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Article ; Online: Therapeutic Prospection of Animal Venoms-Derived Antimicrobial Peptides against Infections by Multidrug-Resistant

Lima, William Gustavo / de Lima, Maria Elena

2023 Volume 15, Issue 4

Abstract: Infections caused by multidrug- ... ...

Abstract	Infections caused by multidrug-resistant
MeSH term(s)	Animals ; Acinetobacter baumannii ; Antimicrobial Peptides ; Acinetobacter Infections/drug therapy ; Acinetobacter Infections/microbiology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/chemistry ; Arthropod Venoms/pharmacology ; Drug Resistance, Multiple, Bacterial ; Microbial Sensitivity Tests
Chemical Substances	Antimicrobial Peptides ; Anti-Bacterial Agents ; Arthropod Venoms
Language	English
Publishing date	2023-04-03
Publishing country	Switzerland
Document type	Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2518395-3
ISSN	2072-6651 ; 2072-6651
ISSN (online)	2072-6651
ISSN	2072-6651
DOI	10.3390/toxins15040268
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Jelleine, a Family of Peptides Isolated from the Royal Jelly of the Honey Bees (

Lima, William Gustavo / Brito, Julio Cesar Moreira / Verly, Rodrigo Moreira / Lima, Maria Elena de

Toxins

2024 Volume 16, Issue 1

Abstract: The jelleine family is a group of four peptides (jelleines I-IV) originally isolated from the royal jelly of honey bee ( ...

Abstract	The jelleine family is a group of four peptides (jelleines I-IV) originally isolated from the royal jelly of honey bee (
MeSH term(s)	Humans ; Bees ; Animals ; Peptides/pharmacology ; Fatty Acids/pharmacology ; Honey ; Larva
Chemical Substances	royal jelly (L497I37F0C) ; Peptides ; Fatty Acids
Language	English
Publishing date	2024-01-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518395-3
ISSN	2072-6651 ; 2072-6651
ISSN (online)	2072-6651
ISSN	2072-6651
DOI	10.3390/toxins16010024
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Article: The Synthetic Peptide LyeTx I mn∆K, Derived from

Vieira, Ana Paula Gonçalves Coelho / de Souza, Amanda Neves / Lima, William Gustavo / Brito, Julio Cesar Moreira / Simião, Daniela Carolina / Gonçalves, Lucas Vinícius Ribeiro / Cordeiro, Lídia Pereira Barbosa / de Oliveira Scoaris, Denise / Fernandes, Simone Odília Antunes / Resende, Jarbas Magalhães / Bechinger, Burkhard / Verly, Rodrigo Moreira / de Lima, Maria Elena

Antibiotics (Basel, Switzerland)

2024 Volume 13, Issue 3

Abstract: The urgent global health challenge posed by methicillin- ... ...

Abstract	The urgent global health challenge posed by methicillin-resistant
Language	English
Publishing date	2024-03-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics13030248
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Article ; Online: Biodistribution and Tumor Targeted Accumulation of Anti-CEA-loaded Iron Nanoparticles.

Correa, Thais Silva / Lima, William Gustavo / do Couto Campos, Aline Beatriz / Galdino, Alexsandro Sobreira / de Oliveira Lima, Emilia Celma / Cardoso, Valbert Nascimento / Antunes Fernandes, Simone Odília / Campos-da-Paz, Mariana

Current pharmaceutical biotechnology

2024

Abstract: Introduction: Active targeting of tumors by nanomaterials favors early diagnosis and the reduction of harsh side effects of chemotherapeuticals.: Method: We synthesized magnetic nanoparticles (64 nm; -40 mV) suspended in a magnetic fluid (MF) and ... ...

