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Article: Management of ectopically erupting permanent molars in a seven-year-old girl: A case report.

Meng, Mingmei / Zhou, Xuedong / Zhang, Qiong / Zou, Jing

JPMA. The Journal of the Pakistan Medical Association

2022 Volume 71, Issue 12, Page(s) 2809–2811

Abstract: Ectopic eruption of permanent first molar is a developmental disturbance, leading to many local problems, such as premature loss of the second primary molars, space loss, increased prevalence of dental caries, supraeruption of the opposing molars, mesial ...

Abstract	Ectopic eruption of permanent first molar is a developmental disturbance, leading to many local problems, such as premature loss of the second primary molars, space loss, increased prevalence of dental caries, supraeruption of the opposing molars, mesial inclination of the permanent maxillary first molars and class II molar relationship. We report the case of a seven-and-a-half-year-old girl with ectopic eruption of permanent maxillary and mandibular first molar, treated by orthodontic separators and slicing the distal surface of the adjacent primary second molar separately. Regular examination and timely interception are important during oral health management of children and is of great significance in alleviating the side effects of ectopic eruption.
Language	English
Publishing date	2022-02-12
Publishing country	Pakistan
Document type	Case Reports
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
DOI	10.47391/JPMA.624
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Article ; Online: Progressive destruction of jaws caused by the delayed treatment of Langerhans cell histiocytosis in a 2-year-old boy: A case report.

Meng, Mingmei / Zhang, Qiong / Zhou, Xuedong / Zou, Jing

Oral radiology

2022 Volume 38, Issue 3, Page(s) 433–437

Abstract: Langerhans cell histiocytosis (LCH) is a disease with varied clinic manifestations. The oral symptoms and signs of LCH localized to the jaws are nonspecific, which may lead to misdiagnosis of this disease. The purpose of this paper was to present the ... ...

Abstract	Langerhans cell histiocytosis (LCH) is a disease with varied clinic manifestations. The oral symptoms and signs of LCH localized to the jaws are nonspecific, which may lead to misdiagnosis of this disease. The purpose of this paper was to present the case of a 2-year, 4-month-old LCH patient with progressive destruction of jaws caused by the delayed treatment due to the global outbreak of COVID-19. The cone beam CT analysis after an interval of 6 months reminded us the great significance of early diagnosis and treatment of LCH.
MeSH term(s)	COVID-19 ; Child, Preschool ; Cone-Beam Computed Tomography ; Histiocytosis, Langerhans-Cell/diagnostic imaging ; Humans ; Infant ; Jaw ; Male ; Time-to-Treatment
Language	English
Publishing date	2022-05-10
Publishing country	Japan
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639456-5
ISSN	1613-9674 ; 0911-6028
ISSN (online)	1613-9674
ISSN	0911-6028
DOI	10.1007/s11282-022-00606-1
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Article ; Online: GC/MS and LC/MS serum metabolomic analysis of Chinese LN patients.

Wang, Wei / Kou, Jun / Long, Jie / Wang, Tao / Zhang, Mingmei / Wei, Meng / Xie, Qingyun

Scientific reports

2024 Volume 14, Issue 1, Page(s) 1523

Abstract: China, being a densely populated nation, faces a substantial economic burden due to a high incidence of lupus nephritis (LN) cases. The concealed onset of LN has resulted in many individuals have missed the optimal timing for treatment. The aim of the ... ...

