords	Gardenia ; acute kidney injury ; blood ; carnosine ; catalase ; creatinine ; gene expression ; glycerol ; histopathology ; inflammation ; kidneys ; lipid peroxidation ; males ; malondialdehyde ; muscles ; myoglobin ; nitric oxide ; oxidative stress ; reactive oxygen species ; rhabdomyolysis ; saffron ; Crocin ; Antioxidant
Language	English
Dates of publication	2022-10
Publishing place	Elsevier Ltd
Document type	Article ; Online
ISSN	2212-4292
DOI	10.1016/j.fbio.2022.101972
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Article ; Online: Upregulation of GLUT4 and PI3K, and downregulation of GSK3 mediate the anti-hyperglycemic effects of proanthocyanidins.

El-Ashmawy, Nahla E / Khedr, Eman G / Alfeky, Nehal H / Ibrahim, Amera O

Medicine international

2022 Volume 2, Issue 3, Page(s) 14

Abstract: Diabetes mellitus is the most common chronic metabolic disorder worldwide. The present study was designed to investigate the potential role of cinnamon bark extract oligomeric proanthocyanidins (OPCs) in controlling streptozotocin (STZ)-induced ... ...

Abstract	Diabetes mellitus is the most common chronic metabolic disorder worldwide. The present study was designed to investigate the potential role of cinnamon bark extract oligomeric proanthocyanidins (OPCs) in controlling streptozotocin (STZ)-induced hyperglycemia and to clarify the underlying molecular mechanisms underlying its effects. For this purpose, 60 male rats were equally divided into six groups as follows: The normal control group; OPC control group (non-diabetic rats treated with OPC at 300 mg/kg orally for 21 days); the untreated diabetic control group; the wortmannin control group [diabetic rats treated with wortmannin at 1 mg/kg, intraperitoneal (i.p.) on the final day of the experiment]; the OPC diabetic group (diabetic rats treated with OPC at 300 mg/kg orally for 21 days); and the OPC diabetic + wortmannin co-treated group (diabetic rats treated with OPC at 300 mg/kg/day for 21 consecutive days and then 24 h after the final OPC dose treated with a single wortmannin injection at 1 mg/kg, i.p.). The results indicated that OPC ameliorated the diabetic state, as evidenced by a significant decrease in serum glucose levels, and a significant increase in the levels of insulin, amylin, insulin receptor phosphorylation, glycogen and glucose transporter-4 translocation; it also improved the lipid profile in STZ-diabetic rats. On the whole, the findings of the present study provide biochemical evidence that OPC treatment is effective as an anti-diabetic and anti-hyperlipidemic agent by enhancing glucose uptake through the activation of insulin receptor kinase activity and the PI3K/Akt pathway.
Language	English
Publishing date	2022-04-11
Publishing country	England
Document type	Journal Article
ISSN	2754-1304
ISSN (online)	2754-1304
DOI	10.3892/mi.2022.39
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Article ; Online: Long non-coding RNA FAM83H-AS1 as an emerging marker for diagnosis, prognosis and therapeutic targeting of cancer.

El-Ashmawy, Nahla E / Al-Ashmawy, Ghada M / Hamouda, Sara M

Cell biochemistry and function

2020 Volume 39, Issue 3, Page(s) 350–356

Abstract: Incidence and mortality rates of cancer continue to increase greatly despite the improved diagnostic and therapeutic methods. Based on GLOBOCAN estimates, the numbers of new cancer cases reported in 2018 were ~18.1 million, while the numbers of cancer ... ...

