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  1. Article ; Online: Flashback Foreword: Pazopanib in Renal Cell Carcinoma and Overall Survival With Sunitinib Versus Interferon-α in Metastatic Renal Cell Carcinoma.

    Carducci, Michael A

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 11, Page(s) 1955–1956

    MeSH term(s) Humans ; Sunitinib ; Carcinoma, Renal Cell/drug therapy ; Interferon-alpha/therapeutic use ; Kidney Neoplasms/pathology ; Indazoles/therapeutic use ; Pyrroles/therapeutic use ; Antineoplastic Agents/therapeutic use
    Chemical Substances Sunitinib (V99T50803M) ; pazopanib (7RN5DR86CK) ; Interferon-alpha ; Indazoles ; Pyrroles ; Antineoplastic Agents
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.00153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial: Bioaerosol emission characteristics and the epidemiological, occupational, and public health risk assessment of waste and wastewater management.

    Yan, Cheng / Viegas, Carla / Han, Yunping / Carducci, Annalaura

    Frontiers in public health

    2023  Volume 11, Page(s) 1111457

    MeSH term(s) Wastewater ; Aerosols/adverse effects ; Public Health ; Risk Assessment
    Chemical Substances Wastewater ; Aerosols
    Language English
    Publishing date 2023-02-17
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1111457
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exudative Retinal Detachment and Ciliochoroidal Effusion in Preeclampsia.

    Munsell, Mary K / Carducci, Nicholas M / Eton, Emily A

    Journal of vitreoretinal diseases

    2023  Volume 7, Issue 3, Page(s) 254–258

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2023-02-17
    Publishing country United States
    Document type Case Reports
    ISSN 2474-1272
    ISSN (online) 2474-1272
    DOI 10.1177/24741264221147986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Organic Pollutants Associated with Plastic Debris in Marine Environment: A Systematic Review of Analytical Methods, Occurrence, and Characteristics.

    Zhao, Hongrui / Federigi, Ileana / Verani, Marco / Carducci, Annalaura

    International journal of environmental research and public health

    2023  Volume 20, Issue 6

    Abstract: Plastic pollution has become one of the most serious environmental problems, and microplastics (MPs, particles < 5 mm size) may behave as a vehicle of organic pollutants, causing detrimental effects to the environment. Studies on MP-sorbed organic ... ...

    Abstract Plastic pollution has become one of the most serious environmental problems, and microplastics (MPs, particles < 5 mm size) may behave as a vehicle of organic pollutants, causing detrimental effects to the environment. Studies on MP-sorbed organic pollutants lack methodological standardization, resulting in a low comparability and replicability. In this work, we reviewed 40 field studies of MP-sorbed organic contaminants using PRISMA guidelines for acquiring information on sampling and analytical protocols. The papers were also scored for their reliability on the basis of 7 criteria, from 0 (minimum) to 21 (maximum). Our results showed a great heterogeneity of the methods used for the sample collection, MPs extraction, and instruments for chemicals' identification. Measures for cross-contamination control during MPs analysis were strictly applied only in 13% of the studies, indicating a need for quality control in MPs-related research. The most frequently detected MP-sorbed chemicals were polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), and organochlorine pesticides (OCPs). Most of the studies showed a good reliability (>75% of the total score), with 32 papers scoring 16 or higher. On the basis of the collected information, a standardizable protocol for the detection of MPs and MP-sorbed chemicals has been suggested for improving the reliability of MPs monitoring studies.
    MeSH term(s) Plastics/analysis ; Environmental Pollutants/analysis ; Reproducibility of Results ; Environmental Monitoring/methods ; Water Pollutants, Chemical/analysis ; Polychlorinated Biphenyls/analysis ; Polycyclic Aromatic Hydrocarbons/analysis
    Chemical Substances Plastics ; Environmental Pollutants ; Water Pollutants, Chemical ; Polychlorinated Biphenyls (DFC2HB4I0K) ; Polycyclic Aromatic Hydrocarbons
    Language English
    Publishing date 2023-03-10
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20064892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pivoting school health and nutrition programmes during COVID-19 in low- and middle-income countries: A scoping review.

