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  1. Article ; Online: Uptake and incorporation of Al, Cr, V, Zn and Mo in hematite: Competition, synergies and influence on structural properties.

    Scullett-Dean, G / Hamilton, J L / Repina, O / Brand, H E A / Burton, E D / Saunders, M / Santini, T C

    Journal of hazardous materials

    2022  Volume 445, Page(s) 130630

    Abstract: This study investigated multiple (di-, tri- and tetra-)incorporation of selected minor and trace elements ( ... ...

    Abstract This study investigated multiple (di-, tri- and tetra-)incorporation of selected minor and trace elements (Al
    Language English
    Publishing date 2022-12-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2022.130630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Conference proceedings: Internet imaging V

    Santini, Simone

    19 - 20 January 2004, San Jose, California, USA ; proceedings of Electronic imaging, science and technology ; [papers presented at the Fifth Internet Imaging Conference, part of the Annual Electronic Imaging Symposium]

    (SPIE ; 5304)

    2004  

    Institution Electronic Imaging Symposium
    Internet Imaging Conference
    Society for Imaging Science and Technology
    Event/congress Annual Electronic Imaging Symposium (2004.01.19-20, SanJoseCalif.) ; Internet Imaging Conference (5, 2004.01.19-20, SanJoseCalif.)
    Author's details sponsored and publ. by IS&T, the Society for Imaging Science and Technology; SPIE, the International Society for Optical Engineering. Simone Santini ..., chairs/ed
    Series title SPIE ; 5304
    Language English
    Size X, 340 S
    Publisher SPIE
    Publishing place Bellingham, Wash
    Document type Book ; Conference proceedings
    ISBN 0819452076 ; 9780819452078
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Article ; Online: Advances in myelodysplastic syndrome.

    Santini, Valeria

    Current opinion in oncology

    2021  Volume 33, Issue 6, Page(s) 681–686

    Abstract: Purpose of review: In this review, the focus is on the most recent improvements in diagnosis, prognostication and therapy of myelodysplastic syndromes (MDS) and on their relevance for clinical management.: Recent findings: Analytical methods to ... ...

    Abstract Purpose of review: In this review, the focus is on the most recent improvements in diagnosis, prognostication and therapy of myelodysplastic syndromes (MDS) and on their relevance for clinical management.
    Recent findings: Analytical methods to refine cytogenetic and molecular assessment of MDS have been proposed, improving prognostic stratification obtained from integration of clinical and genomic data. Novel agents with very different mode of action, as single drugs or added to HMA backbone, show promising clinical results in LR-MDS and HR-MDS. Luspatercept has obtained approval given the fact that in transfusion-dependent erythropoietic-stimulating agent resistant/relapsed LR-MDS induced nearly 50% of transfusion independence. Another investigational agent showing efficacy and possibly disease modifying activity in the same setting is the telomerase inhibitor imetelstat. Results from phase II study with azacytidine and pevonedistat indicate the concrete possibility to enhance durable responses compared with azacitidine single drug. In the same direction are the preliminary results of other agents with different mode of action: magrolimab, venetoclax, sabatolimab, as well as the targeted therapy with enasidenib and ivosidenib. New posttransplant maintenance strategies may concur to prolong response.
    Summary: Better diagnosis and prognostic stratification may allow a more precise and personalized treatment of MDS with novel agent combinations leading to improved therapeutic algorithms.
    MeSH term(s) Clinical Trials, Phase II as Topic ; Humans ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/drug therapy ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2021-09-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1049384-0
    ISSN 1531-703X ; 1040-8746
    ISSN (online) 1531-703X
    ISSN 1040-8746
    DOI 10.1097/CCO.0000000000000790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Influence of cavity configuration on microleakage around Class V restorations bonded with seven self-etching adhesives.

    Santini, Ario / Ivanovic, Vladimir / Ibbetson, Richard / Milia, Egle

    Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.

    2004  Volume 16, Issue 2, Page(s) 128–35; discussion 136

    Abstract: Purpose: The purpose of this study was to evaluate microleakage around Class V resin composite ... occlusogingivally. Selected at random, box-shaped cavities were cut on one side and V-shaped cavities were cut ... cavities, p = .8862; V-shaped cavities, p = .9623; using the ANOVA). Microleakage was not observed ...

