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Article ; Online: Epidemiology of Colorectal Cancer in Patients admitted to Imam Reza hospital in Kermanshah from 2006 to 2011

Seyed Jafar Navabi / Behrouz Beiranvand / Yadollah Pournia / Babak Izadi / Jamal Hosseini / Zia Obeidavi / Bahram Nasiri / Soheil Rahbar

Basic & Clinical Cancer Research, Vol 5, Iss 1&

2012 Volume 2

Abstract: ... of colorectal cancer in Imam Reza hospital in Kermanshah, Iran, in a five-year period. Methods ... This cross-sectional study included all the patients (N=167) admitted to Imam Reza hospital in Kermanshah over a five-year ...

Abstract	Background : The aim of this study was to investigate the epidemiological features of colorectal cancer in Imam Reza hospital in Kermanshah, Iran, in a five-year period. Methods: This cross-sectional study included all the patients (N=167) admitted to Imam Reza hospital in Kermanshah over a five-year period, diagnosed with colorectal cancer through performing colonoscopy and confirming via pathology. The census sampling was applied, and the data collection tool was a questionnaire on demographic variables, smoking history, and family history of cancer in immediate relatives. The data were analyzed using the descriptive statistics of frequencies and ratios, and the statistical tests of t-test and chi-square. Results: The mean age of the patients was 58.67Â±14.31 years old (14-87 years), and 12 % of the patients were under 40 years old. The majority of the patients (52.1%) were males, but no significant difference was found between the two genders in terms of age (P=0.939). The rectum (31.1%), the sigmoid colon (20.4 %), and the ascending colon (18.6%) were the most common tumor sites. Colon adenocarcinoma (96.4%) was the most common reported pathology, 30.5 % of the patients were cigarette smokers, and abdominal pain (22%) was the most common complaint on admission. Conclusion: Given the results of the present study, it is highly recommended that comprehensive studies should be conducted on screening colorectal cancer in high risk populations in order to reduce the incidence and prevalence of the disease and treat it more effectively based on early diagnosis.
Keywords	Adenocarcinoma ; Lymphoma ; Constipation ; Abdominal pain ; Gastrointestinal bleeding ; Kermanshah ; Medicine ; R
Subject code	610
Language	English
Publishing date	2012-12-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: Pediatric head and neck tumors

Rahbar, Reza

A-Z guide to presentation and multimodality management

2014

Author's details	Reza Rahbar ... ed
Language	English
Size	XIII, 389 S. : zahlr. Ill.
Publisher	Springer Science+Business Media
Publishing place	New York u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT018130355
ISBN	978-1-4614-8754-8 ; 9781461487555 ; 1-4614-8754-4 ; 1461487552
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2014 A 189	available for loan (reading room)	Lesesaal EG

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Article ; Online: Pediatric Otolaryngology in COVID-19.

Rickert, Scott / Rahbar, Reza

Otolaryngologic clinics of North America

2022 Volume 55, Issue 6, Page(s) 1321–1335

Abstract: While the majority of the initial attention to symptomatic COVID-19 focused on adult patients as well as adult critical care and first responders, the pandemic drastically altered care throughout the entire health care industry. COVID-19 has had a ... ...

Abstract	While the majority of the initial attention to symptomatic COVID-19 focused on adult patients as well as adult critical care and first responders, the pandemic drastically altered care throughout the entire health care industry. COVID-19 has had a profound effect on the treatment and care of pediatric patients within pediatric otolaryngology. The objective of this article is to highlight the unique ramifications of COVID-19 in general and its effect within pediatric otolaryngology, with a focus on the immediate and potential long-term shifts in practice. This article addresses several aspects of care within pediatric otolaryngology including safety, diagnosis, and treatment of COVID-19 detailing the unique effects of the pandemic on the pediatric otolaryngology specialty and opportunities.
MeSH term(s)	Adult ; Humans ; Child ; COVID-19 ; SARS-CoV-2 ; Pandemics ; Otolaryngology
Language	English
Publishing date	2022-08-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	417489-6
ISSN	1557-8259 ; 0030-6665
ISSN (online)	1557-8259
ISSN	0030-6665
DOI	10.1016/j.otc.2022.07.020
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Article ; Online: Paediatric nasal dermoid: evaluation and management.

Adil, Eelam / Rahbar, Reza

Current opinion in otolaryngology & head and neck surgery

2021 Volume 29, Issue 6, Page(s) 487–491

Abstract: Purpose of review: The aim of this study was to present the evaluation and current management of congenital paediatric nasal dermoid.: Recent findings: There has been a trend towards less invasive surgical excision techniques, including purely ... ...