    Carducci, Bianca / Dominguez, Georgia / Kidd, Emily / Janes, Karlie / Owais, Aatekah / Bhutta, Zulfiqar A

    Journal of global health

    2024  Volume 14, Page(s) 5006

    Abstract: Background: Preventive and promotive interventions delivered by schools can support a healthy lifestyle, positive development, and well-being in children and adolescents. The coronavirus disease 2019 (COVID-19) pandemic presented unique challenges to ... ...

    Abstract Background: Preventive and promotive interventions delivered by schools can support a healthy lifestyle, positive development, and well-being in children and adolescents. The coronavirus disease 2019 (COVID-19) pandemic presented unique challenges to school health and nutrition programmes due to closures and mobility restrictions.
    Methods: We conducted a scoping review to examine how school health and nutrition programmes pivoted during the COVID-19 pandemic, and to provide summative guidance to stakeholders in strategic immediate and long-term response efforts. We searched MEDLINE, Embase, PsycINFO, and grey literature sources for primary (observational, intervention, and programme evaluations) and secondary (reviews, best practices, and recommendations) studies conducted in low- and middle-income countries from January 2020 to June 2023. Programmes that originated in schools, which included children and adolescents (5-19.9 years) were eligible.
    Results: We included 23 studies in this review. They varied in their adaptation strategy and key programmatic focus, including access to school meals (n = 8), health services, such as immunisations, eye health, and water, sanitation, and hygiene-related activities (n = 4), physical activity curriculum and exercise training (n = 3), mental health counselling and curriculum (n = 3), or were multi-component in nature (n = 5). While school meals, physical activity, and mental health programmes were adapted by out-of-school administration (either in the community, households, or virtually), all health services were suspended indefinitely. Importantly, there was an overwhelming lack of quantitative data regarding modified programme coverage, utilisation, and the impact on children and adolescent health and nutrition.
    Conclusions: We found limited evidence of successful adaptation of school health and nutrition programme implementation during the pandemic, especially from Asia and Africa. While the adoption of the World Health Organization health-promoting school global standards and indicators is necessary at the national and school level, future research must prioritise the development of a school-based comprehensive monitoring and evaluation framework to track key indicators related to both health and nutrition of school-aged children and adolescents.
    MeSH term(s) Child ; Adolescent ; Humans ; COVID-19 ; Pandemics/prevention & control ; Developing Countries ; Schools ; Nutritional Status
    Language English
    Publishing date 2024-01-19
    Publishing country Scotland
    Document type Review ; Journal Article
    ZDB-ID 2741629-X
    ISSN 2047-2986 ; 2047-2986
    ISSN (online) 2047-2986
    ISSN 2047-2986
    DOI 10.7189/jogh.14.05006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Prenatal Mental Representations in Italian First-Time Mothers Before and During the COVID-19 Pandemic: A Study with Interviews on Maternal Representations During Pregnancy.

    Smorti, Martina / Mauri, Giulia / Carducci, Alessia / Andreol, Angelica / Bonassi, Lucia

    Maternal and child health journal

    2023  Volume 27, Issue 4, Page(s) 711–718

    Abstract: Introduction: Psychosocial risks increase the levels of not-integrated/ambivalent and restricted/disengaged representations during pregnancy, but no study has specifically analysed the impact of the COVID-19 pandemic on maternal representation styles.!## ...

