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  1. Article ; Online: The potential of lactoferrin, ovotransferrin and lysozyme as antiviral and immune-modulating agents in COVID-19

    Mann, Jaclyn Kelly / Ndung'u, Thumbi

    Abstract: Coronavirus disease 2019 (COVID-19), caused by SARS coronavirus 2 (SARS-CoV-2), is spreading rapidly with no established effective treatments. While most cases are mild, others experience uncontrolled inflammatory responses with oxidative stress, ... ...

    Abstract Coronavirus disease 2019 (COVID-19), caused by SARS coronavirus 2 (SARS-CoV-2), is spreading rapidly with no established effective treatments. While most cases are mild, others experience uncontrolled inflammatory responses with oxidative stress, dysregulation of iron and coagulation as features. Lactoferrin, ovotransferrin and lysozyme are abundant, safe antimicrobials that have wide antiviral as well as immunomodulatory properties. In particular, lactoferrin restores iron homeostasis and inhibits replication of SARS-CoV, which is closely related to SARS-CoV-2. Ovotransferrin has antiviral peptides and activities that are shared with lactoferrin. Both lactoferrin and lysozyme are ‘immune sensing’ as they may stimulate immune responses or resolve inflammation. Mechanisms by which these antimicrobials may treat or prevent COVID-19, as well as sources and forms of these, are reviewed.
    Keywords covid19
    Publisher PMC
    Document type Article ; Online
    DOI 10.2217/fvl-2020-0170
    Database COVID19

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  2. Article: Hen egg white bovine colostrum supplement reduces symptoms of mild/moderate COVID-19: a randomized control trial.

    Mann, Jaclyn Kelly / Reddy, Tarylee / van der Stok, Mary / Ngubane, Ayanda / Mulaudzi, Takalani / Mchunu, Nobuhle / Nevhungoni, Portia / Manickchund, Nithendra / Manickchund, Pariva / Louise Cairns, Chelline Helena / Govender, Vaneshree / Ndung'u, Thumbi / Suleman Moosa, Mahomed Yunus / Gosnell, Bernadett Isabel

    Future science OA

    2023  Volume 9, Issue 8, Page(s) FSO882

    Abstract: Aim: The ability of a hen egg white bovine colostrum supplement to prevent severe COVID-19 was tested in a double-blind randomized control study.: Methods: Adults with mild/moderate COVID-19, risk factors for severe disease, and within 5 days of ... ...

    Abstract Aim: The ability of a hen egg white bovine colostrum supplement to prevent severe COVID-19 was tested in a double-blind randomized control study.
    Methods: Adults with mild/moderate COVID-19, risk factors for severe disease, and within 5 days of symptom onset were assigned to the intervention (n = 77) or placebo (n = 79) arms. Symptoms were documented until day 42 post-enrollment and viral clearance was assessed at 11-13 days post-symptom onset.
    Results: One participant developed severe COVID-19. The severe-type symptom score was lower in the active arm at 11-13 days post-symptom onset (p = 0.049). Chest pain, fever/chills, joint pain/malaise, and sore throat were significantly less frequent in the active arm. No differences in viral clearance were observed.
    Conclusion: The intervention reduced symptoms of mild/moderate COVID-19.
    Clinical trial registration: DOH-27-062021-9191 (South African National Clinical Trials Register).
    Language English
    Publishing date 2023-07-20
    Publishing country England
    Document type Journal Article
    ISSN 2056-5623
    ISSN 2056-5623
    DOI 10.2144/fsoa-2023-0024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hen egg white bovine colostrum supplement reduces symptoms of mild/moderate COVID-19

    Jaclyn Kelly Mann / Tarylee Reddy / Mary van der Stok / Ayanda Ngubane / Takalani Mulaudzi / Nobuhle Mchunu / Portia Nevhungoni / Nithendra Manickchund / Pariva Manickchund / Chelline Helena Louise Cairns / Vaneshree Govender / Thumbi Ndung'u / Mahomed Yunus Suleman Moosa / Bernadett Isabel Gosnell

    Future Science OA (2023)

    a randomized control trial

    2023  

    Abstract: Aim: The ability of a hen egg white bovine colostrum supplement to prevent severe COVID-19 was tested in a double-blind randomized control study. Methods: Adults with mild/moderate COVID-19, risk factors for severe disease, and within 5 days of symptom ... ...

    Abstract Aim: The ability of a hen egg white bovine colostrum supplement to prevent severe COVID-19 was tested in a double-blind randomized control study. Methods: Adults with mild/moderate COVID-19, risk factors for severe disease, and within 5 days of symptom onset were assigned to the intervention (n = 77) or placebo (n = 79) arms. Symptoms were documented until day 42 post-enrollment and viral clearance was assessed at 11–13 days post-symptom onset. Results: One participant developed severe COVID-19. The severe-type symptom score was lower in the active arm at 11–13 days post-symptom onset (p = 0.049). Chest pain, fever/chills, joint pain/malaise, and sore throat were significantly less frequent in the active arm. No differences in viral clearance were observed. Conclusion: The intervention reduced symptoms of mild/moderate COVID-19. Clinical Trial Registration: DOH-27-062021-9191 (South African National Clinical Trials Register)
    Keywords colostrum ; coronavirus ; COVID-19 ; delta ; egg white ; lactoferrin ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Future Science Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Article ; Online: Genomics accurately predicts antimicrobial resistance in Staphylococcus pseudintermedius collected as part of Vet-LIRN resistance monitoring.

