LIVIVO - Search results -

Search results

Result 1 - 10 of total 47

Search options

Article: Genetic Susceptibility to Endometrial Cancer: Risk Factors and Clinical Management.

Dörk, Thilo / Hillemanns, Peter / Tempfer, Clemens / Breu, Julius / Fleisch, Markus C

2020 Volume 12, Issue 9

Abstract: Endometrial cancer (EC) is the most common cancer affecting the female reproductive organs in higher-income states. Apart from reproductive factors and excess weight, genetic predisposition is increasingly recognized as a major factor in endometrial ... ...

Abstract	Endometrial cancer (EC) is the most common cancer affecting the female reproductive organs in higher-income states. Apart from reproductive factors and excess weight, genetic predisposition is increasingly recognized as a major factor in endometrial cancer risk. Endometrial cancer is genetically heterogeneous: while a subgroup of patients belongs to cancer predisposition syndromes (most notably the Lynch Syndrome) with high to intermediate lifetime risks, there are also several common genomic polymorphisms contributing to the spectrum of germline predispositions. Germline variants and somatic events may act in concert to modulate the molecular evolution of the tumor, where mismatch-repair deficiency is common in endometrioid endometrial tumors whereas homologous recombinational repair deficiency has been described for non-endometrioid endometrial tumors. In this review, we will survey the currently known genomic predispositions for endometrial cancer and discuss their relevance for clinical management in terms of counseling, screening and novel treatments.
Language	English
Publishing date	2020-08-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers12092407
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Hereditäre Endometriumkarzinome - Zunehmende Aufmerksamkeit für eine seltene Entität

Fleisch, Markus C. / Möslein, Gabriela / Hepp, Philipp

Onkologie heute

2018 Volume 17, Issue 5, Page(s) 29

Language	German
Document type	Article
ZDB-ID	2147741-3
ISSN	1612-006X
Database	Current Contents Medicine

In stock of ZB MED Cologne/Königswinter

Zs.A 6827: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Machine learning for non-invasive sensing of hypoglycaemia while driving in people with diabetes.

Lehmann, Vera / Zueger, Thomas / Maritsch, Martin / Kraus, Mathias / Albrecht, Caroline / Bérubé, Caterina / Feuerriegel, Stefan / Wortmann, Felix / Kowatsch, Tobias / Styger, Naïma / Lagger, Sophie / Laimer, Markus / Fleisch, Elgar / Stettler, Christoph

Diabetes, obesity & metabolism

2023 Volume 25, Issue 6, Page(s) 1668–1676

Abstract: Aim: To develop and evaluate the concept of a non-invasive machine learning (ML) approach for detecting hypoglycaemia based exclusively on combined driving (CAN) and eye tracking (ET) data.: Materials and methods: We first developed and tested our ML ...

Abstract	Aim: To develop and evaluate the concept of a non-invasive machine learning (ML) approach for detecting hypoglycaemia based exclusively on combined driving (CAN) and eye tracking (ET) data. Materials and methods: We first developed and tested our ML approach in pronounced hypoglycaemia, and then we applied it to mild hypoglycaemia to evaluate its early warning potential. For this, we conducted two consecutive, interventional studies in individuals with type 1 diabetes. In study 1 (n = 18), we collected CAN and ET data in a driving simulator during euglycaemia and pronounced hypoglycaemia (blood glucose [BG] 2.0-2.5 mmol L Results: Here, we show that our ML approach detects pronounced and mild hypoglycaemia with high accuracy (area under the receiver operating characteristics curve 0.88 ± 0.10 and 0.83 ± 0.11, respectively). Conclusions: Our findings suggest that an ML approach based on CAN and ET data, exclusively, enables detection of hypoglycaemia while driving. This provides a promising concept for alternative and non-invasive detection of hypoglycaemia.
MeSH term(s)	Humans ; Hypoglycemia/chemically induced ; Hypoglycemia/diagnosis ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/diagnosis ; Blood Glucose ; Insulin/adverse effects
Chemical Substances	Blood Glucose ; Insulin
Language	English
Publishing date	2023-03-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.15021
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5442: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Laparoskopische Lymphonodektomie: Technik und Ergebnisse.

Fleisch, Markus C / Rein, Daniel T

Gynakologisch-geburtshilfliche Rundschau

2009 Volume 49, Issue 3, Page(s) 117–125

Abstract: For 20 years laparoscopic pelvic and para-aortal lymph node dissection has become increasingly popular as part of minimally invasive surgical treatment concepts for women suffering from gynaecological malignancies. Especially patients suffering from ... ...