    Abstract Purpose: The purpose of this study was to evaluate microleakage around Class V resin composite restorations with different cavity configurations, bonded with one of seven self-etching materials or with an adhesive using the total-etch technique.
    Materials and methods: Ninety-six human molars and premolars were randomly assigned to eight groups and bonded with one of seven self-etching adhesives--Prompt-L-Pop (3M ESPE, St. Paul, MN, USA), Adper Prompt-L-Pop (3M ESPE), Clearfil SE Bond (Kuraray Medical, Okayama, Japan), Prime & Bond NT/NRC (Dentsply DeTrey, Konstanz, Germany), Xeno III (Dentsply DeTrey), One-Up Bond (Tokuyama Dental, Tokuyama, Japan), AdheSE (Ivoclar Vivadent, Schaan, Liechtenstein)-or with Prime & Bond NT (Dentsply DeTrey) using a separate total-etch technique. Cavities were cut in both the lingual and buccal surfaces and were approximately 3 mm mesiodistally, 1.5 mm deep, and 2.0 mm occlusogingivally. Selected at random, box-shaped cavities were cut on one side and V-shaped cavities were cut on the contralateral side. After bonding, the cavities were incrementally filled with a microhybrid composite (Tetric Ceram, Ivoclar Vivadent), cured, and immediately polished with Sof-Lex (3M ESPE) disks. The teeth were thermocycled, and the specimens were examined for microleakage using Procion Brilliant Red (ICI, Slough, UK) as a marker.
    Results: Comparisons of both gingival and enamel margins within each of the groups showed no significant difference owing to configuration factor (C-factor; p > .5 in all cases, calculated with Kruskal-Wallis nonparametric analysis of variance [ANOVA]) and Dunn's multiple comparison test). All groups showed microleakage at the gingival margins irrespective of C-factor or bonding agent (box-shaped cavities, p = .8862; V-shaped cavities, p = .9623; using the ANOVA). Microleakage was not observed at all enamel margins regardless of C-factor or bonding agent, and there were no significant differences between the groups (box-shaped cavities, p = .9869; V-shaped cavities, p = .9550; using the Kruskal-Wallis nonparametric ANOVA).
    MeSH term(s) Adolescent ; Adult ; Bicuspid ; Composite Resins/chemistry ; Dental Bonding ; Dental Caries/therapy ; Dental Cavity Preparation/classification ; Dental Cavity Preparation/methods ; Dental Etching/methods ; Dental Leakage/prevention & control ; Dental Marginal Adaptation ; Dental Restoration, Permanent/methods ; Dentin-Bonding Agents/chemistry ; Humans ; In Vitro Techniques ; Molar ; Random Allocation ; Statistics, Nonparametric
    Chemical Substances Composite Resins ; Dentin-Bonding Agents
    Language English
    Publishing date 2004-10-15
    Publishing country England
    Document type Comparative Study ; Evaluation Studies ; Journal Article
    ZDB-ID 2043146-6
    ISSN 1708-8240 ; 1496-4155
    ISSN (online) 1708-8240
    ISSN 1496-4155
    DOI 10.1111/j.1708-8240.2004.tb00020.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Influence of marginal bevels on microleakage around Class V cavities bonded with seven self-etching agents.

    Santini, Ario / Ivanovic, Vladimir / Ibbetson, Richard / Milia, Egle

    American journal of dentistry

    2004  Volume 17, Issue 4, Page(s) 257–261

    Abstract: Purpose: To evaluate microleakage around Class V resin-based composite restorations in box-shaped ...

