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Article ; Online: Immunosuppressive, antimicrobial and insecticidal activities of inhibitor cystine knot peptides produced by teratocytes of the endoparasitoid wasp Cotesia flavipes (Hymenoptera: Braconidae)

Pinto, Ciro P. G. / Walker, Andrew A. / King, Glenn F. / Rossi, Guilherme D.

Insect Science. 2023 Aug., v. 30, no. 4 p.1105-1117

2023

Abstract: Teratocytes are specialized cells released by parasitoid wasps into their hosts. They are known for producing regulatory molecules that aid the development of immature parasitoids. We have recently reported the primary structures of cystine‐rich peptides, ...

Abstract	Teratocytes are specialized cells released by parasitoid wasps into their hosts. They are known for producing regulatory molecules that aid the development of immature parasitoids. We have recently reported the primary structures of cystine‐rich peptides, including some containing inhibitor cystine knot (ICK) motifs, produced by teratocytes of the parasitoid Cotesia flavipes (Hymenoptera: Braconidae). ICKs are known for their stability and diverse biological functions. In this study, we produced four putative ICK peptides from the teratocytes of C. flavipes using solid‐phase peptide synthesis or recombinant expression in E. coli, and investigated their functions on host immune modulation as well their potential to impair the development of two lepidopterans after ingestion of the peptides. In addition, the peptides were assayed against pathogens and human cells. The peptides did not influence total hemocyte count but suppressed cellular immunity, detectable as a reduction of hemocyte encapsulation (CftICK‐I, CftICK‐II, CftICK‐III) and spread indexes (CftICK‐IV) in the host. None of the peptides influenced the activities of prophenoloxidase and phenoloxidase in the hemolymph of larval Diatraea saccharalis (Lepidoptera: Crambidae). CftICK‐I and CftICK‐II with previously unknown function showed antifungal activity against Candida albicans but were non‐toxic to human cells. CftICK‐I, CftICK‐II, and CftICK‐III increased larval mortality and reduced leaf consumption of D. saccharalis, a permissive host for C. flavipes. The CftICK‐III also increased larval mortality and reduced leaf consumption of Spodoptera frugiperda (Lepidoptera: Noctuidae), a non‐permissive host for C. flavipes. This study highlights biological functions and biotechnological potential of ICK peptides from the teratocytes of C. flavipes.
Keywords	Candida albicans ; Cotesia flavipes ; Diatraea saccharalis ; Escherichia coli ; Spodoptera frugiperda ; antifungal properties ; cell-mediated immunity ; cystine ; encapsulation ; endoparasitoids ; hemocytes ; humans ; immunosuppression ; ingestion ; larvae ; leaves ; monophenol monooxygenase ; mortality ; peptides ; prophenoloxidase ; teratocytes ; wasps
Language	English
Dates of publication	2023-08
Size	p. 1105-1117.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2179775-4
ISSN	1744-7917 ; 1672-9609
ISSN (online)	1744-7917
ISSN	1672-9609
DOI	10.1111/1744-7917.13154
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Immunosuppressive, antimicrobial and insecticidal activities of inhibitor cystine knot peptides produced by teratocytes of the endoparasitoid wasp Cotesia flavipes (Hymenoptera: Braconidae).