Abstract	Incidence and mortality rates of cancer continue to increase greatly despite the improved diagnostic and therapeutic methods. Based on GLOBOCAN estimates, the numbers of new cancer cases reported in 2018 were ~18.1 million, while the numbers of cancer mortalities were ~9.6 million. It remains difficult to diagnose most cancer patients at early stages. Although cancer therapy market is rapidly evolving, the effectiveness of therapy is still inadequate. Therefore, exploring new biomarkers for diagnosis, prognosis and treatment is essential for cancer management. Long non-coding RNAs (lncRNAs) are unique regulatory molecules that control several cellular processes and are implicated in diverse human diseases including cancer. LncRNAs could serve as potential biomarkers for cancer patients to aid diagnosis and determine prognosis. In addition, numerous lncRNAs have proved their ability to predict response to cancer treatment. FAM83H antisense RNA 1 (FAM83H-AS1) is among those highly dysregulated lncRNAs in cancer. FAM83H-AS1 was demonstrated to participate in the progression of different malignancies and also shown to play a vital role in diagnosis, prognosis and treatment. Here, we analyse recent studies concerning the oncogenic role and molecular mechanisms of lncRNA FAM83H-AS1 in the following cancer types: bladder, breast, lung, hepatocellular, colorectal, gastric, pancreatic, ovarian, cervical cancer as well as glioma.
MeSH term(s)	Biomarkers, Tumor/biosynthesis ; Early Detection of Cancer ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplasms/diagnosis ; Neoplasms/metabolism ; Neoplasms/therapy ; Prognosis ; RNA, Long Noncoding/biosynthesis ; RNA, Neoplasm/biosynthesis
Chemical Substances	Biomarkers, Tumor ; RNA, Long Noncoding ; RNA, Neoplasm
Language	English
Publishing date	2020-11-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	283643-9
ISSN	1099-0844 ; 0263-6484
ISSN (online)	1099-0844
ISSN	0263-6484
DOI	10.1002/cbf.3601
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Article ; Online: Comparative Efficacy and Safety Study of Darbepoetin Alfa

El-Ashmawy, Nahla E / Khedr, Eman G / Kotb, Nahla S / Salem, Fathi / Ibrahim, Amera O

Current drug safety

2021 Volume 17, Issue 3, Page(s) 250–258

Abstract: Background: Anemia is one of the most common complications of Chronic Kidney Disease (CKD). The vast majority of Egyptian CKD patients are interchangeably treated with Darbepoetin Alfa (DPA) and Epoetin Alfa (EPA) to achieve and maintain target ... ...

Abstract	Background: Anemia is one of the most common complications of Chronic Kidney Disease (CKD). The vast majority of Egyptian CKD patients are interchangeably treated with Darbepoetin Alfa (DPA) and Epoetin Alfa (EPA) to achieve and maintain target hemoglobin levels. Our study aimed to compare the efficacy and safety of DPA versus EPA for managing anemia amongst Egyptian patients with CKD undergoing dialysis. Methods: A multicenter, open label, randomized, prospective, parallel study was conducted. Patients with CKD undergoing dialysis with Hb level < 10 g/dl were enrolled. The primary efficacy endpoint was the change in hemoglobin concentration at the evaluation period (weeks 20-24). Prespecified adverse events of interest following administration, including blood transfusions requirement, blood pressure and hemoglobin excursions, the relationship between C - Reactive Protein (CRP) and hemoglobin, were assessed. Results: Only 98 of 104 enrolled patients completed the study, fifty patients received EPA, and 48 patients received DPA. Our results showed that a significantly higher percentage of patients who achieved target Hb level ≥ 11 g/dL in DPA treated group vs. EPA as well as the meantime to achieve Hb level ≥ 10 g/dL was shorter in DPA treated group. Safety profiles of both treatments were similar. A negative correlation was observed between serum CRP and hemoglobin level in hemodialysis patients. Conclusion: Our study showed that DPA was more effective and well tolerated in achieving and maintaining Hb levels with lower dosing frequency compared to EPA. Furthermore, CRP is recommended to be routinely measured where patients with higher CRP require high ESA doses.
MeSH term(s)	Anemia/drug therapy ; Anemia/etiology ; Darbepoetin alfa/adverse effects ; Egypt ; Epoetin Alfa/adverse effects ; Erythropoietin/adverse effects ; Hemoglobins/therapeutic use ; Humans ; Kidney Failure, Chronic/chemically induced ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/drug therapy ; Prospective Studies ; Recombinant Proteins/therapeutic use ; Renal Dialysis/adverse effects ; Renal Dialysis/methods ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/therapy
Chemical Substances	Hemoglobins ; Recombinant Proteins ; Erythropoietin (11096-26-7) ; Darbepoetin alfa (15UQ94PT4P) ; Epoetin Alfa (64FS3BFH5W)
Language	English
Publishing date	2021-11-23
Publishing country	United Arab Emirates
Document type	Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	2250840-5
ISSN	2212-3911 ; 1574-8863
ISSN (online)	2212-3911
ISSN	1574-8863
DOI	10.2174/1568009621666211123095129
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