Abstract	China, being a densely populated nation, faces a substantial economic burden due to a high incidence of lupus nephritis (LN) cases. The concealed onset of LN has resulted in many individuals have missed the optimal timing for treatment. The aim of the research is to study the serum metabolomics of Chinese LN patients using gas chromatography (GC)/mass spectrometry (MS) and liquid chromatography (LC)/MS to identify potential diagnostic markers. Fifty LN patients and fifty normal controls, matched for Body Mass Index (BMI) and age, were selected. Serum analysis was conducted using GC/MS and LC/MS, followed by multivariate statistical analysis. Various multidimensional analyses, including principal component analysis, partial least squares discrimination analysis, and orthogonal partial least squares discrimination analysis, along with one-dimensional analyses such as t-tests, were performed. Metabolites with variable importance in projection value > 1 and a p-value < 0.05 were considered critical biomarkers for LN. Furthermore, identified biomarkers delineated relevant metabolic pathways, and a metabolic pathway map was obtained from the database. Forty-one metabolites were identified as potential LN biomarkers, primarily associated with immune regulation, energy metabolism, intestinal microbial metabolism, renal damage, and oxidative stress. The potential for diagnosing LN and other diseases through metabolomics is demonstrated. Future research should explore larger sample sizes, metabolomic comparisons across different diseases and health states, and integration of metabolomics with clinical diagnostics. Such studies will enhance the understanding of metabolomics in medical diagnosis and provide robust support for its practical application.
MeSH term(s)	Humans ; Lupus Nephritis ; Metabolomics/methods ; Gas Chromatography-Mass Spectrometry/methods ; Biomarkers ; Liquid Chromatography-Mass Spectrometry
Chemical Substances	Biomarkers
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52137-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The positive rate of saliva for the detection of 2019-nCoV and possible factors related to the sensitivity results.

Meng, Mingmei / Zhou, Xuedong / Zhang, Qiong / Zou, Jing

Journal of medical virology

2020 Volume 93, Issue 7, Page(s) 4136–4140

MeSH term(s)	COVID-19 ; Humans ; Pharynx ; SARS-CoV-2 ; Saliva
Keywords	covid19
Language	English
Publishing date	2020-11-10
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.26627
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Article ; Online: Roles of DNA methylation in influencing the functions of dental-derived mesenchymal stem cells.

Shi, Liyan / Ye, Xingchen / Zhou, Jing / Fang, Yuwen / Yang, Jiazhen / Meng, Mingmei / Zou, Jing

Oral diseases

2023

Abstract: Objective: DNA methylation as intensively studied epigenetic regulatory mechanism exerts pleiotropic effects on dental-derived mesenchymal stem cells (DMSCs). DMSCs have self-renewal and multidifferentiation potential. Here, this review aims at ... ...

Abstract	Objective: DNA methylation as intensively studied epigenetic regulatory mechanism exerts pleiotropic effects on dental-derived mesenchymal stem cells (DMSCs). DMSCs have self-renewal and multidifferentiation potential. Here, this review aims at summarizing the research status about application of DMSCs in tissue engineering and clarifying the roles of DNA methylation in influencing the functions of DMSCs, with expectation of paving the way for its in-depth exploration in tissue engineering. Method: The current research status about influence of DNA methylation in DMSCs was acquired by MEDLINE (through PubMed) and Web of Science using the keywords 'DNA methylation', 'dental-derived mesenchymal stem cells', 'dental pulp stem cells', 'periodontal ligament stem cells', 'dental follicle stem cells', 'stem cells from the apical papilla', 'stem cells from human exfoliated deciduous teeth', and 'gingival-derived mesenchymal stem cells'. Results: This review indicates DNA methylation affects DMSCs' differentiation and function through inhibiting or enhancing the expression of specific gene resulted by DNA methylation-related genes or relevant inhibitors. Conclusion: DNA methylation can influence DMSCs in aspects of osteogenesis, adipogenesis, immunomodulatory function, and so on. Yet, the present studies about DNA methylation in DMSCs commonly focus on dental pulp stem cells (DPSCs) and periodontal ligament stem cells (PDLSCs). Little has been reported for other DMSCs.
Language	English
Publishing date	2023-10-19
Publishing country	Denmark
Document type	Journal Article ; Review
ZDB-ID	1290529-x
ISSN	1601-0825 ; 1354-523X
ISSN (online)	1601-0825
ISSN	1354-523X
DOI	10.1111/odi.14770
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Article ; Online: Epigenetic regulation of osteogenic differentiation of periodontal ligament stem cells in periodontitis.

Cao, Jingwei / Zhang, Qiong / Yang, Qiyuan / Yu, Yue / Meng, Mingmei / Zou, Jing

Oral diseases

2023 Volume 29, Issue 7, Page(s) 2529–2537

Abstract: Periodontitis is an inflammatory disease characterized by alveolar bone loss. Periodontal ligament stem cells (PDLSCs) have osteogenic differentiation potential, which can be influenced by epigenetics regulation in periodontitis. Therefore, this review ... ...

