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  1. Article: The rising burden of urological diseases: A concern for healthcare resource planning.

    Mann, Uday

    Canadian Urological Association journal = Journal de l'Association des urologues du Canada

    2023  Volume 16, Issue 12, Page(s) 408

    Language English
    Publishing date 2023-01-19
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2431403-1
    ISSN 1911-6470
    ISSN 1911-6470
    DOI 10.5489/cuaj.8177
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  2. Article: The potential impact of COVID-19 on the Canadian Resident Matching Service: Unique future challenges faced by urology residency programs and applicants.

    Mann, Uday / Nayak, Jasmir G

    Canadian Urological Association journal = Journal de l'Association des urologues du Canada

    2020  Volume 14, Issue 5, Page(s) E167–E168

    Keywords covid19
    Language English
    Publishing date 2020-05-04
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2431403-1
    ISSN 1911-6470
    ISSN 1911-6470
    DOI 10.5489/cuaj.6616
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  3. Article ; Online: Risk of major adverse cardiovascular events in rural vs urban settings among patients with erectile dysfunction: a propensity-weighted retrospective cohort study of 430 621 men.

    Mann, Uday / Bal, Dhiraj S / Panchendrabose, Kapilan / Brar, Ranveer / Patel, Premal

    The journal of sexual medicine

    2024  

    Abstract: Background: The relationship between erectile dysfunction (ED) and cardiovascular (CV) events has been postulated, with ED being characterized as a potential harbinger of CV disease. Location of residence is another important consideration, as the ... ...

    Abstract Background: The relationship between erectile dysfunction (ED) and cardiovascular (CV) events has been postulated, with ED being characterized as a potential harbinger of CV disease. Location of residence is another important consideration, as the impact of rural residence has been associated with worse health outcomes.
    Aim: To investigate whether men from rural settings with ED are associated with a higher risk of major adverse CV events (MACEs).
    Methods: A propensity-weighted retrospective cohort study was conducted with provincial health administrative databases. ED was defined as having at least 2 ED prescriptions filled within 1 year. MACE was defined as the first hospitalization for an episode of acute myocardial infarction, heart failure, or stroke that resulted in a hospital visit >24 hours. We classified study groups into ED urban, ED rural, no ED urban, and no ED rural. A multiple logistic regression model was used to determine the propensity score. Stabilized inverse propensity treatment weighting was then applied to the propensity score.
    Outcomes: A Cox proportional hazard model was used to examine our primary outcome of time to a MACE.
    Results: The median time to a MACE was 2731, 2635, 2441, and 2508 days for ED urban (n = 32 341), ED rural (n = 18 025), no ED rural (n = 146 358), and no ED urban (n = 233 897), respectively. The cohort with ED had a higher proportion of a MACE at 8.94% (n = 4503), as opposed to 4.58% (n = 17 416) for the group without ED. As compared with no ED urban, no ED rural was associated with higher risks of a MACE in stabilized time-varying comodels based on inverse probability treatment weighting (hazard ratio, 1.06-1.08). ED rural was associated with significantly higher risks of a MACE vs no ED rural, with the strength of the effect estimates increasing over time (hazard ratio, 1.10-1.74).
    Clinical implications: Findings highlight the need for physicians treating patients with ED to address CV risk factors for primary and secondary prevention of CV diseases.
    Strengths and limitations: This is the most extensive retrospective study demonstrating that ED is an independent risk factor for MACE. Due to limitations in data, we were unable to assess certain comorbidities, including obesity and smoking.
    Conclusions: Our study confirms that ED is an independent risk factor for MACE. Rural men had a higher risk of MACE, with an even higher risk among those who reside rurally and are diagnosed with ED.
    Language English
    Publishing date 2024-04-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2251959-2
    ISSN 1743-6109 ; 1743-6095
    ISSN (online) 1743-6109
    ISSN 1743-6095
    DOI 10.1093/jsxmed/qdae043
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    Zs.A 6417: Show issues Location:
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  4. Article ; Online: An update on male infertility and intratesticular testosterone-insight into novel serum biomarkers.

    Sidhom, Karim / Panchendrabose, Kapilan / Mann, Uday / Patel, Premal

    International journal of impotence research

    2022  Volume 34, Issue 7, Page(s) 673–678

    Abstract: Intratesticular testosterone is vital for spermatogenesis, male fertility, and virility. Currently the only method to assess levels of intratesticular testosterone is to perform testicular biopsy which is invasive and can lead to several complications. ... ...