    Tyson, Gregory H / Ceric, Olgica / Guag, Jake / Nemser, Sarah / Borenstein, Stacey / Slavic, Durda / Lippert, Sarah / McDowell, Rebecca / Krishnamurthy, Aparna / Korosec, Shannon / Friday, Cheryl / Pople, Neil / Saab, Matthew E / Fairbrother, Julie-Hélène / Janelle, Isabelle / McMillan, Deanna / Bommineni, Yugendar R / Simon, David / Mohan, Shipra /
    Sanchez, Susan / Phillips, Ashley / Bartlett, Paula / Naikare, Hemant / Watson, Cynthia / Sahin, Orhan / Stinman, Chloe / Wang, Leyi / Maddox, Carol / DeShambo, Vanessa / Hendrix, Kenitra / Lubelski, Debra / Burklund, Amy / Lubbers, Brian / Reed, Debbie / Jenkins, Tracie / Erol, Erdal / Patel, Mukeshbhai / Locke, Stephan / Fortner, Jordan / Peak, Laura / Balasuriya, Udeni / Mani, Rinosh / Kettler, Niesa / Olsen, Karen / Zhang, Shuping / Shen, Zhenyu / Landinez, Martha Pulido / Thornton, Jay Kay / Thachil, Anil / Byrd, Melissa / Jacob, Megan / Krogh, Darlene / Webb, Brett / Schaan, Lynn / Patil, Amar / Dasgupta, Sarmila / Mann, Shannon / Goodman, Laura B / Franklin-Guild, Rebecca June / Anderson, Renee R / Mitchell, Patrick K / Cronk, Brittany D / Aprea, Missy / Cui, Jing / Jurkovic, Dominika / Prarat, Melanie / Zhang, Yan / Shiplett, Katherine / Campos, Dubra Diaz / Rubio, Joany Van Balen / Ramanchandran, Akhilesh / Talent, Scott / Tewari, Deepanker / Thirumalapura, Nagaraja / Kelly, Donna / Barnhart, Denise / Hall, Lacey / Rankin, Shelley / Dietrich, Jaclyn / Cole, Stephen / Scaria, Joy / Antony, Linto / Lawhon, Sara D / Wu, Jing / McCoy, Christine / Dietz, Kelly / Wolking, Rebecca / Alexander, Trevor / Burbick, Claire / Reimschuessel, Renate

    Veterinary microbiology

    2021  Volume 254, Page(s) 109006

    Abstract: Whole-genome sequencing (WGS) has changed our understanding of bacterial pathogens, aiding outbreak investigations and advancing our knowledge of their genetic features. However, there has been limited use of genomics to understand antimicrobial ... ...

    Abstract Whole-genome sequencing (WGS) has changed our understanding of bacterial pathogens, aiding outbreak investigations and advancing our knowledge of their genetic features. However, there has been limited use of genomics to understand antimicrobial resistance of veterinary pathogens, which would help identify emerging resistance mechanisms and track their spread. The objectives of this study were to evaluate the correlation between resistance genotypes and phenotypes for Staphylococcus pseudintermedius, a major pathogen of companion animals, by comparing broth microdilution antimicrobial susceptibility testing and WGS. From 2017-2019, we conducted antimicrobial susceptibility testing and WGS on S. pseudintermedius isolates collected from dogs in the United States as a part of the Veterinary Laboratory Investigation and Response Network (Vet-LIRN) antimicrobial resistance monitoring program. Across thirteen antimicrobials in nine classes, resistance genotypes correlated with clinical resistance phenotypes 98.4 % of the time among a collection of 592 isolates. Our findings represent isolates from diverse lineages based on phylogenetic analyses, and these strong correlations are comparable to those from studies of several human pathogens such as Staphylococcus aureus and Salmonella enterica. We uncovered some important findings, including that 32.3 % of isolates had the mecA gene, which correlated with oxacillin resistance 97.0 % of the time. We also identified a novel rpoB mutation likely encoding rifampin resistance. These results show the value in using WGS to assess antimicrobial resistance in veterinary pathogens and to reveal putative new mechanisms of resistance.
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Canada ; Dog Diseases/microbiology ; Dogs/microbiology ; Drug Resistance, Bacterial/genetics ; Epidemiological Monitoring/veterinary ; Genomics/methods ; Genomics/standards ; Genotype ; Microbial Sensitivity Tests ; Phenotype ; Phylogeny ; Reproducibility of Results ; Staphylococcal Infections/microbiology ; Staphylococcal Infections/veterinary ; Staphylococcus/drug effects ; Staphylococcus/genetics ; Staphylococcus/isolation & purification ; United States ; Whole Genome Sequencing
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; MecA protein, Staphylococcus pseudintermedius
    Language English
    Publishing date 2021-02-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 753154-0
    ISSN 1873-2542 ; 0378-1135
    ISSN (online) 1873-2542
    ISSN 0378-1135
    DOI 10.1016/j.vetmic.2021.109006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Genomics accurately predicts antimicrobial resistance in Staphylococcus pseudintermedius collected as part of Vet-LIRN resistance monitoring