Title translation	Laparoscopic lymph node dissection: technique and results.
Abstract	For 20 years laparoscopic pelvic and para-aortal lymph node dissection has become increasingly popular as part of minimally invasive surgical treatment concepts for women suffering from gynaecological malignancies. Especially patients suffering from early-stage cervical or endometrial cancers can benefit from the general advantages of a minimally invasive procedure if a comparable degree of radical surgery is achieved. The feasibility and case-control studies published so far suggest comparable indicators of radicality, such as the number of dissected lymph nodes, but also demonstrate potential advantages like a lower intra-operative blood loss, shorter hospital stay and lower postoperative complication rate in comparison with the conventional approach. Regarding long-term survival, reliable data from prospective randomized studies are still lacking but can be expected to be available in the near future.
MeSH term(s)	Female ; Genital Neoplasms, Female/pathology ; Genital Neoplasms, Female/secondary ; Genital Neoplasms, Female/surgery ; Humans ; Laparoscopy/trends ; Lymph Node Excision/methods ; Lymphatic Metastasis
Language	German
Publishing date	2009
Publishing country	Switzerland
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1115393-3
ISSN	1423-0011 ; 1018-8843
ISSN (online)	1423-0011
ISSN	1018-8843
DOI	10.1159/000213060
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 665: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: The Prevention of Positioning Injuries During Gynecologic Surgery. Guideline of the DGGG, OEGGG and SGGG (S2k Level, AWMF Registry Number 015/077, October 2020).

Fleisch, Markus C / Bader, Werner / Balzer, Kai / Bennefeld, Luisa / Boeing, Carsten / Bremerich, Dorothee / Gass, Paul / Geissbuehler, Verena / Koch, Martin C / Nothacker, Monika J / Pietzner, Klaus / Renner, Stefan P / Römer, Thomas / Roth, Stephan / Schütz, Florian / Schulte-Mattler, Wilhelm / Sehouli, Jalid / Lippach, Kristina / Tamussino, Karl /

Teichmann, Alexander / Tempfer, Clemens / Thill, Marc / Tinneberg, Hans-Rudolf / Zarras, Konstantinos

Geburtshilfe und Frauenheilkunde

2021 Volume 81, Issue 4, Page(s) 447–468

Abstract: ... ...

Abstract	Purpose
Language	English
Publishing date	2021-04-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80111-2
ISSN	1438-8804 ; 0016-5751 ; 1615-3359
ISSN (online)	1438-8804
ISSN	0016-5751 ; 1615-3359
DOI	10.1055/a-1378-4209
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Um I Zs.190: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 655: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Diagnostic delay in moderately/poorly differentiated breast cancer types.

Elfgen, Constanze / Baumgartner, Sabrina / Varga, Zsuzsanna / Reeve, Kelly / Tausch, Christoph J / Bjelic-Radisic, Vesna / Fleisch, Markus / Güth, Uwe

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)

2021 Volume 31, Issue 2, Page(s) 152–157

Abstract: Background: Diagnostic delay of breast cancer related to the false-negative assessment of the healthcare provider leads to tumor progression and might worsen the outcome. Previous studies found some factors associated with provider-related diagnostic ... ...

Abstract	Background: Diagnostic delay of breast cancer related to the false-negative assessment of the healthcare provider leads to tumor progression and might worsen the outcome. Previous studies found some factors associated with provider-related diagnostic delay; however, tumor biology has tended not to be considered. The aim of our study was to find differences in diagnostic delay of poorly differentiated breast cancer types. Methods: Data of 970 patients with newly diagnosed moderately/poorly differentiated (G2/3) breast cancer at the age ≥40 years was retrospectively analyzed regarding breast cancer type, diagnostic delay and its consequence, clinical factors and physician's assessment. Multivariate analysis was used to evaluate associated factors with diagnostic delay. Results: We observed a diagnostic delay in 3.8% (n = 37) of all patients. Mean delay time was 128 days, and clinically relevant tumor growth was observed in 43.2% of these cases. Delay was significantly higher in the group of triple-negative breast cancer (9.9% versus 2.7, 5.3 and 1.8% in hormonal receptor (HR)+/human epidermal growth factor receptor 2 (HER2)-, HR-/Her2+ and HR+/Her2+, respectively; P value <0.001). Age, breast density and reason for presentation were not correlated to diagnostic delay. Conclusion: Patients with triple-negative breast cancer are at higher risk of receiving a false-negative assessment and experiencing a diagnostic delay. Our results emphasize the importance of a detailed consideration of clinical risk factors and provider training and suggest a broad indication for a core needle biopsy.
MeSH term(s)	Adult ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/diagnosis ; Breast Neoplasms/drug therapy ; Breast Neoplasms/epidemiology ; Delayed Diagnosis ; Female ; Humans ; Receptor, ErbB-2 ; Retrospective Studies ; Triple Negative Breast Neoplasms/diagnosis ; Triple Negative Breast Neoplasms/epidemiology
Chemical Substances	Biomarkers, Tumor ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2021-05-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1137033-6
ISSN	1473-5709 ; 0959-8278
ISSN (online)	1473-5709
ISSN	0959-8278
DOI	10.1097/CEJ.0000000000000681
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3621: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Structural Insight into IAPP-Derived Amyloid Inhibitors and Their Mechanism of Action.