    Abstract Intratesticular testosterone is vital for spermatogenesis, male fertility, and virility. Currently the only method to assess levels of intratesticular testosterone is to perform testicular biopsy which is invasive and can lead to several complications. Approaches to assess intratesticular testosterone have been understudied but hold promise as future male contraceptive agents and may grant the ability to monitor patients undergoing hormonal changes from therapeutic and diagnostic perspectives. Previous studies have sought to assess the utility of 17-hydroxyprogesterone (17-OHP) and insulin-like factor 3 (INSL3) as accurate surrogate biomarkers of intratesticular testosterone. The aim of this review is thus to highlight the importance of intratesticular testosterone and the consequent advances that have been made to elucidate the potential of biomarkers for intratesticular testosterone in the context of male infertility.
    MeSH term(s) Humans ; Male ; Testosterone/therapeutic use ; Testis ; Spermatogenesis ; Infertility, Male/drug therapy ; Biomarkers
    Chemical Substances Testosterone (3XMK78S47O) ; Biomarkers
    Language English
    Publishing date 2022-01-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1034295-3
    ISSN 1476-5489 ; 0955-9930
    ISSN (online) 1476-5489
    ISSN 0955-9930
    DOI 10.1038/s41443-021-00507-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2910: Show issues Location:
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  5. Article ; Online: Synthesis and in vitro Metabolic Stability of Sterically Shielded Antimycobacterial Phenylalanine Amides.

    Lang, Markus / Ganapathy, Uday S / Mann, Lea / Seidel, Rüdiger W / Goddard, Richard / Erdmann, Frank / Dick, Thomas / Richter, Adrian

    ChemMedChem

    2024  Volume 19, Issue 6, Page(s) e202300593

    Abstract: Nα-aroyl-N-aryl-phenylalanine amides (AAPs) are RNA polymerase inhibitors with activity against Mycobacterium tuberculosis and non-tuberculous mycobacteria. We observed that AAPs rapidly degrade in microsomal suspensions, suggesting that avoiding hepatic ...

    Abstract Nα-aroyl-N-aryl-phenylalanine amides (AAPs) are RNA polymerase inhibitors with activity against Mycobacterium tuberculosis and non-tuberculous mycobacteria. We observed that AAPs rapidly degrade in microsomal suspensions, suggesting that avoiding hepatic metabolism is critical for their effectiveness in vivo. As both amide bonds are potential metabolic weak points of the molecule, we synthesized 16 novel AAP analogs in which the amide bonds are shielded by methyl or fluoro substituents in close proximity. Some derivatives show improved microsomal stability, while being plasma-stable and non-cytotoxic. In parallel with the metabolic stability studies, the antimycobacterial activity of the AAPs against Mycobacterium tuberculosis, Mycobacterium abscessus, Mycobacterium avium and Mycobacterium intracellulare was determined. The stability data are discussed in relation to the antimycobacterial activity of the panel of compounds and reveal that the concept of steric shielding of the anilide groups by a fluoro substituent has the potential to improve the stability and bioavailability of AAPs.
    MeSH term(s) Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Mycobacterium tuberculosis ; Amides/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Amides
    Language English
    Publishing date 2024-02-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2218496-X
    ISSN 1860-7187 ; 1860-7179
    ISSN (online) 1860-7187
    ISSN 1860-7179
    DOI 10.1002/cmdc.202300593
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    Zs.A 6280: Show issues Location:
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  6. Article: The potential impact of COVID-19 on the Canadian Resident Matching Service: Unique future challenges faced by urology residency programs and applicants

    Mann, Uday / Nayak, Jasmir G

    Can Urol Assoc J

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32369010
    Database COVID19

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  7. Article ; Online: Reasons for worldwide decline in male fertility.

    Mann, Uday / Shiff, Benjamin / Patel, Premal

    Current opinion in urology

    2020  Volume 30, Issue 3, Page(s) 296–301

    Abstract: Purpose of review: To review the evidence regarding a decrease in worldwide sperm parameters and discuss potential causative factors.: Recent findings: The topic of worldwide decline in sperm parameters is contentious; however, recent high-quality ... ...

    Abstract Purpose of review: To review the evidence regarding a decrease in worldwide sperm parameters and discuss potential causative factors.
    Recent findings: The topic of worldwide decline in sperm parameters is contentious; however, recent high-quality studies have demonstrated that there is indeed a decline in sperm parameters. Several retrospective and basic science studies have shown possible links for this decline in sperm parameters such as obesity, diet, and environmental toxins.
    Summary: There exist substantial data to suggest a decline in sperm counts over time. Although causative factors have yet to be fully elucidated, potential causes include, increased rates of obesity, poor diet, and exposure to environmental toxins. How this decline in sperm counts reflects fertility has yet to be determined. As such, further studies are necessary to evaluate whether this decline in sperm count correlates with decreased fecundity and how to identify and mitigate potential causative factors.
    MeSH term(s) Cannabis ; Chronic Disease ; Diet ; Environmental Pollutants/adverse effects ; Fertility/physiology ; Hazardous Substances/adverse effects ; Humans ; Infertility, Male/etiology ; Life Style ; Male ; Obesity ; Semen Analysis ; Smoking/epidemiology ; Sperm Count ; Spermatozoa ; Nicotiana
    Chemical Substances Environmental Pollutants ; Hazardous Substances
    Language English
    Publishing date 2020-03-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1091792-5
    ISSN 1473-6586 ; 0963-0643
    ISSN (online) 1473-6586
    ISSN 0963-0643
    DOI 10.1097/MOU.0000000000000745
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    Zs.A 3345: Show issues Location:
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  8. Article: A prospective evaluation of patient perspectives and financial considerations during prostate cancer treatment decision-making.