    Tyson, Gregory H / Ceric, Olgica / Guag, Jake / Nemser, Sarah / Borenstein, Stacey / Slavic, Durda / Lippert, Sarah / McDowell, Rebecca / Krishnamurthy, Aparna / Korosec, Shannon / Friday, Cheryl / Pople, Neil / Saab, Matthew E / Fairbrother, Julie-Hélène / Janelle, Isabelle / McMillan, Deanna / Bommineni, Yugendar R / Simon, David / Mohan, Shipra /
    Sanchez, Susan / Phillips, Ashley / Bartlett, Paula / Naikare, Hemant / Watson, Cynthia / Sahin, Orhan / Stinman, Chloe / Wang, Leyi / Maddox, Carol / DeShambo, Vanessa / Hendrix, Kenitra / Lubelski, Debra / Burklund, Amy / Lubbers, Brian / Reed, Debbie / Jenkins, Tracie / Erol, Erdal / Patel, Mukeshbhai / Locke, Stephan / Fortner, Jordan / Peak, Laura / Balasuriya, Udeni / Mani, Rinosh / Kettler, Niesa / Olsen, Karen / Zhang, Shuping / Shen, Zhenyu / Landinez, Martha Pulido / Thornton, Jay Kay / Thachil, Anil / Byrd, Melissa / Jacob, Megan / Krogh, Darlene / Webb, Brett / Schaan, Lynn / Patil, Amar / Dasgupta, Sarmila / Mann, Shannon / Goodman, Laura B / Franklin-Guild, Rebecca June / Anderson, Renee R / Mitchell, Patrick K / Cronk, Brittany D / Aprea, Missy / Cui, Jing / Jurkovic, Dominika / Prarat, Melanie / Zhang, Yan / Shiplett, Katherine / Campos, Dubra Diaz / Rubio, Joany Van Balen / Ramanchandran, Akhilesh / Talent, Scott / Tewari, Deepanker / Thirumalapura, Nagaraja / Kelly, Donna / Barnhart, Denise / Hall, Lacey / Rankin, Shelley / Dietrich, Jaclyn / Cole, Stephen / Scaria, Joy / Antony, Linto / Lawhon, Sara D / Wu, Jing / McCoy, Christine / Dietz, Kelly / Wolking, Rebecca / Alexander, Trevor / Burbick, Claire / Reimschuessel, Renate

    Veterinary microbiology. 2021 Mar., v. 254

    2021  

    Abstract: Whole-genome sequencing (WGS) has changed our understanding of bacterial pathogens, aiding outbreak investigations and advancing our knowledge of their genetic features. However, there has been limited use of genomics to understand antimicrobial ... ...

    Abstract Whole-genome sequencing (WGS) has changed our understanding of bacterial pathogens, aiding outbreak investigations and advancing our knowledge of their genetic features. However, there has been limited use of genomics to understand antimicrobial resistance of veterinary pathogens, which would help identify emerging resistance mechanisms and track their spread. The objectives of this study were to evaluate the correlation between resistance genotypes and phenotypes for Staphylococcus pseudintermedius, a major pathogen of companion animals, by comparing broth microdilution antimicrobial susceptibility testing and WGS. From 2017–2019, we conducted antimicrobial susceptibility testing and WGS on S. pseudintermedius isolates collected from dogs in the United States as a part of the Veterinary Laboratory Investigation and Response Network (Vet-LIRN) antimicrobial resistance monitoring program. Across thirteen antimicrobials in nine classes, resistance genotypes correlated with clinical resistance phenotypes 98.4 % of the time among a collection of 592 isolates. Our findings represent isolates from diverse lineages based on phylogenetic analyses, and these strong correlations are comparable to those from studies of several human pathogens such as Staphylococcus aureus and Salmonella enterica. We uncovered some important findings, including that 32.3 % of isolates had the mecA gene, which correlated with oxacillin resistance 97.0 % of the time. We also identified a novel rpoB mutation likely encoding rifampin resistance. These results show the value in using WGS to assess antimicrobial resistance in veterinary pathogens and to reveal putative new mechanisms of resistance.
    Keywords Salmonella enterica ; Staphylococcus aureus ; Staphylococcus pseudintermedius ; antibiotic resistance ; genes ; genomics ; humans ; microbiology ; minimum inhibitory concentration ; mutation ; oxacillin ; phylogeny ; rifampicin
    Language English
    Dates of publication 2021-03
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-light
    ZDB-ID 753154-0
    ISSN 1873-2542 ; 0378-1135
    ISSN (online) 1873-2542
    ISSN 0378-1135
    DOI 10.1016/j.vetmic.2021.109006
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2917: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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