Niu, Zheng / Prade, Elke / Malideli, Eleni / Hille, Kathleen / Jussupow, Alexander / Mideksa, Yonatan G / Yan, Li-Mei / Qian, Chen / Fleisch, Markus / Messias, Ana C / Sarkar, Riddhiman / Sattler, Michael / Lamb, Don C / Feige, Matthias J / Camilloni, Carlo / Kapurniotu, Aphrodite / Reif, Bernd

Angewandte Chemie (International ed. in English)

2020 Volume 59, Issue 14, Page(s) 5771–5781

Abstract: Designed peptides derived from the islet amyloid polypeptide (IAPP) cross-amyloid interaction surface with Aβ (termed interaction surface mimics or ISMs) have been shown to be highly potent inhibitors of Aβ amyloid self-assembly. However, the molecular ... ...

Abstract	Designed peptides derived from the islet amyloid polypeptide (IAPP) cross-amyloid interaction surface with Aβ (termed interaction surface mimics or ISMs) have been shown to be highly potent inhibitors of Aβ amyloid self-assembly. However, the molecular mechanism of their function is not well understood. Using solution-state and solid-state NMR spectroscopy in combination with ensemble-averaged dynamics simulations and other biophysical methods including TEM, fluorescence spectroscopy and microscopy, and DLS, we characterize ISM structural preferences and interactions. We find that the ISM peptide R3-GI is highly dynamic, can adopt a β-like structure, and oligomerizes into colloid-like assemblies in a process that is reminiscent of liquid-liquid phase separation (LLPS). Our results suggest that such assemblies yield multivalent surfaces for interactions with Aβ40. Sequestration of substrates into these colloid-like structures provides a mechanistic basis for ISM function and the design of novel potent anti-amyloid molecules.
MeSH term(s)	Amino Acid Sequence ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/metabolism ; Islet Amyloid Polypeptide/chemistry ; Microscopy, Fluorescence ; Molecular Dynamics Simulation ; Nuclear Magnetic Resonance, Biomolecular ; Peptide Fragments/antagonists & inhibitors ; Peptide Fragments/metabolism ; Peptides/chemistry ; Peptides/metabolism ; Substrate Specificity
Chemical Substances	Amyloid beta-Peptides ; Islet Amyloid Polypeptide ; Peptide Fragments ; Peptides ; amyloid beta-protein (1-40)
Language	English
Publishing date	2020-01-28
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.201914559
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article: Endometrial Cancer. Guideline of the DGGG, DKG and DKH (S3-Level, AWMF Registry Number 032/034-OL, September 2022). Part 1 with Recommendations on the Epidemiology, Screening, Diagnosis and Hereditary Factors of Endometrial Cancer, Geriatric Assessment and Supply Structures.

Emons, Günter / Steiner, Eric / Vordermark, Dirk / Uleer, Christoph / Paradies, Kerstin / Tempfer, Clemens / Aretz, Stefan / Cremer, Wolfgang / Hanf, Volker / Mallmann, Peter / Ortmann, Olaf / Römer, Thomas / Schmutzler, Rita K / Horn, Lars-Christian / Kommoss, Stefan / Lax, Sigurd / Schmoeckel, Elisa / Mokry, Theresa / Grab, Dieter /

