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  1. Article ; Online: Plasma levels of CCL21, but not CCL19, independently predict future coronary events in a prospective population-based cohort.

    Katra, Pernilla / Hennings, Viktoria / Nilsson, Jan / Engström, Gunnar / Engelbertsen, Daniel / Bengtsson, Eva / Björkbacka, Harry

    Atherosclerosis

    2023  Volume 366, Page(s) 1–7

    Abstract: Background and aims: The homeostatic chemokines CCL21 and CCL19 have been explored as biomarkers in cardiovascular disease prediction in patients with established cardiovascular disease, but associations between these chemokines and first-time coronary ... ...

    Abstract Background and aims: The homeostatic chemokines CCL21 and CCL19 have been explored as biomarkers in cardiovascular disease prediction in patients with established cardiovascular disease, but associations between these chemokines and first-time coronary event incidence have not been investigated before. Here, we explored associations between CCL21 or CCL19 and first-time incident coronary events in the general population-based Malmö Diet and Cancer cohort with two decades of follow-up.
    Methods: CCL21 and CCL19 levels in plasma were analysed with ELISA and proximity extension assay and associations with disease incidence were explored with conditional logistic regression in a nested case-control cohort (CCL21; n = 676) and with Cox regression in a population-based cohort (CCL19; n = 4636).
    Results: High CCL21 levels in plasma were associated with incident first-time coronary events independently of traditional risk factors (odds ratio of 2.64 with 95% confidence interval 1.62-4.31, p < 0.001, comparing the highest versus the lowest tertile of CCL21), whereas CCL19 was not. CCL19 was, however, associated with incident heart failure, as well as increased all-cause, cardiovascular and cancer mortality independently of age and sex.
    Conclusions: Even though CCL21 and CCL19 both signal through CCR7, these chemokines may not be interchangeable as disease predictors and CCL21 could be used for prediction of future coronary events in individuals without any previous coronary heart disease history.
    MeSH term(s) Humans ; Cardiovascular Diseases ; Chemokine CCL21 ; Chemokines ; Coronary Disease ; Prospective Studies ; Receptors, CCR7
    Chemical Substances CCL21 protein, human ; Chemokine CCL21 ; Chemokines ; Receptors, CCR7 ; CCL19 protein, human
    Language English
    Publishing date 2023-01-12
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2023.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 226: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Distinct populations of eosinophils in the human thymus with capacity to modulate thymocyte maturation.

    Albinsson, Sofie / Lingblom, Christine / Lundqvist, Christina / Hennings, Viktoria / Telemo, Esbjörn / Ekwall, Olov / Wennerås, Christine

    Immunology

    2022  Volume 169, Issue 1, Page(s) 57–68

    Abstract: Local differentiation of eosinophil precursors occurs in the human thymus. Thymic eosinophils are often positioned in the corticomedullary junction between the ... ...

    Abstract Local differentiation of eosinophil precursors occurs in the human thymus. Thymic eosinophils are often positioned in the corticomedullary junction between the CD4
    MeSH term(s) Infant ; Humans ; Thymocytes ; Eosinophils ; Thymus Gland ; Coculture Techniques ; Cell Differentiation ; CD8 Antigens/metabolism
    Chemical Substances CD8 Antigens
    Language English
    Publishing date 2022-12-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80124-0
    ISSN 1365-2567 ; 0019-2805 ; 0953-4954
    ISSN (online) 1365-2567
    ISSN 0019-2805 ; 0953-4954
    DOI 10.1111/imm.13610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Human MHC Class II and Invariant Chain Knock-in Mice Mimic Rheumatoid Arthritis with Allele Restriction in Immune Response and Arthritis Association.

    Romero-Castillo, Laura / Li, Taotao / Do, Nhu-Nguyen / Sareila, Outi / Xu, Bingze / Hennings, Viktoria / Xu, Zhongwei / Svensson, Carolin / Oliveira-Coelho, Ana / Sener, Zeynep / Urbonaviciute, Vilma / Ekwall, Olov / Burkhardt, Harald / Holmdahl, Rikard

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2024  , Page(s) e2401513

    Abstract: Transgenic mice expressing human major histocompatibility complex class II (MHCII) risk alleles are widely used in autoimmune disease research, but limitations arise due to non-physiologic expression. To address this, physiologically relevant mouse ... ...

    Abstract Transgenic mice expressing human major histocompatibility complex class II (MHCII) risk alleles are widely used in autoimmune disease research, but limitations arise due to non-physiologic expression. To address this, physiologically relevant mouse models are established via knock-in technology to explore the role of MHCII in diseases like rheumatoid arthritis. The gene sequences encoding the ectodomains are replaced with the human DRB1*04:01 and 04:02 alleles, DRA, and CD74 (invariant chain) in C57BL/6N mice. The collagen type II (Col2a1) gene is modified to mimic human COL2. Importantly, DRB1*04:01 knock-in mice display physiologic expression of human MHCII also on thymic epithelial cells, in contrast to DRB1*04:01 transgenic mice. Humanization of the invariant chain enhances MHCII expression on thymic epithelial cells, increases mature B cell numbers in spleen, and improves antigen presentation. To validate its functionality, the collagen-induced arthritis (CIA) model is used, where DRB1*04:01 expression led to a higher susceptibility to arthritis, as compared with mice expressing DRB1*04:02. In addition, the humanized T cell epitope on COL2 allows autoreactive T cell-mediated arthritis development. In conclusion, the humanized knock-in mouse faithfully expresses MHCII, confirming the DRB1*04:01 alleles role in rheumatoid arthritis and being also useful for studying MHCII-associated diseases.
    Language English
    Publishing date 2024-04-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202401513
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  4. Article ; Online: The presence of serum anti-SARS-CoV-2 IgA appears to protect primary health care workers from COVID-19.

    Hennings, Viktoria / Thörn, Karolina / Albinsson, Sofie / Lingblom, Christine / Andersson, Kerstin / Andersson, Christer / Järbur, Katarina / Pullerits, Rille / Idorn, Manja / Paludan, Søren R / Eriksson, Kristina / Wennerås, Christine

    European journal of immunology

    2022  Volume 52, Issue 5, Page(s) 800–809

    Abstract: The patterns of humoral and cellular responses to SARS-CoV-2 were studied in Swedish primary health care workers (n = 156) for 6 months during the Covid-19 pandemic. Serum IgA and IgG to SARS-CoV-2, T-cell proliferation and cytokine secretion, ... ...

    Abstract The patterns of humoral and cellular responses to SARS-CoV-2 were studied in Swedish primary health care workers (n = 156) for 6 months during the Covid-19 pandemic. Serum IgA and IgG to SARS-CoV-2, T-cell proliferation and cytokine secretion, demographic and clinical data, PCR-verified infection, and self-reported symptoms were monitored. The multivariate method OPLS-DA was used to identify immune response patterns coupled to protection from Covid-19. Contracting Covid-19 was associated with SARS-CoV-2-specific neutralizing serum IgG, T cell, IFN-γ, and granzyme B responses to SARS-CoV-2, self-reported typical Covid-19 symptoms, male sex, higher BMI, and hypertension. Not contracting Covid-19 was associated with female sex, IgA-dominated, or no antibody responses to SARS-CoV-2, airborne allergy, and smoking. The IgG-responders had SARS-CoV-2-specific T-cell responses including a cytotoxic CD4+ T-cell population expressing CD25, CD38, CD69, CD194, CD279, CTLA-4, and granzyme B. IgA-responders with no IgG response to SARS-CoV-2 constituted 10% of the study population. The IgA responses were partially neutralizing and only seen in individuals who did not succumb to Covid-19. To conclude, serum IgG-dominated responses correlated with T-cell responses to SARS-CoV-2 and PCR-confirmed Covid-19, whereas IgA-dominated responses correlated with not contracting the infection.
    MeSH term(s) Antibodies, Viral ; COVID-19 ; Female ; Granzymes ; Humans ; Immunoglobulin A ; Immunoglobulin G ; Male ; Pandemics/prevention & control ; Primary Health Care ; SARS-CoV-2
    Chemical Substances Antibodies, Viral ; Immunoglobulin A ; Immunoglobulin G ; Granzymes (EC 3.4.21.-)
    Language English
    Publishing date 2022-02-18
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202149655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 489: Show issues Location:
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    Zs.MG 85: Show issues

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  5. Article ; Online: Severe COVID-19 in an APS1 patient with interferon autoantibodies treated with plasmapheresis.

    Lemarquis, Andri / Campbell, Tessa / Aranda-Guillén, Maribel / Hennings, Viktoria / Brodin, Petter / Kämpe, Olle / Blennow, Kaj / Zetterberg, Henrik / Wennerås, Christine / Eriksson, Kristina / Landegren, Nils / Bryceson, Yenan / Berg, Stefan / Ekwall, Olov

    The Journal of allergy and clinical immunology

    2021  Volume 148, Issue 1, Page(s) 96–98

    MeSH term(s) Adaptive Immunity ; Adrenal Cortex Hormones/therapeutic use ; Antibodies, Viral/blood ; Autoantibodies/blood ; COVID-19/immunology ; COVID-19/therapy ; Cells, Cultured ; Child ; Female ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Interferon Type I/immunology ; Interleukins/immunology ; Lymphocyte Activation ; Plasmapheresis/methods ; Polyendocrinopathies, Autoimmune/immunology ; Polyendocrinopathies, Autoimmune/therapy ; SARS-CoV-2/immunology ; Severity of Illness Index ; Transcription Factors/genetics ; AIRE Protein ; Interleukin-22
    Chemical Substances Adrenal Cortex Hormones ; Antibodies, Viral ; Autoantibodies ; Immunoglobulins, Intravenous ; Interferon Type I ; Interleukins ; Transcription Factors ; interferon omega 1
    Language English
    Publishing date 2021-04-16
    Publishing country United States
    Document type Case Reports ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2021.03.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.92: Show issues Location:
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  6. Article ; Online: Domestic pigs are susceptible to infection with influenza B viruses.

    Ran, Zhiguang / Shen, Huigang / Lang, Yuekun / Kolb, Elizabeth A / Turan, Nuri / Zhu, Laihua / Ma, Jingjiao / Bawa, Bhupinder / Liu, Qinfang / Liu, Haixia / Quast, Megan / Sexton, Gabriel / Krammer, Florian / Hause, Ben M / Christopher-Hennings, Jane / Nelson, Eric A / Richt, Juergen / Li, Feng / Ma, Wenjun

    Journal of virology

    2015  Volume 89, Issue 9, Page(s) 4818–4826

    Abstract: ... from each of the two genetically and antigenically distinct lineages of IBVs: B/Brisbane/60/2008 (Victoria lineage) and ... Victoria lineage virus among pigs being observed. Our results demonstrate that pigs are susceptible to IBV ...

    Abstract Unlabelled: Influenza B virus (IBV) causes seasonal epidemics in humans. Although IBV has been isolated from seals, humans are considered the primary host and reservoir of this important pathogen. It is unclear whether other animal species can support the replication of IBV and serve as a reservoir. Swine are naturally infected with both influenza A and C viruses. To determine the susceptibility of pigs to IBV infection, we conducted a serological survey for U.S. Midwest domestic swine herds from 2010 to 2012. Results of this study showed that antibodies to IBVs were detected in 38.5% (20/52) of sampled farms, and 7.3% (41/560) of tested swine serum samples were positive for IBV antibodies. Furthermore, swine herds infected with porcine reproductive and respiratory syndrome virus (PRRSV) showed a higher prevalence of IBV antibodies in our 2014 survey. In addition, IBV was detected in 3 nasal swabs collected from PRRSV-seropositive pigs by real-time RT-PCR and sequencing. Finally, an experimental infection in pigs, via intranasal and intratracheal routes, was performed using one representative virus from each of the two genetically and antigenically distinct lineages of IBVs: B/Brisbane/60/2008 (Victoria lineage) and B/Yamagata/16/1988 (Yamagata lineage). Pigs developed influenza-like symptoms and lung lesions, and they seroconverted after virus inoculation. Pigs infected with B/Brisbane/60/2008 virus successfully transmitted the virus to sentinel animals. Taken together, our data demonstrate that pigs are susceptible to IBV infection; therefore, they warrant further surveillance and investigation of swine as a potential host for human IBV.
    Importance: IBV is an important human pathogen, but its ability to infect other species, for example, pigs, is not well understood. We showed serological evidence that antibodies to two genetically and antigenically distinct lineages of IBVs were present among domestic pigs, especially in swine herds previously infected with PRRSV, an immunosuppressive virus. IBV was detected in 3 nasal swabs from PRRSV-seropositive pigs by real-time reverse transcription-PCR and sequencing. Moreover, both lineages of IBV were able to infect pigs under experimental conditions, with transmissibility of influenza B/Victoria lineage virus among pigs being observed. Our results demonstrate that pigs are susceptible to IBV infections, indicating that IBV is a swine pathogen, and swine may serve as a natural reservoir of IBVs. In addition, pigs may serve as a model to study the mechanisms of transmission and pathogenesis of IBVs.
    MeSH term(s) Animals ; Antibodies, Viral/blood ; Influenza B virus/immunology ; Influenza B virus/isolation & purification ; Lung/pathology ; Lung/virology ; Midwestern United States/epidemiology ; Nasal Mucosa/virology ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/pathology ; Orthomyxoviridae Infections/veterinary ; Orthomyxoviridae Infections/virology ; Real-Time Polymerase Chain Reaction ; Sequence Analysis, DNA ; Seroepidemiologic Studies ; Sus scrofa
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2015-02-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.00059-15
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