Abstract	Introduction: Active targeting of tumors by nanomaterials favors early diagnosis and the reduction of harsh side effects of chemotherapeuticals. Method: We synthesized magnetic nanoparticles (64 nm; -40 mV) suspended in a magnetic fluid (MF) and decorated them with anti-carcinoembryonic antigen (MFCEA; 144 nm; -39 mV). MF and MFCEA nanoparticles were successfully radiolabeled with technetium-99m (99mTc) and intravenously injected in CEA-positive 4T1 tumor-bearing mice to perform biodistribution studies. Both 99mTc-MF and 99mTc-MFCEA had marked uptake by the liver and spleen, and the renal uptake of 99mTc-MFCEA was higher than that observed for 99mTc-MF at 20h. At 1 and 5 hours, the urinary excretion was higher for 99mTc-MF than for 99mTc-MFCEA. Results: These data suggest that anti-CEA decoration might be responsible for a delay in renal clearance. Regarding the tumor, 99mTc-MFCEA showed tumor uptake nearly two times higher than that observed for 99mTc-MFCEA. Similarly, the target-nontarget ratio was higher with 99mTc-MFCEA when compared to the group that received the 99mTc-MF. Conclusion: These data validated the ability of active tumor targeting by the as-developed antiCEA loaded nanoparticles and are very promising results for the future development of a nanodevice for the management of breast cancer and other types of CEA-positive tumors.
Language	English
Publishing date	2024-02-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2132197-8
ISSN	1873-4316 ; 1389-2010
ISSN (online)	1873-4316
ISSN	1389-2010
DOI	10.2174/0113892010268872240104114444
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Article ; Online: Antifungal activity of a shortened analogue of the natural peptide LyeTx I isolated from the venom of the spider Lycosa erythrognatha

Cardoso, Bárbara Gatti / de Lima, William Gustavo / Fernandes, Simone Odília Antunes / Lima, Maria Elena de / Cardoso, Valbert Nascimento

Natural Product Research. 2023 Mar. 4, v. 37, no. 5 p.759-763

2023

Abstract: The increase in the incidence of fungal infections associated with the limited therapeutic arsenal available and the increasing rate of resistance of pathogenic fungi reinforce the need for research of new antifungal agents. Thus, this study aims to ... ...

Abstract	The increase in the incidence of fungal infections associated with the limited therapeutic arsenal available and the increasing rate of resistance of pathogenic fungi reinforce the need for research of new antifungal agents. Thus, this study aims to evaluate the antifungal activity of the peptide LyeTx I mnΔK, a shortened analogue of the natural peptide LyeTx I derived from spider venom, against Candida species. LyeTx I mnΔK showed potent activity against Candida spp. with minimum inhibitory concentration (MIC) and minimum fungicide concentration (MFC) between 4 and 32 µM. The peptide also completely inhibited the yeast-to-hypha transition (at 2 µM) and broke mature biofilms (67% reduction at 32 µM) of C. albicans. In addition, LyeTx I mnΔK did not induce resistance in C. albicans during 21 days of exposure. Therefore, the LyeTx I mnΔK is a promising prototype for the development of new antifungal agents.
Keywords	Candida ; Lycosa ; antifungal properties ; biofilm ; fungi ; fungicides ; minimum inhibitory concentration ; peptides ; prototypes ; spider venoms ; spiders ; therapeutics ; Antimicrobial peptides ; antifungals ; LyeTx I mnΔK ; Candida albicans
Language	English
Dates of publication	2023-0304
Size	p. 759-763.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2022.2079122
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: New Cretaceous (Aptian/Albian) boxer shrimp (Crustacea, Decapoda, Stenopodidea) from the Araripe Sedimentary Basin, NE, Brazil.

Alencar, Damares Ribeiro / Santana, William / Pinheiro, Allysson Pontes / Lima, Daniel / Feitosa Saraiva, Antônio Álamo / de Oliveira, Gustavo Ribeiro

PloS one

2023 Volume 18, Issue 3, Page(s) e0281334

Abstract: Stenopodidean shrimps are mostly cryptic in their habitats and are typically related with coral rubble or dead coral heads, rocks and crevices, and in association with other marine invertebrate such as sponges, crinoids and corals. Here, we describe a ... ...

Abstract	Stenopodidean shrimps are mostly cryptic in their habitats and are typically related with coral rubble or dead coral heads, rocks and crevices, and in association with other marine invertebrate such as sponges, crinoids and corals. Here, we describe a new stenopodidean shrimp, Dubiostenopus parvus n. gen. n. sp., from the Romualdo Formation (Aptian/Albian), Araripe Sedimentary Basin. The specimen studied here was collected in the municipality of Trindade, Pernambuco State, Brazil. The specimen is the imprint of a small shrimp approximately 10 mm in length, with a robust cephalothorax, a well-developed cheliped in the third pereiopod, and a second pleura not overlapping the first. This is the first stenopodidean shrimp described from the Romualdo Formation and the first described from South America. Comparisons with other Brazilian shrimp-like fossils are made, as well as comparisons with all other fossil stenopodideans.
MeSH term(s)	Animals ; Brazil ; Decapoda ; Crustacea ; Fossils ; Ecosystem ; Anthozoa
Language	English
Publishing date	2023-03-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0281334
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Article ; Online: New Cretaceous (Aptian/Albian) boxer shrimp (Crustacea, Decapoda, Stenopodidea) from the Araripe Sedimentary Basin, NE, Brazil.

Damares Ribeiro Alencar / William Santana / Allysson Pontes Pinheiro / Daniel Lima / Antônio Álamo Feitosa Saraiva / Gustavo Ribeiro de Oliveira

PLoS ONE, Vol 18, Iss 3, p e

2023 Volume 0281334

Abstract	Stenopodidean shrimps are mostly cryptic in their habitats and are typically related with coral rubble or dead coral heads, rocks and crevices, and in association with other marine invertebrate such as sponges, crinoids and corals. Here, we describe a new stenopodidean shrimp, Dubiostenopus parvus n. gen. n. sp., from the Romualdo Formation (Aptian/Albian), Araripe Sedimentary Basin. The specimen studied here was collected in the municipality of Trindade, Pernambuco State, Brazil. The specimen is the imprint of a small shrimp approximately 10 mm in length, with a robust cephalothorax, a well-developed cheliped in the third pereiopod, and a second pleura not overlapping the first. This is the first stenopodidean shrimp described from the Romualdo Formation and the first described from South America. Comparisons with other Brazilian shrimp-like fossils are made, as well as comparisons with all other fossil stenopodideans.
Keywords	Medicine ; R ; Science ; Q
Subject code	590
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Antifungal activity of a shortened analogue of the natural peptide LyeTx I isolated from the venom of the spider

Cardoso, Bárbara Gatti / de Lima, William Gustavo / Fernandes, Simone Odília Antunes / de Lima, Maria Elena / Cardoso, Valbert Nascimento

Natural product research

2022 Volume 37, Issue 5, Page(s) 759–763

Abstract	The increase in the incidence of fungal infections associated with the limited therapeutic arsenal available and the increasing rate of resistance of pathogenic fungi reinforce the need for research of new antifungal agents. Thus, this study aims to evaluate the antifungal activity of the peptide LyeTx I mnΔK, a shortened analogue of the natural peptide LyeTx I derived from spider venom, against
MeSH term(s)	Antifungal Agents/pharmacology ; Venoms ; Candida ; Candida albicans ; Peptides/pharmacology ; Microbial Sensitivity Tests ; Biofilms
Chemical Substances	Antifungal Agents ; Venoms ; Peptides
Language	English
Publishing date	2022-06-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2022.2079122
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Article ; Online: 110-million-years-old fossil suggests early parasitism in shrimps.

Lima, Daniel / Alencar, Damares R / Santana, William / Oliveira, Naiara C / Saraiva, Antônio Á F / Oliveira, Gustavo R / Boyko, Christopher B / Pinheiro, Allysson P

Scientific reports

2023 Volume 13, Issue 1, Page(s) 14549

Abstract: Direct evidence of paleo-parasitism in crustaceans is very scarce. Epicaridean isopods are obligatory parasites of crustaceans, including decapods such as crabs, shrimps, and lobsters. Their interaction with hosts is known from fossils as far back as the ...

Abstract	Direct evidence of paleo-parasitism in crustaceans is very scarce. Epicaridean isopods are obligatory parasites of crustaceans, including decapods such as crabs, shrimps, and lobsters. Their interaction with hosts is known from fossils as far back as the Jurassic through deformations of the branchial cuticle on the hosts. Their small size and low fossilization potential, outside of those larvae that have been found in amber, makes understanding the group's evolution challenging. Here, we report the oldest evidence of paleo-parasitism in marine shrimps and an imprint of a putative adult parasite that appears to be an epicaridean isopod. Our results suggest that the parasite-host interaction between epicaridean isopods and marine shrimps started at least 110 million years ago, and the Tethys Sea was a possible dispersal pathway for this lineage of parasites during the Jurassic and Cretaceous, as known for other marine organisms through most of the Mesozoic and Cenozoic. The oldest fossil records of bopyrid swellings associated with a large number of decapods from the Jurassic in Europe suggest that the Tethys region was a center of epicaridean distribution as a whole. Recent parasitic isopods found on dendrobranchiate shrimps are restricted to the Indo-Pacific and may represent a relict group of a lineage of parasites more widely distributed in the Mesozoic.
MeSH term(s)	Animals ; Fossils ; Decapoda ; Isopoda ; Amber ; Europe ; Gastropoda
Chemical Substances	Amber
Language	English
Publishing date	2023-09-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-40554-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Characterization of baru (Dipteryx alata Vog.) and application of its agro-industrial by-product in the formulation of cookies

Helena Nadya Alves Campos Viana / William Gustavo Sganzerla / Luiz Eduardo Nochi Castro / Ana Paula de Lima Veeck

Journal of Agriculture and Food Research, Vol 12, Iss , Pp 100577- (2023)

2023

Abstract: The Brazilian cerrado has a range of unexplored plant species with high technological potential for the food industry. The edible fraction of baru (Dipteryx alata Vog.) is the nut, while agro-industrial by-products (endocarp, mesocarp, and epicarp) are ... ...

Abstract	The Brazilian cerrado has a range of unexplored plant species with high technological potential for the food industry. The edible fraction of baru (Dipteryx alata Vog.) is the nut, while agro-industrial by-products (endocarp, mesocarp, and epicarp) are still rarely used in human nutrition. This study evaluated the nutritional composition, bioactive compounds, and antioxidant activity of baru nuts and its agro-industrial by-product (mesocarp or pulp). Hence, to determine the nutritional enrichment, cookies were produced with different concentrations of baru pulp powder, and the proximate composition, bioactive compounds, and antioxidant activity were investigated. The results obtained demonstrate that the baru nut presented a high lipid (31.80 ± 0.65 g 100 g−1) and protein (22.38 ± 0.37 g 100 g−1) content. The baru agro-industrial by-product was rich in phenolic compounds (276.56 ± 13.16 mg 100 g−1), flavonoids (19.59 ± 0.30 mg 100 g−1), and tannins (137.21 ± 31.21 mg 100 g−1), which reflected its high antioxidant capacity. The replacement of wheat flour by baru agro-industrial by-product in the formulation of cookies improved the protein, phenolic compounds, flavonoids, tannins, and antioxidant activity. Therefore, the application of baru agro-industrial by-product is a viable alternative as a cookie ingredient, while the use of baru in foods can contribute to the exploration of regional products to promote the sustainable development of unexplored plant species.
Keywords	Nutritional composition ; Bioactive compounds ; Antioxidant activity ; By-products ; Valorization ; Agriculture (General) ; S1-972 ; Nutrition. Foods and food supply ; TX341-641
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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