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Article: Diving Medicine: An Exciting Journey Through Time and Future Prospects.

Lampropoulou, Dimitra Ioanna / Papageorgiou, Dimitrios / Pliakou, Evangelia

2024 Volume 16, Issue 3, Page(s) e56947

Abstract: Humans, led by their eternal wish to explore the unknown, have always wanted to perfect their diving skills and conquer the sea world. The adverse conditions experienced by divers brought about medical problems and a new field of medicine. Diving ... ...

Abstract	Humans, led by their eternal wish to explore the unknown, have always wanted to perfect their diving skills and conquer the sea world. The adverse conditions experienced by divers brought about medical problems and a new field of medicine. Diving medicine serves the identification, treatment, and precautions against illnesses that are related to diving activities. While the development of diving equipment is advancing, divers have had the chance to reach greater depths for a longer time. Along with this success, a novel medical condition under the term 'decompression illness' (DCI) was introduced. Although the history of hyperbaric medicine is very long, progress in the field of mechanics has offered great contributions to the management of the disease. The first attempt at DCI guidelines was made by the US Navy in 1944-1945 and resulted in the creation of hyperbaric treatment tables. These tools received international recognition, offering a major advance. Hyperbaric-Diving Medicine holds an important place in modern medical science nowadays with indications for various diseases. At the same time, there is great scientific interest and a lot of research in the use of hyperbaric oxygen for several medical disorders, demonstrating great potential.
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.56947
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Rare Case of Thyroid Metastasis From Colorectal Cancer: Diagnostic and Therapeutic Challenges.

Lampropoulou, Dimitra Ioanna / Pliakou, Evangelia / Panagiotou, Maria Ourania / Mariolis-Sapsakos, Theodoros / Aravantinos, Gerasimos

Cureus

2023 Volume 15, Issue 12, Page(s) e50097

Abstract: The incidence of thyroid metastases among patients suffering from primary colorectal cancer is rare, and only a few cases have been described in the literature. As these metastases are usually asymptomatic, they most frequently present as incidentalomas ... ...

Abstract	The incidence of thyroid metastases among patients suffering from primary colorectal cancer is rare, and only a few cases have been described in the literature. As these metastases are usually asymptomatic, they most frequently present as incidentalomas on follow-up imaging. Hereby, we present and discuss an interesting case of metastatic sigmoid adenocarcinoma of the thyroid gland, diagnosed and treated at our institution.
Language	English
Publishing date	2023-12-07
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.50097
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Synchronous Gastric Adenocarcinoma and Diffuse Large B-Cell Lymphoma in the Pelvis: A Rare Case Presentation.

Pliakou, Evangelia / Lampropoulou, Dimitra-Ioanna / Soupos, Nikolaos / Aravantinos, Gerasimos

Case reports in gastrointestinal medicine

2022 Volume 2022, Page(s) 7535036

Abstract: Multiple primary cancer (MPC) is defined as more than one primary tumour diagnosed at the same patient, either simultaneously or sequentially. Its incidence is low and varies in reporting among medical centers. Diffuse large B-cell lymphoma (DLBCL) is ... ...

Abstract	Multiple primary cancer (MPC) is defined as more than one primary tumour diagnosed at the same patient, either simultaneously or sequentially. Its incidence is low and varies in reporting among medical centers. Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL) while gastric cancer (GC) is the fifth most frequently diagnosed malignancy. The aim of this article is to present a rare case of a female patient who was diagnosed with two synchronous malignancies, an adenocarcinoma of the stomach (SRCC) and an aggressive extranodal NH lymphoma (DLBCL) within 2 months. Given the fact that there is an expanding availability of more sensitive diagnostic and screening methods, we aim to increase surveillance amongst medical doctors and provide valuable information for further systematic analysis and identification of such rare cases of concurrent malignancies.
Language	English
Publishing date	2022-04-28
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627636-7
ISSN	2090-6536 ; 2090-6528
ISSN (online)	2090-6536
ISSN	2090-6528
DOI	10.1155/2022/7535036
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Article ; Online: Skin metastases from gastric cancer, a rare entity masquerading as erysipelas: A case report.

Pliakou, Evangelia / Lampropoulou, Dimitra Ioanna / Nasi, Despoina / Aravantinos, Gerasimos

Molecular and clinical oncology

2022 Volume 16, Issue 6, Page(s) 110

Abstract: Gastric cancer (GC) is the fifth most commonly diagnosed malignancy and the fourth leading cause of cancer death worldwide. Skin metastases from internal organs are rare; skin metastasis from GC occurs even more rarely than skin metastases originating ... ...

Abstract	Gastric cancer (GC) is the fifth most commonly diagnosed malignancy and the fourth leading cause of cancer death worldwide. Skin metastases from internal organs are rare; skin metastasis from GC occurs even more rarely than skin metastases originating from other organs, and is associated with systematic disease and poor prognosis. The present study described an interesting and rare case of an extensive skin rash in a 42-year-old man diagnosed with GC, which was mainly affecting his left hemithorax, abdomen and back. The rash masqueraded as erysipelas and was initially treated as such; however, it did not respond to antibiotics, corticosteroids and antihistamines. Due to its persistence and location, the rash was biopsied and GC metastasis was confirmed. Third-line chemotherapy was administered and the rash decreased in size; however, the patient suffered from disease deterioration with lung metastases and respiratory failure. The patient eventually died 4 months after the diagnosis of skin metastasis. In conclusion, cutaneous metastasis should be considered as a late and difficult to treat metastasis of GC, which requires high surveillance from medical oncologists, and a multidisciplinary approach for prompt and accurate diagnosis.
Language	English
Publishing date	2022-05-11
Publishing country	England
Document type	Case Reports
ZDB-ID	2796865-0
ISSN	2049-9469 ; 2049-9450
ISSN (online)	2049-9469
ISSN	2049-9450
DOI	10.3892/mco.2022.2543
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Article ; Online: Nanoparticle-Mediated Hyperthermia and Cytotoxicity Mechanisms in Cancer.

Bala, Vanessa-Meletia / Lampropoulou, Dimitra Ioanna / Grammatikaki, Stamatiki / Kouloulias, Vassilios / Lagopati, Nefeli / Aravantinos, Gerasimos / Gazouli, Maria

International journal of molecular sciences

2023 Volume 25, Issue 1

Abstract: Hyperthermia has the potential to damage cancerous tissue by increasing the body temperature. However, targeting cancer cells whilst protecting the surrounding tissues is often challenging, especially when implemented in clinical practice. In this ... ...

Abstract	Hyperthermia has the potential to damage cancerous tissue by increasing the body temperature. However, targeting cancer cells whilst protecting the surrounding tissues is often challenging, especially when implemented in clinical practice. In this direction, there are data showing that the combination of nanotechnology and hyperthermia offers more successful penetration of nanoparticles in the tumor environment, thus allowing targeted hyperthermia in the region of interest. At the same time, unlike radiotherapy, the use of non-ionizing radiation makes hyperthermia an attractive therapeutic option. This review summarizes the existing literature regarding the use of hyperthermia and nanoparticles in cancer, with a focus on nanoparticle-induced cytotoxicity mechanisms.
MeSH term(s)	Humans ; Hyperthermia ; Nanoparticles ; Neoplasms/therapy ; Hyperthermia, Induced
Language	English
Publishing date	2023-12-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25010296
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Article ; Online: The Role of EMT-Related lncRNAs in Ovarian Cancer.

Lampropoulou, Dimitra Ioanna / Papadimitriou, Marios / Papadimitriou, Christos / Filippou, Dimitrios / Kourlaba, Georgia / Aravantinos, Gerasimos / Gazouli, Maria

International journal of molecular sciences

2023 Volume 24, Issue 12

Abstract: Ovarian cancer (OC) is one of the deadliest cancers worldwide; late diagnosis and drug resistance are two major factors often responsible for high morbidity and treatment failure. Epithelial-to-mesenchymal transition (EMT) is a dynamic process that has ... ...

Abstract	Ovarian cancer (OC) is one of the deadliest cancers worldwide; late diagnosis and drug resistance are two major factors often responsible for high morbidity and treatment failure. Epithelial-to-mesenchymal transition (EMT) is a dynamic process that has been closely linked with cancer. Long non-coding RNAs (lncRNAs) have been also associated with several cancer-related mechanisms, including EMT. We conducted a literature search in the PubMed database in order to sum up and discuss the role of lncRNAs in regulating OC-related EMT and their underlying mechanisms. Seventy (70) original research articles were identified, as of 23 April 2023. Our review concluded that the dysregulation of lncRNAs is highly associated with EMT-mediated OC progression. A comprehensive understanding of lncRNAs' mechanisms in OC will help in identifying novel and sensitive biomarkers and therapeutic targets for this malignancy.
MeSH term(s)	Humans ; Female ; RNA, Long Noncoding/genetics ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/diagnosis ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic
Chemical Substances	RNA, Long Noncoding
Language	English
Publishing date	2023-06-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241210079
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Article ; Online: MicroRNAs and drug resistance in colorectal cancer with special focus on 5-fluorouracil.

Pouya, Fahima Danesh / Gazouli, Maria / Rasmi, Yousef / Lampropoulou, Dimitra Ioanna / Nemati, Mohadeseh

Molecular biology reports

2022 Volume 49, Issue 6, Page(s) 5165–5178

Abstract: Colorectal cancer is globally one of the most common cancers in all age groups. The current chemotherapy combinations for colorectal cancer treatment include 5-fluorouracil-based regimens; however, drug resistance remains one of the main reasons for ... ...

Abstract	Colorectal cancer is globally one of the most common cancers in all age groups. The current chemotherapy combinations for colorectal cancer treatment include 5-fluorouracil-based regimens; however, drug resistance remains one of the main reasons for chemotherapy failure and disease recurrence. Many studies have determined colorectal cancer chemoresistance mechanisms such as drug efflux, cell cycle arrest, DNA damage repair, apoptosis, autophagy, vital enzymes, epigenetic, epithelial-mesenchymal transition, stem cells, and immune system suppression. Several microRNAs affect drug resistance by regulating the drug resistance-related target genes in colorectal cancer. These drug resistance-related miRNAs may be used as promising biomarkers for predicting drug response or as potential therapeutic targets for treating patients with colorectal cancer. This work reviews and discuss the role of selected microRNAs in 5-fluorouracil resistance and their molecular mechanisms in colorectal cancer.
MeSH term(s)	Cell Line, Tumor ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Drug Resistance, Neoplasm/genetics ; Fluorouracil/pharmacology ; Fluorouracil/therapeutic use ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/metabolism ; Neoplasm Recurrence, Local/genetics
Chemical Substances	MicroRNAs ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2022-02-25
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-022-07227-1
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Article ; Online: The Role of Exosomal Non-Coding RNAs in Colorectal Cancer Drug Resistance.

Lampropoulou, Dimitra Ioanna / Pliakou, Evangelia / Aravantinos, Gerasimos / Filippou, Dimitrios / Gazouli, Maria

International journal of molecular sciences

2022 Volume 23, Issue 3

Abstract: Background: Colorectal cancer (CRC) is one of the most common types of cancer diagnosed worldwide with high morbidity; drug resistance is often responsible for treatment failure in CRC. Non-coding RNAs (ncRNAs) play distinct regulatory roles in ... ...

Abstract	Background: Colorectal cancer (CRC) is one of the most common types of cancer diagnosed worldwide with high morbidity; drug resistance is often responsible for treatment failure in CRC. Non-coding RNAs (ncRNAs) play distinct regulatory roles in tumorigenesis, cancer progression and chemoresistance. Methods: A literature search was conducted in PubMed database in order to sum up and discuss the role of exosomal ncRNAs (ex-ncRNAs) in CRC drug resistance/response and their possible mechanisms. Results: Thirty-six (36) original research articles were identified; these included exosome or extracellular vesicle (EV)-containing microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and small-interfering (siRNAs). No studies were found for piwi-interacting RNAs. Conclusions: Exosomal transfer of ncRNAs has been documented as a new mechanism of CRC drug resistance. Despite being in its infancy, it has emerged as a promising field for research in order to (i) discover novel biomarkers for therapy monitoring and/or (ii) reverse drug desensitization.
MeSH term(s)	Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Drug Resistance, Neoplasm/genetics ; Exosomes/genetics ; Exosomes/metabolism ; Humans ; RNA, Neoplasm/genetics ; RNA, Neoplasm/metabolism ; RNA, Untranslated/genetics ; RNA, Untranslated/metabolism
Chemical Substances	RNA, Neoplasm ; RNA, Untranslated
Language	English
Publishing date	2022-01-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23031473
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Article ; Online: The Role of EMT-Related lncRNAs in Ovarian Cancer

Dimitra Ioanna Lampropoulou / Marios Papadimitriou / Christos Papadimitriou / Dimitrios Filippou / Georgia Kourlaba / Gerasimos Aravantinos / Maria Gazouli

International Journal of Molecular Sciences, Vol 24, Iss 10079, p

2023 Volume 10079

Abstract	Ovarian cancer (OC) is one of the deadliest cancers worldwide; late diagnosis and drug resistance are two major factors often responsible for high morbidity and treatment failure. Epithelial-to-mesenchymal transition (EMT) is a dynamic process that has been closely linked with cancer. Long non-coding RNAs (lncRNAs) have been also associated with several cancer-related mechanisms, including EMT. We conducted a literature search in the PubMed database in order to sum up and discuss the role of lncRNAs in regulating OC-related EMT and their underlying mechanisms. Seventy (70) original research articles were identified, as of 23 April 2023. Our review concluded that the dysregulation of lncRNAs is highly associated with EMT-mediated OC progression. A comprehensive understanding of lncRNAs’ mechanisms in OC will help in identifying novel and sensitive biomarkers and therapeutic targets for this malignancy.
Keywords	lncRNAs ; ovarian cancer ; EMT ; biomarkers ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Nanoparticle-Mediated Hyperthermia and Cytotoxicity Mechanisms in Cancer

Vanessa-Meletia Bala / Dimitra Ioanna Lampropoulou / Stamatiki Grammatikaki / Vassilios Kouloulias / Nefeli Lagopati / Gerasimos Aravantinos / Maria Gazouli

International Journal of Molecular Sciences, Vol 25, Iss 1, p

2023 Volume 296

Abstract	Hyperthermia has the potential to damage cancerous tissue by increasing the body temperature. However, targeting cancer cells whilst protecting the surrounding tissues is often challenging, especially when implemented in clinical practice. In this direction, there are data showing that the combination of nanotechnology and hyperthermia offers more successful penetration of nanoparticles in the tumor environment, thus allowing targeted hyperthermia in the region of interest. At the same time, unlike radiotherapy, the use of non-ionizing radiation makes hyperthermia an attractive therapeutic option. This review summarizes the existing literature regarding the use of hyperthermia and nanoparticles in cancer, with a focus on nanoparticle-induced cytotoxicity mechanisms.
Keywords	cancer ; hyperthermia ; nanoparticles ; cytotoxicity mechanisms ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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