    Abstract Purpose: To evaluate microleakage around Class V resin-based composite restorations in box-shaped cavities with and without marginal bevels, bonded with one of seven self-etching materials and a non-self etching system.
    Methods: 120 extracted human premolars were randomly assigned to eight groups for bonding with the following self-etching agents: Prompt-L Pop, Adper Prompt, Clearfil SE, Prime& Bond NT with NRC, Xeno111, One-Up Bond, AdheSe, or Prime & Bond NT using a total etch technique (36% H2PO4). Box cavities were cut in both the lingual and buocal surfaces. The cavities were made with an ISO 010-fissure diamond bur in a water-cooled high-speed handpiece and were approximately 3 mm wide, 1.5 mm deep, and 2.0 mm high. Selected at random, box-shaped cavities were cut with a 0.5 mm bevel in enamel and dentin on one side and on the contra-lateral side, box-shaped cavities were cut without bevels. Each tooth served as its own control. The teeth were thermocycled and the specimens prepared and examined for microleakage using Procion Red as a marker.
    Results: All gingival margins leaked whether or not a bevel had been placed, when bonded either with a self-etching agent or using a total etch technique with 36% phosphoric acid. There was no significant difference in leakage between the self-etching groups or those using a total etch technique, at the gingival bevel margins, (P= 0.7384) or the gingival non-beveled margins (P= 0.2307; Kruskal-Wallis Test). Microleakage was found with every agent, both occlusally and gingivally, when bonded either with a self-etching agent or using a total-etch technique. There was no significant difference in leakage between the self-etching groups or those using a total etch technique at the enamel bevel margins, (P= 0.9907) or the enamel non-beveled margins (P= 0.9963; Kruskal-Wallis Test).
    MeSH term(s) Acid Etching, Dental ; Adolescent ; Adult ; Coloring Agents ; Composite Resins/chemistry ; Dental Bonding ; Dental Cavity Preparation/classification ; Dental Cavity Preparation/methods ; Dental Enamel/pathology ; Dental Leakage/classification ; Dental Marginal Adaptation ; Dental Restoration, Permanent ; Dentin-Bonding Agents/chemistry ; Humans ; Statistics, Nonparametric ; Surface Properties
    Chemical Substances Coloring Agents ; Composite Resins ; Dentin-Bonding Agents
    Language English
    Publishing date 2004-08
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 645142-1
    ISSN 0894-8275
    ISSN 0894-8275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Effect of prolonged thermal cycling on microleakage around Class V cavities restored with glass-ceramic inserts with different coefficients of thermal expansion: an in vitro study.

    Santini, Ario / Ivanovic, Vladimir / Tan, Chuei Luan / Ibbetson, Richard

    Primary dental care : journal of the Faculty of General Dental Practitioners (UK)

    2007  Volume 13, Issue 4, Page(s) 147–153

    Abstract: Purpose: The purpose of this in vitro study was to evaluate microleakage around Class V glass ... years) were randomly assigned to three groups. Standard Class V preparations were cut in the buccal ...

    Abstract Purpose: The purpose of this in vitro study was to evaluate microleakage around Class V glass-ceramic restorations of different coefficients of thermal expansion after prolonged thermal cycling.
    Materials and methods: One hundred and twenty noncarious extracted human premolars (patient age range 12-20 years) were randomly assigned to three groups. Standard Class V preparations were cut in the buccal surface using customised Cerana burs, size no. 3. Glass-ceramic inserts from two manufacturers (Cerana, Nordiska Dental AB, Helsingborg, Sweden; Beta-Quartz, Hager & Werken GmbH, Duisburg, Germany) were used to restore the cavities and were luted with a hybrid, high-viscous composite (Tetric Ceram, Ivoclar Vivadent, Schaan, Liechtenstein) and a bonding agent (Excite, Ivoclar Vivadent, Schaan, Liechtenstein). A control group, without inserts, was bulk-filled with the same composite used as the luting agent. In accordance with American Dental Association guidelines, half of the preparation was in enamel, half in dentine/cementum and had a mesio-distal width of 3 mm, an occluso-gingival height of 3 mm, and a depth of 2 mm. All margins had butt joints. Sixty teeth, selected at random, were not thermal cycled; the remaining 60 teeth were thermal cycled 4000 times between water baths held at 5 degrees C and 55 degrees C and the specimens prepared and examined for microleakage using 2.0% Procion Red (ICI, Slough, UK) dye, buffered at pH7, as a marker. The results were analysed using the Kruskal-Wallis test (ANOVA) at a 95% significance level.
    Results: At the occlusal margins there was no significant difference in microleakage between the three groups (P>0.5) without thermal cycling. After thermal cycling, microleakage at the occlusal margins was significantly less around cavities restored with Cerana glass-ceramic inserts versus Beta-Quartz and Tetric Ceram (P<0.05 in both cases). At the gingival margins, there was no significant difference in microleakge between the groups before thermal cycling (P>0.5). After thermal cycling, there was significantly less microleakage between Cerana inserts and Tetric Ceram (P<0.05). Comparisons between non-thermal cycled and thermal cycled groups showed there was no significant difference with the Cerana inserts (P=0.5590).
    Clinical implications: The results indicate that, after thermal cycling, restorations restored with Cerana glass-ceramic inserts, which have a coefficient of thermal expansion approximating to that of enamel, show a decrease in marginal microleakage, compared with Beta-Quartz glass-ceramic inserts and Tetric Ceram resin-based composite material. Restorative materials, which have a coefficient of thermal expansion approximating to that of enamel, would seem to be the materials of choice in reducing the problem of marginal microleakege.
    MeSH term(s) Adolescent ; Adult ; Bicuspid ; Ceramics/chemistry ; Child ; Dental Bonding/methods ; Dental Leakage/prevention & control ; Dental Marginal Adaptation ; Dental Materials/chemistry ; Dental Restoration Failure ; Dental Stress Analysis ; Elasticity ; Glass/chemistry ; Humans ; In Vitro Techniques ; Quartz/chemistry ; Thermal Conductivity
    Chemical Substances Beta-Quartz glass-ceramic ; Cerana ; Dental Materials ; Quartz (14808-60-7) ; Glass ceramics (85422-94-2)
    Language English
    Publishing date 2007-01-04
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 2005994-2
    ISSN 1741-9344 ; 1355-7610
    ISSN (online) 1741-9344
    ISSN 1355-7610
    DOI 10.1308/135576106778529017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: arrA is a reliable marker for As(V) respiration.

    Malasarn, D / Saltikov, C W / Campbell, K M / Santini, J M / Hering, J G / Newman, D K

    Science (New York, N.Y.)

    2004  Volume 306, Issue 5695, Page(s) 455

    Abstract: Arsenate [As(V)]-respiring bacteria affect the speciation and mobilization of arsenic ... for human health. Using molecular genetics, we show that the functional gene for As(V) respiration, arrA, is highly ... conserved; that it is required for As(V) reduction to arsenite when arsenic is sorbed onto iron minerals ...

    Abstract Arsenate [As(V)]-respiring bacteria affect the speciation and mobilization of arsenic in the environment. This can lead to arsenic contamination of drinking water supplies and deleterious consequences for human health. Using molecular genetics, we show that the functional gene for As(V) respiration, arrA, is highly conserved; that it is required for As(V) reduction to arsenite when arsenic is sorbed onto iron minerals; and that it can be used to identify the presence and activity of As(V)-respiring bacteria in arsenic-contaminated iron-rich sediments. The expression of arrA thus can be used to monitor sites in which As(V)-respiring bacteria may be controlling arsenic geochemistry.
    MeSH term(s) Archaea/genetics ; Archaea/metabolism ; Arsenates/metabolism ; Arsenite Transporting ATPases ; Arsenites/metabolism ; Bacteria/genetics ; Bacteria/metabolism ; Conserved Sequence ; Ferric Compounds/metabolism ; Genes, Bacterial ; Ion Pumps/genetics ; Ion Pumps/metabolism ; Multienzyme Complexes/genetics ; Multienzyme Complexes/metabolism ; Oxidation-Reduction ; Polymerase Chain Reaction ; Shewanella/genetics ; Shewanella/metabolism
    Chemical Substances Arsenates ; Arsenites ; Ferric Compounds ; Ion Pumps ; Multienzyme Complexes ; Arsenite Transporting ATPases (EC 3.6.3.16) ; arsenite (N5509X556J) ; arsenic acid (N7CIZ75ZPN)
    Language English
    Publishing date 2004-10-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1102374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Enasidenib: a magic bullet for myelodysplastic syndromes?

    Santini, Valeria

    The Lancet. Haematology

    2020  Volume 7, Issue 4, Page(s) e275–e276

    MeSH term(s) Aminopyridines ; Humans ; Myelodysplastic Syndromes ; Triazines
    Chemical Substances Aminopyridines ; Triazines ; enasidenib (3T1SS4E7AG)
    Language English
    Publishing date 2020-03-05
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(20)30039-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Validation of 3D-CMCC Forest Ecosystem Model (v.5.1) against eddy covariance data for ten European forest sites

    A. Collalti / S. Marconi / A. Ibrom / C. Trotta / A. Anav / E. D'Andrea / G. Matteucci / L. Montagnani / B. Gielen / I. Mammarella / T. Grünwald / A. Knohl / R. Valentini / M. Santini

    Geoscientific Model Development Discussions, Vol 8, Iss 8, Pp 6867-

    2015  Volume 6929

    Abstract: This study evaluates the performances of the new version (v.5.1) of 3D-CMCC Forest Ecosystem Model ...