Abstract	Purpose of review: The aim of this study was to present the evaluation and current management of congenital paediatric nasal dermoid. Recent findings: There has been a trend towards less invasive surgical excision techniques, including purely endoscopic excision, endoscopic-assisted approaches and midline excision with nasal bone osteotomies and bone flap. These approaches allow adequate access for both total resection and nasal contour and skull base reconstruction. Following resection, if nasal bone osteotomies are insufficient for restoring nasal appearance, free temporoparietal fascial graft and/or conchal cartilage can be considered. For nasal tip deformities, interdomal sutures and free fat grafting are a suitable option. Summary: Complete surgical excision remains the treatment of choice for nasal dermoid lesions. The surgical approach taken and reconstruction depends on the type of lesion (cyst versus sinus or fistula), location (intranasal versus extranasal), whether or not there is intracranial extension, and experience of the surgical team.
MeSH term(s)	Child ; Dermoid Cyst/diagnosis ; Dermoid Cyst/surgery ; Endoscopy ; Humans ; Nose ; Nose Neoplasms/diagnosis ; Nose Neoplasms/surgery ; Skull Base
Language	English
Publishing date	2021-10-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1232518-1
ISSN	1531-6998 ; 1068-9508
ISSN (online)	1531-6998
ISSN	1068-9508
DOI	10.1097/MOO.0000000000000765
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Zs.A 4814: Show issues

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Article ; Online: Apoptotic-Related MiRNAs Correlated with Functional and Flow Cytometric Parameters in Asthenozoospermic Holstein Bulls After Freeze-Thaw Process.

Taravat, Morteza / Roshanzamir, Amirmahdi / Rahbar, Maryam / Topraggaleh, Tohid Rezaei / Asadpour, Reza / Bucak, Mustafa Numan

Biopreservation and biobanking

2024

Abstract: Many cellular processes in spermatozoa, including apoptosis and motility, are regulated by miRNA. Different miRNAs and molecular pathways are involved in asthenozoospermia (AS) conditions, which are thought to be one of the causes of infertility with ... ...

Abstract	Many cellular processes in spermatozoa, including apoptosis and motility, are regulated by miRNA. Different miRNAs and molecular pathways are involved in asthenozoospermia (AS) conditions, which are thought to be one of the causes of infertility with reduced sperm motility. Thirty-two semen samples from four Holstein bulls with normozoospermia (NS), total motility ≥ 70%, and progressive motility ≥ 60%, and 32 semen samples from four bulls with AS, total motility ≤ 40%, and progressive motility ≤ 32% were used to investigate the function of apoptosis-related miRNAs in the AS group. Samples were then aspirated into a 0.5 mL straw after dilution with a Tris-egg yolk extender and frozen at -196°C. After freezing, semen samples were thawed for 2 weeks at 37°C and sperm kinematic parameters, plasma membrane integrity, acrosome integrity, DNA fragmentation, apoptosis status, and expression of apoptosis-related miRNAs (miR-2114, miR-296-3p, miR-455-3p, and miR345-3p) were evaluated. Our results showed that the functional and flow cytometric parameters of the NS group were significantly better than those of the AS group. In the NS group, miR-455-3pp and miR-2412 were upregulated, while miR-345-3p was downregulated compared with the AS group. In the AS group, miR-296-39, miR-2412, and miR-345-3p levels were strongly correlated with membrane integrity, DNA fragmentation, and apoptosis status. The findings demonstrated that the selected miRNAs based on bioinformatic analysis in AS and NS samples had a substantial association with functional and flow cytometry indicators and may be involved in regulating apoptosis and motility in AS samples.
Language	English
Publishing date	2024-04-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2593993-2
ISSN	1947-5543 ; 1947-5535
ISSN (online)	1947-5543
ISSN	1947-5535
DOI	10.1089/bio.2023.0135
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Article ; Online: Investigating the Economic Burden of Implant Surgery on the Urban Household in Ardabil Province in 2022(Original Article)

Soheila Derisavy Jorfian / Madi Rahbar / Reza Savareh

Journal of Ardabil University of Medical Sciences, Vol 23, Iss 3, Pp 215-

2023 Volume 226

Abstract: Background: despite the many benefits of dental implants, their cost remains a controversial issue. No study in Iran evaluated the costs and benefits of this treatment accurately, so the present study aimed to investigate the economic burden of implant ... ...

Abstract	Background: despite the many benefits of dental implants, their cost remains a controversial issue. No study in Iran evaluated the costs and benefits of this treatment accurately, so the present study aimed to investigate the economic burden of implant surgery on the urban households of Ardabil province in 2021. Methods: in this descriptive-analytical, cross-sectional study, the economic burden of implant surgery was estimated using the cost of illness method and human capital method. In this study, based on the content and purpose, the prevalence-based approach was used and a suitable checklist was prepared. The statistical population was patients referred to public and private centers providing dental services in Ardabil city. The sample size was calculated to be 160 people and a random sampling method was used for sampling. . Data analysis was done with SPSS version 21 software and Excel software. Results: The results of the investigation showed that the total cost of implant surgery per unit was (118680744 Rials), 82.11% of these costs were related to direct medical costs, 10.92% were related to non-medical direct costs, and 6.97% were related to indirect medical expenses. Also, the economic burden of implant surgery on Ardabil society was estimated at 71 trillion 467 billion 62 million 235 thousand 635 Rials. Conclusion: Implant surgery imposes a huge cost on society, so by planning the essential preventive tooth decay strategy, the economic burden imposed by implant surgery on the society of Ardabil can be reduced in the future.
Keywords	implant ; economic burden ; cost ; Medicine (General) ; R5-920
Subject code	670
Language	Persian
Publishing date	2023-10-01T00:00:00Z
Publisher	Ardabil University of Medical Sciences
Document type	Article ; Online
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Article ; Online: Characterization of Eosinophilic Esophagitis in Infants and Toddlers.

Hirsch, Suzanna / Cohen, Alexandra / Rahbar, Reza / Rubinstein, Eitan / Rosen, Rachel

Journal of pediatric gastroenterology and nutrition

2023 Volume 77, Issue 1, Page(s) 86–92

Abstract: Objectives: The objective of this study is to determine demographic and clinical characteristics of infants and toddlers <2 years with eosinophilic esophagitis (EoE) and to assess treatment response in this rarely studied pediatric age group.: Methods! ...

Abstract	Objectives: The objective of this study is to determine demographic and clinical characteristics of infants and toddlers <2 years with eosinophilic esophagitis (EoE) and to assess treatment response in this rarely studied pediatric age group. Methods: Retrospective study of children <2 years diagnosed with EoE at a single center from 2016 to 2018. EoE was defined by ≥15 eosinophils per high power field (eos/hpf) on at least 1 esophageal biopsy. Demographics, symptoms, and endoscopic findings were collected via chart review. EoE treatment [proton pump inhibitor (PPI), swallowed steroids, dietary restriction, or a combination] and treatment responses on all follow-up endoscopies were reviewed, with remission defined as <15 eos/hpf. Results: Forty-two children ages 1.3 ± 0.4 years underwent 3.8 ± 2.3 endoscopies over 3.6 ± 1.7 years of follow-up. Thirty-six children (86%) were male, and comorbidities included atopy (86%), reflux (74%), and a history of cow's milk protein allergy (40%). Common symptoms were feeding difficulties in 67% of patients (with gagging or coughing with feeding in 60% and difficulty with progression to pureed or solid foods in 43%), vomiting (57%), and coughing/wheezing (52%). Of the 37 patients with follow-up endoscopies, 25 (68%) had histologic remission. There was an effect of therapy type on histologic response ( P = 0.004) with the best responses seen on combinations of diet/steroids or diet/PPI and the worst response seen on PPIs alone. All patients showed improvement in ≥1 symptom at the time of first follow-up endoscopy. Conclusions: EoE should be considered in young children with feeding difficulties, vomiting, or respiratory symptoms. All patients improved clinically with standard medical or dietary interventions, however there is dissociation between clinical and histologic response with only 2 of 3 patients achieving histologic remission.
MeSH term(s)	Female ; Animals ; Cattle ; Male ; Eosinophilic Esophagitis/diagnosis ; Eosinophilic Esophagitis/epidemiology ; Eosinophilic Esophagitis/therapy ; Retrospective Studies ; Proton Pump Inhibitors/therapeutic use ; Vomiting/etiology ; Vomiting/drug therapy
Chemical Substances	Proton Pump Inhibitors
Language	English
Publishing date	2023-04-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0000000000003803
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Zs.A 1728: Show issues

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Article ; Online: Complex Pediatric Otolaryngology Subcertification-Now Is the Time.

Messner, Anna H / Rahbar, Reza / Preciado, Diego

JAMA otolaryngology-- head & neck surgery

2021 Volume 147, Issue 7, Page(s) 586–588

MeSH term(s)	Certification ; Clinical Competence ; Education, Medical, Graduate ; Educational Measurement ; Humans ; Otolaryngology/education ; Pediatrics/education ; Specialty Boards ; United States
Language	English
Publishing date	2021-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2701825-8
ISSN	2168-619X ; 2168-6181
ISSN (online)	2168-619X
ISSN	2168-6181
DOI	10.1001/jamaoto.2021.0533
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Article: Interplay of miRNAs and lncRNAs in STAT3 signaling pathway in colorectal cancer progression.

Rahbar Farzam, Omid / Najafi, Souzan / Amini, Mohammad / Rahimi, Zohreh / Dabbaghipour, Reza / Zohdi, Omid / Asemani Shahgoli, Ghazale / Baradaran, Behzad / Akbari, Bahman

Cancer cell international

2024 Volume 24, Issue 1, Page(s) 16

Abstract: In recent decades, colorectal cancer (CRC) has turned into one of the most widespread malignancies, and the incidence of this malignancy is expected to increase. Despite considerable improvements in therapeutic approaches, the prognosis, and the ... ...

Abstract	In recent decades, colorectal cancer (CRC) has turned into one of the most widespread malignancies, and the incidence of this malignancy is expected to increase. Despite considerable improvements in therapeutic approaches, the prognosis, and the management of CRC face many problems. Likely, the main limitation in the successful treatment of CRC is the lack of appropriate clinical therapeutic targets. As an effective target, the signal transducer and activator of transcription 3 (STAT3) are regulated by a wide range of genes and involved in cellular processes, including cell growth, migration, invasion, immunosuppression, and angiogenesis. Aberrant regulation of STAT3 signaling leads to cellular dysfunction, diseases, and malignancies, including CRC. Consequently, targeting this signaling pathway is considered one of the therapeutic strategies used in CRC treatment. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are non-coding RNA molecules with partial or no protein-coding activity that participate in gene regulation at epigenetic, transcriptional, and post-transcriptional levels and regulate multiple signaling pathways, including STAT3 signaling (especially JAK/STAT). Therefore, these regulatory molecules are suggested to be very promising targets to present new insights into overcoming the limitations of conventional therapeutic strategies. Therefore, the current review study aimed to summarize the therapeutic and diagnostic significance of miRNAs and lncRNAs and their therapeutic and diagnostic significance related to the expression and activity of STAT3 in CRC.
Language	English
Publishing date	2024-01-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2091573-1
ISSN	1475-2867
ISSN	1475-2867
DOI	10.1186/s12935-023-03202-3
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Article ; Online: Targeting Efficient Features of Urate Oxidase to Increase Its Solubility.

Rahbar, Mohammad Reza / Nezafat, Navid / Morowvat, Mohammad Hossein / Savardashtaki, Amir / Ghoshoon, Mohammad Bagher / Mehrabani-Zeinabad, Kamran / Ghasemi, Younes

Applied biochemistry and biotechnology

2024

Abstract: With the demand for mass production of protein drugs, solubility has become a serious issue. Extrinsic and intrinsic factors both affect this property. A homotetrameric cofactor-free urate oxidase (UOX) is not sufficiently soluble. To engineer UOX for ... ...

Abstract	With the demand for mass production of protein drugs, solubility has become a serious issue. Extrinsic and intrinsic factors both affect this property. A homotetrameric cofactor-free urate oxidase (UOX) is not sufficiently soluble. To engineer UOX for optimum solubility, it is important to identify the most effective factor that influences solubility. The most effective feature to target for protein engineering was determined by measuring various solubility-related factors of UOX. A large library of homologous sequences was obtained from the databases. The data was reduced to six enzymes from different organisms. On the basis of various sequence- and structure-derived elements, the most and the least soluble enzymes were defined. To determine the best protein engineering target for modification, features of the most and least soluble enzymes were compared. Metabacillus fastidiosus UOX was the most soluble enzyme, while Agrobacterium globiformis UOX was the least soluble. According to the comparison-constant method, positive surface patches caused by arginine residue distribution are appropriate targets for modification. Two Arg to Ala mutations were introduced to the least soluble enzyme to test this hypothesis. These mutations significantly enhanced the mutant's solubility. While different algorithms produced conflicting results, it was difficult to determine which proteins were most and least soluble. Solubility prediction requires multiple algorithms based on these controversies. Protein surfaces should be investigated regionally rather than globally, and both sequence and structural data should be considered. Several other biotechnological products could be engineered using the data reduction and comparison-constant methods used in this study.
Language	English
Publishing date	2024-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	392344-7
ISSN	1559-0291 ; 0273-2289
ISSN (online)	1559-0291
ISSN	0273-2289
DOI	10.1007/s12010-023-04819-w
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