Reinhardt, Michael / Steinke-Lange, Verena / Brucker, Sara Y / Kiesel, Ludwig / Witteler, Ralf / Fleisch, Markus C / Friedrich, Michael / Höcht, Stefan / Lichtenegger, Werner / Mueller, Michael / Runnebaum, Ingo / Feyer, Petra / Hagen, Volker / Juhasz-Böss, Ingolf / Letsch, Anne / Niehoff, Peter / Zeimet, Alain Gustave / Battista, Marco Johannes / Petru, Edgar / Widhalm, Simone / van Oorschot, Birgitt / Panke, Joan Elisabeth / Weis, Joachim / Dauelsberg, Timm / Haase, Heidemarie / Beckmann, Matthias W / Jud, Sebastian / Wight, Edward / Prott, Franz-Josef / Micke, Oliver / Bader, Werner / Reents, Nicola / Henscher, Ulla / Schallenberg, Miriam / Rahner, Nils / Mayr, Doris / Kreißl, Michael / Lindel, Katja / Mustea, Alexander / Strnad, Vratislav / Goerling, Ute / Bauerschmitz, Gerd J / Langrehr, Jan / Neulen, Joseph / Ulrich, Uwe Andreas / Nothacker, Monika J / Blödt, Susanne / Follmann, Markus / Langer, Thomas / Wenzel, Gregor / Weber, Sylvia / Erdogan, Saskia

Geburtshilfe und Frauenheilkunde

2023 Volume 83, Issue 8, Page(s) 919–962

Abstract: ... ...

Abstract	Summary
Language	English
Publishing date	2023-08-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80111-2
ISSN	1438-8804 ; 0016-5751 ; 1615-3359
ISSN (online)	1438-8804
ISSN	0016-5751 ; 1615-3359
DOI	10.1055/a-2066-2051
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Um I Zs.190: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 655: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Women in early-phase clinical drug trials: have things changed over the past 20 years?

Fleisch, Jeanette / Fleisch, Markus C / Thürmann, Petra A

Clinical pharmacology and therapeutics

2005 Volume 78, Issue 5, Page(s) 445–452

MeSH term(s)	Adult ; Clinical Trials, Phase I as Topic/statistics & numerical data ; Clinical Trials, Phase I as Topic/trends ; Clinical Trials, Phase II as Topic/statistics & numerical data ; Clinical Trials, Phase II as Topic/trends ; Female ; Humans ; Male ; Pharmaceutical Preparations/metabolism ; Sex Characteristics ; United States ; Women
Chemical Substances	Pharmaceutical Preparations
Language	English
Publishing date	2005-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	123793-7
ISSN	1532-6535 ; 0009-9236
ISSN (online)	1532-6535
ISSN	0009-9236
DOI	10.1016/j.clpt.2005.08.016
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 20: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Clinical Imaging of the Heterogeneous Group of Triple-negative Breast Cancer.

Müller, Martin / Güth, Uwe / Varga, Zsuzsanna / Reeve, Kelly / Bjelic-Radisic, Vesna / Fleisch, Markus / Tausch, Christoph J / Elfgen, Constanze

Anticancer research

2020 Volume 40, Issue 4, Page(s) 2125–2131

Abstract: Background/aim: Triple-negative breast cancer (TNBC) can be divided into subtypes of basal-like (BL), mesenchymal-like (ML), luminal androgen receptor (LAR), and immunomodulatory (IM). The aim of our study was to assess whether there are distinct ... ...

Abstract	Background/aim: Triple-negative breast cancer (TNBC) can be divided into subtypes of basal-like (BL), mesenchymal-like (ML), luminal androgen receptor (LAR), and immunomodulatory (IM). The aim of our study was to assess whether there are distinct radiologic features within the different TNBC subtypes and whether this has potential clinical impact. Patients and methods: Imaging pictures of 135 patients with TNBC were re-evaluated. TNBC subtyping was performed on asservated tumor tissue using a panel of antibodies. Results: Mammographic margins of LAR-TNBC were more often spiculated (24.3% versus 0-4.1%). BL-TNBC presented more frequent a mass without calcification in mammogram than other subtypes (71.4% versus 48.6-57.9%). In ultrasound, ML and LAR were described more often with smooth borders. Conclusion: The histopathological subtype of TNBC influences its presentation in ultrasound and mammogram. This can reflect a different growth pattern of the subtypes and may have an impact on the early diagnosis of TNBC.
MeSH term(s)	Adult ; Biomarkers, Tumor/genetics ; Cell Proliferation/genetics ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Mammography/methods ; Middle Aged ; Receptors, Androgen/genetics ; Triple Negative Breast Neoplasms/classification ; Triple Negative Breast Neoplasms/diagnostic imaging ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/pathology
Chemical Substances	AR protein, human ; Biomarkers, Tumor ; Receptors, Androgen
Language	English
Publishing date	2020-03-31
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.14171
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1642: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito