LIVIVO - Search results -

Search results

Result 1 - 10 of total 105

Search options

Book ; Online ; E-Book: Understanding gut microbiomes as targets for improving pig gut health

Bailey, Mick / Stokes, Chris

(Burleigh Dodds series in agricultural science ; number 103)

2021

Author's details	edited by Professor Mick Bailey and Emeritus Professor Chris Stokes, University of Bristol, UK
Series title	Burleigh Dodds series in agricultural science ; number 103
Collection
Language	English
Size	1 Online-Ressource (xxiii, 479 Seiten), Illustrationen
Publisher	Burleigh Dodds Science Publishing
Publishing place	Cambridge
Publishing country	Great Britain
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT021209230
ISBN	978-1-78676-490-4 ; 978-1-78676-489-8 ; 9781786764874 ; 1-78676-490-3 ; 1-78676-489-X ; 1786764873
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

Full text online

Accessible to users with ZB MED library card

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article ; Online: Experimental genetic crosses in tsetse flies of the livestock pathogen Trypanosoma congolense savannah.

Peacock, Lori / Kay, Chris / Bailey, Mick / Gibson, Wendy

Parasites & vectors

2024 Volume 17, Issue 1, Page(s) 4

Abstract: Background: In tropical Africa animal trypanosomiasis is a disease that has severe impacts on the health and productivity of livestock in tsetse fly-infested regions. Trypanosoma congolense savannah (TCS) is one of the main causative agents and is ... ...

Abstract	Background: In tropical Africa animal trypanosomiasis is a disease that has severe impacts on the health and productivity of livestock in tsetse fly-infested regions. Trypanosoma congolense savannah (TCS) is one of the main causative agents and is widely distributed across the sub-Saharan tsetse belt. Population genetics analysis has shown that TCS is genetically heterogeneous and there is evidence for genetic exchange, but to date Trypanosoma brucei is the only tsetse-transmitted trypanosome with experimentally proven capability to undergo sexual reproduction, with meiosis and production of haploid gametes. In T. brucei sex occurs in the fly salivary glands, so by analogy, sex in TCS should occur in the proboscis, where the corresponding portion of the developmental cycle takes place. Here we test this prediction using genetically modified red and green fluorescent clones of TCS. Methods: Three fly-transmissible strains of TCS were transfected with genes for red or green fluorescent protein, linked to a gene for resistance to the antibiotic hygromycin, and experimental crosses were set up by co-transmitting red and green fluorescent lines in different combinations via tsetse flies, Glossina pallidipes. To test whether sex occurred in vitro, co-cultures of attached epimastigotes of one red and one green fluorescent TCS strain were set up and sampled at intervals for 28 days. Results: All interclonal crosses of genetically modified trypanosomes produced hybrids containing both red and green fluorescent proteins, but yellow fluorescent hybrids were only present among trypanosomes from the fly proboscis, not from the midgut or proventriculus. It was not possible to identify the precise life cycle stage that undergoes mating, but it is probably attached epimastigotes in the food canal of the proboscis. Yellow hybrids were seen as early as 14 days post-infection. One intraclonal cross in tsetse and in vitro co-cultures of epimastigotes also produced yellow hybrids in small numbers. The hybrid nature of the yellow fluorescent trypanosomes observed was not confirmed by genetic analysis. Conclusions: Despite absence of genetic characterisation of hybrid trypanosomes, the fact that these were produced only in the proboscis and in several independent crosses suggests that they are products of mating rather than cell fusion. The three-way strain compatibility observed is similar to that demonstrated previously for T. brucei, indicating that a simple two mating type system does not apply for either trypanosome species.
MeSH term(s)	Animals ; Tsetse Flies/genetics ; Trypanosoma congolense/genetics ; Livestock ; Trypanosomiasis, African/veterinary ; Trypanosomiasis, African/epidemiology ; Meiosis ; Gastrointestinal Tract ; Crosses, Genetic
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2409480-8
ISSN	1756-3305 ; 1756-3305
ISSN (online)	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-023-06105-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Development of the livestock pathogen Trypanosoma (Nannomonas) simiae in the tsetse fly with description of putative sexual stages from the proboscis.

Peacock, Lori / Kay, Chris / Collett, Clare / Bailey, Mick / Gibson, Wendy

Parasites & vectors

2023 Volume 16, Issue 1, Page(s) 231

Abstract: Background: Tsetse-transmitted African animal trypanosomiasis is recognised as an important disease of ruminant livestock in sub-Saharan Africa, but also affects domestic pigs, with Trypanosoma simiae notable as a virulent suid pathogen that can rapidly ...

Abstract	Background: Tsetse-transmitted African animal trypanosomiasis is recognised as an important disease of ruminant livestock in sub-Saharan Africa, but also affects domestic pigs, with Trypanosoma simiae notable as a virulent suid pathogen that can rapidly cause death. Trypanosoma simiae is widespread in tsetse-infested regions, but its biology has been little studied compared to T. brucei and T. congolense. Methods: Trypanosoma simiae procyclics were cultured in vitro and transfected using protocols developed for T. brucei. Genetically modified lines, as well as wild-type trypanosomes, were transmitted through tsetse flies, Glossina pallidipes, to study T. simiae development in the tsetse midgut, proventriculus and proboscis. The development of proventricular trypanosomes was also studied in vitro. Image and mensural data were collected and analysed. Results: A PFR1::YFP line successfully completed development in tsetse, but a YFP::HOP1 line failed to progress beyond midgut infection. Analysis of image and mensural data confirmed that the vector developmental cycles of T. simiae and T. congolense are closely similar, but we also found putative sexual stages in T. simiae, as judged by morphological similarity to these stages in T. brucei. Putative meiotic dividers were abundant among T. simiae trypanosomes in the proboscis, characterised by a large posterior nucleus and two anterior kinetoplasts. Putative gametes and other meiotic intermediates were also identified by characteristic morphology. In vitro development of proventricular forms of T. simiae followed the pattern previously observed for T. congolense: long proventricular trypanosomes rapidly attached to the substrate and shortened markedly before commencing cell division. Conclusions: To date, T. brucei is the only tsetse-transmitted trypanosome with experimentally proven capability to undergo sexual reproduction, which occurs in the fly salivary glands. By analogy, sexual stages of T. simiae or T. congolense are predicted to occur in the proboscis, where the corresponding portion of the developmental cycle takes place. While no such stages have been observed in T. congolense, for T. simiae putative sexual stages were abundant in the tsetse proboscis. Although our initial attempt to demonstrate expression of a YFP-tagged, meiosis-specific protein was unsuccessful, the future application of transgenic approaches will facilitate the identification of meiotic stages and hybrids in T. simiae.
MeSH term(s)	Animals ; Swine ; Tsetse Flies ; Livestock ; Trypanosoma/genetics ; Trypanosomiasis, African/veterinary ; Meiosis
Language	English
Publishing date	2023-07-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2409480-8
ISSN	1756-3305 ; 1756-3305
ISSN (online)	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-023-05847-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A spatial model of COVID-19 transmission in England and Wales: early spread, peak timing and the impact of seasonality.

Danon, Leon / Brooks-Pollock, Ellen / Bailey, Mick / Keeling, Matt

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

2021 Volume 376, Issue 1829, Page(s) 20200272

Abstract: An outbreak of a novel coronavirus was first reported in China on 31 December 2019. As of 9 February 2020, cases have been reported in 25 countries, including probable human-to-human transmission in England. We adapted an existing national-scale ... ...

Abstract	An outbreak of a novel coronavirus was first reported in China on 31 December 2019. As of 9 February 2020, cases have been reported in 25 countries, including probable human-to-human transmission in England. We adapted an existing national-scale metapopulation model to capture the spread of COVID-19 in England and Wales. We used 2011 census data to inform population sizes and movements, together with parameter estimates from the outbreak in China. We predict that the epidemic will peak 126 to 147 days (approx. 4 months) after the start of person-to-person transmission in the absence of controls. Assuming biological parameters remain unchanged and transmission persists from February, we expect the peak to occur in June. Starting location and model stochasticity have a minimal impact on peak timing. However, realistic parameter uncertainty leads to peak time estimates ranging from 78 to 241 days following sustained transmission. Seasonal changes in transmission rate can substantially impact the timing and size of the epidemic. We provide initial estimates of the epidemic potential of COVID-19. These results can be refined with more precise parameters. Seasonal changes in transmission could shift the timing of the peak into winter, with important implications for healthcare capacity planning. This article is part of the theme issue 'Modelling that shaped the early COVID-19 pandemic response in the UK.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/transmission ; COVID-19/virology ; China/epidemiology ; Disease Outbreaks/statistics & numerical data ; England/epidemiology ; Humans ; Pandemics ; SARS-CoV-2/pathogenicity ; Wales/epidemiology
Language	English
Publishing date	2021-05-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208382-6
ISSN	1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
ISSN (online)	1471-2970
ISSN	0080-4622 ; 0264-3839 ; 0962-8436
DOI	10.1098/rstb.2020.0272
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Einzelsignatur: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Evolution of the immune system at geological and local scales.

