LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 248

Search options

  1. Article: [Long-term side effects of immune checkpoint inhibition].

    Stricker, Helena Marie / Wicki, Andreas

    Therapeutische Umschau. Revue therapeutique

    2023  Volume 80, Issue 8, Page(s) 367–372

    Abstract: Introduction: The use of immune checkpoint inhibitors has fundamentally changed the treatment landscape of solid tumors in recent years. Even in advanced stages or in tumors with historically poor prognosis, such as triple-negative breast cancer, ... ...

    Abstract Introduction: The use of immune checkpoint inhibitors has fundamentally changed the treatment landscape of solid tumors in recent years. Even in advanced stages or in tumors with historically poor prognosis, such as triple-negative breast cancer, progression-free survival, as well as overall survival of affected individuals, have considerably improved. As a result, the side effects and consequences of therapy, their detection, and treatment are becoming an increasingly important part of patient follow-up.
    MeSH term(s) Humans ; Immune Checkpoint Inhibitors/adverse effects ; Neoplasms/drug therapy
    Chemical Substances Immune Checkpoint Inhibitors
    Language German
    Publishing date 2023-11-16
    Publishing country Switzerland
    Document type English Abstract ; Journal Article
    ZDB-ID 82044-1
    ISSN 1664-2864 ; 0040-5930
    ISSN (online) 1664-2864
    ISSN 0040-5930
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.180: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Thesis ; Online: Assessing functional and structural visual outcomes in human acute optic neuritis and murine experimental optic neuritis

    Wicki, Carla A.

    2021  

    Abstract: Optic neuritis (ON) is an acute inflammatory, demyelinating event affecting the optic nerve, and a common manifestation in multiple sclerosis (MS). It can affect MS patients throughout their disease course, and 20 % of patients present with acute ON as ... ...

    Abstract Optic neuritis (ON) is an acute inflammatory, demyelinating event affecting the optic nerve, and a common manifestation in multiple sclerosis (MS). It can affect MS patients throughout their disease course, and 20 % of patients present with acute ON as their initial symptom. ON primarily affects the optic nerve in its myelinated portion, but also triggers neurodegeneration in the entire afferent visual pathway (AVP) through retrograde and anterograde (trans-synaptic) degeneration. Visual outcomes are diverse, including severe persistent visual impairment. High-dose corticosteroids are the current mainstay in the therapy of acute autoimmune ON. However, despite clear acceleration of functional visual recovery in the short-term, any mid- to long-term impact on visual outcomes remains unproven. Apart from its high prevalence and clinical relevance, ON also offers a unique model to study neurodegeneration as well as the potential of neuroprotective and –regenerative therapies: a clinical episode of acute ON can be assigned in its occurrence to an approximate time window, and in its impact on tissue integrity to a discrete, anatomically isolated structure. The AVP is retinotopically organized, linking its structural integrity with clinical function. Almost the entire AVP can be probed using imaging tools of different modalities, including optical coherence tomography (OCT) and structural magnetic resonance imaging (MRI) techniques such as diffusion-tensor-imaging (DTI). Furthermore, the function of the AVP can be assessed by simple but sensitive measurements such as low-contrast visual acuity (LCVA). Therefore, ON provides an optimal paradigm to study the consequences of an MS-relapse on tissue integrity and function. In the first section of this thesis, we reviewed the growing relevance of monitoring the thicknesses of different retinal layers using OCT to reveal AVP damage in MS. We summarized that the thicknesses of the macular ganglion cell and inner plexiform layer (GCIP) and the peripapillary retinal nerve ...
    Keywords info:eu-repo/classification/ddc/570 ; Life sciences
    Subject code 610
    Language English
    Publisher ETH Zurich
    Publishing country ch
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Effect of subdivision of the Lacaune dairy sheep breed on the accuracy of genomic prediction.

    Wicki, M / Raoul, J / Legarra, A

    Journal of dairy science

    2023  Volume 106, Issue 8, Page(s) 5570–5581

    Abstract: Genomic selection was deployed in Lacaune dairy breed in 2015. Lacaune population split in 1972 into 2 breeding companies with associated flocks, and there have been very few exchanges of animals between the subpopulations, leading to divergence of the 2 ...

    Abstract Genomic selection was deployed in Lacaune dairy breed in 2015. Lacaune population split in 1972 into 2 breeding companies with associated flocks, and there have been very few exchanges of animals between the subpopulations, leading to divergence of the 2 subpopulations. In spite of that, there is a joint genomic prediction. The objective of this study is to understand how this structuring affects prediction accuracy. We analyzed all the data available from Lacaune breeding program for milk yield: around 6 million phenotypes, 2 million animals in the pedigree and more than 29,000 genotyped animals, including 3,434 and 2,868 AI rams for each company. To consider missing pedigree, we set up genetic groups using the theory of metafounders. First, we studied the pedigree and genomic structures of the 2 subpopulations calculating F
    MeSH term(s) Humans ; Sheep/genetics ; Male ; Animals ; Reproducibility of Results ; Genome ; Genomics/methods ; Sheep, Domestic/genetics ; Genotype ; Phenotype ; Pedigree ; Models, Genetic
    Language English
    Publishing date 2023-06-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 242499-x
    ISSN 1525-3198 ; 0022-0302
    ISSN (online) 1525-3198
    ISSN 0022-0302
    DOI 10.3168/jds.2022-23114
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 810: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Monitoring critically saturated conditions for shallow landslide occurrence using electrical resistivity tomography

    Wicki, Adrian / Hauck, Christian

    Vadose zone journal. 2022 July, v. 21, no. 4

    2022  

    Abstract: Soil wetness is an important property in determining the variable disposition of hillslopes to shallow landslides. Recent studies have demonstrated the potential of in situ soil wetness information for landslide early warning. However, the spatial ... ...

    Abstract Soil wetness is an important property in determining the variable disposition of hillslopes to shallow landslides. Recent studies have demonstrated the potential of in situ soil wetness information for landslide early warning. However, the spatial representativeness of in situ sensors may be affected by local heterogeneities of soil properties and hydrological processes, and their installation may be destructive. Electrical resistivity tomography (ERT) has been used in the past to estimate plot‐scale soil moisture variation and may overcome these limitations. In this study, we installed and operated an automated ERT monitoring system on a landslide‐prone hillslope in the Napf region (Switzerland). The system was operational during a period of 9 mo, and measurements were conducted at high temporal resolution and under different soil hydrological conditions. Electrical resistivity was measured along two perpendicular profile lines in Wenner–Schlumberger configuration at 0.25‐m electrode spacing. Soil saturation was calculated by the Archie's law and the parameters were fitted with colocated soil moisture sensors. Comparison of ERT‐derived soil moisture with soil wetness from in situ sensors showed a good correlation, and infiltration properties critical for landslide early warning could be reliably reproduced. Further, analysis of spatial saturation variation revealed that ERT was capable to detect heterogeneities of soil hydrological process. Under highly saturated conditions, the reliability of the saturation estimation was affected by an increased number of faulty measurements and the spatial heterogeneity of the infiltration process.
    Keywords automation ; electrical resistance ; electrodes ; landslides ; soil water ; spatial variation ; tomography ; topographic slope ; vadose zone ; Switzerland
    Language English
    Dates of publication 2022-07
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2088189-7
    ISSN 1539-1663
    ISSN 1539-1663
    DOI 10.1002/vzj2.20204
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Clinical and Biological Aspects of Disseminated Tumor Cells and Dormancy in Breast Cancer.

    Ring, Alexander / Spataro, Maria / Wicki, Andreas / Aceto, Nicola

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 929893

    Abstract: Progress in detection and treatment have drastically improved survival for early breast cancer patients. However, distant recurrence causes high mortality and is typically considered incurable. Cancer dissemination ... ...

    Abstract Progress in detection and treatment have drastically improved survival for early breast cancer patients. However, distant recurrence causes high mortality and is typically considered incurable. Cancer dissemination occurs
    Language English
    Publishing date 2022-06-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.929893
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Editorial. Forschritte in der Behandlung des Ösophagus- und Magenkarzinoms

    Wicki, A.

    Schweizer Krebs-Bulletin

    2018  Volume 38, Issue 4, Page(s) 313–314

    Language English ; French ; German
    Document type Article
    ZDB-ID 1340924-4
    Database Current Contents Medicine

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4528: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: [No title information]

    Bärfuss, Chloé / Erard, Alizé / Legrand, Céline / Waelchli, Rahel / Wicki, Chiara

    Revue medicale suisse

    2023  Volume 20, Issue 860, Page(s) 318–319

    Title translation L’apport des défibrillateurs à la société dans le canton de Vaud.
    MeSH term(s) Humans ; Defibrillators
    Language French
    Publishing date 2023-10-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    DOI 10.53738/REVMED.2024.20.860.318
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5998: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Strategien zur gemeinsamen Entscheidungsfindung in der Therapie bei Patient_innen mit onkologischen Erkrankungen.

    Kleber, Martina / Wicki, Andreas / Cheetham, Marcus

    Therapeutische Umschau. Revue therapeutique

    2022  Volume 79, Issue 8, Page(s) 401–408

    Abstract: Strategies for Shared Decision-making in Therapy for Patients with Oncological Disease - Quo vadis? ...

    Title translation Strategies for Shared Decision-making in Therapy for Patients with Oncological Disease - Quo vadis?
    Abstract Strategies for Shared Decision-making in Therapy for Patients with Oncological Disease - Quo vadis?
    MeSH term(s) Communication ; Decision Making ; Humans ; Medical Oncology ; Patient Participation ; Physician-Patient Relations
    Language German
    Publishing date 2022-07-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 82044-1
    ISSN 1664-2864 ; 0040-5930
    ISSN (online) 1664-2864
    ISSN 0040-5930
    DOI 10.1024/0040-5930/a001381
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.180: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Impact of topography on in situ soil wetness measurements for regional landslide early warning – a case study from the Swiss Alpine Foreland

    A. Wicki / P. Lehmann / C. Hauck / M. Stähli

    Natural Hazards and Earth System Sciences, Vol 23, Pp 1059-

    2023  Volume 1077

    Abstract: Recent studies have demonstrated the potential of in situ soil wetness measurements to predict regional shallow landslides. Increasing availability of monitoring data from sensor networks provides valuable information for developing future regional ... ...

    Abstract Recent studies have demonstrated the potential of in situ soil wetness measurements to predict regional shallow landslides. Increasing availability of monitoring data from sensor networks provides valuable information for developing future regional landslide early warning systems (LEWSs); however, most existing monitoring sites are located on flat terrain. The question arises of if the representativeness for regional landslide activity would improve if sensors were installed on a landslide-prone hillslope. To address this, two soil wetness monitoring stations were installed at close proximity on a steep slope and on a flat location in the Napf region (Northern Alpine Foreland of Switzerland), and measurements were conducted over a period of 3 years. As both sites inhibit similar lithological, vegetation, and precipitation characteristics, soil hydrological differences can be attributed to the impact of topography and hydrogeology. At the sloped site, conditions were generally wetter and less variable in time, and evidence was found for temporary lateral water transport along the slope. These differences were systematic and could be reduced by considering relative soil moisture changes. The application of a statistical landslide forecast model showed that both sites were equally able to distinguish critical from non-critical conditions for landslide triggering, which demonstrates the value of existing monitoring sites in flat areas for the application in LEWSs.
    Keywords Environmental technology. Sanitary engineering ; TD1-1066 ; Geography. Anthropology. Recreation ; G ; Environmental sciences ; GE1-350 ; Geology ; QE1-996.5
    Subject code 550
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Copernicus Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article: Stivarga fait ses preuves dans la pratique.

    Wicki, Andreas

    Revue medicale suisse

    2014  Volume 10, Issue 431, Page(s) 1109

    Title translation Stivarga shows effectiveness in practice.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Cecal Neoplasms/drug therapy ; Cecal Neoplasms/pathology ; Humans ; Male ; Middle Aged ; Neoplasm Metastasis ; Phenylurea Compounds/therapeutic use ; Pyridines/therapeutic use ; Treatment Outcome
    Chemical Substances Antineoplastic Agents ; Phenylurea Compounds ; Pyridines ; regorafenib (24T2A1DOYB)
    Language French
    Publishing date 2014-05-21
    Publishing country Switzerland
    Document type Case Reports ; News
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5998: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top