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Article ; Online: Peptide nanomaterials as future antimicrobial technologies.

Laverty, Garry

Future microbiology

2017 Volume 13, Page(s) 5–7

MeSH term(s)	Anti-Infective Agents/chemistry ; Anti-Infective Agents/therapeutic use ; Drug Delivery Systems ; Drug Design ; Humans ; Nanostructures/chemistry ; Nanostructures/therapeutic use ; Peptides/chemistry ; Peptides/pharmacology ; Peptides/therapeutic use ; Peptidomimetics/chemistry ; Peptidomimetics/pharmacology ; Peptidomimetics/therapeutic use
Chemical Substances	Anti-Infective Agents ; Peptides ; Peptidomimetics
Language	English
Publishing date	2017-12-04
Publishing country	England
Document type	Editorial ; Research Support, Non-U.S. Gov't
ISSN	1746-0921
ISSN (online)	1746-0921
DOI	10.2217/fmb-2017-0208
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Article ; Online: Metal Cross-Linked Supramolecular Gel Noodles: Structural Insights and Antibacterial Assessment.

Ghosh, Dipankar / Coulter, Sophie M / Laverty, Garry / Holland, Chris / Doutch, James J / Vassalli, Massimo / Adams, Dave J

Biomacromolecules

2024

Abstract: Achieving precise control over gelator alignment and morphology is crucial for crafting tailored materials and supramolecular structures with distinct properties. We successfully aligned the self-assembled micelles formed by a functionalized dipeptide ... ...

Abstract	Achieving precise control over gelator alignment and morphology is crucial for crafting tailored materials and supramolecular structures with distinct properties. We successfully aligned the self-assembled micelles formed by a functionalized dipeptide 2NapFF into long 1-D "gel noodles" by cross-linking with divalent metal chlorides. We identify the most effective cross-linker for alignment, enhancing mechanical stability, and imparting functional properties. Our study shows that Group 2 metal ions are particularly suited for creating mechanically robust yet flexible gel noodles because of their ionic and nondirectional bonding with carboxylate groups. In contrast, the covalent nature and high directional bonds of
Language	English
Publishing date	2024-04-29
Publishing country	United States
Document type	Journal Article
ISSN	1526-4602
ISSN (online)	1526-4602
DOI	10.1021/acs.biomac.4c00300
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Article ; Online: Unravelling the antimicrobial activity of peptide hydrogel systems: current and future perspectives.

Cross, Emily R / Coulter, Sophie M / Pentlavalli, Sreekanth / Laverty, Garry

Soft matter

2021 Volume 17, Issue 35, Page(s) 8001–8021

Abstract: The use of hydrogels has garnered significant interest as biomaterial and drug delivery platforms for anti-infective applications. For decades antimicrobial peptides have been heralded as a much needed new class of antimicrobial drugs. Self-assembling ... ...

Abstract	The use of hydrogels has garnered significant interest as biomaterial and drug delivery platforms for anti-infective applications. For decades antimicrobial peptides have been heralded as a much needed new class of antimicrobial drugs. Self-assembling peptide hydrogels with inherent antimicrobial ability have recently come to the fore. However, their fundamental antimicrobial properties, selectivity and mechanism of action are relatively undefined. This review attempts to establish a link between antimicrobial efficacy; the self-assembly process; peptide-membrane interactions and mechanical properties by studying several reported peptide systems: β-hairpin/β-loop peptides; multidomain peptides; amphiphilic surfactant-like peptides and ultrashort/low molecular weight peptides. We also explore their role in the formation of amyloid plaques and the potential for an infection etiology in diseases such as Alzheimer's. We look briefly at innovative methods of gel characterization. These may provide useful tools for future studies within this increasingly important field.
MeSH term(s)	Anti-Infective Agents/pharmacology ; Biocompatible Materials ; Hydrogels ; Peptides ; Surface-Active Agents
Chemical Substances	Anti-Infective Agents ; Biocompatible Materials ; Hydrogels ; Peptides ; Surface-Active Agents
Language	English
Publishing date	2021-09-15
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2191476-X
ISSN	1744-6848 ; 1744-683X
ISSN (online)	1744-6848
ISSN	1744-683X
DOI	10.1039/d1sm00839k
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Article ; Online: Peptide Nanomaterials for Drug Delivery Applications.

Pentlavalli, Sreekanth / Coulter, Sophie / Laverty, Garry

Current protein & peptide science

2020 Volume 21, Issue 4, Page(s) 401–412

Abstract: Self-assembled peptides have been shown to form well-defined nanostructures which display outstanding characteristics for many biomedical applications and especially in controlled drug delivery. Such biomaterials are becoming increasingly popular due to ... ...

Abstract	Self-assembled peptides have been shown to form well-defined nanostructures which display outstanding characteristics for many biomedical applications and especially in controlled drug delivery. Such biomaterials are becoming increasingly popular due to routine, standardized methods of synthesis, high biocompatibility, biodegradability and ease of upscale. Moreover, one can modify the structure at the molecular level to form various nanostructures with a wide range of applications in the field of medicine. Through environmental modifications such as changes in pH and ionic strength and the introduction of enzymes or light, it is possible to trigger self-assembly and design a host of different self-assembled nanostructures. The resulting nanostructures include nanotubes, nanofibers, hydrogels and nanovesicles which all display a diverse range of physico-chemical and mechanical properties. Depending on their design, peptide self-assembling nanostructures can be manufactured with improved biocompatibility and in vivo stability and the ability to encapsulate drugs with the capacity for sustained drug delivery. These molecules can act as carriers for drug molecules to ferry cargo intracellularly and respond to stimuli changes for both hydrophilic and hydrophobic drugs. This review explores the types of self-assembling nanostructures, the effects of external stimuli on and the mechanisms behind the assembly process, and applications for such technology in drug delivery.
MeSH term(s)	Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/radiation effects ; Delayed-Action Preparations/administration & dosage ; Delayed-Action Preparations/chemistry ; Delayed-Action Preparations/radiation effects ; Drug Carriers/administration & dosage ; Drug Carriers/chemistry ; Drug Compounding/methods ; Humans ; Hydrogels/administration & dosage ; Hydrogels/chemistry ; Hydrogels/radiation effects ; Hydrogen Bonding ; Hydrogen-Ion Concentration ; Hydrophobic and Hydrophilic Interactions ; Light ; Nanofibers/administration & dosage ; Nanofibers/chemistry ; Nanofibers/radiation effects ; Nanotubes/chemistry ; Nanotubes/radiation effects ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/pathology ; Osmolar Concentration ; Peptides, Cyclic/chemistry ; Peptides, Cyclic/pharmacology ; Protein Conformation, beta-Strand ; Static Electricity ; Temperature
Chemical Substances	Antineoplastic Agents ; Delayed-Action Preparations ; Drug Carriers ; Hydrogels ; Peptides, Cyclic
Language	English
Publishing date	2020-01-02
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2045662-1
ISSN	1875-5550 ; 1389-2037
ISSN (online)	1875-5550
ISSN	1389-2037
DOI	10.2174/1389203721666200101091834
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Zs.A 5884: Show issues

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Article ; Online: Two into one does go: Formulation development of a multipurpose combination vaginal ring releasing dapivirine and metronidazole for prevention of HIV infection and treatment of bacterial vaginosis.

Zhao, Xinyu / Boyd, Peter / Bashi, Yahya Dallal / Murphy, Diarmaid J / McCoy, Clare F / Coulter, Sophie / Laverty, Garry / Malcolm, R Karl

International journal of pharmaceutics

2023 Volume 648, Page(s) 123572

Abstract: Bacterial vaginosis (BV) is a common but often asymptomatic dysbiosis of the human vagina characterized by an imbalance in the normal vaginal microbiota due to loss of lactobacilli and an overgrowth of certain anaerobic bacteria. While BV itself is not a ...

Abstract	Bacterial vaginosis (BV) is a common but often asymptomatic dysbiosis of the human vagina characterized by an imbalance in the normal vaginal microbiota due to loss of lactobacilli and an overgrowth of certain anaerobic bacteria. While BV itself is not a sexually transmitted infection, it is associated with an increased risk in women of various sexually acquired infections, including human immunodeficiency virus (HIV) infection. There is, therefore, a strong rationale for pursuing new multipurpose products that seek to treat or prevent BV alongside preventing HIV infection. With the dapivirine-releasing vaginal ring for HIV prevention now approved in several African countries, here we report formulation development of a next-generation ring product that releases both dapivirine (DPV) and the antibiotic drug metronidazole (MET). Following thermal analysis studies to characterize the phase behaviour of DPV-MET mixtures and rheological analysis to assess the cure characteristics of the active silicone elastomer mixes, matrix-type rings were manufactured containing 25 or 200 mg DPV in combination with 100, 250, 500, 1000 or 2000 mg MET. The results for drug content, in vitro release, mechanical testing, and Gardnerella vaginalis time-kill experiments demonstrate the feasibility of incorporating both DPV and MET in a matrix-type ring formulation and indicate that clinically effective release rates may be possible.
MeSH term(s)	Female ; Humans ; Vaginosis, Bacterial/drug therapy ; Vaginosis, Bacterial/prevention & control ; Metronidazole ; HIV Infections/drug therapy ; HIV Infections/prevention & control ; Vagina/microbiology ; Contraceptive Devices, Female
Chemical Substances	Metronidazole (140QMO216E) ; Dapivirine (TCN4MG2VXS)
Language	English
Publishing date	2023-11-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2023.123572
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Zs.A 1409: Show issues

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Article ; Online: Pharmaceutical Formulation and Characterization of Dipeptide Nanotubes for Drug Delivery Applications.

Porter, Simon L / Coulter, Sophie M / Pentlavalli, Sreekanth / Laverty, Garry

Macromolecular bioscience

2020 Volume 20, Issue 7, Page(s) e2000115

Abstract: Peptide nanotubes are promising materials for a variety of biomedical applications with ultrashort (≤7 amino acids) forms providing particular promise for clinical translation. The manufacture of peptide nanotubes has, however, been associated with toxic ...

Abstract	Peptide nanotubes are promising materials for a variety of biomedical applications with ultrashort (≤7 amino acids) forms providing particular promise for clinical translation. The manufacture of peptide nanotubes has, however, been associated with toxic organic solvents restricting clinical use. The purpose of this work is to formulate dipeptide nanotubes using mild techniques easily translated to industrial upscale and to characterize their physiochemical and biological properties. Phenylalanine-phenylalanine variants can be successfully formulated using distilled water as demonstrated here. Formulations are homogenous in shape (tubular), with apparent size (50-260 nm) and a zeta potential of up to +30 mV. L-(H
MeSH term(s)	Cell Line, Tumor ; Circular Dichroism ; Dipeptides/chemistry ; Drug Compounding ; Drug Delivery Systems ; Drug Liberation ; Humans ; Nanotubes/chemistry ; Particle Size ; Static Electricity
Chemical Substances	Dipeptides
Language	English
Publishing date	2020-06-02
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2039130-4
ISSN	1616-5195 ; 1616-5187
ISSN (online)	1616-5195
ISSN	1616-5187
DOI	10.1002/mabi.202000115
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Article ; Online: Development of a teaching model to advance skills in industrial pharmaceutical formulation and regulatory aspects.

Laverty, Garry / Belaid, Luc / Coulter, Cathy / Porter, Simon

Currents in pharmacy teaching & learning

2018 Volume 10, Issue 10, Page(s) 1419–1428

Abstract: Background and purpose: To design and critically evaluate a laboratory-scale pharmaceutical formulation practical that enables pharmaceutical science students to develop work-based skills relating to industrial pharmacy such as problem solving, ... ...

Abstract	Background and purpose: To design and critically evaluate a laboratory-scale pharmaceutical formulation practical that enables pharmaceutical science students to develop work-based skills relating to industrial pharmacy such as problem solving, pharmaceutical calculations, research, legal checking, communication, practical aptitude, handling of medicinal products, record keeping, and ability to interpret, analyze and report data. Educational activity and setting: Nine laboratory practical sessions were designed whereby students formulated a range of dosage forms and conducted corrective and preventative actions (CAPAs) exercises. A master batch formula outlined the specifications for each product and a practical sheet was provided for the students to record their activities. Student evaluation of the exercise was performed via a self-administered 17-item questionnaire in the final week. Findings: Twenty-four students completed the workshops over two year groups (2015 year group n = 11, 2016 year group n = 13). The mean score across both groups was 15.6 out of 20. Discussion: The questionnaire had a 100% response rate and the majority of students agreed that the classes were a useful teaching method and that they fostered key skills required for pharmaceutical formulation and regulation. Summary: Laboratory classes effectively delivered course content relating to industrial-based pharmaceutical formulation and helped to develop relevant skills.
MeSH term(s)	Curriculum/trends ; Drug Compounding/methods ; Drug and Narcotic Control/methods ; Education, Pharmacy/methods ; Humans ; Models, Educational ; Preceptorship/methods ; Program Development/methods ; Surveys and Questionnaires ; Teaching/standards
Language	English
Publishing date	2018-08-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2515217-8
ISSN	1877-1300 ; 1877-1297
ISSN (online)	1877-1300
ISSN	1877-1297
DOI	10.1016/j.cptl.2018.07.011
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Article ; Online: Enzyme-Triggered l-α/d-Peptide Hydrogels as a Long-Acting Injectable Platform for Systemic Delivery of HIV/AIDS Drugs.

Coulter, Sophie M / Pentlavalli, Sreekanth / Vora, Lalitkumar K / An, Yuming / Cross, Emily R / Peng, Ke / McAulay, Kate / Schweins, Ralf / Donnelly, Ryan F / McCarthy, Helen O / Laverty, Garry

Advanced healthcare materials

2023 Volume 12, Issue 18, Page(s) e2203198

Abstract: Eradicating HIV/AIDS by 2030 is a central goal of the World Health Organization. Patient adherence to complicated dosage regimens remains a key barrier. There is a need for convenient long-acting formulations that deliver drugs over sustained periods. ... ...

Abstract	Eradicating HIV/AIDS by 2030 is a central goal of the World Health Organization. Patient adherence to complicated dosage regimens remains a key barrier. There is a need for convenient long-acting formulations that deliver drugs over sustained periods. This paper presents an alternative platform, an injectable in situ forming hydrogel implant to deliver a model antiretroviral drug (zidovudine [AZT]) over 28 days. The formulation is a self-assembling ultrashort d or l-α peptide hydrogelator, namely phosphorylated (naphthalene-2-ly)-acetyl-diphenylalanine-lysine-tyrosine-OH (NapFFKY[p]-OH), covalently conjugated to zidovudine via an ester linkage. Rheological analysis demonstrates phosphatase enzyme instructed self-assembly, with hydrogels forming within minutes. Small angle neutron scattering data suggest hydrogels form narrow radius (≈2 nm), large length fibers closely fitting the flexible cylinder elliptical model. d-Peptides are particularly promising for long-acting delivery, displaying protease resistance for 28 days. Drug release, via hydrolysis of the ester linkage, progress under physiological conditions (37 °C, pH 7.4, H
MeSH term(s)	Rats ; Animals ; Hydrogels/pharmacology ; Anti-HIV Agents/pharmacology ; Anti-HIV Agents/therapeutic use ; Zidovudine/pharmacology ; Zidovudine/therapeutic use ; Rats, Sprague-Dawley ; Peptides/pharmacology ; Peptides/therapeutic use ; HIV Infections/drug therapy ; Esters
Chemical Substances	Hydrogels ; Anti-HIV Agents ; Zidovudine (4B9XT59T7S) ; Peptides ; Esters
Language	English
Publishing date	2023-03-17
Publishing country	Germany
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202203198
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Zs.A 6966: Show issues

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Article: Ultrashort Peptide Hydrogels Display Antimicrobial Activity and Enhance Angiogenic Growth Factor Release by Dental Pulp Stem/Stromal Cells.

Afami, Marina E / El Karim, Ikhlas / About, Imad / Coulter, Sophie M / Laverty, Garry / Lundy, Fionnuala T

Materials (Basel, Switzerland)

2021 Volume 14, Issue 9

Abstract: Recent studies on peptide hydrogels have shown that ultrashort peptides (<8 amino acids) can self-assemble into hydrogels. Ultrashort peptides can be designed to incorporate antimicrobial motifs, such as positively charged lysine residues, so that the ... ...

Abstract	Recent studies on peptide hydrogels have shown that ultrashort peptides (<8 amino acids) can self-assemble into hydrogels. Ultrashort peptides can be designed to incorporate antimicrobial motifs, such as positively charged lysine residues, so that the peptides have inherent antimicrobial characteristics. Antimicrobial hydrogels represent a step change in tissue engineering and merit further investigation, particularly in applications where microbial infection could compromise healing. Herein, we studied the biocompatibility of dental pulp stem/stromal cells (DPSCs) with an ultrashort peptide hydrogel, (naphthalene-2-ly)-acetyl-diphenylalanine-dilysine-OH (NapFF
Language	English
Publishing date	2021-04-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma14092237
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Article: Multicomponent Peptide Hydrogels as an Innovative Platform for Cell-Based Tissue Engineering in the Dental Pulp.

Afami, Marina E / El Karim, Ikhlas / About, Imad / Krasnodembskaya, Anna D / Laverty, Garry / Lundy, Fionnuala T

Pharmaceutics

2021 Volume 13, Issue 10

Abstract: In light of the increasing levels of antibiotic resistance, nanomaterials and novel biologics are urgently required to manage bacterial infections. To date, commercially available self-assembling peptide hydrogels have not been studied extensively for ... ...

Abstract	In light of the increasing levels of antibiotic resistance, nanomaterials and novel biologics are urgently required to manage bacterial infections. To date, commercially available self-assembling peptide hydrogels have not been studied extensively for their ability to inhibit micro-organisms relevant to tissue engineering sites such as dental root canals. In this work, we assess the biocompatibility of dental pulp stem/stromal cells with commercially available multicomponent peptide hydrogels. We also determine the effects of dental pulp stem/stromal cell (DPSC) culture in hydrogels on growth factor/cytokine expression. Furthermore, to investigate novel aspects of self-assembling peptide hydrogels, we determine their antimicrobial activity against the oral pathogens
Language	English
Publishing date	2021-09-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics13101575
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