Bailey, Mick

Current opinion in HIV and AIDS

2012 Volume 7, Issue 3, Page(s) 214–220

Abstract: Purpose of review: This review will contest the idea that the adaptive immune system of mammals represents an evolutionary advance which superseded the less evolved, innate immune system of invertebrates. General conclusions about the evolution of ... ...

Abstract	Purpose of review: This review will contest the idea that the adaptive immune system of mammals represents an evolutionary advance which superseded the less evolved, innate immune system of invertebrates. General conclusions about the evolution of immune systems will be applied to current infectious diseases of humans common in conditions of poverty. Recent findings: Many invertebrates have mechanisms for diversifying the repertoire of receptors specific for pathogen-associated molecules. The lamprey uses true genetic rearrangement to produce a repertoire comparable to that of our antibody-based system. Both adaptive immune systems may have evolved independently from an efficient, pre-existing, lymphocyte-based, innate immune system, the importance of which has only recently been described in mammals.Genetic variation in human populations is associated with susceptibility and resistance to infectious diseases. Specifically, human leucocyte antigen and natural killer receptor alleles are associated with susceptibility or resistance to HIV. However, the extent to which these will exert long-term selective pressure is unclear. Summary: Human pathogens do to exert selective pressures on the immune system, but these are unlikely to do more than change allele frequencies in the short term. In the long term, pathogen-driven evolution seems to promote expansion of recognition repertoire in adaptive and innate immune systems.
MeSH term(s)	Animals ; Communicable Diseases/immunology ; Evolution, Molecular ; Host-Pathogen Interactions/immunology ; Humans ; Immune System Phenomena/genetics ; Immune System Phenomena/physiology
Language	English
Publishing date	2012-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2502511-9
ISSN	1746-6318 ; 1746-630X
ISSN (online)	1746-6318
ISSN	1746-630X
DOI	10.1097/COH.0b013e3283522b56
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6812: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Sequential production of gametes during meiosis in trypanosomes

Lori Peacock / Chris Kay / Chloe Farren / Mick Bailey / Mark Carrington / Wendy Gibson

Communications Biology, Vol 4, Iss 1, Pp 1-

2021 Volume 10

Abstract: Lori Peacock et al. report the sequence of meiosis in Trypanosoma brucei cells from the salivary glands of tsetse flies using image analyses and expression of the cell fusion protein HAP2. From the recovered cell types and expression of HAP2 in meiotic ... ...

Abstract	Lori Peacock et al. report the sequence of meiosis in Trypanosoma brucei cells from the salivary glands of tsetse flies using image analyses and expression of the cell fusion protein HAP2. From the recovered cell types and expression of HAP2 in meiotic intermediates, these results indicate that haploid gametes are produced sequentially.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: A spatial model of CoVID-19 transmission in England and Wales: early spread and peak timing

Danon, Leon / Brooks-Pollock, Ellen / Bailey, Mick / Keeling, Matt J

medRxiv

Keywords	covid19
Language	English
Publishing date	2020-02-14
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2020.02.12.20022566
Database	COVID19

Full text online

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Sequential production of gametes during meiosis in trypanosomes.

Peacock, Lori / Kay, Chris / Farren, Chloe / Bailey, Mick / Carrington, Mark / Gibson, Wendy

Communications biology

2021 Volume 4, Issue 1, Page(s) 555

Abstract: Meiosis is a core feature of eukaryotes that occurs in all major groups, including the early diverging excavates. In this group, meiosis and production of haploid gametes have been described in the pathogenic protist, Trypanosoma brucei, and mating ... ...