    Rai, Karnvir S / Mann, Uday / Harasemiw, Oksana / Tangri, Navdeep / Eng, Amanda / Patel, Premal / Nayak, Jasmir G

    Canadian Urological Association journal = Journal de l'Association des urologues du Canada

    2023  Volume 17, Issue 9, Page(s) E244–E251

    Abstract: Introduction: In universal healthcare systems, patients may still encounter financial obstacles from cancer treatments, potentially influencing treatment decision-making. We investigated the relationship between socioeconomic status and treatment ... ...

    Abstract Introduction: In universal healthcare systems, patients may still encounter financial obstacles from cancer treatments, potentially influencing treatment decision-making. We investigated the relationship between socioeconomic status and treatment decision-making as it pertains to patient values, preferences, and perceived barriers to care for localized prostate cancer.
    Methods: We conducted a prospective study of patients undergoing a prostate biopsy for the initial detection of prostate cancer. Sociodemographic variables were collected, with validated instruments used to determine health literacy levels. Patients were divided into two groups using self-reported income; those with a positive identification of prostate cancer underwent additional surveys to ascertain their knowledge of their diagnosis, treatment-related preferences, and socioeconomic barriers to care. Descriptive statistics were used.
    Results: Of 160 patients, approximately one-third were classified as having low health literacy. Within the low-income group, education levels were lower (34.6% had less than high school education vs. 10.2% in the high-income group) and unemployment rates higher (75.0% unemployed vs. 38.9% in the high-income group). Low-income patients with prostate cancer placed greater importance on indirect out-of-pocket expenses related to treatment (78.3% vs. 33.3%, p=0.001), higher emphasis on treatment-related travel time (50% vs. 15.1%, p=0.004), and more often had difficulty paying for healthcare services in the past (30.9% vs. 9.1%, p=0.02).
    Conclusions: Patients with lower household incomes have unique treatment values and decision-making preferences. They may experience additional challenges and barriers to obtaining cancer care, at least partly related to indirect costs. These findings should be considered when framing prostate cancer treatment discussions and designing patient-facing health information.
    Language English
    Publishing date 2023-07-17
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2431403-1
    ISSN 1911-6470
    ISSN 1911-6470
    DOI 10.5489/cuaj.8228
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  9. Article ; Online: Synthesis and Characterization of Phenylalanine Amides Active against

    Lang, Markus / Ganapathy, Uday S / Mann, Lea / Abdelaziz, Rana / Seidel, Rüdiger W / Goddard, Richard / Sequenzia, Ilaria / Hoenke, Sophie / Schulze, Philipp / Aragaw, Wassihun Wedajo / Csuk, René / Dick, Thomas / Richter, Adrian

    Journal of medicinal chemistry

    2023  Volume 66, Issue 7, Page(s) 5079–5098

    Abstract: ... ...

    Abstract N
    MeSH term(s) Animals ; Amides ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Mammals ; Microbial Sensitivity Tests ; Mycobacterium abscessus ; Mycobacterium Infections, Nontuberculous/microbiology ; Mycobacterium tuberculosis
    Chemical Substances Amides ; Anti-Bacterial Agents ; MMV688845
    Language English
    Publishing date 2023-03-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c00009
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  10. Article ; Online: In Vitro

    Mann, Lea / Ganapathy, Uday S / Abdelaziz, Rana / Lang, Markus / Zimmerman, Matthew D / Dartois, Véronique / Dick, Thomas / Richter, Adrian

    Microbiology spectrum

    2022  Volume 10, Issue 6, Page(s) e0276022

    Abstract: In a library screen of tuberculosis-active compounds for anti-Mycobacterium abscessus activity, we previously identified the synthetic phenylalanine amide MMV688845. In Mycobacterium tuberculosis, this class was shown to target the RpoB subunit of RNA ... ...

    Abstract In a library screen of tuberculosis-active compounds for anti-Mycobacterium abscessus activity, we previously identified the synthetic phenylalanine amide MMV688845. In Mycobacterium tuberculosis, this class was shown to target the RpoB subunit of RNA polymerase, engaging a binding site distinct from that of the rifamycins. Due to its bactericidal activity, rifampicin is a key drug for the treatment of tuberculosis (TB). However, this natural product shows poor potency against M. abscessus due to enzymatic modification, and its clinical use is limited. Here, we carried out
    MeSH term(s) Humans ; Mycobacterium abscessus ; Mycobacterium Infections, Nontuberculous/drug therapy ; Mycobacterium Infections, Nontuberculous/microbiology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Rifampin/pharmacology ; Rifampin/therapeutic use ; Mycobacterium tuberculosis ; Microbial Sensitivity Tests
    Chemical Substances Anti-Bacterial Agents ; Rifampin (VJT6J7R4TR)
    Language English
    Publishing date 2022-11-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.02760-22
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