Pinto, Ciro P G / Walker, Andrew A / King, Glenn F / Rossi, Guilherme D

Insect science

2022 Volume 30, Issue 4, Page(s) 1105–1117

Abstract	Teratocytes are specialized cells released by parasitoid wasps into their hosts. They are known for producing regulatory molecules that aid the development of immature parasitoids. We have recently reported the primary structures of cystine-rich peptides, including some containing inhibitor cystine knot (ICK) motifs, produced by teratocytes of the parasitoid Cotesia flavipes (Hymenoptera: Braconidae). ICKs are known for their stability and diverse biological functions. In this study, we produced four putative ICK peptides from the teratocytes of C. flavipes using solid-phase peptide synthesis or recombinant expression in E. coli, and investigated their functions on host immune modulation as well their potential to impair the development of two lepidopterans after ingestion of the peptides. In addition, the peptides were assayed against pathogens and human cells. The peptides did not influence total hemocyte count but suppressed cellular immunity, detectable as a reduction of hemocyte encapsulation (CftICK-I, CftICK-II, CftICK-III) and spread indexes (CftICK-IV) in the host. None of the peptides influenced the activities of prophenoloxidase and phenoloxidase in the hemolymph of larval Diatraea saccharalis (Lepidoptera: Crambidae). CftICK-I and CftICK-II with previously unknown function showed antifungal activity against Candida albicans but were non-toxic to human cells. CftICK-I, CftICK-II, and CftICK-III increased larval mortality and reduced leaf consumption of D. saccharalis, a permissive host for C. flavipes. The CftICK-III also increased larval mortality and reduced leaf consumption of Spodoptera frugiperda (Lepidoptera: Noctuidae), a non-permissive host for C. flavipes. This study highlights biological functions and biotechnological potential of ICK peptides from the teratocytes of C. flavipes.
MeSH term(s)	Humans ; Animals ; Wasps ; Hymenoptera ; Cystine ; Insecticides ; Escherichia coli ; Larva ; Moths ; Peptides ; Anti-Infective Agents ; Host-Parasite Interactions
Chemical Substances	Cystine (48TCX9A1VT) ; Insecticides ; Peptides ; Anti-Infective Agents
Language	English
Publishing date	2022-12-19
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2179775-4
ISSN	1744-7917 ; 1672-9609
ISSN (online)	1744-7917
ISSN	1672-9609
DOI	10.1111/1744-7917.13154
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Article ; Online: Proteotranscriptomics reveals the secretory dynamics of teratocytes, regulators of parasitization by an endoparasitoid wasp.

Pinto, Ciro P G / Walker, Andrew A / Robinson, Samuel D / King, Glenn F / Rossi, Guilherme D

Journal of insect physiology

2022 Volume 139, Page(s) 104395

Abstract: Parasitoid wasps have evolved sophisticated mechanisms of host regulation that establish a favorable environment for the development of immature parasitoids. While maternal venom and symbiotic virus-like particles are well-known mechanisms of host ... ...

Abstract	Parasitoid wasps have evolved sophisticated mechanisms of host regulation that establish a favorable environment for the development of immature parasitoids. While maternal venom and symbiotic virus-like particles are well-known mechanisms of host regulation, another less-studied mechanism is the secretion of host regulation factors by cells called teratocytes, extra-embryonic cells released during parasitoid larval eclosion. Consequently, identification and characterization of teratocyte secretory products has not been reported in detail for any parasitoid wasp. We aimed to analyze teratocyte secretory products released into hemolymph of the larval sugarcane borer Diatraea saccharalis (Fabricius, 1794) (Lepidoptera: Crambidae) by its biological control agent, the koinobiont endoparasitoid wasp Cotesia flavipes Cameron, 1891 (Hymenoptera: Braconidae). Teratocytes were released upon eclosion of parasitoid larvae four days after parasitization (DAP) and increased in number and size until six DAP. Total D. saccharalis hemocyte viability was reduced immediately after parasitization until DAP 2, while total hemocyte count was lower from the third DAP, and phenoloxidase and lysozyme activity were disrupted compared to non-parasitized controls. To examine the secretory products of teratocytes, we generated a teratocyte transcriptome and compared its in silico translated open reading frames to mass spectra obtained from hemolymph from parasitized and unparasitized hosts. This led to the identification of 57 polypeptides secreted by teratocytes, the abundance of which we tracked over 0-10 DAP. Abundant teratocyte products included proteins similar to bracovirus proteins and multiple disulfide-rich peptides. Most teratocyte products accumulated in hemolymph, reaching their highest concentrations immediately before parasitoid pupation. Our results provide insights into host regulation by teratocytes and reveal molecules that may be useful in biotechnology.
MeSH term(s)	Animals ; Hemocytes ; Host-Parasite Interactions ; Larva ; Moths ; Polydnaviridae ; Wasps/physiology
Language	English
Publishing date	2022-04-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1879-1611
ISSN (online)	1879-1611
DOI	10.1016/j.jinsphys.2022.104395
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Article ; Online: [18]F-fluoroethyl-l-tyrosine positron emission tomography for radiotherapy target delineation: Results from a Radiation Oncology credentialing program.

Barry, Nathaniel / Koh, Eng-Siew / Ebert, Martin A / Moore, Alisha / Francis, Roslyn J / Rowshanfarzad, Pejman / Hassan, Ghulam Mubashar / Ng, Sweet P / Back, Michael / Chua, Benjamin / Pinkham, Mark B / Pullar, Andrew / Phillips, Claire / Sia, Joseph / Gorayski, Peter / Le, Hien / Gill, Suki / Croker, Jeremy / Bucknell, Nicholas /

Bettington, Catherine / Syed, Farhan / Jung, Kylie / Chang, Joe / Bece, Andrej / Clark, Catherine / Wada, Mori / Cook, Olivia / Whitehead, Angela / Rossi, Alana / Grose, Andrew / Scott, Andrew M

Physics and imaging in radiation oncology

2024 Volume 30, Page(s) 100568

Abstract: Background and purpose: The [18]F-fluoroethyl-l-tyrosine (FET) PET in Glioblastoma (FIG) study is ...

Abstract	Background and purpose: The [18]F-fluoroethyl-l-tyrosine (FET) PET in Glioblastoma (FIG) study is an Australian prospective, multi-centre trial evaluating FET PET for newly diagnosed glioblastoma management. The Radiation Oncology credentialing program aimed to assess the feasibility in Radiation Oncologist (RO) derivation of standard-of-care target volumes (TV Materials and methods: Central review and analysis of TV Results: Data from 19 ROs across 10 trial sites (54 initial submissions, 8 resubmissions requested, 4 conditional passes) was assessed with an initial pass rate of 77.8 %; all resubmissions passed. TV Conclusions: The credentialing program demonstrated feasibility in successful credentialing of 19 ROs across 10 sites, increasing national expertise in TV
Language	English
Publishing date	2024-03-13
Publishing country	Netherlands
Document type	Journal Article
ISSN	2405-6316
ISSN (online)	2405-6316
DOI	10.1016/j.phro.2024.100568
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Article: [WITHDRAWN] Neuron-dependent tuft cell expansion initiates sinonasal allergic Type 2 inflammation.

Ortiz-Carpena, Jorge F / Inclan-Rico, Juan M / Pastore, Christopher F / Hung, Li-Yin / Wilkerson, William B / Weiner, Molly B / Lin, Cailu / Gentile, Maria Elena / Cohen, Noam A / Saboor, Ishmail Abdus / Vaughan, Andrew E / Rossi, Heather L / Herbert, De'Broski R

bioRxiv : the preprint server for biology

2023

Abstract: The authors have withdrawn this manuscript owing to inaccuracies in the calculation of tuft cell numbers and errors in the selection of immunofluorescence images used to support our claims. Therefore, the authors do not wish this work to be cited as ... ...

Abstract	The authors have withdrawn this manuscript owing to inaccuracies in the calculation of tuft cell numbers and errors in the selection of immunofluorescence images used to support our claims. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author.
Language	English
Publishing date	2023-09-19
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.07.04.547596
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Article ; Online: Immersion Time Determines Performance of Artificial Habitats in Commercial Harbours by Changing Biodiversity of Colonising Invertebrate Assemblages

Varenne, Alix / Richardson, Laura E. / Radford, Andrew N. / Rossi, F. / Lecaillon, Gilles / Gudefin, Anaïs / Bérenger, Lucas / Abadie, Etienne / Boissery, Pierre / Lenfant, Philippe / Simpson, Stephen D.

Diversity. 2023 Apr. 01, v. 15, no. 4

2023

Abstract: In highly modified coastal environments, such as commercial harbours, the installation of artificial habitats has garnered support as a means of enhancing local biological recruitment and connectivity. The success of these measures depends largely on the ...

Abstract	In highly modified coastal environments, such as commercial harbours, the installation of artificial habitats has garnered support as a means of enhancing local biological recruitment and connectivity. The success of these measures depends largely on the patterns of species colonisation. Using post-installation monitoring data, we compared the composition of assemblages of invertebrates colonising artificial habitats that were immersed for different periods (~6 vs. ~18 months) in three commercial harbours along the French Mediterranean coast. The artificial habitats were colonised by taxonomically diverse invertebrate assemblages of ecological and economic importance, including molluscs, crustaceans, and echinoids. Composition differed significantly with the immersion time of the artificial habitats, with total abundance, species richness, and evenness being significantly higher after ~18 than after ~6 months of immersion, indicating that long periods are necessary to enrich these new habitats with economically and ecologically important species. These results can inform restoration protocols and emphasise the value of post-installation monitoring programs.
Keywords	invertebrates ; species richness ; Mediterranean region
Language	English
Dates of publication	2023-0401
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2518137-3
ISSN	1424-2818
ISSN	1424-2818
DOI	10.3390/d15040505
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Article: Proteotranscriptomics reveals the secretory dynamics of teratocytes, regulators of parasitization by an endoparasitoid wasp

Pinto, Ciro P.G. / Walker, Andrew A. / Robinson, Samuel D. / King, Glenn F. / Rossi, Guilherme D.

Journal of insect physiology. 2022 May, June, v. 139

2022

Abstract	Parasitoid wasps have evolved sophisticated mechanisms of host regulation that establish a favorable environment for the development of immature parasitoids. While maternal venom and symbiotic virus-like particles are well-known mechanisms of host regulation, another less-studied mechanism is the secretion of host regulation factors by cells called teratocytes, extra-embryonic cells released during parasitoid larval eclosion. Consequently, identification and characterization of teratocyte secretory products has not been reported in detail for any parasitoid wasp. We aimed to analyze teratocyte secretory products released into hemolymph of the larval sugarcane borer Diatraea saccharalis (Fabricius, 1794) (Lepidoptera: Crambidae) by its biological control agent, the koinobiont endoparasitoid wasp Cotesia flavipes Cameron, 1891 (Hymenoptera: Braconidae). Teratocytes were released upon eclosion of parasitoid larvae four days after parasitization (DAP) and increased in number and size until six DAP. Total D. saccharalis hemocyte viability was reduced immediately after parasitization until DAP 2, while total hemocyte count was lower from the third DAP, and phenoloxidase and lysozyme activity were disrupted compared to non-parasitized controls. To examine the secretory products of teratocytes, we generated a teratocyte transcriptome and compared its in silico translated open reading frames to mass spectra obtained from hemolymph from parasitized and unparasitized hosts. This led to the identification of 57 polypeptides secreted by teratocytes, the abundance of which we tracked over 0–10 DAP. Abundant teratocyte products included proteins similar to bracovirus proteins and multiple disulfide-rich peptides. Most teratocyte products accumulated in hemolymph, reaching their highest concentrations immediately before parasitoid pupation. Our results provide insights into host regulation by teratocytes and reveal molecules that may be useful in biotechnology.
Keywords	Cotesia flavipes ; Diatraea saccharalis ; biological control agents ; biotechnology ; computer simulation ; eclosion ; endoparasitoids ; hemocytes ; lysozyme ; monophenol monooxygenase ; parasitic wasps ; parasitism ; polypeptides ; pupation ; secretion ; teratocytes ; transcriptome ; venoms ; viability ; wasps
Language	English
Dates of publication	2022-05
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0022-1910
DOI	10.1016/j.jinsphys.2022.104395
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Article ; Online: Venom composition of the endoparasitoid wasp Cotesia flavipes (Hymenoptera: Braconidae) and functional characterization of a major venom peptide.

Pinto, Ciro P G / Walker, Andrew A / Robinson, Samuel D / Chin, Yanni K-Y / King, Glenn F / Rossi, Guilherme D

Toxicon : official journal of the International Society on Toxinology

2021 Volume 202, Page(s) 1–12

Abstract: Endoparasitoid wasps use complex biochemical arsenals to suppress the normal humoral and cellular immune responses of their hosts in order to transform them into a suitable environment for development of their eggs and larvae. Venom injected during ... ...

Abstract	Endoparasitoid wasps use complex biochemical arsenals to suppress the normal humoral and cellular immune responses of their hosts in order to transform them into a suitable environment for development of their eggs and larvae. Venom injected during oviposition is a key component of this arsenal, but the functions of individual venom toxins are still poorly understood. Furthermore, there has been little investigation of the potential biotechnological use of these venom toxins, for example for control of agricultural pests. The endoparasitoid Cotesia flavipes (Hymenoptera: Braconidae) is a biocontrol agent reared in biofactories and released extensively in Brazil to control the sugarcane borer Diatraea saccharalis (Lepidoptera: Crambidae). The objectives of this work were to reveal venom components produced by C. flavipes and explore the function of a major venom peptide, Cf4. Using a combined proteomic/transcriptomic approach, we identified 38 putative venom toxins including both linear and disulfide-rich peptides, hydrolases, protease inhibitors, apolipophorins, lipid-binding proteins, and proteins of the odorant binding families. Because of its high abundance in the venom, we selected Cf4, a 33-residue peptide with three disulfide bonds, for synthesis and further characterization. We found that synthetic Cf4 reduced the capacity of D. saccharalis hemocytes to encapsulate foreign bodies without any effect on phenoloxidase activity, consistent with a role in disruption of the cellular host immune response. Feeding leaves coated with Cf4 to neonate D. saccharalis resulted in increased mortality and significantly reduced feeding compared to caterpillars fed untreated leaves, indicating that Cf4 is a potential candidate for insect pest control through ingestion. This study adds to our knowledge of endoparasitoid wasp venoms composition, host regulation mechanisms and their biotechnological potential for pest management.
MeSH term(s)	Animals ; Female ; Host-Parasite Interactions ; Humans ; Infant, Newborn ; Moths ; Peptides ; Proteomics ; Wasp Venoms ; Wasps
Chemical Substances	Peptides ; Wasp Venoms
Language	English
Publishing date	2021-09-20
Publishing country	England
Document type	Journal Article
ZDB-ID	204479-1
ISSN	1879-3150 ; 0041-0101
ISSN (online)	1879-3150
ISSN	0041-0101
DOI	10.1016/j.toxicon.2021.09.002
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Article ; Online: Trefoil Factor Family: A Troika for Lung Repair and Regeneration.

Rossi, Heather L / Ortiz-Carpena, Jorge F / Tucker, Devon / Vaughan, Andrew E / Mangalmurti, Nilam S / Cohen, Noam A / Herbert, De'Broski R

American journal of respiratory cell and molecular biology

2021 Volume 66, Issue 3, Page(s) 252–259

Abstract: Tissue damage in the upper and lower airways caused by mechanical abrasion, noxious chemicals, or pathogenic organisms must be followed by rapid restorative processes; otherwise, persistent immunopathology and disease may ensue. This review will discuss ... ...

Abstract	Tissue damage in the upper and lower airways caused by mechanical abrasion, noxious chemicals, or pathogenic organisms must be followed by rapid restorative processes; otherwise, persistent immunopathology and disease may ensue. This review will discuss evidence for the important role served by trefoil factor (TFF) family members in healthy and diseased airways of humans and rodents. Collectively, these peptides serve to both maintain and restore homeostasis through their regulation of the mucous layer and their control of cell motility, cell differentiation, and immune function in the upper and lower airways. We will also discuss important differences in which trefoil member tracks with homeostasis and disease between humans and mice, which poses a challenge for research in this area. Moreover, we discuss new evidence supporting newly identified receptor binding partners in the leucine-rich repeat and immunoglobulin-like domain-containing NoGo (LINGO) family in mediating the biological effects of TFF proteins in mouse models of epithelial repair and infection. Recent advances in our knowledge regarding TFF peptides suggest that they may be reasonable therapeutic targets in the treatment of upper and lower airway diseases of diverse etiologies. Further work understanding their role in airway homeostasis, repair, and inflammation will benefit from these newly uncovered receptor-ligand interactions.
MeSH term(s)	Animals ; Lung/metabolism ; Mice ; Peptides/metabolism ; Proteins ; Trefoil Factor-2 ; Trefoil Factors
Chemical Substances	Peptides ; Proteins ; Trefoil Factor-2 ; Trefoil Factors
Language	English
Publishing date	2021-11-16
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	1025960-0
ISSN	1535-4989 ; 1044-1549
ISSN (online)	1535-4989
ISSN	1044-1549
DOI	10.1165/rcmb.2021-0373TR
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Article: Skin cancer in skin of color.

Alexis, Andrew F / Rossi, Anthony M

Cutis

2012 Volume 89, Issue 5, Page(s) 208–211

MeSH term(s)	Continental Population Groups ; Delayed Diagnosis ; Health Services Accessibility ; Humans ; Melanoma/diagnosis ; Melanoma/ethnology ; Melanoma/pathology ; Prognosis ; Skin Neoplasms/diagnosis ; Skin Neoplasms/ethnology ; Skin Neoplasms/pathology ; Skin Pigmentation
Language	English
Publishing date	2012-05
Publishing country	United States
Document type	Editorial
ZDB-ID	391840-3
ISSN	0011-4162 ; 0151-9522
ISSN	0011-4162 ; 0151-9522
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