    Abstract Introduction: Psychosocial risks increase the levels of not-integrated/ambivalent and restricted/disengaged representations during pregnancy, but no study has specifically analysed the impact of the COVID-19 pandemic on maternal representation styles.
    Objectives: (1) to compare maternal representation styles in primiparous women who became pregnant before and during the COVID-19 pandemic and (2) to analyse the content of representation styles during the COVID-19 pandemic.
    Methods: A total of 37 Italian pregnant women were recruited from 2019 to 2021. The sample was divided into two groups: the pre-COVID-19 group (22 women, mean age = 33.14 years; SD = 3.78) and the COVID-19 group (15 women, mean age = 35.9 years; SD = 4.6). Interviews on maternal representations during pregnancy were administered and analysed for style and content.
    Results: Women during the COVID-19 pandemic reported more restricted/disengaged and less integrated/balanced representation styles than women pre-COVID-19. Content analysis showed that the COVID-19 pandemic led women to focus more on concrete aspects of pregnancy in lieu of emotional aspects, thus leading them to develop more restricted/disengaged representation styles.
    Conclusions for practice: In future pandemics pregnant women should be supported in focusing their attention to emotions, sensations and fantasies about themselves as mothers and their children.
    MeSH term(s) Child ; Female ; Pregnancy ; Humans ; Adult ; COVID-19/epidemiology ; Pandemics ; Mothers/psychology ; Pregnant Women/psychology ; Emotions
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1339905-6
    ISSN 1573-6628 ; 1092-7875
    ISSN (online) 1573-6628
    ISSN 1092-7875
    DOI 10.1007/s10995-022-03573-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Role of bromodomain and extraterminal (BET) proteins in prostate cancer.

    Mandl, Adel / Markowski, Mark C / Carducci, Michael A / Antonarakis, Emmanuel S

    Expert opinion on investigational drugs

    2023  Volume 32, Issue 3, Page(s) 213–228

    Abstract: Introduction: The bromodomain and extraterminal (BET) family of proteins are epigenetic readers of acetylated histones and are critical activators of oncogenic networks across many cancers. Therapeutic targeting of BET proteins has been an attractive ... ...

    Abstract Introduction: The bromodomain and extraterminal (BET) family of proteins are epigenetic readers of acetylated histones and are critical activators of oncogenic networks across many cancers. Therapeutic targeting of BET proteins has been an attractive area of clinical development for metastatic castration-resistant prostate cancer. In recent years, many structurally diverse BET inhibitors have been discovered and tested. Preclinical studies have demonstrated significant antiproliferative activity of BET inhibitors against prostate cancer. However, their clinical success as monotherapies has been limited by treatment-associated toxicities, primary and acquired drug resistance, and a lack of predictive biomarkers of benefit.
    Areas covered: This review provides an overview of advancements in BET inhibitor design, preclinical research, and conclusions from clinical trials in prostate cancer. We speculate on incorporating BET inhibitors into combination regimens with other agents to improve the therapeutic index of BET inhibition in treating prostate cancer.
    Expert opinion: The therapeutic potential of BET inhibitors for prostate cancer has been demonstrated in preclinical studies. However, further research is needed to identify biomarkers that can predict sensitivity to BET inhibitors and to develop novel, highly selective inhibitors to reduce toxicities. Finally, BET inhibitors are likely to hold the most clinical potential in combination with other agents.
    MeSH term(s) Male ; Humans ; Proteins ; Prostatic Neoplasms/drug therapy ; Cell Cycle Proteins ; Antineoplastic Agents/adverse effects
    Chemical Substances Proteins ; Cell Cycle Proteins ; Antineoplastic Agents
    Language English
    Publishing date 2023-03-09
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2023.2186851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: How to Evaluate If Microorganisms Isolated From Sterile Drug Production Environments Monitoring Are Undesirable.

    Ceccanti, Stefano / Vecchiani, Sandra / Leonangeli, Giulia / Burgalassi, Susi / Federigi, Ileana / Carducci, Annalaura / Verani, Marco

    Journal of pharmaceutical sciences

    2024  

    Abstract: This study addresses the identification of undesirable microorganisms (MOs) recovered during the environmental monitoring in manufacture of sterile medicinal products. We developed a methodology evaluation based on a decision tree; then, such approach ... ...