Abstract	Meiosis is a core feature of eukaryotes that occurs in all major groups, including the early diverging excavates. In this group, meiosis and production of haploid gametes have been described in the pathogenic protist, Trypanosoma brucei, and mating occurs in the salivary glands of the insect vector, the tsetse fly. Here, we searched for intermediate meiotic stages among trypanosomes from tsetse salivary glands. Many different cell types were recovered, including trypanosomes in Meiosis I and gametes. Significantly, we found trypanosomes containing three nuclei with a 1:2:1 ratio of DNA contents. Some of these cells were undergoing cytokinesis, yielding a mononucleate gamete and a binucleate cell with a nuclear DNA content ratio of 1:2. This cell subsequently produced three more gametes in two further rounds of division. Expression of the cell fusion protein HAP2 (GCS1) was not confined to gametes, but also extended to meiotic intermediates. We propose a model whereby the two nuclei resulting from Meiosis I undergo asynchronous Meiosis II divisions with sequential production of haploid gametes.
MeSH term(s)	Animals ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; DNA/genetics ; Germ Cells/metabolism ; Germ Cells/physiology ; Meiosis/genetics ; Meiosis/physiology ; Reproduction/physiology ; Trypanosoma/genetics ; Trypanosoma/metabolism ; Trypanosoma/physiology ; Tsetse Flies/genetics
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2021-05-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-021-02058-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: 21st century research-One Health, resilience, welfare, and disease.

Reyher, Kristen K / Allen, Kate / Bailey, Mick / Dowsey, Andrew / Hezzell, Melanie / Lambton, Sarah / Mann, Jamie / Mendl, Michael / Peachey, Laura / Parkin, Tim

American journal of veterinary research

2022 Volume 83, Issue 8

MeSH term(s)	Animals ; One Health ; Social Welfare/history
Language	English
Publishing date	2022-07-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	390796-x
ISSN	1943-5681 ; 0002-9645
ISSN (online)	1943-5681
ISSN	0002-9645
DOI	10.2460/ajvr.22.06.0101
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 422: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The mucosal immune system: recent developments and future directions in the pig.

Bailey, Mick

Developmental and comparative immunology

2009 Volume 33, Issue 3, Page(s) 375–383

Abstract: In most animals, the mucosal immune system effectively controls expression of active immune responses to pathogen and tolerance to harmless antigens. Our understanding of the function and control of the mucosal immune system has advanced as a result of ... ...

Abstract	In most animals, the mucosal immune system effectively controls expression of active immune responses to pathogen and tolerance to harmless antigens. Our understanding of the function and control of the mucosal immune system has advanced as a result of studies in rodents and humans. The discoveries of regulatory T-cells and T-helper-17 cells, and studies on the interactions between epithelial and dendritic cells, demonstrate its complexity. In pigs, some of the systems and reagents for determining the relevance of these mechanisms are present, and indicate lines for future work. However, many empirical studies of the effect of manipulation of the mucosal immune system in the pig by prebiotics, probiotics and feed additives have been carried out. Interpretation of these results needs to be made with care, since manipulation of the mucosal immune system may improve its efficiency under a specific set of environmental and husbandry conditions, but impair it under others.
MeSH term(s)	Animals ; Antigen Presentation ; Cell Movement ; Chemokines/metabolism ; Humans ; Immunity, Cellular ; Immunity, Mucosal ; Interleukin-17/metabolism ; Lymphocyte Activation ; Mice ; Probiotics/metabolism ; Receptors, Lymphocyte Homing/immunology ; Receptors, Lymphocyte Homing/metabolism ; Swine/immunology ; T-Lymphocyte Subsets/cytology ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; T-Lymphocytes, Regulatory/cytology ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism
Chemical Substances	Chemokines ; Interleukin-17 ; Receptors, Lymphocyte Homing
Language	English
Publishing date	2009-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	752411-0
ISSN	1879-0089 ; 0145-305X
ISSN (online)	1879-0089
ISSN	0145-305X
DOI	10.1016/j.dci.2008.07.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1327: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito