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  1. Article ; Online: Routine childhood immunization may protect against COVID-19.

    Salman, Samar / Salem, Mohamed Labib

    Medical hypotheses

    2020  Volume 140, Page(s) 109689

    Keywords covid19
    Language English
    Publishing date 2020-03-25
    Publishing country United States
    Document type Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109689
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Higher cytotoxic activities of CD8

    Salem, Mohamed Labib / Atia, Ismail / Elmashad, Nehal M

    BMC immunology

    2023  Volume 24, Issue 1, Page(s) 24

    Abstract: Introduction: Cytotoxic (CD8+) and natural killer (NK) cells play critical roles in anti-tumor immunity. Dysfunction in these cells is considered as one of the extrinsic mechanisms for tumor relapse.: Aim: We aimed in this study to assess cytotoxic ... ...

    Abstract Introduction: Cytotoxic (CD8+) and natural killer (NK) cells play critical roles in anti-tumor immunity. Dysfunction in these cells is considered as one of the extrinsic mechanisms for tumor relapse.
    Aim: We aimed in this study to assess cytotoxic activities of CD8 + T and NK cells in the peripheral blood from lung cancer patients before and after induction of chemotherapy.
    Subjects and methods: Healthy (n = 5) volunteers and lung cancer patients (n = 15:5 before, 5 during, and 5 after induction of chemotherapy) were recruited. Flow cytometry was used to analyze the numbers of CD8 + T cells, NK and CD56
    Results: After culture, significant increases in the number of GzB expressing cells gated on CD3+, CD4+, CD8 + and NKCD8 + T cells in the PBMCs from lung cancer patients before induction of chemotherapy as compared to control individuals as well as patients during and after induction of chemotherapy. Serum levels of IL-1 and CXCL8 in patients before induction of chemotherapy showed 37- and 40-fold increases, respectively, as compared to control individuals. Both GzB expression and cytokines levels in patients during and after chemotherapy were similar.
    Conclusion: Polyclonal stimulation of PBMCs can restore the cytolytic activities of cytotoxic CD8 and NK cells from lung cancer patients even after chemotherapy.
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes ; Leukocytes, Mononuclear/metabolism ; Neoplasm Recurrence, Local/metabolism ; Killer Cells, Natural ; Cytokines/metabolism ; Lung Neoplasms/diagnosis ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041500-X
    ISSN 1471-2172 ; 1471-2172
    ISSN (online) 1471-2172
    ISSN 1471-2172
    DOI 10.1186/s12865-023-00553-4
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  3. Article ; Online: Could injured skin be a reservoir for SARS-CoV-2 virus spread?

    Elgarhy, Lamia Hamouda / Salem, Mohamed Labib

    Clinics in dermatology

    2020  Volume 38, Issue 6, Page(s) 762–763

    MeSH term(s) COVID-19/transmission ; Humans ; Skin/virology ; Skin Diseases, Viral/transmission
    Language English
    Publishing date 2020-06-09
    Publishing country United States
    Document type Letter
    ZDB-ID 1064149-x
    ISSN 1879-1131 ; 0738-081X
    ISSN (online) 1879-1131
    ISSN 0738-081X
    DOI 10.1016/j.clindermatol.2020.06.004
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    Se 972: Show issues Location:
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  5. Article ; Online: The possible beneficial adjuvant effect of influenza vaccine to minimize the severity of COVID-19.

    Salem, Mohamed Labib / El-Hennawy, Dina

    Medical hypotheses

    2020  Volume 140, Page(s) 109752

    Keywords covid19
    Language English
    Publishing date 2020-04-22
    Publishing country United States
    Document type Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Routine childhood immunization may protect against COVID-19

    Salman, Samar / Salem, Mohamed Labib

    Medical Hypotheses

    2020  Volume 140, Page(s) 109689

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109689
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Brief in vitro IL-12 conditioning of CD8

    Salem, Mohamed Labib / Salman, Samar / Barnawi, Ibrahim O

    Cancer immunology, immunotherapy : CII

    2021  Volume 70, Issue 10, Page(s) 2751–2759

    Abstract: Cancer immunotherapy represents a potential treatment approach through non-specific and specific enhancement of the immune responses. Adoptive cell therapy (ACT) is a potential modality of immunotherapy that depends on harvesting T cells from the tumor- ... ...

    Abstract Cancer immunotherapy represents a potential treatment approach through non-specific and specific enhancement of the immune responses. Adoptive cell therapy (ACT) is a potential modality of immunotherapy that depends on harvesting T cells from the tumor-bearing host, activating them in vitro and infusing them back to the same host. Several cytokines, in particular IL-2, IL-7 and IL-15, have been used to enhance survival T cells in vitro. Although effective, conditioning of T cells in vitro with these cytokines requires long-term culture which results in the loss of expression of their trafficking receptors mainly CD62L. It also results in exhaustion of the activated T cells and reduction in their functions upon adoptive transfer in vivo. Our recent studies and those of other groups showed that brief (3 days) conditioning of CD8
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes/metabolism ; Cell- and Tissue-Based Therapy/methods ; Humans ; Immunotherapy/methods ; Interleukin-12/metabolism ; Mice
    Chemical Substances Interleukin-12 (187348-17-0)
    Language English
    Publishing date 2021-05-08
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 195342-4
    ISSN 1432-0851 ; 0340-7004
    ISSN (online) 1432-0851
    ISSN 0340-7004
    DOI 10.1007/s00262-021-02887-7
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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Could injured skin be a reservoir for SARS-CoV-2 virus spread?

    Elgarhy, Lamia Hamouda / Salem, Mohamed Labib

    Clinics in Dermatology ; ISSN 0738-081X

    2020  

    Keywords Dermatology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.clindermatol.2020.06.004
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Perspectives on Antibiotic Stewardship Programs among Health Care Providers at Two University Hospitals in Egypt.

    Salem, Marwa Rashad / Youssef, Meray Rene Labib / Shalaby, Silvia Farouk / Mahmoud, Ahmed Taher / Ismail, Mohamed / Ibrahim, Sally Kamal

    International journal of environmental research and public health

    2023  Volume 20, Issue 5

    Abstract: The perspectives of healthcare professionals on antibiotic stewardship programs (ASPs) should be explored. Any antibiotic stewardship strategy must be individualized based on patient needs, prescription habits, and local resources. The current study ... ...

    Abstract The perspectives of healthcare professionals on antibiotic stewardship programs (ASPs) should be explored. Any antibiotic stewardship strategy must be individualized based on patient needs, prescription habits, and local resources. The current study aimed to explore the perspectives of healthcare providers on antibiotics stewardship and their awareness of these perspectives. Furthermore, potential barriers to the application of ASPs should be identified and addressed. This exploratory cross-sectional study utilized a qualitative method to evaluate critical care physicians, pediatricians, and clinical pharmacists (
    MeSH term(s) Humans ; Female ; Adult ; Male ; Hospitals, University ; Antimicrobial Stewardship ; Cross-Sectional Studies ; Egypt ; Health Personnel ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20053777
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