    Abstract This study evaluates the performances of the new version (v.5.1) of 3D-CMCC Forest Ecosystem Model (FEM) in simulating gross primary production (GPP), against eddy covariance GPP data for ten FLUXNET forest sites across Europe. A new carbon allocation module, coupled with new both phenological and autotrophic respiration schemes, was implemented in this new version. Model ability in reproducing timing and magnitude of daily and monthly GPP fluctuations is validated at intra-annual and inter-annual scale, including extreme anomalous seasons. With the purpose to test the 3D-CMCC FEM applicability over Europe without a site-related calibration, the model has been deliberately parameterized with a single set of species-specific parameterizations for each forest ecosystem. The model consistently reproduces both in timing and in magnitude daily and monthly GPP variability across all sites, with the exception of the two Mediterranean sites. We find that 3D-CMCC FEM tends to better simulate the timing of inter-annual anomalies than their magnitude within measurements uncertainty. In six of eight sites where data were available the model well reproduces the 2003 summer drought event. Finally, for three sites we evaluate if a more accurate representation of forest structural characteristics (i.e. cohorts, forest layers) and species composition can improve model results. In two of the three sites results reveal that model slightly increases its performances, although, statistically speaking, not in a relevant way.
    Keywords Geography (General) ; G1-922
    Subject code 551
    Language English
    Publishing date 2015-08-01T00:00:00Z
    Publisher Copernicus Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Marginal microleakage around class V cavities restored with glass ceramic inserts of different coefficients of thermal expansion.

    Tan, Chuei Luan / Santini, Ario

    The Journal of clinical dentistry

    2005  Volume 16, Issue 1, Page(s) 26–31

    Abstract: Objective: Evaluate microleakage around Class V resin restorations restored with glass ceramic ... premolars (patient age range 12-20 years) were randomly assigned to three groups. Standard Class V ...

    Abstract Objective: Evaluate microleakage around Class V resin restorations restored with glass ceramic inserts of different coefficients of thermal expansion.
    Methodology: Sixty non-carious extracted human premolars (patient age range 12-20 years) were randomly assigned to three groups. Standard Class V preparations were cut in the buccal surface using customized Cerana burs, size 3. Glass ceramic inserts from two manufacturers (Cerana and Beta-Quartz) were used to restore the cavities, and were luted with a hybrid, high-viscous composite (Tetric Ceram) and a bonding agent (Excite). A control group, without inserts, was bulk-filled with a hybrid, high-viscous composite (Tetric Ceram). In accordance with American Dental Association (ADA) guidelines, half the preparation was in enamel and half in dentine/cementum, and had a mesio-distal width of 3 mm, an occluso-gingival height of 3 mm, and a depth of 2 mm. All margins had butt joints. The teeth were thermocycled 4000 times between water baths held at 5 degrees C and 55 degrees C, and the specimens prepared and examined for microleakage using 2.0% Procion Red dye, buffered at pH 7 as a marker.
    Results: Microleakage was significantly less around cavities restored with Cerana glass ceramic inserts than around cavities restored with Beta Quartz glass ceramic inserts or the control cavities at both the occlusal and gingival margins, p = 0.003 and p = 0.014, respectively. Comparisons of both occlusal and gingival margins within both test groups and the control group showed there was significantly less microleakage at the enamel-resin interface than at the dentine-resin interface (p < 0.05 in all cases).
    Conclusion: The results strongly suggest that restorations restored with Cerana glass ceramic inserts, which have a coefficient of therml expansion approximating that of enamel, result in a decrease in marginal microleakage compared to Beta Quartz glass ceramic inserts and Tetric Ceram resin-based composite material.
    MeSH term(s) Acrylic Resins/chemistry ; Adolescent ; Adult ; Bicuspid ; Ceramics/chemistry ; Child ; Composite Resins/chemistry ; Dental Caries/therapy ; Dental Leakage ; Glass/chemistry ; Humans ; Polyurethanes/chemistry ; Quartz/chemistry ; Statistics, Nonparametric
    Chemical Substances Acrylic Resins ; Beta-Quartz glass-ceramic ; Cerana ; Composite Dental Resin ; Composite Resins ; Polyurethanes ; Tetric ceram ; Quartz (14808-60-7) ; Glass ceramics (85422-94-2)
    Language English
    Publishing date 2005
    Publishing country United States
    Document type Clinical Trial ; Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 1027470-4
    ISSN 0895-8831
    ISSN 0895-8831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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