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  1. Article ; Online: Robust S

    Stephaniuk, Nadia T / Nascimento, Mitchell A / Nikoo, Sahar / Heyer, Elodie / Watanabe, Lara K / Rawson, Jeremy M

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2022  Volume 28, Issue 15, Page(s) e202103846

    Abstract: Cocrystallization of the dithiadiazolyl (DTDA) radicals p- ... ...

    Abstract Cocrystallization of the dithiadiazolyl (DTDA) radicals p-XC
    Language English
    Publishing date 2022-02-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202103846
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  2. Article ; Online: Transnational determinants of health for Central American migrants to the U.S.: Results of a qualitative study.

    Edberg, Mark / Benavides-Rawson, Jorge / Rivera, Ivonne / Shaikh, Hina / Monge, Rebeca / Grinker, Richard

    Global public health

    2020  Volume 16, Issue 3, Page(s) 415–430

    Abstract: ... to health risk factors for domestic U.S. populations. These are, however, often disassociated from the broader ... adjustment to the U.S. These domains were conceptualised as one transnational continuum, with health outcomes ... in multiple health outcomes (including PTSD) in the U.S. It also showed some patterns of resiliency, as well ...

    Abstract While some research on health determinants for immigrant/refugee populations has considered migration itself as a health determinant, much of this research employs constructs that focus on factors such as language, acculturation, norms, behaviours, beliefs, and social support, in a manner analogous to health risk factors for domestic U.S. populations. These are, however, often disassociated from the broader context of migration and its transnational continuum. As a contribution towards addressing that gap, this study reports on 75 life history interviews from recent Central American immigrants to assess potential health determinants in three linked domains - home country situation, migration experience, and adjustment to the U.S. These domains were conceptualised as one transnational continuum, with health outcomes potentially resulting from combined effects across domains. Interview data showed, among other results, extensive experience with/victimisation from violence in the home countries and during migration, resulting in multiple health outcomes (including PTSD) in the U.S. It also showed some patterns of resiliency, as well as added stressors from the current political environment. The results and protocol from this pilot study are useful for broader research efforts in multiple global settings, and as narratives, should also help counter negative public representations and support improved treatment.
    MeSH term(s) Acculturation ; Central America ; Humans ; Pilot Projects ; Refugees ; Transients and Migrants
    Language English
    Publishing date 2020-06-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2234129-8
    ISSN 1744-1706 ; 1744-1692
    ISSN (online) 1744-1706
    ISSN 1744-1692
    DOI 10.1080/17441692.2020.1779329
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  3. Book ; Online ; E-Book: Nutrition for elite athletes

    Rawson, Eric S.

    2016  

    Author's details ed. by Eric S. Rawson
    Keywords Athletes/Nutrition
    Subject code 613.2024796
    Language English
    Size XVIII, 298 S. : Ill.
    Publisher CRC Press
    Publishing place Boca Raton, Fla. u.a.
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT018914489
    ISBN 978-1-4665-5799-4 ; 9781466557987 ; 1-4665-5799-0 ; 1466557982
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Online: Fuckhead

    Rawson, David

    2013  

    Abstract: ... the Fury, and the TV sitcom Community's Abed Nadir, Rawson movingly, and with wry humor, articulates ... What is a fuckhead? David Rawson's Fuckhead is a surreal exploration of the literature, film ... fictional memoir, Rawson's work tells the story of an unnamed narrator whose familial relationships are ...

    Abstract What is a fuckhead? David Rawson's Fuckhead is a surreal exploration of the literature, film, nature and expectations of disability, and of fuckheads in literature and film. Part lyric essay, part fictional memoir, Rawson's work tells the story of an unnamed narrator whose familial relationships are defined by his VATER syndrome. Abused by his mother and stripped of a voice by his brother's need to be Tom Cruise via Rain Man, he sets out into a universe of literary tropes. I have always been of the mind that the novelist is allowed access to all experiences, as long as he ultimately has something to say. Plutarch and Samuel Johnson are typing somewhere in the desert of the next world, composing the ultimate collection of biographical criticism, explaining how David Lynch's entire filmography owes a debt to his club feet. But I and the friends who bought my novel agree the author is dead. The work is particularly interested in the relationship between Steinbeck's Of Mice and Men and what the narrator argues is Denis Johnson's reimagining of that work in the short story "Emergency" (in Johnson's Jesus' Son). But in accumulating characters with disabilities as widely diverse as Darth Vader, Benjy of Faulkner's The Sound and the Fury, and the TV sitcom Community's Abed Nadir, Rawson movingly, and with wry humor, articulates the assumptions and clichés faced by persons with disabilities, all the while creating a new family with his unlikely gathering of "fuckheads."
    Keywords History (General)
    Size 1 electronic resource (76 p.)
    Publisher punctum books
    Publishing place Verlagsort nicht ermittelbar
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020195655
    ISBN 9780615883410 ; 0615883419
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article: Prostate-Specific Antigen Trends Predict the Probability of Prostate Cancer in a Very Large U.S. Veterans Affairs Cohort.

    Karnes, R Jeffrey / MacKintosh, F Roy / Morrell, Christopher H / Rawson, Lori / Sprenkle, Preston C / Kattan, Michael W / Colicchia, Michele / Neville, Thomas B

    Frontiers in oncology

    2018  Volume 8, Page(s) 296

    Abstract: If prostate-specific antigen (PSA) trends help identify elevated prostate cancer (PCa) risk, they might provide early warning of progressing cancer for further evaluation and justify annual testing. Our objective was to determine whether PSA trends ... ...

    Abstract If prostate-specific antigen (PSA) trends help identify elevated prostate cancer (PCa) risk, they might provide early warning of progressing cancer for further evaluation and justify annual testing. Our objective was to determine whether PSA trends predict PCa likelihood. A biopsy cohort of 361,657 men was obtained from a Veterans Affairs database (1999-2012). PSA trends were estimated for the 310,458 men with at least 2 PSA tests prior to biopsy. Cancer tumors may grow exponentially with cells doubling periodically. We hypothesized that PSA from prostate cancer grows exponentially above a no cancer baseline. We estimated PSA trends on that basis along with five descriptive variables: last PSA before biopsy, growth rate in PSA from cancer above a baseline, PSA variability around the trend, number of PSA tests, and time span of tests. PSA variability is a new variable that measures percentage deviations of PSA tests from estimated trends with 0% variability for a smoothly increasing trend. Logistic regression models were used to estimate relationships between the probability of PCa at biopsy and the trend variables and age. All five PSA trend variables and age were significant predictors of prostate cancer at biopsy (
    Language English
    Publishing date 2018-08-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2018.00296
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  6. Article ; Online: Copper-promoted aerial oxidation of benzothiadiazines: access to benzothiadiazine S-oxide heterocycles.

    Clark, Ewan R / Hayward, John J / Leontowicz, Bryce J / Anwar, Muhammad U / Pilkington, Melanie / Rawson, Jeremy M

    Dalton transactions (Cambridge, England : 2003)

    2015  Volume 44, Issue 5, Page(s) 2071–2074

    Abstract: ... affords the first structurally characterised examples of thiadiazine S-oxides (). The isolation ... of the homoleptic Cu(II) 3-(2'-pyridyl)benzothiadiazide-S-oxide complex provides insight into the reaction mechanism. ...

    Abstract Cu(II)-promoted aerial oxidation of a series of benzothiadiazines () under ambient conditions affords the first structurally characterised examples of thiadiazine S-oxides (). The isolation of the homoleptic Cu(II) 3-(2'-pyridyl)benzothiadiazide-S-oxide complex provides insight into the reaction mechanism.
    Language English
    Publishing date 2015-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/c4dt03467h
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  7. Article ; Online: Health technology assessment and price negotiation alignment for rare disorder drugs in Canada: Who benefits?

    Rawson, Nigel S B

    Orphanet journal of rare diseases

    2022  Volume 17, Issue 1, Page(s) 218

    Abstract: ... except Quebec's) and the pan-Canadian Pharmaceutical Alliance (pCPA), which conducts price negotiations ... drug plans, but there was no distinct trend. The drug's price likely played a role in listing decisions ... When DRDs were listed, drug plans had access criteria consistent with CADTH's or stronger for all the DRDs ...

    Abstract Background: Since 2014, the Canadian Agency for Drugs and Technologies in Health (CADTH), which performs health technology assessments for all federal, provincial and territorial government drug programs (except Quebec's) and the pan-Canadian Pharmaceutical Alliance (pCPA), which conducts price negotiations with manufacturers for all government drug programs, have been aligning their processes.
    Objective: To examine trends in CADTH recommendations for non-oncology drugs for rare disorders (DRDs) released between 2014 and 2021, results of pCPA negotiations for the same drugs, and listings in government drug plans to assess who benefits from the alignment.
    Results: Recommendations were positive in 87% of the reviews, although all included clinical criteria for use and/or economic conditions. Almost 90% of the DRDs with a positive recommendation had a successful price negotiation and 71% of those with a negative recommendation had no negotiation. Although no recommendation published before mid-2016 had a specified price reduction, almost 95% of those issued afterwards included the price reduction required to achieve a specific low cost-effectiveness threshold. The median time between the DRDs receiving marketing approval and a completed price negotiation was 663 days. Negotiations for DRDs completed after 2017 generally had fewer listings in government drug plans, but there was no distinct trend. The drug's price likely played a role in listing decisions. When DRDs were listed, drug plans had access criteria consistent with CADTH's or stronger for all the DRDs.
    Conclusions: The governments who own, fund and manage CADTH and the pCPA benefit from their alignment. The alignment is less beneficial for patients waiting for access to the DRDs. The time taken by CADTH and pCPA actions and individual government drug plans to make listing decisions delays access. CADTH's clinical criteria have become more extensive and are applied rigorously by drug plans which restricts patient access to DRDs. Canadians with rare disorders urgently need their governments to implement a long-overdue, comprehensive rare disease strategy to ensure DRDs are reviewed and reimbursed quickly and equitably to provide adequate health care to all who need them.
    MeSH term(s) Canada ; Cost-Benefit Analysis ; Drug Costs ; Humans ; Negotiating ; Rare Diseases/drug therapy ; Technology Assessment, Biomedical/methods
    Language English
    Publishing date 2022-06-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2225857-7
    ISSN 1750-1172 ; 1750-1172
    ISSN (online) 1750-1172
    ISSN 1750-1172
    DOI 10.1186/s13023-022-02390-x
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  8. Article ; Online: Canadians Need Improved Access to Drugs for Rare Diseases, Not More Denial.

    Rawson, Nigel S B / Adams, John

    HealthcarePapers

    2023  Volume 21, Issue 2, Page(s) 4–10

    Abstract: Sirrs et al. (2023a) discuss what they consider "explosive growth" (p. 11) in the research and development (R&D) and commercialization of expensive drugs for rare diseases (DRDs). They contend that the "status quo is no longer an option" (Sirrs et al. ... ...

    Abstract Sirrs et al. (2023a) discuss what they consider "explosive growth" (p. 11) in the research and development (R&D) and commercialization of expensive drugs for rare diseases (DRDs). They contend that the "status quo is no longer an option" (Sirrs et al. 2023b: 75), so it is critical to drastically reduce the prices of DRDs and/or ration access.
    MeSH term(s) Humans ; Rare Diseases/drug therapy ; Canada
    Language English
    Publishing date 2023-07-07
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2141700-3
    ISSN 1929-6339 ; 1488-917X
    ISSN (online) 1929-6339
    ISSN 1488-917X
    DOI 10.12927/hcpap.2023.27112
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5882: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Prioritisation for therapies based on a disorder's severity: ethics and practicality.

    Rawson, Nigel S B / Adams, John

    Journal of medical ethics

    2022  Volume 48, Issue 2, Page(s) 95–96

    Language English
    Publishing date 2022-01-21
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 194927-5
    ISSN 1473-4257 ; 0306-6800
    ISSN (online) 1473-4257
    ISSN 0306-6800
    DOI 10.1136/medethics-2021-108099
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1163: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Gulliver and the Gentle Reader

    Claude RAWSON

    E-REA, Vol 18, Iss

    2021  Volume 2

    Abstract: The satire in Swift’s anatomy of the human animal in Gulliver’s Travels is unusually radical ... shifting instability in the register of the irony. The naïve Gulliver’s praise of humanity, as well ... of this separation. While knowing that the details of Gulliver’s enraged diatribes are substantiated by the facts ...

    Abstract The satire in Swift’s anatomy of the human animal in Gulliver’s Travels is unusually radical, comprehensive and aggressive. In the first three books it conventionally attacks humans for what they do, but at the end of book III and throughout book IV humans are attacked for what they are. From the beginning, the reader is wrongfooted by an unusually quarrelsome intimacy on the part of the narrative, and a constantly shifting instability in the register of the irony. The naïve Gulliver’s praise of humanity, as well as his deranged condemnation of it in the final book, are both separate from the implied voice of the satirist, which always makes itself felt. But the reader is left uncertain as to the exact degree and tone of this separation. While knowing that the details of Gulliver’s enraged diatribes are substantiated by the facts of the narrative, the unhinged nature of the speaker’s voice must be discounted as being in Timon’s manner which Swift explicitly disavowed in a famous letter to his friend Pope. The reader is thus left without the comfort and foothold of an extreme denunciation which could be dismissed as self-disarming precisely because the implied satirist’s voice is disengaged from the character. This is part of what Swift meant when he told Pope that the story was designed to vex the world rather than divert it.
    Keywords Jonathan Swift ; Gulliver’s Travels ; satire ; irony ; reader ; English language ; PE1-3729 ; Social sciences (General) ; H1-99
    Subject code 820
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Laboratoire d’Etudes et de Recherches sur le Monde Anglophone (LERMA)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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