    Abstract This study addresses the identification of undesirable microorganisms (MOs) recovered during the environmental monitoring in manufacture of sterile medicinal products. We developed a methodology evaluation based on a decision tree; then, such approach was applied to hypothetical scenarios of uncommon MOs isolation in sterile drugs production settings. The scenarios were formulated on the basis of our field experience, in terms of both MOs selection and types of sampling site. The MOs were chosen in order to include emerging pathogens and MOs responsible for drug recall, and several sampling sites were considered for their detection (air, surfaces, and personnel). The classification of the unusual MOs revealed that most of them were undesirable, because they represented the loss of environmental control or a potential impact on the quality of the product. In some cases, the uncommon MOs were not considered as undesirable. Therefore, our results demonstrated the importance of a methodology, also in terms of recovery rate of unusual MOs and of the threshold probability for the unacceptability (e.g., 1% or 5%). The proposed methodology allowed an easy and documented evaluation for the undesirable MOs isolated from the environment of the analyzed settings for sterile drugs production.
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3151-3
    ISSN 1520-6017 ; 0022-3549
    ISSN (online) 1520-6017
    ISSN 0022-3549
    DOI 10.1016/j.xphs.2024.01.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Conference proceedings: Moving beyond hormone refractory prostate cancer

    Carducci, Michael A.

    ... based on a Symposium Entitled, "Moving Beyond Hormone-Refractory Prostate Cancer," which was held on September 18, 2004, in Chicago, Illinois

    (Urology ; 65,5A = Suppl.)

    2005  

    Title variant Moving beyond hormone-refractory prostate cancer
    Event/congress Symposium Entitled Moving Beyond Hormone Refractory Prostate Cancer (2004, ChicagoIll.)
    Author's details guest ed.: Michael A. Carducci
    Series title Urology ; 65,5A = Suppl.
    Collection
    Language English
    Size 38 S. : graph. Darst.
    Publisher Elsevier Science
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT014394228
    Database Catalogue ZB MED Medicine, Health

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  10. Article ; Online: Phenotypes and Genotypes of Inherited Disorders of Biogenic Amine Neurotransmitter Metabolism.

    Mastrangelo, Mario / Tolve, Manuela / Artiola, Cristiana / Bove, Rossella / Carducci, Claudia / Carducci, Carla / Angeloni, Antonio / Pisani, Francesco / Leuzzi, Vincenzo

    Genes

    2023  Volume 14, Issue 2

    Abstract: Inherited disorders of biogenic amine metabolism are genetically determined conditions resulting in dysfunctions or lack of enzymes involved in the synthesis, degradation, or transport of dopamine, serotonin, adrenaline/noradrenaline, and their ... ...

    Abstract Inherited disorders of biogenic amine metabolism are genetically determined conditions resulting in dysfunctions or lack of enzymes involved in the synthesis, degradation, or transport of dopamine, serotonin, adrenaline/noradrenaline, and their metabolites or defects of their cofactor or chaperone biosynthesis. They represent a group of treatable diseases presenting with complex patterns of movement disorders (dystonia, oculogyric crises, severe/hypokinetic syndrome, myoclonic jerks, and tremors) associated with a delay in the emergence of postural reactions, global development delay, and autonomic dysregulation. The earlier the disease manifests, the more severe and widespread the impaired motor functions. Diagnosis mainly depends on measuring neurotransmitter metabolites in cerebrospinal fluid that may address the genetic confirmation. Correlations between the severity of phenotypes and genotypes may vary remarkably among the different diseases. Traditional pharmacological strategies are not disease-modifying in most cases. Gene therapy has provided promising results in patients with DYT-DDC and in vitro models of DYT/PARK-SLC6A3. The rarity of these diseases, combined with limited knowledge of their clinical, biochemical, and molecular genetic features, frequently leads to misdiagnosis or significant diagnostic delays. This review provides updates on these aspects with a final outlook on future perspectives.
    MeSH term(s) Humans ; Movement Disorders ; Dopamine/metabolism ; Neurotransmitter Agents/metabolism ; Genotype ; Phenotype
    Chemical Substances Dopamine (VTD58H1Z2X) ; Neurotransmitter Agents
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14020263
    Database MEDical Literature Analysis and Retrieval System OnLINE

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