Abstract	Periodontitis is an inflammatory disease characterized by alveolar bone loss. Periodontal ligament stem cells (PDLSCs) have osteogenic differentiation potential, which can be influenced by epigenetics regulation in periodontitis. Therefore, this review aimed to shed light on the role of different epigenetic mechanisms in the osteogenic differentiation of PDLSCs and to consider the prospects of their possible therapeutic applications in periodontitis. Databases MEDLINE (through PubMed) and Web of Science were searched for the current knowledge of epigenetics in osteogenic differentiation of PDLSCs using the keywords "periodontal ligament stem cells", "epigenetic regulation", "epigenetics", "osteogenic differentiation", and "osteogenesis". All studies introducing epigenetic regulation and PDLSCs were retrieved. This review shows that epigenetic factors like DNMT, KDM6A, HDACi, some miRNAs, and lncRNAs can induce the osteogenic differentiation of PDLSCs in the noninflammatory microenvironment. However, the osteogenic differentiation of PDLSCs is inhibited in the inflammatory microenvironment through the upregulated DNA methylation of osteogenesis-related genes and specific changes in histone modification and noncoding RNA. Epigenetics of osteogenic differentiation of PDLSCs in inflammation exhibits the contrary effect compared with a noninflammatory environment. The application of epigenetic drugs to regulate the abnormal epigenetic status in periodontitis and focus on alveolar bone regeneration is promising.
MeSH term(s)	Humans ; Osteogenesis/genetics ; Periodontal Ligament ; Epigenesis, Genetic ; Periodontitis/genetics ; Stem Cells ; Cell Differentiation/genetics ; Cells, Cultured
Language	English
Publishing date	2023-01-13
Publishing country	Denmark
Document type	Journal Article ; Review
ZDB-ID	1290529-x
ISSN	1601-0825 ; 1354-523X
ISSN (online)	1601-0825
ISSN	1354-523X
DOI	10.1111/odi.14491
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Article ; Online: Epidemiology, resistant pathogens, and causes of early death in cases of bloodstream infection in patients with hematological malignancies from 2012-2019.

Li, Meng / Du, Mingmei / Li, Honghua / Liu, Daihong / Liu, Yunxi

Infectious medicine

2022 Volume 1, Issue 1, Page(s) 23–30

Abstract: Purpose: To investigate the epidemiology, causative pathogen antibiotic susceptibility, and mortality risk factors of bloodstream infection (BSI) in patients with hematological malignancies (HMs).: Methods: Single-center retrospective analysis of BSI ...

Abstract	Purpose: To investigate the epidemiology, causative pathogen antibiotic susceptibility, and mortality risk factors of bloodstream infection (BSI) in patients with hematological malignancies (HMs). Methods: Single-center retrospective analysis of BSI cases in patients with HMs in a Chinese tertiary hospital from 2012-2019. Results: Among 17,796 analyzed admissions, 508 BSI episodes (2.9%; 95% confidence interval: 2.6%-3.2%) were identified. Of 522 resulting isolates, 326 (62.5%) were Gram-negative, 173 (33.1%) were Gram-positive. The BSI incidence among patients with different HMs (severe aplastic anemia: 6.7%; acute leukemia: 6.2%; myelodysplastic syndrome: 3.2%; multiple myeloma: 1.3%; and lymphoma: 1.0%) differed significantly ( Conclusions: Gram-negative bacteria were the most common pathogens, with
Language	English
Publishing date	2022-03-03
Publishing country	China
Document type	Journal Article
ISSN	2772-431X
ISSN (online)	2772-431X
DOI	10.1016/j.imj.2022.02.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Retrospective Analysis of Epidemiology, Risk Factors, and Outcomes of Health Care-Acquired Carbapenem-Resistant Klebsiella pneumoniae Bacteremia in a Chinese Tertiary Hospital, 2010-2019.

Li, Meng / Yang, Shanshan / Yao, Hongwu / Liu, Yunxi / Du, Mingmei

Infectious diseases and therapy

2022 Volume 12, Issue 2, Page(s) 473–485

Abstract: Introduction: In the present study, we aimed to describe the proportion of carbapenem-resistant Klebsiella pneumoniae bloodstream infection (CRKP-BSI) in KP-BSI in one Chinese tertiary hospital over 10 years and determine the risk factors and outcomes ... ...

Abstract	Introduction: In the present study, we aimed to describe the proportion of carbapenem-resistant Klebsiella pneumoniae bloodstream infection (CRKP-BSI) in KP-BSI in one Chinese tertiary hospital over 10 years and determine the risk factors and outcomes of CRKP-BSI. Methods: We retrospectively analyzed clinical and microbiological data of patients with KP-BSI from January 2010 to December 2019 to identify risk factors, clinical features, and outcomes using multivariate logistic regression analysis. KP-BSI only included monomicrobial BSI and health care-acquired BSI. Results: Among the total 687 isolates of KP-BSI in this study, the rate of CRKP was 39.0% (268/687); this rate in the intensive care unit (ICU) was 65.6% and that in seven high-risk departments (including four ICUs, respiratory medicine, gastroenterology medicine, and hepatobiliary surgery) was 74.6%. The annual rate of CRKP in KP-BSI ranged from 0.0% in 2010 to 54.5% in 2019. The 28-day mortality was 36.2% in patients with CRKP-BSI and 11.7% in those with carbapenem-susceptible K. pneumoniae (CSKP) BSI. Multivariable logistic regression analysis showed that prior ICU stay (odds ratio [OR] 2.485, P < 0.001), hospital stay ≥ 30 days prior to BSI (OR 1.815, P = 0.007), prior mechanical ventilation (OR 2.020, P = 0.014), prior urinary catheter (OR 1.999, P = 0.003), prior carbapenem use (OR 3.840, P < 0.001), hepatobiliary disease (OR 2.943, P < 0.001), pancreatitis (OR 2.700, P = 0.026), and respiratory disease (OR 2.493, P = 0.009) were risk factors of CRKP-BSI. Patients with a first admission (OR 0.662, P = 0.046) had a lower percentage of CRKP-BSI. Conclusion: The rapidly rising rate of CRKP-BSI in KP with high mortality requires increased attention. Exposure to carbapenems, ICU stay, invasive mechanical ventilation or urinary catheter, prolonged hospital stay, hepatobiliary disease, pancreatitis, and respiratory disease were found to be risk factors for CRKP-BSI. Strict control measures should be implemented to prevent the emergence and spread of CRKP, especially in high-risk departments.
Language	English
Publishing date	2022-12-15
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2701611-0
ISSN	2193-6382 ; 2193-8229
ISSN (online)	2193-6382
ISSN	2193-8229
DOI	10.1007/s40121-022-00732-7
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Article: The positive rate of saliva for the detection of 2019-nCoV and possible factors related to the sensitivity results

Meng, Mingmei / Zhou, Xuedong / Zhang, Qiong / Zou, Jing

J. med. virol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #891887
Database	COVID19

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Article ; Online: Influence factors of extra-articular manifestations in rheumatoid arthritis

Chen Xing / Zhang Mingmei / Wang Tao / Li Yunming / Wei Meng

Open Medicine, Vol 15, Iss 1, Pp 787-

2020 Volume 795

Abstract: Extra-articular manifestations (EAMs) are serious outcomes or complications of rheumatoid arthritis (RA) with increasing mortality and morbidity. The purpose was to explore the factors influencing EAMs, tissue-specific/systemic EAMs, and the concurrence ... ...

Abstract	Extra-articular manifestations (EAMs) are serious outcomes or complications of rheumatoid arthritis (RA) with increasing mortality and morbidity. The purpose was to explore the factors influencing EAMs, tissue-specific/systemic EAMs, and the concurrence of several EAMs.
Keywords	rheumatoid arthritis ; extra-articular manifestations ; tissue-specific/systemic eams ; influential factors ; Medicine ; R
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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